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Asset Manager ← All Institutions

Frazier Life Sciences Management, L.P.

Q2 2025 · Filed 2025-08-14
Market Value
$2.2B
+20.7%
Holdings
49
New Purchases
7
Added To
15
Closed
5
Reduced
5
Top 10 Concentration
67.1%
Turnover
24.5%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
VRNA 14.79% 12.25% +2.55% $320M
PHAT 5.53% 3.54% +1.99% $120M
AURA 1.48% 0.00% +1.48% $32M
ZLAB 2.11% 0.71% +1.41% $46M
EOLS 1.04% 0.00% +1.04% $22M
AKRO 0.90% 0.00% +0.90% $20M
CYTK 0.85% 0.00% +0.85% $18M
JBIO 0.82% 0.00% +0.82% $18M
MBX 3.16% 2.46% +0.69% $68M
TVTX 0.69% 0.00% +0.69% $15M
LXEO 0.82% 0.18% +0.64% $18M
VALN 0.38% 0.00% +0.38% $8M
RARE 1.65% 1.33% +0.32% $36M
COGT 0.58% 0.31% +0.26% $12M
BBIO 7.59% 7.33% +0.26% $164M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
KRYS 4.37% 6.93% -2.55% $95M
RYTM 0.00% 2.01% -2.01% $0
TARS 2.62% 4.01% -1.39% $57M
ARQT 6.40% 7.67% -1.27% $138M
MIRM 15.98% 17.08% -1.09% $346M
TRVI 2.59% 3.60% -1.01% $56M
MRUS 0.00% 0.88% -0.88% $0
IRON 4.05% 4.86% -0.81% $88M
KALV 2.55% 3.15% -0.59% $55M
SVRA 1.21% 1.77% -0.56% $26M
ACAD 0.00% 0.44% -0.44% $0
PCVX 0.71% 1.14% -0.42% $15M
RCKT 0.00% 0.40% -0.40% $0
ERAS 1.33% 1.73% -0.39% $29M
PVLA 0.75% 1.08% -0.32% $16M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 4 $539M 24.9%
Mid Cap 21 $1.0B 48.1%
Small Cap 19 $527M 24.3%
Micro Cap 5 $58M 2.7%

Portfolio Analytics

Avg Market Cap
$5.0B
Median Market Cap
$2.0B
Avg P/E
29.5
Median P/E
39.0
Avg Dividend Yield
—%
Avg Beta
0.89
# Stocks
49
# ETFs / Funds
0

Top Holdings (49 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 MIRM 15.98% 6,795,121 $346M $50.89 $40M
2 VRNA 14.79% 3,383,950 $320M $94.58 $101M -73,900 -2.1%
3 BBIO 7.59% 3,800,457 $164M $43.18 $33M
4 ARQT 6.40% 9,874,511 $138M $14.02 $1M +1,089,227 +12.4%
5 PHAT 5.53% 12,466,489 $120M $9.59 $56M +2,357,210 +23.3%
6 KRYS 4.37% 688,460 $95M $137.46 -$29M
7 IRON 4.05% 1,654,834 $88M $52.96 $530K -100,000 -5.7%
8 MBX 3.16% 5,985,347 $68M $11.41 $24M
9 TARS 2.62% 1,397,527 $57M $40.51 -$15M
10 TRVI 2.59% 10,259,409 $56M $5.47 -$8M
11 MAZE 2.59% 4,567,275 $56M $12.27 $11M +438,274 +10.6%
12 KALV 2.55% 4,887,867 $55M $11.30 -$1M
13 ZLAB 2.11% 1,308,138 $46M $34.97 $33M +958,138 +273.8%
14 AGIO 1.97% 1,279,754 $43M $33.26 $11M +209,900 +19.6%
15 RVMD 1.70% 997,455 $37M $36.79 $1M
16 RARE 1.65% 983,715 $36M $36.36 $12M +325,000 +49.3%
17 AURA 1.48% 5,100,000 $32M $6.26 +5,100,000 NEW
18 ERAS 1.33% 22,729,436 $29M $1.27 -$2M +153,585 +0.7%
19 ALKS 1.32% 1,000,647 $29M $28.61 $9M +399,518 +66.5%
20 SVRA 1.21% 11,462,301 $26M $2.28 -$6M
21 MREO 1.18% 9,440,112 $26M $2.71 $8M +1,620,249 +20.7%
22 EOLS 1.04% 2,435,550 $22M $9.21 +2,435,550 NEW
23 HLVX 0.98% 10,617,062 $21M $1.99 $6M
24 CGON 0.93% 770,000 $20M $26.00 $1M
25 AKRO 0.90% 366,784 $20M $53.36 +366,784 NEW
26 CYTK 0.85% 554,731 $18M $33.04 +554,731 NEW
27 LXEO 0.82% 4,424,725 $18M $4.02 $14M +3,469,210 +363.1%
28 RNAM 0.82% 625,000 $18M $28.40 $2M +100,000 +19.1%
29 JBIO 0.82% 1,772,116 $18M $9.99 +1,772,116 NEW
30 PVLA 0.75% 722,400 $16M $22.54 -$3M +32,388 +4.7%
31 PCVX 0.71% 474,405 $15M $32.51 -$5M -65,000 -12.1%
32 TVTX 0.69% 1,002,092 $15M $14.80 +1,002,092 NEW
33 DYN 0.66% 1,505,984 $14M $9.52 -$760K +62,643 +4.3%
34 COGT 0.58% 1,734,601 $12M $7.18 $7M +798,025 +85.2%
35 IMCR 0.56% 384,782 $12M $31.38 $3M +83,612 +27.8%
36 ORIC 0.50% 1,065,334 $11M $10.15 $3M -344,859 -24.4%
37 AUTL 0.49% 4,623,324 $11M $2.28 $3M
38 VALN 0.38% 1,458,333 $8M $5.65 +1,458,333 NEW
39 DSGN 0.30% 1,953,547 $7M $3.37 -$957K
40 ORKA 0.30% 583,327 $7M $11.21 $554K
41 SLN 0.26% 970,130 $6M $5.80 $2M -178,461 -15.5%
42 ALLO 0.20% 3,868,750 $4M $1.13 -$1M
43 MGNX 0.18% 3,175,665 $4M $1.21 -$191K
44 ELEV 0.10% 5,993,579 $2M $0.37 $647K
45 IMTX —% -$6M -1,247,911 -100.0% SOLD
46 RYTM —% -$36M -678,760 -100.0% SOLD
47 RCKT —% -$7M -1,079,025 -100.0% SOLD
48 MRUS —% -$16M -373,100 -100.0% SOLD
49 ACAD —% -$8M -470,338 -100.0% SOLD

New Positions

SymbolValue% Port
AURA $32M 1.48%
EOLS $22M 1.04%
AKRO $20M 0.90%
CYTK $18M 0.85%
JBIO $18M 0.82%
TVTX $15M 0.69%
VALN $8M 0.38%

Sold Out Positions

SymbolValue% Port
ACAD —%
IMTX —%
RCKT —%
RYTM —%
MRUS —%
View SEC EDGAR Filings for Frazier Life Sciences Management, L.P. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms