| Profitability | 11/100 |
| Growth | 24/100 |
| Momentum | 30/100 |
| Quality | 41/100 |
| Earnings Quality | 41/100 |
| Balance Sheet | 0/100 |
| Value | 36/100 |
| Risk (safety) | 100/100 |
| Overall | 29.6/100 |
| Symbol | IS Score |
|---|---|
| REGN | 68 |
| VRTX | 76 |
| ARGX | 74 |
| ONC | 78 |
| ALNY | 68 |
| ROIV | 38 |
| MRNA | 30 |
These two disagree — business quality 30, price structure 82 out of 100, so the price reads better than the business does. We publish the disagreement rather than resolving it: they answer different questions, and the gap between them is information, not an error.
| Trigger | Where it stands now | What it would mean |
|---|---|---|
| IS Score reaches 55 and holds two consecutive quarters | now 29.6 | would move us up one band |
| IS Score stops falling - one quarter higher than the prior | last four: 21 → 33 → 32 → 30 | the direction matters more than the level |
| Technical vote share back above 50% | now 100% | price structure no longer broken |
| Institutional holder count rises two quarters running | peak 953 → now 784 | fewer institutions willing to hold is our clearest warning |
This page is InsiderStreet's own reading, produced from the data in the rest of this document. It is not a price target and not investment advice. Analyst consensus and street price targets appear later under their own heading and are the street's numbers, not ours.
| Quarter | Holders | 13F shares | Value | Reported own% |
|---|---|---|---|---|
| 2026 Q2 | 784 | 324.8M | $22.3B | 82.0% |
| 2026 Q1 | 725 | 308.2M | $15.5B | 77.8% |
| 2025 Q4 | 674 | 304.3M | $8.9B | 76.8% |
| 2025 Q3 | 642 | 275.1M | $7.1B | 69.5% |
| 2025 Q2 | 670 | 291.9M | $8.0B | 73.7% |
| 2025 Q1 | 692 | 282.2M | $8.0B | 71.2% |
| 2024 Q4 | 744 | 277.2M | $12.1B | 70.0% |
| 2024 Q3 | 788 | 261.4M | $17.3B | 66.0% |
| 2024 Q2 | 953 | 262.1M | $30.9B | 66.2% |
| 2024 Q1 | 903 | 263.3M | $27.9B | 66.5% |
| 2023 Q4 | 880 | 256.7M | $25.4B | 64.8% |
| 2023 Q3 | 882 | 246.8M | $25.3B | 62.3% |
| Insider | Role | Date | Type | Shares | Value | Post-Txn Owned |
|---|---|---|---|---|---|---|
| Hoge Stephen | President | 2026-10-15 | SELL | 39,145 | $8.64M | 1,636,565 |
| Hoge Stephen | President | 2026-10-14 | SELL | 38,774 | $8.28M | 1,599,708 |
| Hoge Stephen | President | 2026-10-14 | SELL | 450 | $0.10M | 1,599,258 |
| Mock James M | Chief Financial Officer | 2026-10-05 | EXERCISE | 1,454 | — | 60,829 |
| Mock James M | Chief Financial Officer | 2026-10-05 | TAX W/H | 704 | $0.13M | 60,125 |
| Mock James M | Chief Financial Officer | 2026-10-05 | EXERCISE | 1,454 | — | 0 |
| Hoge Stephen | President | 2026-09-15 | SELL | 40,281 | $5.88M | 1,562,029 |
| Hoge Stephen | President | 2026-09-14 | SELL | 40,294 | $5.81M | 1,525,858 |
| 6-mo decomposition (Form 4) | Txns | Shares | Value | Signal weight |
|---|---|---|---|---|
| S — Open-market sales | 19 | 888,806 | $73.1M | Counted |
| M — Exercises (paired A/D) | 54 | 968,332 | $14.6M | None — mechanics |
| F — Tax withholding | 35 | 76,607 | $6.0M | None — compensation |
| P — Open-market purchases | 0 | 0 | $0 | Counted — none occurred |
| Filed | Filer | Shares registered | Est. proceeds |
|---|---|---|---|
| 2026-10-15 | Hoge Stephen | 39,145 | $8.6M |
| 2026-10-14 | Hoge Stephen | 39,224 | $8.4M |
| 2026-09-15 | Hoge Stephen | 40,281 | $5.9M |
| 2026-09-14 | Hoge Stephen | 40,294 | $5.8M |
| Trailing 12 mo | 19 filings | 1,135,701 | $86M |
| Filed | Form | Reporting person | % of class | Shares |
|---|---|---|---|---|
| 2026-08-12 | SCHEDULE 13G | Capital World Investors | 5.60% | 22.3M sh |
| 2026-08-06 | SCHEDULE 13G/A | Abigail P. Johnson | 13.10% | 51.8M sh |
| 2026-07-24 | SCHEDULE 13G/A | BAILLIE GIFFORD & CO | 4.60% | 18.2M sh |
| 2026-03-27 | SCHEDULE 13G/A | The Vanguard Group | — | exit/reporting change |
| Member | Chamber | Trade | Size band | Traded | Disclosed |
|---|---|---|---|---|---|
| Maria Elvira Salazar | House | SELL | $1,001 - $15,000 | 2026-09-24 | 2026-10-08 |
| Ro Khanna | House | BUY | $1,001 - $15,000 | 2026-09-11 | 2026-10-09 |
| Ro Khanna | House | BUY | $1,001 - $15,000 | 2026-09-04 | 2026-10-09 |
| Manager | Shares | Value |
|---|---|---|
| Banque Pictet & Cie Sa | 2.2M | $414M |
| Douglas Lane & Associates, Llc | 1.2M | $224M |
| Beau Ventures, Llc | 1.0M | $193M |
| Fny Investment Advisers, Llc | 107,610 | $21M |
| Czech National Bank | 106,680 | $21M |
| Td Waterhouse Canada Inc. | 72,591 | $14M |
| Fund | Weight | Position |
|---|---|---|
| VITSX | 0.1% | $2.2B |
| VTI | 0.1% | $2.2B |
| VSMPX | 0.1% | $2.2B |
| VTSAX | 0.1% | $2.2B |
| QQQ | 0.4% | $1.9B |
| VOO | 0.1% | $1.9B |
| ATS Venue (4-wk) | Shares | Avg trade |
|---|---|---|
| Ubsa Ubs Ats | 9.3M | 67 sh |
| Incr Intelligent Cross Llc | 6.7M | 70 sh |
| Sgmt Sigma X2 | 4.6M | 69 sh |
| Ebxl Level Ats | 4.2M | 47 sh |
| Mstx Ms Trajectory Cross (Ats-1) | 3.7M | 96 sh |
| Iats Ibkr Ats | 3.5M | 137 sh |
| Region | Revenue | Share |
|---|---|---|
| UNITED STATES | $1.2B | 65% |
| Rest Of The World | $603M | 33% |
| Europe | $53M | 3% |
Moat score 32/100 — None; primary source Cost Advantage.
| Officer | Title |
|---|---|
| Stéphane Bancel | Chief Executive Officer & Director |
| Stephen Hoge | President |
| James Mock | Chief Financial Officer |
| Shannon Thyme Klinger | Chief Legal Officer & Corporate Secretary |
| Period | EPS est. | EPS actual | EPS surprise | Rev est. ($M) | Rev actual ($M) | Rev surprise |
|---|
| YoY growth | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Revenue | +2107.6% | +6.4% | -63.7% | -53.3% | -39.2% |
| Gross profit | +1878.4% | -11.0% | -84.0% | -19.5% | -38.0% |
| Operating income | -1842.3% | -29.2% | -145.0% | -6.9% | -22.1% |
| Net income | -1733.3% | -31.5% | -156.4% | -24.5% | -20.8% |
| $B · FY ends | FY21 | FY22 | FY23 | FY24 | FY25 | Trend |
|---|---|---|---|---|---|---|
| Revenue | 17.7 | 18.9 | 6.8 | 3.2 | 1.9 | |
| Cost of revenue | 2.6 | 5.4 | 4.7 | 1.5 | 0.9 | |
| Gross profit | 15.1 | 13.5 | 2.2 | 1.7 | 1.1 | |
| R&D expense | 2.0 | 3.3 | 4.8 | 4.5 | 3.1 | |
| SG&A expense | 0.6 | 1.1 | 1.5 | 1.2 | 1.0 | |
| Operating income | 13.3 | 9.4 | -4.2 | -3.9 | -3.1 | |
| EBITDA | 13.5 | 9.8 | -3.3 | -3.4 | -2.6 | |
| D&A | 0.2 | 0.3 | 0.6 | 0.2 | 0.2 | |
| Pretax income | 13.3 | 9.6 | -3.9 | -3.6 | -2.8 | |
| Income tax | 1.1 | 1.2 | 0.8 | -0.0 | 0.1 | |
| Net income | 12.2 | 8.4 | -4.7 | -3.6 | -2.8 | |
| Diluted EPS ($) | 28.29 | 20.10 | -12.34 | -9.27 | -7.26 | |
| Diluted shares (M) | 431 | 416 | 382 | 384 | 389 |
| $B | FY22 | FY23 | FY24 | FY25 | |
|---|---|---|---|---|---|
| Cash & equivalents | 3.2 | 2.9 | 1.9 | 2.6 | |
| ST investments | 6.7 | 5.7 | 5.1 | 3.2 | |
| Receivables (net) | 1.7 | 1.1 | 0.6 | 0.2 | |
| Total current assets | 13.4 | 10.3 | 8.1 | 6.5 | |
| PP&E (net) | 2.1 | 2.7 | 3.0 | 2.9 | |
| Goodwill + intangibles | 0.0 | 0.1 | 0.1 | 0.0 | |
| Total assets | 25.9 | 18.4 | 14.1 | 12.3 | |
| Accounts payable | 0.5 | 0.5 | 0.4 | 0.3 | |
| Short-term debt | 0.0 | 0.0 | 0.0 | 0.0 | |
| Deferred revenue | 2.0 | 0.6 | 0.2 | 0.1 | |
| Total current liabilities | 4.9 | 3.0 | 2.2 | 2.0 | |
| Long-term debt | 0.0 | 0.0 | 0.0 | 1.2 | |
| Total liabilities | 6.7 | 4.6 | 3.2 | 3.7 | |
| Shareholders' equity | 19.1 | 13.9 | 10.9 | 8.7 |
| $B | FY22 | FY23 | FY24 | FY25 | |
|---|---|---|---|---|---|
| Net income | 8.4 | (4.7) | (3.6) | (2.8) | |
| D&A | 0.3 | 0.6 | 0.2 | 0.2 | |
| Stock-based compensation | 0.2 | 0.3 | 0.4 | 0.5 | |
| Working capital change | (3.5) | (0.1) | (0.1) | 0.3 | |
| Operating cash flow | 5.0 | (3.1) | (3.0) | (1.9) | |
| Capital expenditures | (0.4) | (0.7) | (1.1) | (0.2) | |
| Investing cash flow | (5.2) | 4.2 | 1.9 | 1.9 | |
| Buybacks | (3.3) | (1.2) | 0.0 | 0.0 | |
| Dividends paid | 0.0 | 0.0 | 0.0 | 0.0 | |
| Debt issuance / (repay) | (0.2) | (0.3) | (0.0) | 0.5 | |
| Financing cash flow | (3.4) | (1.4) | 0.1 | 0.6 | |
| Free cash flow | 4.6 | (3.8) | (4.1) | (2.1) |
| Ratio | FY21 | FY22 | FY23 | FY24 | FY25 | TTM | Trend |
|---|---|---|---|---|---|---|---|
| PROFITABILITY | |||||||
| ROE | 146.1% | 50.3% | -28.6% | -28.8% | -28.9% | -39% | |
| ROA | 76.2% | 33.1% | -21.3% | -21.9% | -21.3% | -28.7% | |
| ROIC | 281.8% | 78.9% | -51.6% | -67.4% | -50.9% | -39.2% | |
| Gross margin | 85.2% | 71.3% | 31.5% | 54.2% | 55.3% | -12.6% | |
| Operating margin | 75.0% | 49.9% | -61.9% | -123.3% | -158.1% | -149.0% | |
| Net margin | 68.8% | 44.3% | -68.8% | -111.3% | -145.2% | -141.4% | |
| EBITDA margin | 76.3% | 51.8% | -47.9% | -106.1% | -131.3% | -127.0% | |
| FCF margin | 75.2% | 24.3% | -56.0% | -126.8% | -105.7% | — | |
| VALUATION | |||||||
| P/E | 8.97 | 8.70 | -8.33 | -4.50 | -4.10 | -27.3 | |
| P/B | 7.74 | 3.80 | 2.84 | 1.47 | 1.34 | 12.8 | |
| P/S | 6.17 | 3.85 | 5.75 | 5.00 | 5.95 | 39.07 | |
| P/FCF | 8.21 | 15.88 | -10.27 | -3.95 | -5.63 | -71.2 | |
| EV/EBITDA | 7.37 | 6.44 | -9.72 | -2.87 | -3.01 | -30.6 | |
| EV/Revenue | 5.62 | 3.39 | 4.68 | 3.04 | 3.95 | 38.9 | |
| Earnings yield | 11.1% | 11.5% | -12.0% | -22.2% | -24.4% | -3.65% | |
| FCF yield | 12.2% | 6.3% | -9.7% | -25.3% | -17.8% | -1.41% | |
| Ratio | FY21 | FY22 | FY23 | FY24 | FY25 | TTM | Trend |
|---|---|---|---|---|---|---|---|
| LEVERAGE & SOLVENCY | |||||||
| Current ratio | 1.76 | 2.73 | 3.42 | 3.67 | 3.29 | 2.29 | |
| Quick ratio | 1.60 | 2.54 | 3.36 | 3.62 | 3.22 | 2.18 | |
| Debt / equity | 0.06 | 0.06 | 0.09 | 0.07 | 0.22 | 0.19 | |
| Debt / assets | 3.7% | 4.6% | 6.7% | 5.3% | 15.5% | 11.7% | |
| Net debt / EBITDA | -0.73 | -0.88 | 2.24 | 1.85 | 1.52 | 0.15 | |
| Interest coverage | 739.06 | 331.17 | -102.74 | -149.29 | -276.60 | — | |
| Ratio | FY21 | FY22 | FY23 | FY24 | FY25 | TTM | Trend |
|---|---|---|---|---|---|---|---|
| EFFICIENCY | |||||||
| Asset turnover | 1.11 | 0.75 | 0.31 | 0.20 | 0.15 | 0.20 | |
| Receivables turnover | 7.77 | 8.28 | 6.00 | 5.12 | 7.17 | 21.6 | |
| DSO (days) | 47 | 44 | 61 | 71 | 51 | 17 | |
| DPO (days) | 22 | 27 | 39 | 115 | 79 | 24 | |
| Cash conversion cycle | 128 | 98 | 66 | -4 | 1 | 33 | |
| GROWTH (YoY) | |||||||
| Revenue growth | 2107.6% | 6.4% | -63.8% | -53.1% | -39.3% | — | |
| Net income growth | 1733.3% | -31.5% | -156.4% | 24.5% | 20.8% | — | |
| EPS growth | 1603.3% | -27.1% | -157.8% | 22.5% | 22.2% | — | |
| FCF growth | 580.6% | -65.6% | -183.5% | -6.0% | 49.3% | — | |
| PER SHARE ($) | |||||||
| EPS (diluted, TTM) | 28.31 | 20.65 | -11.93 | -9.25 | -7.20 | -7.96 | |
| Book value / share | 32.82 | 47.22 | 35.07 | 28.31 | 22.07 | 17.07 | |
| Revenue / share | 41.15 | 46.60 | 17.28 | 8.31 | 4.96 | 5.63 | |
| FCF / share | 30.94 | 11.31 | -9.68 | -10.53 | -5.24 | -3.09 | |
| Cash / share | 24.89 | 24.45 | 21.78 | 18.25 | 14.79 | 12.97 | |
| SHAREHOLDER RETURN & SCORES | |||||||
| Buyback yield | 0.8% | 4.6% | 2.9% | 0.0% | 0.0% | 0.01% | |
| Altman Z-Score | 9.64 | 9.82 | 6.34 | 3.85 | 2.56 | 12.7 | |
| Piotroski F-Score | 6 | 5 | 4 | 5 | 3 | 2/9 | |
| Beneish M-Score | 7.84 | -2.29 | -3.62 | -2.07 | -3.84 | -4.42 | |
| Model | Score | Zone | Note |
|---|---|---|---|
| Piotroski F-Score | 2 / 9 | Weak | |
| Altman Z-Score | 12.7 | Safe (>2.99) | Safe |
| Income quality | N/M | Loss-making | OCF ÷ net income not meaningful with negative earnings; OCF itself is the signal |
| Beneish M-Score | -4.42 | Non-manipulator | vs −2.22 threshold |
| DuPont Decomposition (TTM) | Value |
|---|---|
| Tax burden | 1.02 |
| Interest burden | 1.01 |
| Operating margin | -137.8% |
| Asset turnover | 0.19× |
| Financial leverage | 1.42× |
| = ROE | -39% |
| Growth Quality (live) | Value |
|---|---|
| Revenue stability | 0.48 |
| Earnings stability | 0.46 |
| Earnings persistence | 0.97 |
| Revenue CAGR 3y | -40.5% |
| EPS CAGR 3y | — |
| FCF CAGR 3y | — |
| Company | Mkt cap | P/E | ROE | Net margin | Rev growth | Piotroski | 1-yr ret |
|---|---|---|---|---|---|---|---|
| REGN | $81.4B | 18.9 | 14% | 30.2% | +9.3% | 7/9 | +39.1% |
| VRTX | $126.7B | 28.9 | 24% | 33.0% | +10.6% | 6/9 | +22.3% |
| ARGX | $51.5B | 29.6 | 47% | 29.8% | +242.1% | 5/9 | -2.2% |
| ONC | $39.4B | 25.6 | 15% | 13.9% | +34.3% | 8/9 | +16.0% |
| ALNY | $31.0B | 38.0 | 101% | 12.7% | +95.1% | 6/9 | — |
| ROIV | $24.2B | -88.2 | -6% | — | -67.6% | 1/9 | — |
| INCY | $22.9B | 13.9 | 31% | 35.0% | +26.9% | 8/9 | — |
| UTHR | $22.9B | 17.6 | 19% | 42.5% | +2.5% | 6/9 | — |
| Consensus estimates | Revenue mean | High / Low | EPS mean | High / Low | # EPS est. |
|---|---|---|---|---|---|
| FY2026 | $2.10B | $2.20B / $1.96B | $-8.31 | $-7.81 / $-10.32 | 17 |
| FY2027 | $2.43B | $2.99B / $1.97B | $-4.74 | $-2.90 / $-7.56 | 17 |
| FY2028 | $3.42B | $7.39B / $2.21B | $-2.72 | $0.60 / $-5.35 | 15 |
| Window | Avg Target | vs. Price | # Targets |
|---|---|---|---|
| Last Month | $137.00 | -37.2% | 1 |
| Last Quarter | $126.82 | -41.8% | 11 |
| Last Year | $67.18 | -69.2% | 33 |
| All Time | $117.31 | -46.2% | 96 |
| Moving Average | Value | Distance | % Distance | Signal |
|---|---|---|---|---|
| SMA 20 | $201.18 | +16.83 | +8.37% | Above |
| SMA 50 | $154.93 | +63.08 | +40.72% | Above |
| SMA 200 | $75.84 | +142.17 | +187.46% | Above |
| EMA 9 | $215.24 | +2.77 | +1.29% | Above |
| EMA 21 | $197.77 | +20.24 | +10.23% | Above |
| EMA 50 | $162.14 | +55.87 | +34.46% | Above |
| EMA 200 | $92.90 | +125.11 | +134.67% | Above |
| Level | Value | Level | Value |
|---|---|---|---|
| Pivot / R1 / R2 | $231.94 / $246.85 / $257.21 | S1 / S2 | $221.58 / $206.67 |
| Bollinger (20,2) | $168.71 – $233.64 | Squeeze | Off |
| 52-wk range | $22.28 – $242.29 | Off 52-wk high | -10.0% |
| ATR (14) | $16.88 (7.7%) | Historical vol | 94.1% |
| Computed from live weekly prices | MRNA | S&P 500 |
|---|---|---|
| Weekly volatility (σ, 1y) | 26.24% | 1.83% |
| Best / worst week (1y) | +173.9% / -15.0% | — |
| Max drawdown (5y, monthly) | -94.2% | — |
| 1-week VaR (95%) | -13.8% | — |
| Beta (5y) | 0.90 | 1.00 |
| Reading | MRNA | Biotechnology n=1,668 | Healthcare n=5,272 | All US symbols n=70,435 |
|---|---|---|---|---|
| Overall | +30.6 | -37.6 | -24.0 | -20.5 |
| Trend | +52.1 | -39.5 | -25.6 | -21.3 |
| Momentum | +58.8 | -48.5 | -28.5 | -15.8 |
| Volume | +61.6 | -38.8 | -25.0 | -3.8 |
| Executive | Total comp | Structure |
|---|---|---|
| Stéphane Bancel Chief Executive Officer | $19.9M | 56% equity+incentive |
| Stephen Hoge, M.D. President | $18.1M | 67% equity+incentive |
| James Mock Chief Financial Officer | $5.9M | 64% equity+incentive |
| Shannon Thyme Klinger Chief Legal Officer an | $5.4M | 64% equity+incentive |
| Pillar (live disclosure scores) | Score |
|---|---|
| Environmental | 61 |
| Social | 61 |
| Governance | 51 |
| Composite ESG | 58 |
| Filed | 8-K contents | Items |
|---|---|---|
| 2026-09-30 | Officer/Director Change; Regulation FD; Exhibits | 5.02,7.01,9.01 |
| 2026-09-01 | Material Agreement; Financial Obligation; Unregistered Equity Sales; O | 1.01,2.03,3.02,8.01,9.01 |
| 2026-07-31 | Earnings Release; Exhibits | 2.02,9.01 |
| 2026-07-08 | Officer/Director Change; Regulation FD; Exhibits | 5.02,7.01,9.01 |
| 2026-05-01 | Earnings Release; Exhibits | 2.02,9.01 |
| 2026-03-05 | Entry into Material Definitive Agreement | 1.01 |
| 2026-02-13 | Results of Operations and Financial Condition; Financial Statements an | 2.02,9.01 |
| 2026-02-11 | Regulation FD Disclosure; Other Events; Financial Statements and Exhib | 7.01,8.01,9.01 |
Methodology. Every figure originates in InsiderStreet's production data layer and is computed deterministically by the same engines that power insiderstreet.ai. This factsheet contains no model-written text. Sections without underlying data are omitted rather than estimated.
| Data domain | Source | Coverage for this report |
|---|---|---|
| Price & volume | market_db.historical_prices | 52 rows |
| Fundamentals | income_statements_annual | 6 rows · 2020 to 2025 |
| Reported vs consensus | fact/earnings_calendar | 24 rows · 2020-10-29 to 2026-07-31 |
| Analyst estimates | dim/forward_estimates | 3 rows · 2026-12-31 to 2028-12-31 |
| Institutional ownership (13F) | holdings_db.institutional_ownership_summary | 33 rows · 2010 to 2026 |
| Insider transactions (Form 4) | edgar/form4 | 12 rows · 2026-09-10 to 2026-10-15 |
| Proposed sales (Form 144) | edgar/form144 | 1 record |
| Beneficial ownership (13D/G) | edgar/13dg | 4 rows · 2026-03-27 to 2026-08-12 |
| Short-sale volume (FINRA) | edgar/short_volume_daily | 60 rows · 2026-07-23 to 2026-10-15 |
| Dark pool (ATS, tier 1) | edgar/darkpool_weekly | 12 rows · 2026-06-15 to 2026-08-31 |
| ETF & fund holding | etf_holdings_changelog (30d) | 1 record |
| Peer set | stock_peers_dynamic | 8 rows |
| Industry medians | industry_medians | 1 record |
| Congressional trades | congress_db (House + Senate) | 1 record |
| ESG | fact/esg_disclosures | 1 record |
Method. Every figure in this factsheet is looked up from a named field computed in code. It contains no model-written text.
Not covered. Short interest as a percent of float and days-to-cover are not in this data set — the short-sale figures above are FINRA volume, a flow, and cannot support squeeze or covering analysis. Options positioning and intraday data are also absent. 13F ownership is filed 45 days after quarter end and congressional trades are disclosed on a lag, so both describe a past position, not a current one.