AMEX · inception 2006-02-06 · beta 1.10 · avg volume 9,134,268 · holdings as of 2026-10-15 · prices through 2026-10-16
AUM$7.5B
Holdings159
Top-10 weight18.0%
1-yr return+33.2%
Max drawdown 5y-53.2%
Volatility 1y28.8%
Performance vs S&P 500 (SPY)
■ XBI■ SPY
Total return
1m
3m
6m
YTD
1y
3y
5y
XBI
-8.8%
-4.4%
+4.1%
+18.8%
+33.2%
+102.8%
+17.2%
SPY
+0.3%
+2.9%
+7.5%
+11.7%
+15.1%
+80.0%
+84.9%
Rebased to 100 five years ago, weekly adjusted closes. Max drawdown is the largest peak-to-trough fall in that window (trough 2022-05-11). 3y and 5y returns are cumulative.
Top holdings
#
Ticker
Name
Weight
1
MRNA
MODERNA INC
2.58%
2
NTRA
NATERA INC
1.84%
3
TWST
TWIST BIOSCIENCE CORP
1.82%
4
ABBV
ABBVIE INC
1.73%
5
BIIB
BIOGEN INC
1.71%
6
AMGN
AMGEN INC
1.68%
7
HALO
HALOZYME THERAPEUTICS INC
1.68%
8
IOVA
IOVANCE BIOTHERAPEUTICS INC
1.67%
9
UTHR
UNITED THERAPEUTICS CORP
1.64%
10
GILD
GILEAD SCIENCES INC
1.63%
Exposure
Sector
Healthcare99.3%
Financial Services0.6%
Unclassified0.2%
Country
US95.3%
CH1.4%
IE1.4%
GB1.2%
NL0.4%
Unclassified0.2%
Weights of holdings joined to company profiles; bonds, cash and derivatives fall under Unclassified.
InsiderStreet scores of the holdings
Holdings-weighted score
Score
Percentile vs ETFs
Overall
48/100
8
Quality
55/100
3
Profitability
42/100
7
Balance sheet
58/100
29
Earnings quality
51/100
2
Growth
56/100
39
Value
38/100
3
Momentum
62/100
4
Risk (safety)
75/100
46
Portfolio fundamentals
Value
P/E
57.0
P/B
11.0
P/S
8.3
Earnings yield
1.8%
FCF yield
3.4%
ROE
5.3%
Net margin
3.9%
Revenue growth (yoy)
+34.7%
Dividend yield
0.12%
Debt / equity
1.22
Scores are weighted by holding; 99% of the fund's weight is in companies we score. Percentile ranks the fund among ETFs with at least half their weight scored. A score describes the holdings, not the outlook for the fund.
Most similar ETFs by holdings overlap
ETF
Name
Overlap
Shared holdings
AUM
LABU
Direxion Daily S&P Biotech Bull 3X Shares
99.9%
156
$1.1B
TDNA
T. Rowe Price Biotech ETF
58.8%
69
$9.1M
BIPIX
ProFunds Biotechnology UltraSector Fund Invest
54.7%
108
$320.2M
BBP
Virtus Biotech ETF
48.1%
47
$40.8M
IBB
iShares Biotechnology ETF
43.8%
122
$10.4B
IBBQ
Invesco Nasdaq Biotechnology ETF
43.3%
118
$79.9M
Overlap = sum over shared holdings of the smaller of the two weights.