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ATYR NASDAQ

aTyr Pharma, Inc.
1W: -5.6% 1M: -37.4% 3M: -49.2% YTD: -30.4% 1Y: -84.9%
$0.49
-0.04 (-7.28%)
 
Weekly Expected Move ±36.9%
$0 $0 $1 $1 $1
NASDAQ · Healthcare · Biotechnology · Alpha Radar Strong Sell · Power 25 · $48.0M mcap · 96M float · 1.95% daily turnover · Short 34% of daily vol

Edge Score

Quantitative competitive moat analysis scoring five pillars of durable advantage — cost leadership, brand intangibles, switching costs, network effects, and efficient scale — using industry percentile rankings on a 0–100 scale.

WEAK EDGE
47.7 / 100
NoneWeakNarrowWide
Primary source: Switching Costs  ·  ROIC: -7009.6%
Cost Advantage
45
Intangibles
41
Switching Cost
86
Network Effect
24
Scale
22
The Edge Score quantifies a company's competitive moat using five pillars: Cost Advantage (20%, operating margin and SG&A efficiency vs industry peers), Intangible Assets (25%, gross margin premium, R&D intensity, brand pricing power), Switching Costs (25%, revenue stability, earnings consistency, customer retention proxied by operating leverage), Network Effects (15%, revenue growth with expanding margins, market share dominance), and Efficient Scale (15%, market concentration, ROIC sustainability). Each pillar is scored 0–100 using industry percentile rankings, then weighted into a composite. Wide ≥ 70, Narrow ≥ 55, Weak ≥ 40, None < 40. ATYR shows a Weak competitive edge (47.7/100) — limited structural advantages that may face competitive pressure. The primary source of advantage is Switching Costs. Negative ROIC of -7009.6% indicates the company is currently destroying value, though this may reflect a growth investment phase.

Analyst Insights

Wall Street analyst consensus based on price targets and buy/sell/hold recommendations from institutional research coverage over the trailing 12 months.

Analyst Price Targets
$0
Low
$5
Avg Target
$5
High
Based on 4 analyst ratings (12 mo)
Analyst Recommendations
Strong Buy: 0Buy: 3Hold: 7Sell: 0Strong Sell: 0
Rating Summary
ConsensusHold
Avg Target$5.13
Analysts4
Price Target Change History
DateFirmAnalystOldNewChangeUpside @ CallStock@Call
2025-09-15 RBC Capital Brian Abrahams Initiated $2 +47.8% $1.01
2025-09-15 Wells Fargo Derek Archila Initiated $1 -1.5% $1.01
2025-09-15 Leerink Partners Faisal Khurshid Initiated $1 -1.5% $1.01
2025-08-22 Jefferies Roger Song Initiated $17 +217.8% $5.35

Financial Rating

Composite financial health rating (A+ to F) based on discounted cash flow valuation, return on equity, return on assets, debt-to-equity leverage, and relative P/E and P/B multiples.

C
May 22, 2026
DCF
1
ROE
1
ROA
1
D/E
2
P/E
1
P/B
4
The Financial Rating evaluates six fundamental factors — discounted cash flow (DCF) valuation, return on equity (ROE), return on assets (ROA), debt-to-equity leverage (D/E), and relative price-to-earnings (P/E) and price-to-book (P/B) multiples — each scored 1–5. ATYR receives an overall rating of C. Strongest factors: P/B (4/5). Areas of concern: DCF (1/5), ROE (1/5), ROA (1/5), D/E (2/5), P/E (1/5).
Rating Change History
DateFromTo
2026-03-09 C- C
2026-03-06 C C-

InsiderStreet Scorecard

Proprietary multi-factor scorecard rating companies across seven fundamental dimensions — profitability, balance sheet strength, earnings quality, growth, value, momentum, and safety — each scored 0–100.

Grade A+
Profitability
Balance Sheet
86
Earnings Quality
35
Growth
Value
40
Momentum
Safety
0
Cash Flow
30

Risk & Quality Signals

Academic financial models used by institutional investors to assess bankruptcy risk, earnings manipulation, financial strength, and credit quality.

Altman Z-Score
-9.01
Distress Zone
Piotroski F-Score
2/9
Beneish M-Score
Ohlson O-Score
-1.95
Bankruptcy prob: 12.5%
Moderate
Credit Rating
BB
Score: 43.7/100
Trend: Stable
Earnings Quality
OCF/NI: 0.84x
Accruals: -11.5%
The Altman Z-Score (1968) combines five ratios — working capital, retained earnings, EBIT, market value of equity, and sales, all relative to total assets or liabilities — into a single bankruptcy predictor. ATYR scores -9.01, placing it in the Distress Zone (safe > 2.99, distress < 1.81). Historically, companies in this range face elevated bankruptcy risk. The Piotroski F-Score (2000) is a 9-point binary checklist — four profitability tests (positive ROA, positive cash flow, improving ROA, cash flow exceeding net income), three leverage tests (declining debt ratio, improving current ratio, no share dilution), and two efficiency tests (improving gross margin, improving asset turnover). Each pass scores 1 point. ATYR scores 2/9, suggesting weak financial fundamentals — the company fails the majority of these accounting tests. The Ohlson O-Score (1980) is a 9-variable logistic regression that estimates bankruptcy probability using firm size, leverage, working capital, current ratio, profitability (ROA), cash flow coverage, negative equity flag, consecutive losses flag, and earnings trajectory. The raw score is converted to a probability via logistic transformation. ATYR's implied 12.5% bankruptcy probability is elevated and warrants attention to the balance sheet. Our Credit Rating model scores companies on five weighted components — solvency (30%), earning power (25%), leverage (20%), liquidity (15%), and cash flow quality (10%) — then blends the absolute score with sector and industry peer rankings. For companies with large buyback programs, equity is adjusted by adding back cumulative 5-year repurchases (capped at 80% of FCF generated) to avoid penalizing shareholder-friendly capital allocation. ATYR receives an estimated rating of BB (score: 43.7/100), with a stable trend.

Valuation

Key valuation multiples comparing the stock's market price to its earnings, revenue, book value, and cash flows. Lower multiples may indicate relative undervaluation versus peers.

P/E
-0.69x
PEG
-0.07x
P/S
252.87x
P/B
0.83x
P/FCF
-1.29x
P/OCF
EV/EBITDA
-0.14x
EV/Revenue
51.69x
EV/EBIT
-0.14x
EV/FCF
-0.17x
Earnings Yield
-91.57%
FCF Yield
-77.54%
Shareholder Yield
0.00%
Graham Number
Equity-based multiples (P/E, P/B, P/FCF) compare the stock price to per-share fundamentals and are affected by capital structure. Enterprise value multiples (EV/EBITDA, EV/Revenue, EV/FCF) strip out debt and cash, making them more useful for cross-company comparisons regardless of how companies are financed. The Graham Number — √(22.5 × EPS × Book Value) — is Benjamin Graham's formula for the maximum price a defensive investor should pay. ATYR currently has negative earnings — the P/E ratio is not meaningful.

DuPont Decomposition (5-Factor)

The 5-factor DuPont framework breaks Return on Equity into its component drivers — tax efficiency, interest burden, operating profitability, asset utilization, and financial leverage — to reveal what truly drives shareholder returns.

Tax Burden
1.000
NI / EBT
×
Interest Burden
0.969
EBT / EBIT
×
EBIT Margin
-380.479
EBIT / Rev
×
Asset Turnover
0.002
Rev / Assets
×
Equity Multiplier
1.389
Assets / Equity
=
ROE
-101.9%
The 5-factor DuPont identity decomposes ROE as: Tax Burden × Interest Burden × EBIT Margin × Asset Turnover × Equity Multiplier = ROE. This reveals whether returns are driven by operating performance, financial leverage, or tax efficiency — three very different sources of profitability. ATYR's ROE of -101.9% is driven by Asset Turnover (0.002), indicating efficient use of assets to generate revenue. A tax burden ratio of 1.00 indicates minimal tax leakage — the company retains over 90% of pre-tax earnings.

Graham-Dodd Adjusted Valuation

Our adaptation of Graham's growth formula (Fair P/E = 8.5 + 2g) from The Intelligent Investor. The classic version relies on analyst growth projections, which can be unreliable. This adjusted model substitutes the company's realized 3-year EPS CAGR — a backward-looking, verifiable measure of actual earnings power — grounding the valuation in demonstrated performance rather than forecasts.

Adj. Growth Rate
0.00%
Fair P/E
8.50x
Intrinsic Value
Price/Value
Margin of Safety
Premium
Assessment
Overvalued

Profitability Trends

Historical profitability ratios tracking how efficiently the company converts revenue into returns for shareholders over time.

Leverage & Solvency Trends

Debt and liquidity metrics showing the company's financial leverage and ability to meet short-term and long-term obligations.

Efficiency & Working Capital Trends

Operating efficiency metrics measuring how quickly the company converts inventory to sales, collects receivables, and manages its cash conversion cycle.

Growth Trends (YoY %)

Year-over-year growth rates for key financial metrics, showing the trajectory of revenue, earnings, and cash flow generation.

Earnings Stability

R-squared of linear regression measuring how predictably revenue, earnings, and margins follow a trend over the trailing 5 years. 1.0 = perfectly predictable; lower values indicate erratic or cyclical behavior.

Monte Carlo Price Simulation

Geometric Brownian Motion with 1,000 antithetic paths over 1 year, seeded from 496 days of historical volatility. Percentile bands show the range of statistically plausible outcomes — this is a statistical model, not a forecast.

Current Price
$0.49
Median 1Y
$0.07
5th Pctile
$0.00
95th Pctile
$1.11
Ann. Volatility
161.6%
25th–75th percentile 5th–95th percentile Median path Historical

Executive Compensation

C-suite compensation breakdown including salary, stock awards, options, and incentive pay. The CEO-to-employee pay ratio and Gini coefficient measure pay distribution fairness.

C-Suite Compensation

ExecutiveSalaryStockTotal
Sanjay S. Shukla,
M.D., M.S. President and CEO
$638,977 $— $3,456,253
Jill M. Broadfoot
Chief Financial Officer
$471,790 $— $1,309,913
Nancy E. Denyes
General Counsel
$451,570 $— $1,284,841

CEO Pay Ratio

11:1
CEO-to-Employee Pay Ratio
CEO Total Comp: $3,456,253
Avg Employee Cost (SGA/emp): $303,414
Employees: 58

C-Suite Pay Equality (Gini)

CEO Compensation Mix

Workforce & Productivity

Workforce efficiency metrics measuring revenue, profit, and R&D spend per employee — key indicators of operational leverage and human capital productivity.

Employees
58
-1.7% YoY
Revenue / Employee
$3,276
Rev: $190,000
Profit / Employee
$-1,277,897
NI: $-74,118,000
SGA / Employee
$303,414
Avg labor cost proxy
R&D / Employee
$1,038,259
Innovation spend

Scaling Efficiency

All Ratios & Metrics

Complete fundamental data with up to 20 periods of history, sparkline trends, and current values across 13 categories and 130+ financial metrics.

Profitability
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
ROE -18.0% -37.0% -69.3% -90.6% -82.9% -93.5% -1.1% -1.0% -1.02%
ROA -13.5% -27.8% -50.1% -65.5% -61.3% -69.1% -77.6% -73.3% -73.33%
ROIC -1.8% -3.7% -3.6% -4.7% -5.0% -5.6% -74.2% -70.1% -70.10%
ROCE -16.6% -34.0% -62.6% -81.9% -85.6% -94.9% -97.0% -91.5% -91.49%
Gross Margin -115.5%
Operating Margin -140.8%
Net Margin -135.5%
EBITDA Margin -134.6%
FCF Margin -331.5% -326.6% -312.1% -312.09%
OCF Margin -331.2% -326.2% -311.0% -310.96%
ROIC Economic snapshot only -72.82%
Cash ROA snapshot only -62.75%
Cash ROIC snapshot only -71.53%
CROIC snapshot only -71.79%
NOPAT Margin snapshot only -304.73%
Pretax Margin snapshot only -368.59%
R&D / Revenue snapshot only 293.27%
SGA / Revenue snapshot only 93.46%
SBC / Revenue snapshot only 20.63%
Valuation
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
P/E Ratio -6.92 -3.97 -6.17 -4.12 -6.86 -0.93 -1.04 -1.09 -0.686
P/S Ratio 368.88 403.96 402.50 252.869
P/B Ratio 1.24 1.47 4.28 3.73 6.53 1.00 1.14 1.13 0.829
P/FCF -5.51 -3.97 -6.40 -4.20 -8.21 -1.11 -1.24 -1.29 -1.290
P/OCF
EV/EBITDA -1.75 -1.45 -4.78 -3.08 -5.79 -0.15 -0.13 -0.14 -0.138
EV/Revenue 59.18 53.15 51.69 51.685
EV/EBIT -1.71 -1.42 -4.69 -3.02 -5.68 -0.14 -0.13 -0.14 -0.136
EV/FCF -1.45 -1.50 -5.14 -3.25 -7.15 -0.18 -0.16 -0.17 -0.166
Earnings Yield -14.5% -25.2% -16.2% -24.3% -14.6% -1.1% -96.6% -91.6% -91.57%
FCF Yield -18.1% -25.2% -15.6% -23.8% -12.2% -89.9% -80.9% -77.5% -77.54%
Price/Tangible Book snapshot only 1.133
Shareholder Yield snapshot only 0.00%
Leverage & Solvency
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Current Ratio 6.27 6.27 5.48 5.48 5.48 5.48 5.30 5.30 5.297
Quick Ratio 6.27 6.27 5.48 5.48 5.48 5.48 5.30 5.30 5.297
Debt/Equity 0.17 0.17 0.19 0.19 0.19 0.19 0.18 0.18 0.178
Net Debt/Equity -0.92 -0.92 -0.84 -0.84 -0.84 -0.84 -0.99 -0.99 -0.988
Debt/Assets 0.13 0.13 0.14 0.14 0.14 0.14 0.13 0.13 0.128
Debt/EBITDA -0.89 -0.44 -0.26 -0.20 -0.19 -0.17 -0.16 -0.17 -0.170
Net Debt/EBITDA 4.91 2.39 1.17 0.90 0.86 0.77 0.89 0.94 0.939
Interest Coverage
Equity Multiplier 1.33 1.33 1.38 1.38 1.38 1.38 1.40 1.40 1.395
Cash Ratio snapshot only 5.195
Cash to Debt snapshot only 6.539
FCF to Debt snapshot only -4.928
Defensive Interval snapshot only 569.9 days
Efficiency & Turnover
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Asset Turnover 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.002
Inventory Turnover
Receivables Turnover (trade) 0.00 0.00 0.00 0.00 0.00 0.09 0.15 0.15 0.146
Payables Turnover 0.00 0.00 2.83 2.83 3.11 8.75 5.39 5.48 5.484
DSO (trade) 4007 2506 2506 2506.0 days
DIO 0 0 0 0 0 0 0.0 days
DPO 129 129 117 42 68 67 66.6 days
Cash Conversion Cycle (trade) 3966 2438 2439 2439.5 days
Fixed Asset Turnover snapshot only 0.018
Cash Velocity snapshot only 0.002
Capital Intensity snapshot only 495.595
Growth (YoY)
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Revenue
Net Income -3.1% -1.2% -52.7% -10.4% -10.43%
EPS -2.3% -74.6% -28.9% 2.6% 2.58%
FCF -1.7% -87.3% -32.7% 4.7% 4.68%
EBITDA -3.1% -1.2% -49.6% -8.0% -7.96%
Op. Income -3.0% -1.2% -51.4% -9.3% -9.30%
OCF Growth snapshot only 4.95%
Asset Growth snapshot only -2.75%
Equity Growth snapshot only -3.63%
Debt Growth snapshot only -9.41%
Shares Change snapshot only 13.36%
Growth Quality
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Revenue Stability
Earnings Stability
Margin Stability
Rev. Growth Consistency 0.00 0.00 0.00 0.00 0.00 0.50 0.50 0.50 0.500
Earn. Growth Consistency 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.000
FCF Positive Streak 0 0 0 0 0 0 0 0 0
Earnings Persistence
Earnings Smoothness
ROE Trend
Gross Margin Trend
FCF Margin Trend
Sustainable Growth Rate
Internal Growth Rate
Cash Flow Quality
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
OCF/Net Income 1.25 1.00 0.96 0.98 0.83 0.84 0.84 0.84 0.844
FCF/OCF 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.004
FCF/Net Income snapshot only 0.847
CapEx/Revenue 37.4% 40.5% 1.1% 1.13%
CapEx/Depreciation snapshot only 0.160
Accruals Ratio 0.03 0.00 -0.02 -0.01 -0.10 -0.11 -0.13 -0.11 -0.115
Sloan Accruals snapshot only -0.034
Cash Flow Adequacy snapshot only -274.805
Dividends & Buybacks
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Dividend Yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.00%
Dividend/Share $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00
Payout Ratio
FCF Payout Ratio
Total Payout Ratio
Div. Increase Streak
Chowder Number
Buyback Yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.00%
Net Buyback Yield -12.0% -10.1% -10.8% -19.6% -12.2% -1.2% -86.6% -62.4% -62.36%
Total Shareholder Return -12.0% -10.1% -10.8% -19.6% -12.2% -1.2% -86.6% -62.4% -62.36%
DuPont Factors
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Tax Burden (NI/EBT) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.000
Interest Burden (EBT/EBIT) 0.94 0.95 0.95 0.95 0.95 0.97 0.97 0.97 0.969
EBIT Margin -408.69 -403.31 -380.48 -380.479
Asset Turnover 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.002
Equity Multiplier 1.33 1.33 1.38 1.38 1.35 1.35 1.39 1.39 1.389
Per Share
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
EPS (Diluted TTM) $-0.23 $-0.44 $-0.59 $-0.73 $-0.74 $-0.77 $-0.76 $-0.71 $-0.71
Book Value/Share $1.25 $1.20 $0.85 $0.81 $0.78 $0.72 $0.69 $0.69 $0.59
Tangible Book/Share $1.25 $1.20 $0.85 $0.81 $0.78 $0.72 $0.69 $0.69 $0.69
Revenue/Share $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00
FCF/Share $-0.28 $-0.44 $-0.57 $-0.72 $-0.62 $-0.65 $-0.63 $-0.60 $-0.60
OCF/Share $-0.28 $-0.44 $-0.56 $-0.72 $-0.62 $-0.65 $-0.63 $-0.60 $-0.60
Cash/Share $1.36 $1.30 $0.87 $0.83 $0.80 $0.74 $0.80 $0.80 $0.68
EBITDA/Share $-0.23 $-0.46 $-0.61 $-0.76 $-0.76 $-0.79 $-0.77 $-0.72 $-0.72
Debt/Share $0.21 $0.20 $0.16 $0.15 $0.15 $0.14 $0.12 $0.12 $0.12
Net Debt/Share $-1.15 $-1.10 $-0.71 $-0.68 $-0.65 $-0.61 $-0.68 $-0.68 $-0.68
Academic Models
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Altman Z-Score -9.007
Altman Z-Prime snapshot only -18.623
Piotroski F-Score 1 1 2 2 1 2 2 2 2
Beneish M-Score
Ohlson O-Score snapshot only -1.949
ROIC (Greenblatt) snapshot only -95.79%
Net-Net WC snapshot only $0.54
EVA snapshot only $-57981700.00
Credit
Metric Trend Q2'24 Q3'24 Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Credit Rating snapshot only BB
Credit Score 44.41 44.61 44.45 44.42 49.83 44.33 44.03 43.66 43.664
Credit Grade snapshot only 12
Credit Trend snapshot only -0.752
Implied Spread (bps) snapshot only 475.000
Industry Credit Rank snapshot only 39
Sector Credit Rank snapshot only 36

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms