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SEPN NASDAQ

Septerna, Inc.
1W: -1.4% 1M: +8.0% 3M: +2.4% YTD: -0.2% 1Y: +196.4%
$28.36
+0.44 (+1.58%)
 
Weekly Expected Move ±9.9%
$22 $24 $27 $30 $32
NASDAQ · Healthcare · Biotechnology · Alpha Radar Strong Buy · Power 66 · $1.3B mcap · 19M float · 1.71% daily turnover · Short 58% of daily vol

Edge Score

Quantitative competitive moat analysis scoring five pillars of durable advantage — cost leadership, brand intangibles, switching costs, network effects, and efficient scale — using industry percentile rankings on a 0–100 scale.

WEAK EDGE
47.0 / 100
NoneWeakNarrowWide
Primary source: Switching Costs  ·  ROIC: -304.2%
Cost Advantage
55
Intangibles
33
Switching Cost
72
Network Effect
43
Scale
22
The Edge Score quantifies a company's competitive moat using five pillars: Cost Advantage (20%, operating margin and SG&A efficiency vs industry peers), Intangible Assets (25%, gross margin premium, R&D intensity, brand pricing power), Switching Costs (25%, revenue stability, earnings consistency, customer retention proxied by operating leverage), Network Effects (15%, revenue growth with expanding margins, market share dominance), and Efficient Scale (15%, market concentration, ROIC sustainability). Each pillar is scored 0–100 using industry percentile rankings, then weighted into a composite. Wide ≥ 70, Narrow ≥ 55, Weak ≥ 40, None < 40. SEPN shows a Weak competitive edge (47.0/100) — limited structural advantages that may face competitive pressure. The primary source of advantage is Switching Costs. Negative ROIC of -304.2% indicates the company is currently destroying value, though this may reflect a growth investment phase.

Analyst Insights

Wall Street analyst consensus based on price targets and buy/sell/hold recommendations from institutional research coverage over the trailing 12 months.

Analyst Price Targets
$0
Low
$60
Avg Target
$60
High
Based on 5 analyst ratings (12 mo)
Analyst Recommendations
Strong Buy: 0Buy: 6Hold: 0Sell: 0Strong Sell: 0
Rating Summary
ConsensusBuy
Avg Target$60.00
Analysts1
Price Target Change History
DateFirmAnalystOldNewChangeUpside @ CallStock@Call
2026-03-10 Cantor Fitzgerald Josh Schimmer Initiated $60 +113.8% $28.06
2026-01-20 H.C. Wainwright Initiated $35 +34.3% $26.07
2025-12-19 Raymond James Martin Auster Initiated $38 +38.0% $27.54
2025-12-15 Truist Financial Initiated $34 +33.5% $25.47
2025-11-14 Wells Fargo Derek Archila $18 $28 +10 +45.5% $19.24
2025-05-16 Wells Fargo Derek Archila $11 $18 +7 +82.9% $9.84
2025-03-28 Wells Fargo $14 $11 -3 +80.3% $6.10
2025-02-18 Wells Fargo Derek Archila Initiated $14 +8.0% $12.96

Financial Rating

Composite financial health rating (A+ to F) based on discounted cash flow valuation, return on equity, return on assets, debt-to-equity leverage, and relative P/E and P/B multiples.

C-
May 22, 2026
DCF
1
ROE
1
ROA
1
D/E
3
P/E
1
P/B
2
The Financial Rating evaluates six fundamental factors — discounted cash flow (DCF) valuation, return on equity (ROE), return on assets (ROA), debt-to-equity leverage (D/E), and relative price-to-earnings (P/E) and price-to-book (P/B) multiples — each scored 1–5. SEPN receives an overall rating of C-. Areas of concern: DCF (1/5), ROE (1/5), ROA (1/5), P/E (1/5), P/B (2/5).
Rating Change History
DateFromTo
2026-05-14 C C-
2026-05-11 C- C
2026-03-10 C C-
2026-03-09 C+ C

InsiderStreet Scorecard

Proprietary multi-factor scorecard rating companies across seven fundamental dimensions — profitability, balance sheet strength, earnings quality, growth, value, momentum, and safety — each scored 0–100.

62 Grade D
Profitability
20
Balance Sheet
87
Earnings Quality
28
Growth
80
Value
38
Momentum
74
Safety
80
Cash Flow
77
The InsiderStreet Scorecard rates companies across eight dimensions: Profitability (margins, ROA, ROE), Balance Sheet (leverage, liquidity, coverage), Earnings Quality (accruals, cash conversion), Growth (revenue and earnings trajectory), Value (P/E, P/B, earnings yield, Graham criteria), Momentum (revenue and earnings acceleration), Safety (Altman Z-Score risk adjustment), and Cash Flow (operating cash flow quality, FCF conversion, cash coverage). The overall score blends 35% quality, 35% value, and 30% momentum, with a penalty for distress-zone Altman scores. SEPN scores highest in Balance Sheet (87/100) and lowest in Profitability (20/100). A grade of D flags significant fundamental concerns across multiple dimensions.

Risk & Quality Signals

Academic financial models used by institutional investors to assess bankruptcy risk, earnings manipulation, financial strength, and credit quality.

Altman Z-Score
3.02
Safe Zone
Piotroski F-Score
5/9
Beneish M-Score
103.22
Possible Manipulator
Ohlson O-Score
-8.67
Bankruptcy prob: 0.0%
Low Risk
Credit Rating
A+
Score: 78.3/100
Trend: Improving
Earnings Quality
OCF/NI: -2.99x
Accruals: -27.3%
The Altman Z-Score (1968) combines five ratios — working capital, retained earnings, EBIT, market value of equity, and sales, all relative to total assets or liabilities — into a single bankruptcy predictor. SEPN scores 3.02, placing it in the Safe Zone (safe > 2.99, distress < 1.81). Bankruptcy is statistically unlikely within the next two years. The Piotroski F-Score (2000) is a 9-point binary checklist — four profitability tests (positive ROA, positive cash flow, improving ROA, cash flow exceeding net income), three leverage tests (declining debt ratio, improving current ratio, no share dilution), and two efficiency tests (improving gross margin, improving asset turnover). Each pass scores 1 point. SEPN scores 5/9, indicating moderate financial health — some areas of strength offset by weaknesses in others. The Beneish M-Score (1999) is an 8-variable model that detects earnings manipulation by comparing year-over-year changes in receivables, gross margins, asset quality, sales growth, depreciation, SG&A, leverage, and accruals. Scores above −1.78 statistically resemble past manipulators. SEPN's score of 103.22 exceeds the −1.78 red flag threshold — this does not confirm manipulation but indicates the earnings profile resembles past manipulators statistically. The Ohlson O-Score (1980) is a 9-variable logistic regression that estimates bankruptcy probability using firm size, leverage, working capital, current ratio, profitability (ROA), cash flow coverage, negative equity flag, consecutive losses flag, and earnings trajectory. The raw score is converted to a probability via logistic transformation. SEPN's implied 0.0% bankruptcy probability is well within safe territory. Our Credit Rating model scores companies on five weighted components — solvency (30%), earning power (25%), leverage (20%), liquidity (15%), and cash flow quality (10%) — then blends the absolute score with sector and industry peer rankings. For companies with large buyback programs, equity is adjusted by adding back cumulative 5-year repurchases (capped at 80% of FCF generated) to avoid penalizing shareholder-friendly capital allocation. SEPN receives an estimated rating of A+ (score: 78.3/100), with a improving trend.

Valuation

Key valuation multiples comparing the stock's market price to its earnings, revenue, book value, and cash flows. Lower multiples may indicate relative undervaluation versus peers.

P/E
-35.68x
PEG
-0.39x
P/S
17.92x
P/B
3.40x
P/FCF
10.06x
P/OCF
9.97x
EV/EBITDA
-10.64x
EV/Revenue
9.80x
EV/EBIT
-10.38x
EV/FCF
6.62x
Earnings Yield
-3.35%
FCF Yield
9.94%
Shareholder Yield
0.00%
Graham Number
Equity-based multiples (P/E, P/B, P/FCF) compare the stock price to per-share fundamentals and are affected by capital structure. Enterprise value multiples (EV/EBITDA, EV/Revenue, EV/FCF) strip out debt and cash, making them more useful for cross-company comparisons regardless of how companies are financed. The Graham Number — √(22.5 × EPS × Book Value) — is Benjamin Graham's formula for the maximum price a defensive investor should pay. SEPN currently has negative earnings — the P/E ratio is not meaningful.

DuPont Decomposition (5-Factor)

The 5-factor DuPont framework breaks Return on Equity into its component drivers — tax efficiency, interest burden, operating profitability, asset utilization, and financial leverage — to reveal what truly drives shareholder returns.

Tax Burden
1.010
NI / EBT
×
Interest Burden
0.523
EBT / EBIT
×
EBIT Margin
-0.944
EBIT / Rev
×
Asset Turnover
0.137
Rev / Assets
×
Equity Multiplier
1.313
Assets / Equity
=
ROE
-9.0%
The 5-factor DuPont identity decomposes ROE as: Tax Burden × Interest Burden × EBIT Margin × Asset Turnover × Equity Multiplier = ROE. This reveals whether returns are driven by operating performance, financial leverage, or tax efficiency — three very different sources of profitability. SEPN's ROE of -9.0% is driven by Asset Turnover (0.137), indicating efficient use of assets to generate revenue. A tax burden ratio of 1.01 indicates minimal tax leakage — the company retains over 90% of pre-tax earnings.

Graham-Dodd Adjusted Valuation

Our adaptation of Graham's growth formula (Fair P/E = 8.5 + 2g) from The Intelligent Investor. The classic version relies on analyst growth projections, which can be unreliable. This adjusted model substitutes the company's realized 3-year EPS CAGR — a backward-looking, verifiable measure of actual earnings power — grounding the valuation in demonstrated performance rather than forecasts.

Adj. Growth Rate
0.00%
Fair P/E
8.50x
Intrinsic Value
Price/Value
Margin of Safety
Premium
Assessment
Overvalued

Profitability Trends

Historical profitability ratios tracking how efficiently the company converts revenue into returns for shareholders over time.

Leverage & Solvency Trends

Debt and liquidity metrics showing the company's financial leverage and ability to meet short-term and long-term obligations.

Efficiency & Working Capital Trends

Operating efficiency metrics measuring how quickly the company converts inventory to sales, collects receivables, and manages its cash conversion cycle.

Growth Trends (YoY %)

Year-over-year growth rates for key financial metrics, showing the trajectory of revenue, earnings, and cash flow generation.

Earnings Stability

R-squared of linear regression measuring how predictably revenue, earnings, and margins follow a trend over the trailing 5 years. 1.0 = perfectly predictable; lower values indicate erratic or cyclical behavior.

Monte Carlo Price Simulation

Geometric Brownian Motion with 1,000 antithetic paths over 1 year, seeded from 394 days of historical volatility. Percentile bands show the range of statistically plausible outcomes — this is a statistical model, not a forecast.

Current Price
$28.36
Median 1Y
$21.30
5th Pctile
$4.30
95th Pctile
$108.55
Ann. Volatility
97.2%
Analyst Target
$60.00
25th–75th percentile 5th–95th percentile Median path Historical Analyst target

Executive Compensation

C-suite compensation breakdown including salary, stock awards, options, and incentive pay. The CEO-to-employee pay ratio and Gini coefficient measure pay distribution fairness.

C-Suite Compensation

ExecutiveSalaryStockTotal
Gil M. Labrucherie,
CFA, J.D. Chief Financial Officer
$479,489 $— $3,240,351
Jeffrey Finer, M.D.,
Ph.D Chief Executive Officer
$635,000 $— $2,933,339
Liz Bhatt, M.S.,
M.B.A President and Chief Operating Officer
$500,000 $— $1,590,770

CEO Pay Ratio

7034:1
CEO-to-Employee Pay Ratio
CEO Total Comp: $2,933,339
Avg Employee Cost (SGA/emp): $417
Employees: 70,000

C-Suite Pay Equality (Gini)

CEO Compensation Mix

Workforce & Productivity

Workforce efficiency metrics measuring revenue, profit, and R&D spend per employee — key indicators of operational leverage and human capital productivity.

Employees
70,000
0.0% YoY
Revenue / Employee
$656
Rev: $45,951,000
Profit / Employee
$-698
NI: $-48,879,000
SGA / Employee
$417
Avg labor cost proxy
R&D / Employee
$1,394
Innovation spend

Scaling Efficiency

All Ratios & Metrics

Complete fundamental data with up to 20 periods of history, sparkline trends, and current values across 13 categories and 130+ financial metrics.

Profitability
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
ROE -4.9% -10.0% -15.9% -14.0% -12.2% -9.0% -8.99%
ROA -4.5% -9.2% -14.7% -12.9% -9.3% -6.8% -6.85%
ROIC -20.6% -42.3% -66.5% -64.3% -3.7% -3.0% -3.04%
ROCE -5.6% -11.4% -17.9% -20.2% -15.9% -13.4% -13.39%
Gross Margin 1.0% 1.0% 1.0% 1.0% 1.0% 98.4% 98.41%
Operating Margin -116.6% -118.3% -243.5% 12.2% -66.4% -50.1% -50.15%
Net Margin -97.5% -98.1% -208.7% 38.0% -44.5% -32.6% -32.56%
EBITDA Margin -114.8% -116.5% -240.1% -44.1% -64.8% -48.6% -48.56%
FCF Margin -101.7% -105.1% -119.3% 4.7% 2.4% 1.5% 1.48%
OCF Margin -98.9% -102.8% -117.4% 4.7% 2.4% 1.5% 1.49%
ROIC Economic snapshot only -10.89%
Cash ROA snapshot only 18.10%
Cash ROIC snapshot only 7.46%
CROIC snapshot only 7.39%
NOPAT Margin snapshot only -60.89%
Pretax Margin snapshot only -49.40%
R&D / Revenue snapshot only 1.49%
SGA / Revenue snapshot only 45.11%
SBC / Revenue snapshot only 3.68%
Valuation
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
P/E Ratio -35.88 -6.04 -6.97 -14.59 -25.24 -29.84 -35.680
P/S Ratio 3498.01 590.25 848.77 38.91 26.85 14.89 17.923
P/B Ratio 1.77 0.61 1.11 2.04 3.23 2.82 3.398
P/FCF -34.38 -5.62 -7.11 8.32 11.25 10.06 10.058
P/OCF 8.23 11.20 9.97 9.968
EV/EBITDA -17.10 1.43 -1.80 -6.06 -10.94 -10.64 -10.639
EV/Revenue 1962.88 -164.85 257.05 24.15 18.86 9.80 9.800
EV/EBIT -16.84 1.40 -1.78 -5.95 -10.72 -10.38 -10.385
EV/FCF -19.29 1.57 -2.15 5.16 7.90 6.62 6.622
Earnings Yield -2.8% -16.6% -14.3% -6.9% -4.0% -3.4% -3.35%
FCF Yield -2.9% -17.8% -14.1% 12.0% 8.9% 9.9% 9.94%
Price/Tangible Book snapshot only 2.816
EV/OCF snapshot only 6.563
EV/Gross Profit snapshot only 9.857
Shareholder Yield snapshot only 0.00%
Leverage & Solvency
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Current Ratio 27.77 27.77 27.77 27.77 4.73 4.73 4.727
Quick Ratio 27.77 27.77 27.77 27.77 4.73 4.73 4.727
Debt/Equity 0.06 0.06 0.06 0.06 0.06 0.06 0.062
Net Debt/Equity -0.77 -0.77 -0.77 -0.77 -0.96 -0.96 -0.962
Debt/Assets 0.06 0.06 0.06 0.06 0.04 0.04 0.040
Debt/EBITDA -1.05 -0.51 -0.32 -0.29 -0.30 -0.35 -0.355
Net Debt/EBITDA 13.38 6.53 4.15 3.70 4.64 5.52 5.521
Interest Coverage
Equity Multiplier 1.09 1.09 1.09 1.09 1.56 1.56 1.561
Cash Ratio snapshot only 4.499
Cash to Debt snapshot only 16.554
FCF to Debt snapshot only 4.526
Defensive Interval snapshot only 1149.0 days
Efficiency & Turnover
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Asset Turnover 0.00 0.00 0.00 0.05 0.09 0.14 0.137
Inventory Turnover
Receivables Turnover 1.24 2.52 3.22 128.92 8.73 13.73 13.728
Payables Turnover 0.00 0.00 0.00 0.00 0.00 0.06 0.062
DSO 294 145 113 3 42 27 26.6 days
DIO 0 0.0 days
DPO 5845 5844.8 days
Cash Conversion Cycle -5818 -5818.2 days
Fixed Asset Turnover snapshot only 2.786
Cash Velocity snapshot only 0.185
Capital Intensity snapshot only 8.251
Growth (YoY)
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Revenue 215.8% 166.6% 166.65%
Net Income -1.4% 14.5% 14.48%
EPS -73.0% 16.1% 16.05%
FCF 6.1% 3.4% 3.36%
EBITDA -2.3% -33.5% -33.54%
Op. Income -1.8% -10.0% -9.99%
OCF Growth snapshot only 3.44%
Asset Growth snapshot only 30.58%
Equity Growth snapshot only -9.08%
Debt Growth snapshot only -7.27%
Shares Change snapshot only 1.87%
Growth Quality
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Revenue Stability
Earnings Stability
Margin Stability
Rev. Growth Consistency 0.00 0.00 0.00 0.00 0.50 0.50 0.500
Earn. Growth Consistency 0.00 0.00 0.00 0.00 0.00 0.50 0.500
FCF Positive Streak 0 0 0 0 0 0 0
Earnings Persistence
Earnings Smoothness
ROE Trend
Gross Margin Trend
FCF Margin Trend
Sustainable Growth Rate
Internal Growth Rate
Cash Flow Quality
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
OCF/Net Income 1.01 1.05 0.96 -1.77 -2.25 -2.99 -2.994
FCF/OCF 1.03 1.02 1.02 0.99 1.00 0.99 0.991
FCF/Net Income snapshot only -2.967
CapEx/Revenue 2.9% 2.3% 1.9% 4.8% 1.1% 1.3% 1.34%
CapEx/Depreciation snapshot only 0.595
Accruals Ratio 0.00 0.00 -0.01 -0.36 -0.30 -0.27 -0.273
Sloan Accruals snapshot only -0.041
Cash Flow Adequacy snapshot only 111.466
Dividends & Buybacks
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Dividend Yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.00%
Dividend/Share $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00
Payout Ratio
FCF Payout Ratio 0.0% 0.0% 0.0% 0.00%
Total Payout Ratio
Div. Increase Streak
Chowder Number
Buyback Yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.00%
Net Buyback Yield -41.0% -1.2% -65.2% -35.5% -0.1% -0.2% -0.18%
Total Shareholder Return -41.0% -1.2% -65.2% -35.5% -0.1% -0.2% -0.18%
DuPont Factors
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Tax Burden (NI/EBT) 0.99 1.00 1.00 1.00 1.00 1.01 1.010
Interest Burden (EBT/EBIT) 0.84 0.84 0.84 0.66 0.60 0.52 0.523
EBIT Margin -116.59 -117.47 -144.74 -4.06 -1.76 -0.94 -0.944
Asset Turnover 0.00 0.00 0.00 0.05 0.09 0.14 0.137
Equity Multiplier 1.09 1.09 1.09 1.09 1.31 1.31 1.313
Per Share
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
EPS (Diluted TTM) $-0.64 $-0.96 $-1.52 $-1.29 $-1.10 $-0.81 $-0.81
Book Value/Share $12.97 $9.56 $9.51 $9.21 $8.63 $8.53 $8.46
Tangible Book/Share $12.97 $9.56 $9.51 $9.21 $8.63 $8.53 $8.53
Revenue/Share $0.01 $0.01 $0.01 $0.48 $1.04 $1.61 $1.61
FCF/Share $-0.67 $-1.03 $-1.49 $2.26 $2.48 $2.39 $2.39
OCF/Share $-0.65 $-1.01 $-1.46 $2.29 $2.49 $2.41 $2.41
Cash/Share $10.84 $7.99 $7.95 $7.70 $8.84 $8.74 $7.76
EBITDA/Share $-0.75 $-1.13 $-1.78 $-1.93 $-1.79 $-1.49 $-1.49
Debt/Share $0.79 $0.58 $0.58 $0.56 $0.53 $0.53 $0.53
Net Debt/Share $-10.05 $-7.41 $-7.37 $-7.14 $-8.30 $-8.21 $-8.21
Academic Models
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Altman Z-Score 3.015
Altman Z-Prime snapshot only 7.153
Piotroski F-Score 1 1 2 3 4 5 5
Beneish M-Score 96.55 103.22 103.223
Ohlson O-Score snapshot only -8.672
ROIC (Greenblatt) snapshot only -19.48%
Net-Net WC snapshot only $4.39
EVA snapshot only $-45438930.00
Credit
Metric Trend Q4'24 Q1'25 Q2'25 Q3'25 Q4'25 Q1'26 Current
Credit Rating snapshot only A+
Credit Score 76.29 76.25 76.42 82.93 78.32 78.30 78.297
Credit Grade snapshot only 5
Credit Trend snapshot only 2.047
Implied Spread (bps) snapshot only 125.000
Industry Credit Rank snapshot only 85
Sector Credit Rank snapshot only 75

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms