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THRD NASDAQ

Third Harmonic Bio, Inc.
1W: +0.0% 1M: -1.3% 3M: +4.3% 1Y: -50.5%
$5.38
Last traded 2025-08-12 — delisted
NASDAQ · Healthcare · Biotechnology · $242.8M mcap · 22M float · 1.18% daily turnover · Short 69% of daily vol

Edge Score

Quantitative competitive moat analysis scoring five pillars of durable advantage — cost leadership, brand intangibles, switching costs, network effects, and efficient scale — using industry percentile rankings on a 0–100 scale.

NO EDGE
30.7 / 100
NoneWeakNarrowWide
Primary source: Network Effects  ·  ROIC: -1589.5%
Cost Advantage
32
Intangibles
41
Switching Cost
17
Network Effect
43
Scale
22
The Edge Score quantifies a company's competitive moat using five pillars: Cost Advantage (20%, operating margin and SG&A efficiency vs industry peers), Intangible Assets (25%, gross margin premium, R&D intensity, brand pricing power), Switching Costs (25%, revenue stability, earnings consistency, customer retention proxied by operating leverage), Network Effects (15%, revenue growth with expanding margins, market share dominance), and Efficient Scale (15%, market concentration, ROIC sustainability). Each pillar is scored 0–100 using industry percentile rankings, then weighted into a composite. Wide ≥ 70, Narrow ≥ 55, Weak ≥ 40, None < 40. THRD has No discernible competitive edge (30.7/100). The business operates without significant structural advantages. The primary source of advantage is Network Effects. Negative ROIC of -1589.5% indicates the company is currently destroying value, though this may reflect a growth investment phase.

Analyst Insights

Wall Street analyst consensus based on price targets and buy/sell/hold recommendations from institutional research coverage over the trailing 12 months.

Analyst Price Targets
Analyst Recommendations
Strong Buy: 0Buy: 1Hold: 4Sell: 0Strong Sell: 0
Rating Summary
ConsensusHold
Avg Target$—
Analysts0
Price Target Change History
DateFirmAnalystOldNewChangeUpside @ CallStock@Call
2024-08-09 Morgan Stanley Michael Ulz $5 $20 +15 +84.2% $10.86
2024-06-17 Stifel Nicolaus Alex Thompson Initiated $23 +77.6% $12.95
2024-06-07 Raymond James Laura Prendergast Initiated $18 +24.2% $14.49
2022-12-16 Morgan Stanley Initiated $5 +17.1% $4.27
2022-12-16 Jefferies Initiated $4 -16.3% $4.30

InsiderStreet Scorecard

Proprietary multi-factor scorecard rating companies across seven fundamental dimensions — profitability, balance sheet strength, earnings quality, growth, value, momentum, and safety — each scored 0–100.

Grade A+
Profitability
Balance Sheet
85
Earnings Quality
74
Growth
12
Value
41
Momentum
20
Safety
100
Cash Flow
30

Risk & Quality Signals

Academic financial models used by institutional investors to assess bankruptcy risk, earnings manipulation, financial strength, and credit quality.

Altman Z-Score
9.54
Safe Zone
Piotroski F-Score
2/9
Beneish M-Score
Ohlson O-Score
-1.36
Bankruptcy prob: 20.4%
Moderate
Credit Rating
A+
Score: 76.2/100
Trend: Stable
Earnings Quality
OCF/NI: 0.78x
Accruals: -4.1%
The Altman Z-Score (1968) combines five ratios — working capital, retained earnings, EBIT, market value of equity, and sales, all relative to total assets or liabilities — into a single bankruptcy predictor. THRD scores 9.54, placing it in the Safe Zone (safe > 2.99, distress < 1.81). Bankruptcy is statistically unlikely within the next two years. The Piotroski F-Score (2000) is a 9-point binary checklist — four profitability tests (positive ROA, positive cash flow, improving ROA, cash flow exceeding net income), three leverage tests (declining debt ratio, improving current ratio, no share dilution), and two efficiency tests (improving gross margin, improving asset turnover). Each pass scores 1 point. THRD scores 2/9, suggesting weak financial fundamentals — the company fails the majority of these accounting tests. The Ohlson O-Score (1980) is a 9-variable logistic regression that estimates bankruptcy probability using firm size, leverage, working capital, current ratio, profitability (ROA), cash flow coverage, negative equity flag, consecutive losses flag, and earnings trajectory. The raw score is converted to a probability via logistic transformation. THRD's implied 20.4% bankruptcy probability is elevated and warrants attention to the balance sheet. Our Credit Rating model scores companies on five weighted components — solvency (30%), earning power (25%), leverage (20%), liquidity (15%), and cash flow quality (10%) — then blends the absolute score with sector and industry peer rankings. For companies with large buyback programs, equity is adjusted by adding back cumulative 5-year repurchases (capped at 80% of FCF generated) to avoid penalizing shareholder-friendly capital allocation. THRD receives an estimated rating of A+ (score: 76.2/100), with a stable trend.

Valuation

Key valuation multiples comparing the stock's market price to its earnings, revenue, book value, and cash flows. Lower multiples may indicate relative undervaluation versus peers.

P/E
-8.35x
PEG
0.19x
P/S
5058.07x
P/B
0.89x
P/FCF
-3.74x
P/OCF
EV/EBITDA
1.90x
EV/Revenue
-2624.85x
EV/EBIT
1.90x
EV/FCF
3.02x
Earnings Yield
-34.29%
FCF Yield
-26.75%
Shareholder Yield
0.00%
Graham Number
Equity-based multiples (P/E, P/B, P/FCF) compare the stock price to per-share fundamentals and are affected by capital structure. Enterprise value multiples (EV/EBITDA, EV/Revenue, EV/FCF) strip out debt and cash, making them more useful for cross-company comparisons regardless of how companies are financed. The Graham Number — √(22.5 × EPS × Book Value) — is Benjamin Graham's formula for the maximum price a defensive investor should pay. THRD currently has negative earnings — the P/E ratio is not meaningful.

DuPont Decomposition (5-Factor)

The 5-factor DuPont framework breaks Return on Equity into its component drivers — tax efficiency, interest burden, operating profitability, asset utilization, and financial leverage — to reveal what truly drives shareholder returns.

Tax Burden
1.000
NI / EBT
×
Interest Burden
0.806
EBT / EBIT
×
EBIT Margin
-1381.208
EBIT / Rev
×
Asset Turnover
0.000
Rev / Assets
×
Equity Multiplier
1.033
Assets / Equity
=
ROE
-19.3%
The 5-factor DuPont identity decomposes ROE as: Tax Burden × Interest Burden × EBIT Margin × Asset Turnover × Equity Multiplier = ROE. This reveals whether returns are driven by operating performance, financial leverage, or tax efficiency — three very different sources of profitability. THRD's ROE of -19.3% is driven by Asset Turnover (0.000), indicating efficient use of assets to generate revenue. A tax burden ratio of 1.00 indicates minimal tax leakage — the company retains over 90% of pre-tax earnings.

Graham-Dodd Adjusted Valuation

Our adaptation of Graham's growth formula (Fair P/E = 8.5 + 2g) from The Intelligent Investor. The classic version relies on analyst growth projections, which can be unreliable. This adjusted model substitutes the company's realized 3-year EPS CAGR — a backward-looking, verifiable measure of actual earnings power — grounding the valuation in demonstrated performance rather than forecasts.

Adj. Growth Rate
0.00%
Fair P/E
8.50x
Intrinsic Value
Price/Value
Margin of Safety
Premium
Assessment
Overvalued

Profitability Trends

Historical profitability ratios tracking how efficiently the company converts revenue into returns for shareholders over time.

Leverage & Solvency Trends

Debt and liquidity metrics showing the company's financial leverage and ability to meet short-term and long-term obligations.

Efficiency & Working Capital Trends

Operating efficiency metrics measuring how quickly the company converts inventory to sales, collects receivables, and manages its cash conversion cycle.

Growth Trends (YoY %)

Year-over-year growth rates for key financial metrics, showing the trajectory of revenue, earnings, and cash flow generation.

Earnings Stability

R-squared of linear regression measuring how predictably revenue, earnings, and margins follow a trend over the trailing 5 years. 1.0 = perfectly predictable; lower values indicate erratic or cyclical behavior.

Monte Carlo Price Simulation

Geometric Brownian Motion with 1,000 antithetic paths over 1 year, seeded from 730 days of historical volatility. Percentile bands show the range of statistically plausible outcomes — this is a statistical model, not a forecast.

Current Price
$5.38
Median 1Y
$1.92
5th Pctile
$0.28
95th Pctile
$13.47
Ann. Volatility
112.5%
25th–75th percentile 5th–95th percentile Median path Historical
All Ratios & Metrics

Complete fundamental data with up to 20 periods of history, sparkline trends, and current values across 13 categories and 130+ financial metrics.

Profitability
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
ROE 17.6% -7.6% -10.7% -13.3% -18.9% -5.8% -5.3% -6.5% -14.0% -16.4% -19.3% -19.29%
ROA -6.4% -7.3% -10.4% -12.9% -10.7% -5.6% -5.2% -6.3% -13.6% -15.9% -18.7% -18.68%
ROIC 3.9% -3.9% -6.0% -7.8% -4.4% -4.4% -4.3% -5.0% -10.5% -14.1% -15.9% -15.90%
ROCE -7.0% -7.6% -11.6% -15.3% -16.1% -16.1% -15.9% -17.1% -19.4% -20.5% -23.1% -23.06%
Gross Margin 98.4% 50.0%
Operating Margin -12.4% -342.5%
Net Margin -8.2% -273.1%
EBITDA Margin -12.4% -342.2%
FCF Margin -24.6% -24.2% -29.8% -34.5% -719.0% -868.7% -868.69%
OCF Margin -24.4% -24.0% -29.8% -34.5% -718.8% -868.5% -868.48%
ROE 3Y Avg snapshot only -11.66%
ROA 3Y Avg snapshot only -11.29%
ROIC Economic snapshot only -18.16%
Cash ROA snapshot only -14.15%
Cash ROIC snapshot only -12.65%
CROIC snapshot only -12.65%
NOPAT Margin snapshot only -1091.15%
Pretax Margin snapshot only -1113.48%
R&D / Revenue snapshot only 852.48%
SGA / Revenue snapshot only 528.48%
SBC / Revenue snapshot only 252.77%
Valuation
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
P/E Ratio -21.08 -7.74 -5.25 -4.94 -11.05 -27.14 -25.46 -29.20 -14.28 -9.35 -2.92 -8.350
P/S Ratio 523.86 454.08 630.65 669.68 8857.44 3247.13 5058.074
P/B Ratio -3.70 0.59 0.56 0.66 0.88 1.63 1.41 1.96 2.08 1.49 0.55 0.886
P/FCF -16.05 -8.42 -6.07 -6.16 -10.43 -21.27 -18.78 -21.18 -19.38 -12.32 -3.74 -3.738
P/OCF
EV/EBITDA -5.45 5.30 3.62 2.12 0.66 -3.94 -2.65 -5.63 -5.58 -2.44 1.90 1.902
EV/Revenue 206.73 136.96 313.52 352.55 2985.46 -2624.85 -2624.852
EV/EBIT -5.21 5.20 3.58 2.10 0.66 -3.93 -2.65 -5.62 -5.58 -2.43 1.90 1.900
EV/FCF -4.15 5.73 4.56 3.05 1.27 -8.39 -5.66 -10.53 -10.21 -4.15 3.02 3.022
Earnings Yield -4.7% -12.9% -19.0% -20.2% -9.1% -3.7% -3.9% -3.4% -7.0% -10.7% -34.3% -34.29%
FCF Yield -6.2% -11.9% -16.5% -16.2% -9.6% -4.7% -5.3% -4.7% -5.2% -8.1% -26.8% -26.75%
PEG Ratio snapshot only 0.194
Price/Tangible Book snapshot only 0.547
Shareholder Yield snapshot only 0.00%
Leverage & Solvency
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
Current Ratio 22.72 51.80 51.80 51.80 51.80 50.29 50.29 50.29 50.29 40.87 40.87 40.869
Quick Ratio 22.72 51.80 51.80 51.80 51.80 50.29 50.29 50.29 50.29 40.87 40.87 40.869
Debt/Equity -0.00 0.02 0.02 0.02 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.011
Net Debt/Equity -0.98 -0.98 -0.98 -0.98 -0.99 -0.99 -0.99 -0.99 -0.99 -0.99 -0.988
Debt/Assets 0.00 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.011
Debt/EBITDA -0.00 -0.20 -0.13 -0.10 -0.09 -0.09 -0.09 -0.08 -0.07 -0.05 -0.05 -0.048
Net Debt/EBITDA 15.63 13.08 8.43 6.40 6.04 6.04 6.14 5.69 5.02 4.79 4.25 4.255
Interest Coverage -10.20 -15.73 -20.66 -21.70
Equity Multiplier -2.77 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.033
Cash Ratio snapshot only 40.099
Cash to Debt snapshot only 88.860
FCF to Debt snapshot only -12.998
Defensive Interval snapshot only 1569.7 days
Efficiency & Turnover
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
Asset Turnover 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.000
Inventory Turnover
Receivables Turnover
Payables Turnover 0.00 0.02 0.02 0.10 0.20 0.18 0.19 0.11 0.02 0.03 0.03 0.032
DSO 0 0 0 0 0 0 0.0 days
DIO 0 0 0 0 0 0 0 0 0 0 0.0 days
DPO 20046 20046 3698 1846 1995 1931 3332 14619 11482 11294 11294.1 days
Cash Conversion Cycle -1995 -1931 -3332 -14619 -11482 -11294 -11294.1 days
Fixed Asset Turnover snapshot only 0.015
Cash Velocity snapshot only 0.000
Capital Intensity snapshot only 6137.667
Growth (YoY)
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
Revenue -94.3% -94.3% -94.26%
Net Income -1.8% 26.2% 51.8% 53.1% -70.7% -1.8% -2.6% -2.58%
EPS 35.7% 27.2% 52.8% 54.3% -64.0% -1.7% -2.2% -2.21%
FCF -1.3% -2.5% 24.5% 19.5% -18.8% -67.6% -1.1% -1.06%
EBITDA -4.7% -1.0% -28.1% -4.8% -12.1% -33.9% -53.3% -53.31%
Op. Income -2.0% -0.6% 36.8% 44.4% -1.1% -1.6% -2.1% -2.07%
OCF Growth snapshot only -1.08%
Asset Growth snapshot only 6.08%
Equity Growth snapshot only 5.97%
Debt Growth snapshot only -18.85%
Shares Change snapshot only 11.70%
Growth Quality
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
Revenue Stability 0.75 0.00 0.00 0.003
Earnings Stability 1.00 0.58 0.34 0.338
Margin Stability
Rev. Growth Consistency 0.00 0.00 0.00 0.00 0.00 0.50 0.50 0.50 0.50 0.00 0.00 0.000
Earn. Growth Consistency 0.00 0.00 0.00 0.00 0.00 0.50 0.50 0.50 0.00 0.00 0.00 0.000
FCF Positive Streak 0 0 0 0 0 0 0 0 0 0 0 0
Earnings Persistence 0.50 0.50 0.50 0.500
Earnings Smoothness
ROE Trend -0.09 -0.11 -0.106
Gross Margin Trend
FCF Margin Trend
Sustainable Growth Rate
Internal Growth Rate
Cash Flow Quality
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
OCF/Net Income 1.31 0.92 0.86 0.80 1.05 1.27 1.34 1.38 0.74 0.76 0.78 0.780
FCF/OCF 1.00 1.00 1.00 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.000
FCF/Net Income snapshot only 0.780
CapEx/Revenue 20.2% 20.2% 0.1% 0.1% 20.8% 20.8% 20.83%
CapEx/Depreciation snapshot only 0.200
Accruals Ratio 0.02 -0.01 -0.01 -0.03 0.01 0.01 0.02 0.02 -0.04 -0.04 -0.04 -0.041
Sloan Accruals snapshot only 0.057
Cash Flow Adequacy snapshot only -4168.700
Dividends & Buybacks
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
Dividend Yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.00%
Dividend/Share $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00
Payout Ratio
FCF Payout Ratio
Total Payout Ratio
Div. Increase Streak
Chowder Number
Buyback Yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.00%
Net Buyback Yield 0.0% -1.2% -1.2% -1.0% -78.1% -0.2% -0.2% -0.4% -9.1% -11.9% -32.4% -32.40%
Total Shareholder Return 0.0% -1.2% -1.2% -1.0% -78.1% -0.2% -0.2% -0.4% -9.1% -11.9% -32.4% -32.40%
DuPont Factors
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
Tax Burden (NI/EBT) 1.00 1.11 1.08 1.06 1.10 1.00 1.00 1.00 1.00 1.00 1.00 1.000
Interest Burden (EBT/EBIT) 0.96 0.89 0.84 0.81 0.44 0.37 0.34 0.39 0.74 0.77 0.81 0.806
EBIT Margin -52.58 -51.74 -55.76 -63.20 -1226.50 -1381.21 -1381.208
Asset Turnover 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.000
Equity Multiplier -2.77 1.03 1.03 1.03 1.77 1.03 1.03 1.03 1.03 1.03 1.03 1.033
Per Share
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
EPS (Diluted TTM) $-0.90 $-0.56 $-0.78 $-0.97 $-0.58 $-0.40 $-0.37 $-0.45 $-0.95 $-1.10 $-1.19 $-1.19
Book Value/Share $-5.12 $7.34 $7.33 $7.31 $7.28 $6.74 $6.69 $6.63 $6.51 $6.90 $6.35 $6.07
Tangible Book/Share $-5.12 $7.34 $7.33 $7.31 $7.28 $6.74 $6.69 $6.63 $6.51 $6.90 $6.35 $6.35
Revenue/Share $0.00 $0.00 $0.00 $0.00 $0.00 $0.02 $0.02 $0.02 $0.02 $0.00 $0.00 $0.00
FCF/Share $-1.18 $-0.51 $-0.68 $-0.78 $-0.61 $-0.52 $-0.50 $-0.61 $-0.70 $-0.84 $-0.93 $-0.55
OCF/Share $-1.18 $-0.51 $-0.68 $-0.78 $-0.61 $-0.51 $-0.50 $-0.61 $-0.70 $-0.84 $-0.93 $-0.55
Cash/Share $14.07 $7.34 $7.32 $7.30 $7.28 $6.74 $6.69 $6.63 $6.51 $6.90 $6.35 $6.05
EBITDA/Share $-0.90 $-0.55 $-0.86 $-1.12 $-1.19 $-1.10 $-1.07 $-1.15 $-1.28 $-1.42 $-1.47 $-1.47
Debt/Share $0.00 $0.11 $0.11 $0.11 $0.11 $0.10 $0.10 $0.10 $0.10 $0.08 $0.07 $0.07
Net Debt/Share $-14.07 $-7.23 $-7.21 $-7.19 $-7.17 $-6.64 $-6.59 $-6.54 $-6.42 $-6.82 $-6.28 $-6.28
Academic Models
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
Altman Z-Score 9.541
Altman Z-Prime snapshot only 20.335
Piotroski F-Score 1 2 2 2 2 2 2 2 2 2 2 2
Beneish M-Score -6.89
Ohlson O-Score snapshot only -1.363
ROIC (Greenblatt) snapshot only -23.13%
Net-Net WC snapshot only $6.26
EVA snapshot only $-52704920.00
Credit
Metric Trend Q3'22 Q4'22 Q1'23 Q2'23 Q3'23 Q4'23 Q1'24 Q2'24 Q3'24 Q4'24 Q1'25 Current
Credit Rating snapshot only A+
Credit Score 20.00 65.60 65.10 65.27 65.44 76.71 76.44 76.56 76.30 76.29 76.25 76.249
Credit Grade snapshot only 5
Credit Trend snapshot only -0.195
Implied Spread (bps) snapshot only 125.000
Industry Credit Rank snapshot only 79
Sector Credit Rank snapshot only 70

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms