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Asset Manager ← All Institutions

Sio Capital Management, LLC

Q3 2025 · Filed 2025-11-13
Market Value
$371M
+63.5%
Holdings
53
+4
New Purchases
14
Added To
6
Closed
12
Reduced
8
Top 10 Concentration
63.4%
Turnover
49.1%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
CELC 10.48% 0.00% +10.48% $39M
ALKS 5.46% 0.00% +5.46% $20M
DNTH 6.13% 1.94% +4.19% $23M
HSIC 3.92% 0.00% +3.92% $15M
KVUE 3.69% 0.00% +3.69% $14M
SNY 7.16% 3.99% +3.17% $27M
GSK 3.13% 0.00% +3.13% $12M
HAE 2.60% 0.00% +2.60% $10M
KALV 2.25% 0.00% +2.25% $8M
CRNX 1.96% 0.00% +1.96% $7M
RAPP 1.48% 0.00% +1.48% $6M
NVCR 1.44% 0.00% +1.44% $5M
TFX 1.32% 0.00% +1.32% $5M
SLP 1.30% 0.00% +1.30% $5M
AQST 2.26% 1.38% +0.88% $8M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
GMED 0.00% 6.39% -6.39% $0
NBIX 0.00% 5.58% -5.58% $0
ANNX 0.00% 4.33% -4.33% $0
MMS 13.74% 16.96% -3.23% $51M
CNC 3.73% 6.28% -2.55% $14M
AORT 0.00% 2.18% -2.18% $0
BMRN 3.29% 5.46% -2.17% $12M
MRK 4.01% 6.07% -2.06% $15M
ANIP 1.38% 3.25% -1.87% $5M
EWTX 1.34% 3.12% -1.78% $5M
SEPN 0.96% 2.72% -1.76% $4M
IRON 5.07% 6.65% -1.58% $19M
AVNS 0.00% 1.56% -1.56% $0
TYRA 1.94% 3.42% -1.48% $7M
MRUS 0.00% 1.45% -1.45% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 1 $15M 4.0%
Large Cap 7 $78M 21.0%
Mid Cap 16 $205M 55.2%
Small Cap 19 $62M 16.8%
Micro Cap 10 $11M 3.0%

Portfolio Analytics

Avg Market Cap
$13.3B
Median Market Cap
$1.5B
Avg P/E
26.7
Median P/E
21.2
Avg Dividend Yield
0.01%
Avg Beta
0.83
# Stocks
53
# ETFs / Funds
0

Top Holdings (53 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 MMS 13.74% 557,615 $51M $91.37 $12M +9,529 +1.7%
2 CELC 10.48% 786,526 $39M $49.40 +786,526 NEW
3 SNY 7.16% 562,703 $27M $47.20 $18M +375,203 +200.1%
4 DNTH 6.13% 577,750 $23M $39.35 $18M +341,680 +144.7%
5 ALKS 5.46% 674,840 $20M $30.00 +674,840 NEW
6 IRON 5.07% 284,787 $19M $66.08 $4M
7 MRK 4.01% 177,300 $15M $83.93 $1M +3,349 +1.9%
8 HSIC 3.92% 219,207 $15M $66.37 +219,207 NEW
9 CNC 3.73% 387,600 $14M $35.68 -$419K +125,100 +47.7%
10 KVUE 3.69% 844,000 $14M $16.23 +844,000 NEW
11 BMRN 3.29% 225,114 $12M $54.16 -$182K
12 GSK 3.13% 268,873 $12M $43.16 +268,873 NEW
13 HAE 2.60% 198,035 $10M $48.74 +198,035 NEW
14 AQST 2.26% 1,498,095 $8M $5.59 $5M +550,606 +58.1%
15 KALV 2.25% 683,819 $8M $12.18 +683,819 NEW
16 AVR 2.15% 1,772,601 $8M $4.50 $1M -66,421 -3.6%
17 CRNX 1.96% 174,841 $7M $41.65 +174,841 NEW
18 TYRA 1.94% 514,947 $7M $13.99 -$550K -295,327 -36.5%
19 RAPP 1.48% 185,265 $6M $29.70 +185,265 NEW
20 NVCR 1.44% 413,829 $5M $12.92 +413,829 NEW
21 ANIP 1.38% 55,723 $5M $91.60 -$2M -57,200 -50.6%
22 EWTX 1.34% 307,181 $5M $16.22 -$2M -232,549 -43.1%
23 TFX 1.32% 40,057 $5M $122.36 +40,057 NEW
24 SLP 1.30% 320,307 $5M $15.07 +320,307 NEW
25 PRQR 1.19% 2,075,139 $4M $2.13 $187K
26 PMVP 1.00% 2,636,548 $4M $1.40 -$268K -1,098,848 -29.4%
27 SEPN 0.96% 189,199 $4M $18.81 -$3M -395,236 -67.6%
28 IDYA 0.91% 124,230 $3M $27.21 $769K
29 ERAS 0.81% 1,369,748 $3M $2.18 $1M
30 VIR 0.74% 478,343 $3M $5.71 $320K
31 SVRA 0.70% 726,851 $3M $3.57 $938K
32 VTYX 0.70% 829,178 $3M $3.11 -$220K -478,786 -36.6%
33 OVID 0.50% 1,427,495 $2M $1.30 $1M -804,505 -36.0%
34 BBOT 0.41% 130,628 $2M $11.58 +130,628 NEW
35 CNTX 0.35% 1,341,636 $1M $0.97 $421K
36 TELA 0.26% 636,300 $948K $1.49 -$286K
37 FHTX 0.16% 122,889 $601K $4.89 $23K
38 BOLD 0.05% 163,679 $201K $1.23 $36K
39 TERN 0.02% 10,100 $76K $7.51 $38K
40 NXTC 0.02% 10,940 $64K $5.86 +10,940 NEW
41 HUMAW —% 49,998 $12K $0.24 -$7K
42 TVTX —% -$2M -122,210 -100.0% SOLD
43 AORT —% -$5M -158,736 -100.0% SOLD
44 ENTA —% -$1M -178,774 -100.0% SOLD
45 GMED —% -$14M -245,570 -100.0% SOLD
46 ALEC —% -$1M -845,531 -100.0% SOLD
47 MBX —% -$3M -241,000 -100.0% SOLD
48 EMBC —% -$302K -31,169 -100.0% SOLD
49 AVNS —% -$4M -288,849 -100.0% SOLD
50 ANNX —% -$10M -4,095,764 -100.0% SOLD
51 ATXS —% -$2M -318,256 -100.0% SOLD
52 NBIX —% -$13M -100,725 -100.0% SOLD
53 MRUS —% -$3M -62,719 -100.0% SOLD

Options Breakdown

0 Calls $0 Call Value 3 Puts $0 Put Value

Top Puts

SymbolSharesValueStatus
INMB $0 SOLD
ATYR $0 SOLD
IDXX $0 SOLD

New Positions

SymbolValue% Port
CELC $39M 10.48%
ALKS $20M 5.46%
HSIC $15M 3.92%
KVUE $14M 3.69%
GSK $12M 3.13%
HAE $10M 2.60%
KALV $8M 2.25%
CRNX $7M 1.96%
RAPP $6M 1.48%
NVCR $5M 1.44%
TFX $5M 1.32%
SLP $5M 1.30%
BBOT $2M 0.41%
NXTC $64K 0.02%

Sold Out Positions

SymbolValue% Port
GMED —%
AORT —%
AVNS —%
ENTA —%
EMBC —%
MBX —%
ANNX —%
ALEC —%
NBIX —%
TVTX —%
MRUS —%
ATXS —%
View SEC EDGAR Filings for Sio Capital Management, LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms