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Asset Manager ← All Institutions

Sio Capital Management, LLC

Q4 2025 · Filed 2026-02-17
Market Value
$571M
+53.9%
Holdings
62
+9
New Purchases
21
Added To
8
Closed
8
Reduced
13
Top 10 Concentration
58.3%
Turnover
46.8%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
CI 8.30% 0.00% +8.30% $47M
ZBH 6.07% 0.00% +6.07% $35M
OGN 4.30% 0.00% +4.30% $25M
ICLR 4.06% 0.00% +4.06% $23M
WAY 3.52% 0.00% +3.52% $20M
LIVN 3.47% 0.00% +3.47% $20M
GPCR 2.46% 0.00% +2.46% $14M
BTSG 2.02% 0.00% +2.02% $12M
CRL 1.92% 0.00% +1.92% $11M
TARA 1.60% 0.00% +1.60% $9M
CCRN 1.52% 0.00% +1.52% $9M
SNY 8.25% 7.16% +1.09% $47M
ABVX 1.02% 0.00% +1.02% $6M
ABC 0.94% 0.00% +0.94% $5M
MCK 0.92% 0.00% +0.92% $5M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MMS 7.57% 13.74% -6.17% $43M
ALKS 0.47% 5.46% -4.99% $3M
IRON 0.80% 5.07% -4.27% $5M
MRK 0.00% 4.01% -4.01% $0
HSIC 0.00% 3.92% -3.92% $0
GSK 0.00% 3.13% -3.13% $0
DNTH 3.43% 6.13% -2.70% $20M
KALV 0.00% 2.25% -2.25% $0
CELC 8.34% 10.48% -2.14% $48M
CNC 1.98% 3.73% -1.75% $11M
NVCR 0.00% 1.44% -1.44% $0
HAE 1.30% 2.60% -1.30% $7M
SLP 0.00% 1.30% -1.30% $0
AQST 1.12% 2.26% -1.13% $6M
SEPN 0.00% 0.96% -0.96% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 1 $0 0.0%
Large Cap 10 $202M 35.3%
Mid Cap 23 $275M 48.2%
Small Cap 16 $70M 12.2%
Micro Cap 12 $24M 4.3%

Portfolio Analytics

Avg Market Cap
$15.2B
Median Market Cap
$2.4B
Avg P/E
23.5
Median P/E
21.0
Avg Dividend Yield
0.00%
Avg Beta
0.81
# Stocks
62
# ETFs / Funds
0

Top Holdings (62 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 CELC 8.34% 477,067 $48M $99.74 $9M -309,459 -39.4%
2 CI 8.30% 172,203 $47M $275.23 +172,203 NEW
3 SNY 8.25% 971,686 $47M $48.46 $21M +408,983 +72.7%
4 MMS 7.57% 500,304 $43M $86.32 -$8M -57,311 -10.3%
5 ZBH 6.07% 385,642 $35M $89.92 +385,642 NEW
6 KVUE 4.43% 1,465,442 $25M $17.25 $12M +621,442 +73.6%
7 OGN 4.30% 3,421,765 $25M $7.17 +3,421,765 NEW
8 ICLR 4.06% 127,202 $23M $182.22 +127,202 NEW
9 WAY 3.52% 613,725 $20M $32.75 +613,725 NEW
10 LIVN 3.47% 322,382 $20M $61.53 +322,382 NEW
11 DNTH 3.43% 474,503 $20M $41.21 -$3M -103,247 -17.9%
12 GPCR 2.46% 201,500 $14M $69.55 +201,500 NEW
13 BMRN 2.42% 232,688 $14M $59.43 $2M +7,574 +3.4%
14 TYRA 2.42% 526,002 $14M $26.29 $7M +11,055 +2.1%
15 BTSG 2.02% 308,010 $12M $37.45 +308,010 NEW
16 CNC 1.98% 274,350 $11M $41.15 -$3M -113,250 -29.2%
17 CRL 1.92% 54,985 $11M $199.48 +54,985 NEW
18 TFX 1.86% 86,876 $11M $122.04 $6M +46,819 +116.9%
19 AVR 1.64% 1,874,641 $9M $4.99 $1M +102,040 +5.8%
20 TARA 1.60% 1,715,394 $9M $5.33 +1,715,394 NEW
21 CCRN 1.52% 1,068,821 $9M $8.10 +1,068,821 NEW
22 HAE 1.30% 92,631 $7M $80.15 -$2M -105,404 -53.2%
23 ANIP 1.21% 87,272 $7M $78.94 $2M +31,549 +56.6%
24 AQST 1.12% 993,095 $6M $6.46 -$2M -505,000 -33.7%
25 EWTX 1.03% 237,481 $6M $24.81 $911K -69,700 -22.7%
26 ABVX 1.02% 43,124 $6M $134.85 +43,124 NEW
27 CRNX 1.02% 124,841 $6M $46.55 -$1M -50,000 -28.6%
28 RAPP 0.98% 185,265 $6M $30.34 $119K
29 ABC 0.94% 15,900 $5M $337.75 +15,900 NEW
30 MCK 0.92% 6,400 $5M $820.29 +6,400 NEW
31 IRON 0.80% 57,586 $5M $79.41 -$14M -227,201 -79.8%
32 PRQR 0.77% 2,164,181 $4M $2.02 -$48K +89,042 +4.3%
33 FULC 0.76% 382,000 $4M $11.31 +382,000 NEW
34 SVRA 0.65% 613,888 $4M $6.03 $1M -112,963 -15.5%
35 ORKA 0.63% 118,126 $4M $30.31 +118,126 NEW
36 VTYX 0.61% 387,751 $4M $9.03 $923K -441,427 -53.2%
37 PMVP 0.58% 2,636,548 $3M $1.25 -$395K
38 VIR 0.51% 478,343 $3M $6.03 $153K
39 ALKS 0.47% 95,353 $3M $27.98 -$18M -579,487 -85.9%
40 IDYA 0.46% 75,730 $3M $34.57 -$762K -48,500 -39.0%
41 KYMR 0.44% 32,235 $3M $77.81 +32,235 NEW
42 OVID 0.41% 1,427,495 $2M $1.63 $471K
43 CNTX 0.35% 1,341,636 $2M $1.47 $672K
44 HYPR 0.34% 2,000,000 $2M $0.98 +2,000,000 NEW
45 BBOT 0.29% 130,628 $2M $12.52 $123K
46 ADGM 0.23% 1,288,461 $1M $1.04 +1,288,461 NEW
47 TELA 0.13% 636,300 $751K $1.18 -$197K
48 FHTX 0.12% 122,889 $664K $5.40 $63K
49 SENS 0.11% 115,784 $639K $5.52 +115,784 NEW
50 ENTA 0.11% 40,000 $631K $15.77 +40,000 NEW
51 TERN 0.07% 10,100 $408K $40.40 $332K
52 BOLD 0.03% 163,679 $196K $1.20 -$5K
53 NXTC 0.03% 10,940 $155K $14.19 $91K
54 HUMAW —% 49,998 $5K $0.10 -$7K
55 MRK —% -$15M -177,300 -100.0% SOLD
56 GSK —% -$12M -268,873 -100.0% SOLD
57 ERAS —% -$3M -1,369,748 -100.0% SOLD
58 KALV —% -$8M -683,819 -100.0% SOLD
59 SEPN —% -$4M -189,199 -100.0% SOLD
60 SLP —% -$5M -320,307 -100.0% SOLD
61 NVCR —% -$5M -413,829 -100.0% SOLD
62 HSIC —% -$15M -219,207 -100.0% SOLD

Options Breakdown

0 Calls $0 Call Value 2 Puts $31M Put Value

Top Puts

SymbolSharesValueStatus
RYTM 265,700 $28M NEW
ELTX 296,900 $2M NEW

New Positions

SymbolValue% Port
CI $47M 8.30%
ZBH $35M 6.07%
OGN $25M 4.30%
ICLR $23M 4.06%
WAY $20M 3.52%
LIVN $20M 3.47%
GPCR $14M 2.46%
BTSG $12M 2.02%
CRL $11M 1.92%
TARA $9M 1.60%
CCRN $9M 1.52%
ABVX $6M 1.02%
ABC $5M 0.94%
MCK $5M 0.92%
FULC $4M 0.76%

Sold Out Positions

SymbolValue% Port
GSK —%
MRK —%
ERAS —%
KALV —%
NVCR —%
HSIC —%
SLP —%
SEPN —%
View SEC EDGAR Filings for Sio Capital Management, LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms