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Rock Springs Capital Management LP

Q3 2025 · Filed 2025-11-14
Market Value
$1.6B
+6.8%
Holdings
95
-2
New Purchases
9
Added To
21
Closed
9
Reduced
34
Top 10 Concentration
39.6%
Turnover
18.9%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
TVTX 3.19% 1.86% +1.33% $52M
MDGL 3.89% 2.79% +1.10% $63M
CDTX 1.47% 0.43% +1.04% $24M
RYTM 4.46% 3.58% +0.88% $72M
MIRM 3.44% 2.74% +0.70% $56M
MLYS 0.95% 0.29% +0.66% $15M
RVMD 3.84% 3.22% +0.62% $62M
HTFL 0.52% 0.00% +0.52% $8M
LENZ 0.68% 0.16% +0.52% $11M
COGT 0.89% 0.38% +0.51% $14M
ZBIO 0.79% 0.41% +0.39% $13M
MBX 0.30% 0.00% +0.30% $5M
DYN 0.64% 0.36% +0.28% $10M
KYMR 1.57% 1.29% +0.28% $25M
BBIO 0.27% 0.00% +0.27% $4M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
BPMC 0.00% 1.56% -1.56% $0
UNH 0.00% 1.04% -1.04% $0
LLY 4.95% 5.97% -1.02% $80M
RARE 2.31% 3.33% -1.02% $37M
OSCR 0.00% 0.99% -0.99% $0
ACHC 0.26% 1.04% -0.78% $4M
ISRG 2.26% 2.93% -0.67% $37M
WST 0.16% 0.73% -0.58% $3M
EVH 1.54% 2.09% -0.55% $25M
PHR 1.08% 1.57% -0.48% $18M
NUVL 0.00% 0.47% -0.47% $0
AKRO 1.83% 2.25% -0.42% $30M
INSP 0.50% 0.92% -0.41% $8M
ZLAB 1.65% 2.00% -0.35% $27M
BSX 2.17% 2.51% -0.34% $35M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 2 $80M 5.0%
Large Cap 19 $566M 34.9%
Mid Cap 36 $709M 43.7%
Small Cap 25 $213M 13.1%
Micro Cap 13 $55M 3.4%

Portfolio Analytics

Avg Market Cap
$26.4B
Median Market Cap
$2.7B
Avg P/E
47.1
Median P/E
35.3
Avg Dividend Yield
0.00%
Avg Beta
0.87
# Stocks
94
# ETFs / Funds
1

Top Holdings (95 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 ARGX 6.48% 142,750 $105M $737.56 $8M -33,000 -18.8%
2 LLY 4.95% 105,400 $80M $763.00 -$10M -11,100 -9.5%
3 RYTM 4.46% 717,102 $72M $100.99 $18M -144,051 -16.7%
4 MDGL 3.89% 137,746 $63M $458.66 $21M -2,550 -1.8%
5 RVMD 3.84% 1,335,270 $62M $46.70 $13M +4,310 +0.3%
6 MRUS 3.46% 597,051 $56M $94.15 $267K -466,557 -43.9%
7 MIRM 3.44% 761,126 $56M $73.31 $14M -57,080 -7.0%
8 INSM 3.41% 385,000 $55M $144.01 $3M -140,000 -26.7%
9 TVTX 3.19% 2,164,773 $52M $23.90 $23M +256,565 +13.4%
10 IRTC 2.49% 235,000 $40M $171.99 $3M -7,500 -3.1%
11 AGIO 2.37% 958,542 $38M $40.14 $6M -31,203 -3.1%
12 RARE 2.31% 1,246,341 $37M $30.08 -$13M -144,731 -10.4%
13 ISRG 2.26% 82,000 $37M $447.23 -$8M
14 BSX 2.17% 360,250 $35M $97.63 -$3M +5,250 +1.5%
15 XENE 2.11% 851,744 $34M $40.15 $5M -79,937 -8.6%
16 ALNY 2.08% 74,250 $34M $456.00 $1M -25,750 -25.8%
17 EXAS 2.00% 593,500 $32M $54.71 $2M +21,500 +3.8%
18 PEN 1.88% 120,500 $31M $253.32 -$2M -8,000 -6.2%
19 AKRO 1.83% 626,526 $30M $47.48 -$4M -14,000 -2.2%
20 SRRK 1.82% 794,133 $30M $37.24 $1M
21 ZLAB 1.65% 791,193 $27M $33.89 -$4M -80,199 -9.2%
22 GPCR 1.64% 951,154 $27M $28.00 $3M -184,725 -16.3%
23 KYMR 1.57% 450,374 $25M $56.60 $6M
24 THC 1.56% 125,000 $25M $203.04 $2M -5,000 -3.9%
25 EVH 1.54% 2,950,000 $25M $8.46 -$7M +129,300 +4.6%
26 CAI 1.48% 793,651 $24M $30.25 $3M
27 CDTX 1.47% 249,402 $24M $95.76 $17M +115,269 +85.9%
28 DXCM 1.31% 316,900 $21M $67.29 -$4M +30,150 +10.5%
29 OMDA 1.25% 919,950 $20M $22.11 $4M -1
30 CLDX 1.15% 721,538 $19M $25.87 $2M -91,115 -11.2%
31 VERA 1.10% 617,396 $18M $29.06 $3M
32 PHR 1.08% 749,116 $18M $23.52 -$6M -88,184 -10.5%
33 TARS 1.06% 288,344 $17M $59.43 $2M -85,406 -22.9%
34 CMPX 0.96% 4,474,702 $16M $3.50 $3M -488,253 -9.8%
35 PHVS 0.96% 623,402 $16M $24.95 $5M
36 BRKS 0.96% 540,400 $16M $28.72 -$805K +10,000 +1.9%
37 MLYS 0.95% 408,313 $15M $37.92 $11M +83,800 +25.8%
38 FOLD 0.94% 1,947,374 $15M $7.88 $4M -12,960 -0.7%
39 XBI 0.94% 151,750 $15M $100.20 $3M
40 ACLX 0.90% 178,982 $15M $82.10 $2M -7,332 -3.9%
41 SMMT 0.90% 710,000 $15M $20.66 -$440K
42 COGT 0.89% 1,008,308 $14M $14.36 $9M +208,109 +26.0%
43 ELVN 0.86% 686,107 $14M $20.47 -$26K -15,301 -2.2%
44 ZBIO 0.79% 580,677 $13M $22.20 $7M -59,790 -9.3%
45 NBIX 0.78% 89,750 $13M $140.38 $1M +950 +1.1%
46 ARDX 0.78% 2,286,273 $13M $5.51 $4M
47 DHR 0.75% 61,500 $12M $198.26 $538K +2,500 +4.2%
48 LENZ 0.68% 236,227 $11M $46.58 $9M +152,245 +181.3%
49 DYN 0.64% 824,061 $10M $12.65 $5M +243,063 +41.8%
50 MREO 0.58% 4,570,649 $9M $2.06 -$3M +105,357 +2.4%
51 ACRS 0.54% 4,609,309 $9M $1.90 $2M -160,000 -3.4%
52 GOSS 0.53% 3,266,960 $9M $2.63 $5M
53 HTFL 0.52% 250,000 $8M $33.66 +250,000 NEW
54 INSP 0.50% 110,500 $8M $74.20 -$6M +3,000 +2.8%
55 EW 0.42% 88,000 $7M $77.77 -$3M -43,000 -32.8%
56 AMLX 0.42% 499,764 $7M $13.59 $4M
57 REGN 0.39% 11,300 $6M $562.27 $421K
58 BCAX 0.36% 370,666 $6M $15.79 $3M +34,596 +10.3%
59 JANX 0.32% 210,366 $5M $24.44 $284K +100 +0.1%
60 MBX 0.30% 282,624 $5M $17.50 +282,624 NEW
61 TMO 0.30% 10,000 $5M $485.02 $796K
62 BBIO 0.27% 85,000 $4M $51.94 +85,000 NEW
63 ATEC 0.27% 302,500 $4M $14.54 $1M +35,000 +13.1%
64 ACHC 0.26% 170,000 $4M $24.76 -$12M -526,000 -75.6%
65 OCUL 0.22% 300,000 $4M $11.69 +300,000 NEW
66 TLPH 0.20% 3,589,186 $3M $0.89 $3M +3,272,726 +1034.2%
67 ALKS 0.20% 106,537 $3M $30.00 +106,537 NEW
68 SION 0.18% 99,429 $3M $29.41 $1M
69 EDAP 0.18% 1,270,000 $3M $2.29 $813K
70 WST 0.16% 9,750 $3M $262.33 -$9M -41,280 -80.9%
71 APLS 0.13% 92,000 $2M $22.63 $623K +7,700 +9.1%
72 NGNE 0.11% 104,339 $2M $17.33 $248K
73 KRRO 0.11% 35,719 $2M $47.89 $1M
74 CNTA 0.10% 69,240 $2M $24.25 +69,240 NEW
75 CATX 0.09% 444,383 $2M $3.43 -$4K
76 APLT 0.08% 2,075,991 $1M $0.60 $610K
77 MRSN 0.07% 152,586 $1M $7.76 +152,586 NEW
78 IMVT 0.07% 72,965 $1M $16.12 -$2M -148,535 -67.1%
79 EYPT 0.03% 31,655 $451K $14.24 +31,655 NEW
80 CRL 0.03% 2,700 $422K $156.46 $13K
81 PCVX 0.02% 11,100 $400K $36.02 $39K
82 NVAX 0.02% 45,000 $390K $8.67 $51K -8,900 -16.5%
83 PRTA 0.02% 25,398 $248K $9.76 -$3M -467,203 -94.8%
84 MLTX 0.01% 28,200 $202K $7.17 +28,200 NEW
85 NUVB-WT —% 134,028 $27K $0.20 -$9K
86 CGEN —% 13,430 $20K $1.47 -$2M -976,560 -98.6%
87 ADAP —% -$595K -2,483,468 -100.0% SOLD
88 OSCR —% -$15M -700,000 -100.0% SOLD
89 NUVL —% -$7M -93,328 -100.0% SOLD
90 BPMC —% -$24M -185,500 -100.0% SOLD
91 CGEM —% -$5M -668,233 -100.0% SOLD
92 ETNB —% -$393K -40,000 -100.0% SOLD
93 SRPT —% -$1M -68,600 -100.0% SOLD
94 UNH —% -$16M -50,500 -100.0% SOLD
95 LUNG —% -$2M -651,100 -100.0% SOLD

New Positions

SymbolValue% Port
HTFL $8M 0.52%
MBX $5M 0.30%
BBIO $4M 0.27%
OCUL $4M 0.22%
ALKS $3M 0.20%
CNTA $2M 0.10%
MRSN $1M 0.07%
EYPT $451K 0.03%
MLTX $202K 0.01%

Sold Out Positions

SymbolValue% Port
OSCR —%
UNH —%
LUNG —%
CGEM —%
NUVL —%
SRPT —%
ETNB —%
BPMC —%
ADAP —%
View SEC EDGAR Filings for Rock Springs Capital Management LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms