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Avoro Capital Advisors LLC

Q3 2025 · Filed 2025-11-14
Market Value
$6.5B
+39.8%
Holdings
31
-1
New Purchases
3
Added To
9
Closed
3
Reduced
11
Top 10 Concentration
74.2%
Turnover
19.4%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
QURE 3.97% 1.08% +2.89% $259M
CNTA 4.01% 1.40% +2.60% $262M
GPCR 2.21% 0.00% +2.21% $144M
ARWR 5.75% 3.58% +2.17% $376M
MRUS 5.10% 3.55% +1.55% $334M
TRML 1.87% 0.87% +1.00% $122M
RNAM 5.09% 4.28% +0.81% $333M
MDGL 12.86% 12.13% +0.73% $841M
ORKA 0.39% 0.00% +0.39% $26M
OCUL 1.83% 1.47% +0.36% $120M
SEPN 0.38% 0.28% +0.11% $25M
TNGX 0.07% 0.00% +0.07% $5M
ETNB 1.44% 1.42% +0.02% $94M
TSHA 1.09% 1.07% +0.01% $71M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MLTX 0.22% 4.19% -3.97% $14M
ARGX 11.17% 13.84% -2.68% $730M
UTHR 12.96% 14.55% -1.59% $848M
AKRO 2.87% 3.99% -1.12% $188M
BPMC 0.00% 1.03% -1.03% $0
ALKS 1.03% 1.77% -0.75% $67M
BCRX 0.15% 0.86% -0.72% $9M
KYMR 5.50% 6.11% -0.62% $359M
VERA 2.76% 3.17% -0.41% $180M
FOLD 1.81% 2.20% -0.39% $118M
GLUE 0.00% 0.36% -0.36% $0
KRYS 7.50% 7.81% -0.32% $490M
XENE 3.32% 3.61% -0.30% $217M
APLS 4.23% 4.52% -0.29% $277M
RARE 0.00% 0.26% -0.26% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 5 $3.1B 47.8%
Mid Cap 16 $2.8B 42.2%
Small Cap 9 $645M 9.9%
Micro Cap 1 $5M 0.1%

Portfolio Analytics

Avg Market Cap
$6.3B
Median Market Cap
$2.4B
Avg P/E
36.3
Median P/E
39.0
Avg Dividend Yield
—%
Avg Beta
0.71
# Stocks
31
# ETFs / Funds
0

Top Holdings (31 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 UTHR 12.96% 2,022,222 $848M $419.21 $167M -347,778 -14.7%
2 MDGL 12.86% 1,833,000 $841M $458.66 $273M -42,000 -2.2%
3 ARGX 11.17% 990,000 $730M $737.56 $83M -185,000 -15.7%
4 KRYS 7.50% 2,777,777 $490M $176.53 $125M +117,777 +4.4%
5 ARWR 5.75% 10,900,000 $376M $34.49 $208M +300,000 +2.8%
6 KYMR 5.50% 6,350,000 $359M $56.60 $73M -205,555 -3.1%
7 MRUS 5.10% 3,542,500 $334M $94.15 $168M +386,945 +12.3%
8 RNAM 5.09% 7,645,000 $333M $43.57 $133M +595,000 +8.4%
9 APLS 4.23% 12,222,222 $277M $22.63 $65M
10 CNTA 4.01% 10,808,080 $262M $24.25 $196M +5,808,080 +116.2%
11 QURE 3.97% 4,444,444 $259M $58.37 $209M +819,444 +22.6%
12 XENE 3.32% 5,400,000 $217M $40.15 $48M
13 AKRO 2.87% 3,955,555 $188M $47.48 $1M +455,555 +13.0%
14 VERA 2.76% 6,210,000 $180M $29.06 $32M -90,000 -1.4%
15 GPCR 2.21% 5,155,555 $144M $28.00 +5,155,555 NEW
16 TRML 1.87% 2,555,555 $122M $47.83 $81M
17 OCUL 1.83% 10,250,000 $120M $11.69 $51M +2,850,000 +38.5%
18 FOLD 1.81% 15,025,000 $118M $7.88 $15M -2,975,000 -16.5%
19 ETNB 1.44% 6,387,790 $94M $14.70 $28M -362,210 -5.4%
20 TSHA 1.09% 21,700,000 $71M $3.27 $21M
21 ALKS 1.03% 2,240,000 $67M $30.00 -$16M -660,000 -22.8%
22 ORKA 0.39% 1,333,340 $26M $19.23 +1,333,340 NEW
23 SEPN 0.38% 1,337,500 $25M $18.81 $12M +100,000 +8.1%
24 MNKD 0.37% 4,468,877 $24M $5.37 $2M -1,381,123 -23.6%
25 MLTX 0.22% 2,000,000 $14M $7.17 -$182M -2,150,000 -51.8%
26 BCRX 0.15% 1,250,000 $9M $7.59 -$31M -3,250,000 -72.2%
27 WHWK 0.08% 2,849,402 $5M $1.90 $85K
28 TNGX 0.07% 545,000 $5M $8.40 +545,000 NEW
29 RARE —% -$12M -330,000 -100.0% SOLD
30 GLUE —% -$17M -3,725,000 -100.0% SOLD
31 BPMC —% -$48M -375,000 -100.0% SOLD

New Positions

SymbolValue% Port
GPCR $144M 2.21%
ORKA $26M 0.39%
TNGX $5M 0.07%

Sold Out Positions

SymbolValue% Port
RARE —%
GLUE —%
BPMC —%
View SEC EDGAR Filings for Avoro Capital Advisors LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms