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Asset Manager ← All Institutions

Avoro Capital Advisors LLC

Q4 2025 · Filed 2026-03-16
Market Value
$8.8B
+35.3%
Holdings
37
+6
New Purchases
9
Added To
8
Closed
8
Reduced
6
Top 10 Concentration
75.5%
Turnover
45.9%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
CELC 3.51% 0.00% +3.51% $310M
GPCR 5.15% 2.21% +2.95% $456M
XBI 2.89% 0.00% +2.89% $256M
ARWR 7.98% 5.75% +2.23% $705M
TERN 1.99% 0.00% +1.99% $176M
RVMD 1.95% 0.00% +1.95% $173M
UTHR 14.36% 12.96% +1.39% $1.3B
KYMR 6.58% 5.50% +1.08% $582M
VERA 3.37% 2.76% +0.61% $298M
PTCT 0.59% 0.00% +0.59% $52M
KRYS 8.05% 7.50% +0.55% $712M
VRDN 0.53% 0.00% +0.53% $47M
LXEO 0.37% 0.00% +0.37% $33M
TSHA 1.35% 1.09% +0.26% $119M
GHRS 0.26% 0.00% +0.26% $23M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MRUS 0.00% 5.10% -5.10% $0
AKRO 0.00% 2.87% -2.87% $0
QURE 1.66% 3.97% -2.30% $147M
TRML 0.00% 1.87% -1.87% $0
FOLD 0.00% 1.81% -1.81% $0
ARGX 9.41% 11.17% -1.75% $833M
ETNB 0.00% 1.44% -1.44% $0
MDGL 11.90% 12.86% -0.96% $1.1B
APLS 3.47% 4.23% -0.76% $307M
RNAM 4.45% 5.09% -0.64% $393M
ALKS 0.44% 1.03% -0.58% $39M
XENE 2.75% 3.32% -0.57% $243M
OCUL 1.48% 1.83% -0.35% $131M
MLTX 0.00% 0.22% -0.22% $0
BCRX 0.00% 0.15% -0.15% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 7 $4.4B 50.2%
Mid Cap 18 $3.8B 43.4%
Small Cap 11 $562M 6.4%
Micro Cap 1 $7M 0.1%

Portfolio Analytics

Avg Market Cap
$7.1B
Median Market Cap
$4.5B
Avg P/E
32.5
Median P/E
38.9
Avg Dividend Yield
—%
Avg Beta
0.71
# Stocks
36
# ETFs / Funds
1

Top Holdings (37 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 UTHR 14.36% 2,606,060 $1.3B $487.25 $422M +583,838 +28.9%
2 MDGL 11.90% 1,807,500 $1.1B $582.34 $212M -25,500 -1.4%
3 ARGX 9.41% 990,000 $833M $840.95 $102M
4 KRYS 8.05% 2,888,888 $712M $246.54 $222M +111,111 +4.0%
5 ARWR 7.98% 10,625,000 $705M $66.39 $329M -275,000 -2.5%
6 KYMR 6.58% 7,474,747 $582M $77.81 $222M +1,124,747 +17.7%
7 GPCR 5.15% 6,555,555 $456M $69.55 $312M +1,400,000 +27.2%
8 RNAM 4.45% 5,455,000 $393M $72.13 $60M -2,190,000 -28.6%
9 CNTA 4.12% 14,555,555 $364M $25.01 $102M +3,747,475 +34.7%
10 CELC 3.51% 3,111,111 $310M $99.74 +3,111,111 NEW
11 APLS 3.47% 12,222,222 $307M $25.12 $30M
12 VERA 3.37% 5,888,888 $298M $50.64 $118M -321,112 -5.2%
13 XBI 2.89% 2,100,000 $256M $121.93 +2,100,000 NEW
14 XENE 2.75% 5,424,444 $243M $44.82 $26M +24,444 +0.5%
15 TERN 1.99% 4,350,000 $176M $40.40 +4,350,000 NEW
16 RVMD 1.95% 2,170,000 $173M $79.65 +2,170,000 NEW
17 QURE 1.66% 6,150,000 $147M $23.93 -$112M +1,705,556 +38.4%
18 OCUL 1.48% 10,777,777 $131M $12.14 $11M +527,777 +5.2%
19 TSHA 1.35% 21,700,000 $119M $5.50 $48M
20 PTCT 0.59% 685,000 $52M $75.96 +685,000 NEW
21 VRDN 0.53% 1,500,000 $47M $31.12 +1,500,000 NEW
22 ORKA 0.46% 1,333,340 $40M $30.31 $15M
23 ALKS 0.44% 1,400,000 $39M $27.98 -$28M -840,000 -37.5%
24 SEPN 0.42% 1,337,500 $37M $27.88 $12M
25 LXEO 0.37% 3,300,000 $33M $9.93 +3,300,000 NEW
26 MNKD 0.28% 4,444,444 $25M $5.67 $1M -24,433 -0.6%
27 GHRS 0.26% 1,800,000 $23M $12.70 +1,800,000 NEW
28 INCY 0.15% 135,000 $13M $98.77 +135,000 NEW
29 WHWK 0.08% 2,849,402 $7M $2.42 $1M
30 MLTX —% -$14M -2,000,000 -100.0% SOLD
31 FOLD —% -$118M -15,025,000 -100.0% SOLD
32 TRML —% -$122M -2,555,555 -100.0% SOLD
33 AKRO —% -$188M -3,955,555 -100.0% SOLD
34 BCRX —% -$9M -1,250,000 -100.0% SOLD
35 TNGX —% -$5M -545,000 -100.0% SOLD
36 MRUS —% -$334M -3,542,500 -100.0% SOLD
37 ETNB —% -$94M -6,387,790 -100.0% SOLD

Options Breakdown

2 Calls $0 Call Value 0 Puts $0 Put Value

Top Calls

SymbolSharesValueStatus
GPCR $0 SOLD
UTHR $0 SOLD

New Positions

SymbolValue% Port
CELC $310M 3.51%
XBI $256M 2.89%
TERN $176M 1.99%
RVMD $173M 1.95%
PTCT $52M 0.59%
VRDN $47M 0.53%
LXEO $33M 0.37%
GHRS $23M 0.26%
INCY $13M 0.15%

Sold Out Positions

SymbolValue% Port
BCRX —%
MLTX —%
TNGX —%
FOLD —%
TRML —%
AKRO —%
MRUS —%
ETNB —%
View SEC EDGAR Filings for Avoro Capital Advisors LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms