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Asset Manager ← All Institutions

GREAT POINT PARTNERS LLC

Q4 2025 · Filed 2026-02-17
Market Value
$306M
+38.7%
Holdings
38
+6
New Purchases
12
Added To
6
Closed
10
Reduced
3
Top 10 Concentration
62.5%
Turnover
57.9%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
IRON 6.49% 0.00% +6.49% $20M
RAPT 6.43% 0.00% +6.43% $20M
VOR 5.85% 0.00% +5.85% $18M
APGE 9.22% 5.47% +3.75% $28M
KALV 3.62% 0.00% +3.62% $11M
CTNM 2.99% 0.00% +2.99% $9M
FULC 2.96% 0.00% +2.96% $9M
IMVT 6.23% 3.65% +2.58% $19M
RARE 2.25% 0.00% +2.25% $7M
CGEM 2.14% 0.00% +2.14% $7M
EVMN 1.82% 0.00% +1.82% $6M
SLN 1.60% 0.00% +1.60% $5M
JBIO 4.06% 2.47% +1.59% $12M
CLYM 1.28% 0.00% +1.28% $4M
AVTX 0.74% 0.00% +0.74% $2M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
RZLT 0.73% 10.44% -9.71% $2M
ABVX 0.00% 5.77% -5.77% $0
NKTR 2.91% 7.73% -4.82% $9M
CYTK 0.00% 3.73% -3.73% $0
XENE 0.00% 3.64% -3.64% $0
AMLX 6.91% 10.47% -3.56% $21M
IONS 0.00% 2.37% -2.37% $0
AKRO 0.00% 2.23% -2.23% $0
TSHA 0.00% 2.22% -2.22% $0
DBVT 0.00% 1.72% -1.72% $0
LEGN 0.00% 1.68% -1.68% $0
NGNE 2.36% 3.51% -1.15% $7M
ABSI 0.00% 1.10% -1.10% $0
ZURA 6.53% 7.49% -0.95% $20M
SLNO 6.05% 6.89% -0.84% $19M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mid Cap 13 $127M 41.4%
Small Cap 17 $136M 44.4%
Micro Cap 8 $43M 14.1%

Portfolio Analytics

Avg Market Cap
$2.2B
Median Market Cap
$1.1B
Avg P/E
27.1
Median P/E
27.1
Avg Dividend Yield
—%
Avg Beta
0.76
# Stocks
38
# ETFs / Funds
0

Top Holdings (38 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 APGE 9.22% 374,000 $28M $75.48 $16M +70,000 +23.0%
2 AMLX 6.91% 1,750,000 $21M $12.08 -$2M +50,000 +2.9%
3 ZURA 6.53% 3,815,930 $20M $5.24 $3M — —
4 IRON 6.49% 250,000 $20M $79.41 — +250,000 — NEW
5 RAPT 6.43% 581,187 $20M $33.87 — +581,187 — NEW
6 IMVT 6.23% 750,000 $19M $25.42 $11M +250,000 +50.0%
7 SLNO 6.05% 400,000 $19M $46.30 $3M +175,000 +77.8%
8 VOR 5.85% 1,370,107 $18M $13.08 — +1,370,107 — NEW
9 DNTH 4.71% 350,000 $14M $41.21 $4M +84,197 +31.7%
10 JBIO 4.06% 806,273 $12M $15.43 $7M +173,674 +27.4%
11 KALV 3.62% 685,632 $11M $16.15 — +685,632 — NEW
12 CTNM 2.99% 800,000 $9M $11.43 — +800,000 — NEW
13 EPRX 2.96% 1,200,000 $9M $7.55 $2M — —
14 FULC 2.96% 800,000 $9M $11.31 — +800,000 — NEW
15 NKTR 2.91% 210,732 $9M $42.28 -$8M -89,268 -29.8%
16 UPB 2.66% 300,000 $8M $27.15 $3M — —
17 NGNE 2.36% 350,000 $7M $20.60 -$533K -96,814 -21.7%
18 RARE 2.25% 300,000 $7M $23.00 — +300,000 — NEW
19 CNTX 2.25% 4,683,711 $7M $1.47 $2M — —
20 CGEM 2.14% 634,032 $7M $10.35 — +634,032 — NEW
21 EVMN 1.82% 325,000 $6M $17.12 — +325,000 — NEW
22 ORKA 1.82% 183,330 $6M $30.31 $2M — —
23 SLN 1.60% 808,032 $5M $6.08 — +808,032 — NEW
24 UNCY 1.50% 796,558 $5M $5.77 $1M — —
25 CLYM 1.28% 979,534 $4M $4.00 — +979,534 — NEW
26 SANA 0.93% 700,000 $3M $4.07 $364K — —
27 AVTX 0.74% 124,666 $2M $18.16 — +124,666 — NEW
28 RZLT 0.73% 951,809 $2M $2.36 -$21M -1,500,000 -61.2%
29 DBVT —% — — — -$4M -378,594 -100.0% SOLD
30 LEGN —% — — — -$4M -113,460 -100.0% SOLD
31 XENE —% — — — -$8M -200,000 -100.0% SOLD
32 AKRO —% — — — -$5M -103,848 -100.0% SOLD
33 PLRX —% — — — -$1M -850,000 -100.0% SOLD
34 TSHA —% — — — -$5M -1,500,000 -100.0% SOLD
35 CYTK —% — — — -$8M -150,000 -100.0% SOLD
36 IONS —% — — — -$5M -80,000 -100.0% SOLD
37 ABVX —% — — — -$13M -150,000 -100.0% SOLD
38 ABSI —% — — — -$2M -796,438 -100.0% SOLD

Options Breakdown

1 Calls $0 Call Value 1 Puts $0 Put Value

Top Calls

SymbolSharesValueStatus
HRMY — $0 SOLD

Top Puts

SymbolSharesValueStatus
CAPR — $0 SOLD

New Positions

SymbolValue% Port
IRON $20M 6.49%
RAPT $20M 6.43%
VOR $18M 5.85%
KALV $11M 3.62%
CTNM $9M 2.99%
FULC $9M 2.96%
RARE $7M 2.25%
CGEM $7M 2.14%
EVMN $6M 1.82%
SLN $5M 1.60%
CLYM $4M 1.28%
AVTX $2M 0.74%

Sold Out Positions

SymbolValue% Port
ABSI — —%
IONS — —%
ABVX — —%
LEGN — —%
CYTK — —%
TSHA — —%
XENE — —%
DBVT — —%
PLRX — —%
AKRO — —%
View SEC EDGAR Filings for GREAT POINT PARTNERS LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms