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Asset Manager ← All Institutions

RA CAPITAL MANAGEMENT, L.P.

Q4 2025 · Filed 2026-02-17
Market Value
$6.9B
+22.9%
Holdings
82
+10
New Purchases
21
Added To
12
Closed
16
Reduced
7
Top 10 Concentration
60.9%
Turnover
45.1%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
CDTX 10.75% 5.73% +5.02% $743M
RNAM 9.01% 6.69% +2.32% $623M
BCRX 1.79% 0.00% +1.79% $123M
TYRA 4.64% 3.03% +1.61% $321M
PRAX 1.59% 0.00% +1.59% $110M
OLMA 0.94% 0.00% +0.94% $65M
EVMN 0.86% 0.00% +0.86% $59M
NUVL 2.74% 1.92% +0.82% $189M
SYRE 0.77% 0.00% +0.77% $53M
EWTX 3.74% 3.01% +0.74% $259M
LXEO 0.72% 0.00% +0.72% $50M
JBIO 0.82% 0.16% +0.66% $57M
CAPR 0.63% 0.00% +0.63% $44M
GRAL 0.53% 0.00% +0.53% $37M
TSHA 1.87% 1.37% +0.50% $130M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ETNB 0.00% 5.20% -5.20% $0
ACLX 1.19% 4.43% -3.24% $83M
JANX 2.23% 4.86% -2.63% $154M
LENZ 0.97% 3.46% -2.49% $67M
MLYS 3.84% 4.94% -1.09% $266M
DNTH 0.96% 2.00% -1.04% $66M
SRRK 0.00% 0.77% -0.77% $0
GPCR 0.00% 0.76% -0.76% $0
VOR 1.02% 1.72% -0.69% $71M
FULC 0.99% 1.67% -0.68% $68M
MTSR 0.00% 0.63% -0.63% $0
GHRS 1.41% 1.95% -0.54% $97M
PCVX 7.16% 7.66% -0.50% $495M
TVTX 0.00% 0.49% -0.49% $0
LRMR 0.00% 0.35% -0.35% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 3 $637M 9.2%
Mid Cap 25 $3.4B 49.1%
Small Cap 34 $2.0B 28.3%
Micro Cap 20 $924M 13.4%

Portfolio Analytics

Avg Market Cap
$2.8B
Median Market Cap
$770M
Avg P/E
33.0
Median P/E
34.5
Avg Dividend Yield
—%
Avg Beta
1.13
# Stocks
82
# ETFs / Funds
0

Top Holdings (82 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 CDTX 10.75% 3,365,523 $743M $220.89 $421M — —
2 RYTM 10.32% 6,666,837 $714M $107.04 $140M +985,478 +17.4%
3 RNAM 9.01% 8,641,031 $623M $72.13 $247M — —
4 PCVX 7.16% 10,724,599 $495M $46.14 $64M -1,241,392 -10.4%
5 SION 5.89% 9,905,045 $407M $41.14 $100M -540,277 -5.2%
6 TYRA 4.64% 12,198,625 $321M $26.29 $150M — —
7 MLYS 3.84% 7,323,750 $266M $36.29 -$12M — —
8 EWTX 3.74% 10,428,437 $259M $24.81 $90M — —
9 SEPN 2.82% 6,995,858 $195M $27.88 $63M — —
10 NUVL 2.74% 1,880,057 $189M $100.59 $81M +633,601 +50.8%
11 IRON 2.27% 1,976,132 $157M $79.41 $53M +399,026 +25.3%
12 JANX 2.23% 11,189,693 $154M $13.80 -$119M — —
13 PEPG 1.89% 20,064,545 $131M $6.51 $38M — —
14 TSHA 1.87% 23,555,648 $130M $5.50 $53M — —
15 SBTX 1.83% 10,860,977 $127M $11.65 $17M — —
16 BCRX 1.79% 15,827,186 $123M $7.80 — +15,827,186 — NEW
17 BCAX 1.69% 6,955,993 $117M $16.83 $7M — —
18 PRAX 1.59% 373,787 $110M $294.74 — +373,787 — NEW
19 GHRS 1.41% 7,676,697 $97M $12.70 -$12M — —
20 GERN 1.22% 63,771,366 $84M $1.32 $1M +3,392,000 +5.6%
21 ACLX 1.19% 1,267,156 $83M $65.20 -$167M -1,769,371 -58.3%
22 CLYM 1.12% 11,293,828 $78M $6.88 $15M -20,125,439 -64.0%
23 VOR 1.02% 5,404,998 $71M $13.08 -$26M +3,422,697 +172.7%
24 BLTE 1.00% 432,484 $69M $159.96 $4M -442,516 -50.6%
25 FULC 0.99% 6,053,960 $68M $11.31 -$26M -4,175,139 -40.8%
26 LENZ 0.97% 4,178,823 $67M $16.00 -$128M — —
27 DNTH 0.96% 1,611,733 $66M $41.21 -$46M -1,255,000 -43.8%
28 OLMA 0.94% 2,600,000 $65M $25.00 — +2,600,000 — NEW
29 EVMN 0.86% 3,458,770 $59M $17.12 — +3,458,770 — NEW
30 JBIO 0.82% 3,671,083 $57M $15.43 $47M +2,608,757 +245.6%
31 SYRE 0.77% 1,621,620 $53M $32.76 — +1,621,620 — NEW
32 LXEO 0.72% 5,000,000 $50M $9.93 — +5,000,000 — NEW
33 LBRX 0.71% 2,208,604 $49M $22.26 $21M +431,646 +24.3%
34 MNPR 0.63% 667,207 $44M $65.30 $2M +156,000 +30.5%
35 CAPR 0.63% 1,507,844 $44M $28.86 — +1,507,844 — NEW
36 FDMT 0.61% 5,653,211 $42M $7.50 $3M +1,090,000 +23.9%
37 ADGI 0.61% 17,119,096 $42M $2.47 $23M — —
38 ARTV 0.61% 9,853,302 $42M $4.29 $14M — —
39 GRAL 0.53% 428,266 $37M $85.59 — +428,266 — NEW
40 ASMB 0.50% 1,020,410 $35M $34.01 $9M — —
41 SLDB 0.47% 5,811,423 $33M $5.64 -$3M — —
42 ABOS 0.46% 14,932,063 $32M $2.11 $6M — —
43 BNTC 0.36% 1,850,000 $25M $13.47 — +1,850,000 — NEW
44 CTNM 0.36% 2,179,711 $25M $11.43 -$19K +57,711 +2.7%
45 RZLT 0.31% 9,180,000 $22M $2.36 — +9,180,000 — NEW
46 ACRV 0.29% 8,340,508 $20M $2.41 $5M — —
47 NKTX 0.29% 10,805,129 $20M $1.85 -$2M — —
48 OVID 0.25% 10,714,000 $17M $1.63 — +10,714,000 — NEW
49 PALI 0.24% 7,124,116 $17M $2.35 — +7,124,116 — NEW
50 SABS 0.24% 4,401,500 $16M $3.74 $8M — —
51 CCCC 0.22% 8,000,000 $15M $1.91 — +8,000,000 — NEW
52 MDLN 0.20% 335,000 $14M $42.00 — +335,000 — NEW
53 DSGN 0.20% 1,461,381 $14M $9.38 $10M +985,682 +207.2%
54 INSP 0.19% 141,964 $13M $92.23 $5M +27,063 +23.6%
55 AVTX 0.17% 662,968 $12M $18.16 $4M — —
56 RANI 0.17% 8,500,000 $11M $1.35 — +8,500,000 — NEW
57 PCSC 0.14% 750,000 $10M $13.03 $2M — —
58 ACET 0.12% 948,249 $8M $8.42 — +948,249 — NEW
59 WGS 0.11% 58,044 $8M $130.06 $1M — —
60 WAY 0.07% 144,400 $5M $32.75 — +144,400 — NEW
61 HOWL 0.06% 6,681,307 $4M $0.63 -$9M — —
62 HNGE 0.05% 80,113 $4M $46.45 — +80,113 — NEW
63 PGNY 0.04% 96,628 $2M $25.68 $402K — —
64 KIDS 0.03% 109,959 $2M $17.76 — +109,959 — NEW
65 HCAT 0.03% 793,749 $2M $2.39 — +793,749 — NEW
66 PTN 0.02% 70,000 $1M $15.38 — +70,000 — NEW
67 PRME —% — — — -$17M -3,000,000 -100.0% SOLD
68 TVTX —% — — — -$27M -1,150,000 -100.0% SOLD
69 ETNB —% — — — -$292M -19,889,683 -100.0% SOLD
70 SRRK —% — — — -$43M -1,166,788 -100.0% SOLD
71 EVH —% — — — -$5M -579,052 -100.0% SOLD
72 IFRX —% — — — -$3M -1,973,233 -100.0% SOLD
73 MTSR —% — — — -$35M -675,525 -100.0% SOLD
74 GKOS —% — — — -$4M -54,180 -100.0% SOLD
75 RCUS —% — — — -$15M -1,136,364 -100.0% SOLD
76 TNGX —% — — — -$17M -2,000,000 -100.0% SOLD
77 GPCR —% — — — -$42M -1,517,418 -100.0% SOLD
78 ELDN —% — — — -$9M -3,566,338 -100.0% SOLD
79 CTMX —% — — — -$8M -2,661,331 -100.0% SOLD
80 LRMR —% — — — -$20M -6,045,351 -100.0% SOLD
81 EXAS —% — — — -$3M -54,939 -100.0% SOLD
82 SRZN —% — — — -$8M -602,626 -100.0% SOLD

New Positions

SymbolValue% Port
BCRX $123M 1.79%
PRAX $110M 1.59%
OLMA $65M 0.94%
EVMN $59M 0.86%
SYRE $53M 0.77%
LXEO $50M 0.72%
CAPR $44M 0.63%
GRAL $37M 0.53%
BNTC $25M 0.36%
RZLT $22M 0.31%
OVID $17M 0.25%
PALI $17M 0.24%
CCCC $15M 0.22%
MDLN $14M 0.20%
RANI $11M 0.17%

Sold Out Positions

SymbolValue% Port
RCUS — —%
EVH — —%
GKOS — —%
ELDN — —%
GPCR — —%
IFRX — —%
LRMR — —%
PRME — —%
TVTX — —%
SRRK — —%
SRZN — —%
TNGX — —%
CTMX — —%
EXAS — —%
ETNB — —%
View SEC EDGAR Filings for RA CAPITAL MANAGEMENT, L.P. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms