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Asset Manager ← All Institutions

EcoR1 Capital, LLC

Q2 2025 · Filed 2025-08-14
Market Value
$1.4B
-5.1%
Holdings
47
-7
New Purchases
6
Added To
4
Closed
12
Reduced
4
Top 10 Concentration
75.5%
Turnover
38.3%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ITOS 7.62% 0.00% +7.62% $107M
TNGX 3.89% 0.99% +2.90% $54M
ANAB 12.50% 9.93% +2.57% $175M
LKFT 2.07% 0.26% +1.81% $29M
CRSP 4.83% 3.21% +1.62% $68M
VRNA 1.35% 0.00% +1.35% $19M
QURE 3.97% 2.87% +1.11% $56M
ALKS 1.02% 0.00% +1.02% $14M
IMNM 2.71% 1.86% +0.85% $38M
PCRX 0.78% 0.00% +0.78% $11M
KURA 1.73% 1.18% +0.55% $24M
AKRO 1.68% 1.21% +0.47% $23M
MTSR 0.55% 0.09% +0.46% $8M
ETON 2.07% 1.71% +0.36% $29M
NGNE 1.36% 1.01% +0.35% $19M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
PRTA 0.00% 9.72% -9.72% $0
SRPT 0.00% 5.59% -5.59% $0
APLS 14.72% 17.64% -2.92% $206M
JAZZ 12.94% 14.36% -1.42% $181M
XNCR 3.45% 4.43% -0.98% $48M
CRNX 8.81% 9.75% -0.94% $123M
BEAM 0.00% 0.70% -0.70% $0
DNA 0.00% 0.57% -0.57% $0
BCYC 0.00% 0.52% -0.52% $0
VERV 0.00% 0.39% -0.39% $0
JANX 2.43% 2.69% -0.26% $34M
KROS 0.00% 0.13% -0.13% $0
ORIC 1.17% 1.29% -0.12% $16M
RLAY 0.00% 0.11% -0.11% $0
KLRS 0.00% 0.11% -0.11% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 4 $237M 16.9%
Mid Cap 12 $715M 51.1%
Small Cap 21 $413M 29.5%
Micro Cap 10 $34M 2.5%

Portfolio Analytics

Avg Market Cap
$3.7B
Median Market Cap
$893M
Avg P/E
72.5
Median P/E
39.4
Avg Dividend Yield
—%
Avg Beta
0.91
# Stocks
47
# ETFs / Funds
0

Top Holdings (47 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 APLS 14.72% 11,895,808 $206M $17.31 -$54M
2 JAZZ 12.94% 1,706,469 $181M $106.12 -$31M
3 ANAB 12.50% 7,880,094 $175M $22.20 $28M
4 CRNX 8.81% 4,288,120 $123M $28.76 -$20M
5 ITOS 7.62% 10,688,978 $107M $9.97 +10,688,978 NEW
6 CRSP 4.83% 1,389,276 $68M $48.64 $20M
7 QURE 3.97% 3,988,971 $56M $13.94 $13M
8 TNGX 3.89% 10,630,736 $54M $5.12 $40M
9 XNCR 3.45% 6,144,767 $48M $7.86 -$17M
10 IMNM 2.71% 4,079,415 $38M $9.30 $10M
11 JANX 2.43% 1,469,818 $34M $23.10 -$6M
12 LKFT 2.07% 1,036,945 $29M $27.99 $25M +881,939 +569.0%
13 ETON 2.07% 2,030,544 $29M $14.25 $4M +91,256 +4.7%
14 KURA 1.73% 4,200,000 $24M $5.77 $7M +1,559,702 +59.1%
15 AKRO 1.68% 440,000 $23M $53.36 $6M
16 MDGL 1.62% 75,000 $23M $302.64 -$2M
17 NGNE 1.36% 1,271,342 $19M $14.95 $4M
18 VRNA 1.35% 200,000 $19M $94.58 +200,000 NEW
19 TECX 1.33% 935,121 $19M $19.87 $2M
20 ORIC 1.17% 1,618,068 $16M $10.15 -$3M -1,800,000 -52.7%
21 ALKS 1.02% 500,000 $14M $28.61 +500,000 NEW
22 RNAM 1.01% 500,000 $14M $28.40 -$2M -57,576 -10.3%
23 MBX 0.94% 1,149,794 $13M $11.41 $4M -109,479 -8.7%
24 VYGR 0.87% 3,917,546 $12M $3.11 -$1M
25 PCRX 0.78% 457,471 $11M $23.90 +457,471 NEW
26 REPL 0.56% 850,341 $8M $9.29 -$391K
27 MTSR 0.55% 271,529 $8M $28.45 $6M +221,529 +443.1%
28 ADAP 0.47% 27,404,070 $7M $0.24 $1M
29 DAWN 0.40% 862,068 $6M $6.50 -$1M
30 HLVX 0.34% 2,420,243 $5M $1.99 +2,420,243 NEW
31 0HIY.L 0.32% 573,183 $4M $7.72 $1M
32 WHWK 0.15% 1,091,417 $2M $1.87 -$2M -990,583 -47.6%
33 MGNX 0.14% 1,602,717 $2M $1.21 +1,602,717 NEW
34 NUVB-WT 0.13% 963,333 $2M $1.95 $183K
35 SRZNW 0.04% 66,665 $596K $8.94 -$181K
36 BEAM —% -$10M -526,685 -100.0% SOLD
37 DNA —% -$8M -1,462,328 -100.0% SOLD
38 BCYC —% -$8M -910,000 -100.0% SOLD
39 TCRX —% -$915K -662,833 -100.0% SOLD
40 UPB —% -$367K -60,000 -100.0% SOLD
41 PRME —% -$1M -700,000 -100.0% SOLD
42 VERV —% -$6M -1,250,000 -100.0% SOLD
43 SRPT —% -$82M -1,292,386 -100.0% SOLD
44 RLAY —% -$2M -641,426 -100.0% SOLD
45 KROS —% -$2M -187,500 -100.0% SOLD
46 KLRS —% -$2M -201,718 -100.0% SOLD
47 PRTA —% -$143M -11,584,280 -100.0% SOLD

New Positions

SymbolValue% Port
ITOS $107M 7.62%
VRNA $19M 1.35%
ALKS $14M 1.02%
PCRX $11M 0.78%
HLVX $5M 0.34%
MGNX $2M 0.14%

Sold Out Positions

SymbolValue% Port
DNA —%
BCYC —%
KLRS —%
KROS —%
PRTA —%
PRME —%
RLAY —%
BEAM —%
UPB —%
TCRX —%
SRPT —%
VERV —%
View SEC EDGAR Filings for EcoR1 Capital, LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms