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EcoR1 Capital, LLC

Q3 2025 · Filed 2025-11-14
Market Value
$1.7B
+20.9%
Holdings
41
-6
New Purchases
6
Added To
4
Closed
12
Reduced
3
Top 10 Concentration
79.5%
Turnover
43.9%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
QURE 13.76% 3.97% +9.79% $233M
ORIC 4.77% 1.17% +3.60% $81M
BBOT 1.93% 0.00% +1.93% $33M
ANAB 14.26% 12.50% +1.76% $241M
CRNX 10.56% 8.81% +1.74% $179M
TNGX 5.28% 3.89% +1.39% $89M
LKFT 3.41% 2.07% +1.34% $58M
MBX 2.20% 0.94% +1.26% $37M
RNAM 1.97% 1.01% +0.96% $33M
AQST 0.87% 0.00% +0.87% $15M
XNCR 4.26% 3.45% +0.81% $72M
CNTA 0.79% 0.00% +0.79% $13M
ETON 2.61% 2.07% +0.54% $44M
PRME 0.51% 0.00% +0.51% $9M
CRSP 5.32% 4.83% +0.49% $90M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
APLS 4.61% 14.72% -10.11% $78M
ITOS 0.00% 7.62% -7.62% $0
JANX 0.00% 2.43% -2.43% $0
AKRO 0.00% 1.68% -1.68% $0
VRNA 0.00% 1.35% -1.35% $0
TECX 0.00% 1.33% -1.33% $0
KURA 0.46% 1.73% -1.28% $8M
PCRX 0.00% 0.78% -0.78% $0
VYGR 0.19% 0.87% -0.69% $3M
REPL 0.00% 0.56% -0.56% $0
ADAP 0.00% 0.47% -0.47% $0
DAWN 0.00% 0.40% -0.40% $0
HLVX 0.00% 0.34% -0.34% $0
WHWK 0.00% 0.15% -0.15% $0
MGNX 0.00% 0.14% -0.14% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 4 $293M 17.3%
Mid Cap 11 $768M 45.4%
Small Cap 17 $612M 36.2%
Micro Cap 9 $19M 1.2%

Portfolio Analytics

Avg Market Cap
$4.2B
Median Market Cap
$918M
Avg P/E
87.6
Median P/E
40.0
Avg Dividend Yield
—%
Avg Beta
0.90
# Stocks
41
# ETFs / Funds
0

Top Holdings (41 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 ANAB 14.26% 7,880,094 $241M $30.62 $66M
2 QURE 13.76% 3,988,971 $233M $58.37 $177M
3 JAZZ 13.30% 1,706,469 $225M $131.80 $44M
4 CRNX 10.56% 4,288,120 $179M $41.65 $55M
5 CRSP 5.32% 1,389,276 $90M $64.81 $22M
6 TNGX 5.28% 10,630,736 $89M $8.40 $35M
7 ORIC 4.77% 6,728,116 $81M $12.00 $64M +5,110,048 +315.8%
8 APLS 4.61% 3,447,156 $78M $22.63 -$128M -8,448,652 -71.0%
9 XNCR 4.26% 6,144,767 $72M $11.73 $24M
10 LKFT 3.41% 1,667,119 $58M $34.64 $29M +630,174 +60.8%
11 IMNM 2.82% 4,079,415 $48M $11.71 $10M
12 ETON 2.61% 2,030,544 $44M $21.73 $15M
13 MBX 2.20% 2,123,604 $37M $17.50 $24M +973,810 +84.7%
14 MDGL 2.03% 75,000 $34M $458.66 $12M
15 RNAM 1.97% 765,000 $33M $43.57 $19M +265,000 +53.0%
16 BBOT 1.93% 2,823,126 $33M $11.58 +2,823,126 NEW
17 NGNE 1.30% 1,271,342 $22M $17.33 $3M
18 ALKS 0.89% 500,000 $15M $30.00 $695K
19 AQST 0.87% 2,625,000 $15M $5.59 +2,625,000 NEW
20 MTSR 0.84% 271,529 $14M $52.33 $6M
21 CNTA 0.79% 550,000 $13M $24.25 +550,000 NEW
22 PRME 0.51% 1,543,326 $9M $5.54 +1,543,326 NEW
23 0HIY.L 0.49% 573,183 $8M $14.33 $4M
24 KURA 0.46% 872,500 $8M $8.85 -$17M -3,327,500 -79.2%
25 PEPG 0.22% 800,000 $4M $4.62 +800,000 NEW
26 NUVB-WT 0.21% 963,333 $4M $3.70 $2M
27 VYGR 0.19% 670,303 $3M $4.67 -$9M -3,247,243 -82.9%
28 CMPS 0.09% 265,137 $2M $5.73 +265,137 NEW
29 SRZNW 0.05% 66,665 $859K $12.89 $263K
30 ADAP —% -$7M -27,404,070 -100.0% SOLD
31 REPL —% -$8M -850,341 -100.0% SOLD
32 DAWN —% -$6M -862,068 -100.0% SOLD
33 VRNA —% -$19M -200,000 -100.0% SOLD
34 ITOS —% -$107M -10,688,978 -100.0% SOLD
35 JANX —% -$34M -1,469,818 -100.0% SOLD
36 MGNX —% -$2M -1,602,717 -100.0% SOLD
37 TECX —% -$19M -935,121 -100.0% SOLD
38 AKRO —% -$23M -440,000 -100.0% SOLD
39 PCRX —% -$11M -457,471 -100.0% SOLD
40 HLVX —% -$5M -2,420,243 -100.0% SOLD
41 WHWK —% -$2M -1,091,417 -100.0% SOLD

Options Breakdown

1 Calls $0 Call Value 0 Puts $0 Put Value

Top Calls

SymbolSharesValueStatus
QURE $0 SOLD

New Positions

SymbolValue% Port
BBOT $33M 1.93%
AQST $15M 0.87%
CNTA $13M 0.79%
PRME $9M 0.51%
PEPG $4M 0.22%
CMPS $2M 0.09%

Sold Out Positions

SymbolValue% Port
JANX —%
MGNX —%
PCRX —%
REPL —%
TECX —%
WHWK —%
DAWN —%
AKRO —%
HLVX —%
ITOS —%
ADAP —%
VRNA —%
View SEC EDGAR Filings for EcoR1 Capital, LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms