— Know what they know.
Not Investment Advice
Asset Manager ← All Institutions

EcoR1 Capital, LLC

Q3 2025 · Filed 2025-11-14
Market Value
$1.9B
+13.4%
Holdings
41
-7
New Purchases
6
Added To
4
Closed
12
Reduced
3
Top 10 Concentration
81.3%
Turnover
43.9%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ZYME 21.20% 17.67% +3.53% $392M
ORIC 4.36% 1.01% +3.36% $81M
ANAB 13.04% 10.72% +2.32% $241M
CRNX 9.65% 7.56% +2.09% $179M
BBOT 1.77% 0.00% +1.77% $33M
TNGX 4.82% 3.34% +1.49% $89M
LKFT 3.12% 1.78% +1.34% $58M
MBX 2.01% 0.80% +1.20% $37M
JAZZ 12.15% 11.10% +1.05% $225M
XNCR 3.89% 2.96% +0.93% $72M
RNAM 1.80% 0.87% +0.93% $33M
AQST 0.79% 0.00% +0.79% $15M
CRSP 4.86% 4.14% +0.72% $90M
CNTA 0.72% 0.00% +0.72% $13M
ETON 2.38% 1.77% +0.61% $44M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
APLS 4.21% 12.62% -8.40% $78M
ITOS 0.00% 6.53% -6.53% $0
JANX 0.00% 2.08% -2.08% $0
AKRO 0.00% 1.44% -1.44% $0
VRNA 0.00% 1.16% -1.16% $0
TECX 0.00% 1.14% -1.14% $0
KURA 0.42% 1.49% -1.07% $8M
PCRX 0.00% 0.67% -0.67% $0
VYGR 0.17% 0.75% -0.58% $3M
REPL 0.00% 0.48% -0.48% $0
ADAP 0.00% 0.40% -0.40% $0
DAWN 0.00% 0.34% -0.34% $0
HLVX 0.00% 0.30% -0.30% $0
WHWK 0.00% 0.13% -0.13% $0
MGNX 0.00% 0.12% -0.12% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 4 $293M 15.8%
Mid Cap 10 $516M 27.9%
Small Cap 18 $1.0B 55.3%
Micro Cap 9 $19M 1.1%

Portfolio Analytics

Avg Market Cap
$4.5B
Median Market Cap
$1.4B
Avg P/E
59.3
Median P/E
55.2
Avg Dividend Yield
—%
Avg Beta
0.89
# Stocks
41
# ETFs / Funds
0

Top Holdings (41 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 ZYME 21.20% 22,970,388 $392M $17.08 $104M — —
2 ANAB 13.04% 7,880,094 $241M $30.62 $66M — —
3 JAZZ 12.15% 1,706,469 $225M $131.80 $44M — —
4 CRNX 9.65% 4,288,120 $179M $41.65 $55M — —
5 CRSP 4.86% 1,389,276 $90M $64.81 $22M — —
6 TNGX 4.82% 10,630,736 $89M $8.40 $35M — —
7 ORIC 4.36% 6,728,116 $81M $12.00 $64M +5,110,048 +315.8%
8 APLS 4.21% 3,447,156 $78M $22.63 -$128M -8,448,652 -71.0%
9 XNCR 3.89% 6,144,767 $72M $11.73 $24M — —
10 LKFT 3.12% 1,667,119 $58M $34.64 $29M +630,174 +60.8%
11 IMNM 2.58% 4,079,415 $48M $11.71 $10M — —
12 ETON 2.38% 2,030,544 $44M $21.73 $15M — —
13 MBX 2.01% 2,123,604 $37M $17.50 $24M +973,810 +84.7%
14 MDGL 1.86% 75,000 $34M $458.66 $12M — —
15 RNAM 1.80% 765,000 $33M $43.57 $19M +265,000 +53.0%
16 BBOT 1.77% 2,823,126 $33M $11.58 — +2,823,126 — NEW
17 NGNE 1.19% 1,271,342 $22M $17.33 $3M — —
18 ALKS 0.81% 500,000 $15M $30.00 $695K — —
19 AQST 0.79% 2,625,000 $15M $5.59 — +2,625,000 — NEW
20 MTSR 0.77% 271,529 $14M $52.33 $6M — —
21 CNTA 0.72% 550,000 $13M $24.25 — +550,000 — NEW
22 PRME 0.46% 1,543,326 $9M $5.54 — +1,543,326 — NEW
23 ATRA 0.44% 573,183 $8M $14.33 $4M — —
24 KURA 0.42% 872,500 $8M $8.85 -$17M -3,327,500 -79.2%
25 PEPG 0.20% 800,000 $4M $4.62 — +800,000 — NEW
26 NUVB-WT 0.19% 963,333 $4M $3.70 $2M — —
27 VYGR 0.17% 670,303 $3M $4.67 -$9M -3,247,243 -82.9%
28 CMPS 0.08% 265,137 $2M $5.73 — +265,137 — NEW
29 SRZNW 0.05% 66,665 $859K $12.89 $263K — —
30 JANX —% — — — -$34M -1,469,818 -100.0% SOLD
31 TECX —% — — — -$19M -935,121 -100.0% SOLD
32 ADAP —% — — — -$7M -27,404,070 -100.0% SOLD
33 PCRX —% — — — -$11M -457,471 -100.0% SOLD
34 MGNX —% — — — -$2M -1,602,717 -100.0% SOLD
35 VRNA —% — — — -$19M -200,000 -100.0% SOLD
36 ITOS —% — — — -$107M -10,688,978 -100.0% SOLD
37 AKRO —% — — — -$23M -440,000 -100.0% SOLD
38 WHWK —% — — — -$2M -1,091,417 -100.0% SOLD
39 HLVX —% — — — -$5M -2,420,243 -100.0% SOLD
40 REPL —% — — — -$8M -850,341 -100.0% SOLD
41 DAWN —% — — — -$6M -862,068 -100.0% SOLD

New Positions

SymbolValue% Port
BBOT $33M 1.77%
AQST $15M 0.79%
CNTA $13M 0.72%
PRME $9M 0.46%
PEPG $4M 0.20%
CMPS $2M 0.08%

Sold Out Positions

SymbolValue% Port
PCRX — —%
MGNX — —%
JANX — —%
REPL — —%
TECX — —%
WHWK — —%
ADAP — —%
AKRO — —%
DAWN — —%
ITOS — —%
VRNA — —%
HLVX — —%
View SEC EDGAR Filings for EcoR1 Capital, LLC →

Sign in to InsiderStreet

You'll also get our free weekly newsletter with
smart money signals, market insights, and alpha ideas.
Unsubscribe anytime.

For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms