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EcoR1 Capital, LLC

Q4 2025 · Filed 2026-02-17
Market Value
$1.6B
-6.5%
Holdings
37
-4
New Purchases
8
Added To
2
Closed
11
Reduced
3
Top 10 Concentration
82.8%
Turnover
51.4%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ANAB 24.15% 14.26% +9.89% $382M
JAZZ 18.34% 13.30% +5.04% $290M
CNTA 4.93% 0.79% +4.14% $78M
CRNX 12.62% 10.56% +2.06% $200M
MBX 4.23% 2.20% +2.04% $67M
CGON 2.03% 0.00% +2.03% $32M
ZBIO 1.81% 0.00% +1.81% $29M
GPCR 1.47% 0.00% +1.47% $23M
PCVX 1.31% 0.00% +1.31% $21M
IMNM 3.88% 2.82% +1.05% $61M
VYGR 0.99% 0.19% +0.81% $16M
MNKD 0.60% 0.00% +0.60% $9M
NGNE 1.66% 1.30% +0.35% $26M
NUVB-WT 0.55% 0.21% +0.33% $9M
BBOT 2.23% 1.93% +0.30% $35M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
QURE 0.00% 13.76% -13.76% $0
TNGX 0.00% 5.28% -5.28% $0
APLS 0.00% 4.61% -4.61% $0
MDGL 0.00% 2.03% -2.03% $0
RNAM 0.00% 1.97% -1.97% $0
ORIC 3.48% 4.77% -1.29% $55M
XNCR 3.15% 4.26% -1.11% $50M
ALKS 0.00% 0.89% -0.89% $0
MTSR 0.00% 0.84% -0.84% $0
CRSP 4.61% 5.32% -0.72% $73M
PRME 0.00% 0.51% -0.51% $0
KURA 0.00% 0.46% -0.46% $0
ETON 2.17% 2.61% -0.44% $34M
PEPG 0.00% 0.22% -0.22% $0
CMPS 0.00% 0.09% -0.09% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 3 $290M 18.3%
Mid Cap 12 $870M 55.0%
Small Cap 15 $382M 24.1%
Micro Cap 7 $40M 2.5%

Portfolio Analytics

Avg Market Cap
$2.9B
Median Market Cap
$1.1B
Avg P/E
39.4
Median P/E
39.4
Avg Dividend Yield
—%
Avg Beta
0.83
# Stocks
37
# ETFs / Funds
0

Top Holdings (37 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 ANAB 24.15% 7,880,094 $382M $48.48 $141M
2 JAZZ 18.34% 1,706,469 $290M $170.00 $65M
3 CRNX 12.62% 4,288,120 $200M $46.55 $21M
4 CNTA 4.93% 3,115,000 $78M $25.01 $65M +2,565,000 +466.4%
5 CRSP 4.61% 1,389,276 $73M $52.44 -$17M
6 MBX 4.23% 2,123,604 $67M $31.54 $30M
7 IMNM 3.88% 2,855,590 $61M $21.48 $14M -1,223,825 -30.0%
8 ORIC 3.48% 6,728,116 $55M $8.18 -$26M
9 LKFT 3.45% 1,667,119 $55M $32.70 -$3M
10 XNCR 3.15% 3,251,112 $50M $15.31 -$22M -2,893,655 -47.1%
11 BBOT 2.23% 2,823,126 $35M $12.52 $3M
12 ETON 2.17% 2,030,544 $34M $16.91 -$10M
13 CGON 2.03% 772,000 $32M $41.52 +772,000 NEW
14 ZBIO 1.81% 789,500 $29M $36.31 +789,500 NEW
15 NGNE 1.66% 1,271,342 $26M $20.60 $4M
16 GPCR 1.47% 334,380 $23M $69.55 +334,380 NEW
17 PCVX 1.31% 450,000 $21M $46.14 +450,000 NEW
18 AQST 1.07% 2,625,000 $17M $6.46 $2M
19 VYGR 0.99% 4,002,847 $16M $3.93 $13M +3,332,544 +497.2%
20 0HIY.L 0.66% 573,183 $10M $18.09 $2M
21 MNKD 0.60% 1,660,000 $9M $5.67 +1,660,000 NEW
22 NUVB-WT 0.55% 963,333 $9M $8.96 $5M
23 EOLS 0.28% 675,000 $4M $6.65 +675,000 NEW
24 MREO 0.21% 7,856,466 $3M $0.42 +7,856,466 NEW
25 CAMP 0.13% 325,000 $2M $6.13 +325,000 NEW
26 SRZNW 0.01% 4,444 $100K $22.60 -$759K -62,221 -93.3%
27 MDGL —% -$34M -75,000 -100.0% SOLD
28 RNAM —% -$33M -765,000 -100.0% SOLD
29 PRME —% -$9M -1,543,326 -100.0% SOLD
30 MTSR —% -$14M -271,529 -100.0% SOLD
31 CMPS —% -$2M -265,137 -100.0% SOLD
32 APLS —% -$78M -3,447,156 -100.0% SOLD
33 KURA —% -$8M -872,500 -100.0% SOLD
34 QURE —% -$233M -3,988,971 -100.0% SOLD
35 PEPG —% -$4M -800,000 -100.0% SOLD
36 ALKS —% -$15M -500,000 -100.0% SOLD
37 TNGX —% -$89M -10,630,736 -100.0% SOLD

New Positions

SymbolValue% Port
CGON $32M 2.03%
ZBIO $29M 1.81%
GPCR $23M 1.47%
PCVX $21M 1.31%
MNKD $9M 0.60%
EOLS $4M 0.28%
MREO $3M 0.21%
CAMP $2M 0.13%

Sold Out Positions

SymbolValue% Port
MDGL —%
ALKS —%
KURA —%
PRME —%
PEPG —%
TNGX —%
CMPS —%
QURE —%
APLS —%
RNAM —%
MTSR —%
View SEC EDGAR Filings for EcoR1 Capital, LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms