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Asset Manager ← All Institutions

EcoR1 Capital, LLC

Q4 2025 · Filed 2026-02-17
Market Value
$2.2B
+18.4%
Holdings
38
-3
New Purchases
9
Added To
2
Closed
10
Reduced
3
Top 10 Concentration
85.1%
Turnover
50.0%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ZYME 27.61% 21.20% +6.41% $605M
ANAB 17.44% 13.04% +4.40% $382M
CNTA 3.56% 0.72% +2.84% $78M
CGON 1.46% 0.00% +1.46% $32M
ZBIO 1.31% 0.00% +1.31% $29M
JAZZ 13.24% 12.15% +1.09% $290M
GPCR 1.06% 0.00% +1.06% $23M
MBX 3.06% 2.01% +1.05% $67M
PCVX 0.95% 0.00% +0.95% $21M
VYGR 0.72% 0.17% +0.55% $16M
MNKD 0.43% 0.00% +0.43% $9M
IMNM 2.80% 2.58% +0.22% $61M
EOLS 0.20% 0.00% +0.20% $4M
NUVB-WT 0.39% 0.19% +0.20% $9M
IBIO 0.20% 0.00% +0.20% $4M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
TNGX 0.00% 4.82% -4.82% $0
APLS 0.00% 4.21% -4.21% $0
MDGL 0.00% 1.86% -1.86% $0
ORIC 2.51% 4.36% -1.85% $55M
RNAM 0.00% 1.80% -1.80% $0
XNCR 2.27% 3.89% -1.62% $50M
CRSP 3.33% 4.86% -1.54% $73M
ETON 1.57% 2.38% -0.82% $34M
ALKS 0.00% 0.81% -0.81% $0
MTSR 0.00% 0.77% -0.77% $0
LKFT 2.49% 3.12% -0.63% $55M
CRNX 9.11% 9.65% -0.54% $200M
PRME 0.00% 0.46% -0.46% $0
KURA 0.00% 0.42% -0.42% $0
PEPG 0.00% 0.20% -0.20% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 3 $290M 13.2%
Mid Cap 10 $470M 21.5%
Small Cap 17 $1.4B 63.3%
Micro Cap 8 $44M 2.0%

Portfolio Analytics

Avg Market Cap
$3.2B
Median Market Cap
$1.6B
Avg P/E
56.8
Median P/E
38.7
Avg Dividend Yield
—%
Avg Beta
0.82
# Stocks
38
# ETFs / Funds
0

Top Holdings (38 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 ZYME 27.61% 22,970,388 $605M $26.33 $212M — —
2 ANAB 17.44% 7,880,094 $382M $48.48 $141M — —
3 JAZZ 13.24% 1,706,469 $290M $170.00 $65M — —
4 CRNX 9.11% 4,288,120 $200M $46.55 $21M — —
5 CNTA 3.56% 3,115,000 $78M $25.01 $65M +2,565,000 +466.4%
6 CRSP 3.33% 1,389,276 $73M $52.44 -$17M — —
7 MBX 3.06% 2,123,604 $67M $31.54 $30M — —
8 IMNM 2.80% 2,855,590 $61M $21.48 $14M -1,223,825 -30.0%
9 ORIC 2.51% 6,728,116 $55M $8.18 -$26M — —
10 LKFT 2.49% 1,667,119 $55M $32.70 -$3M — —
11 XNCR 2.27% 3,251,112 $50M $15.31 -$22M -2,893,655 -47.1%
12 BBOT 1.61% 2,823,126 $35M $12.52 $3M — —
13 ETON 1.57% 2,030,544 $34M $16.91 -$10M — —
14 CGON 1.46% 772,000 $32M $41.52 — +772,000 — NEW
15 ZBIO 1.31% 789,500 $29M $36.31 — +789,500 — NEW
16 NGNE 1.20% 1,271,342 $26M $20.60 $4M — —
17 GPCR 1.06% 334,380 $23M $69.55 — +334,380 — NEW
18 PCVX 0.95% 450,000 $21M $46.14 — +450,000 — NEW
19 AQST 0.77% 2,625,000 $17M $6.46 $2M — —
20 VYGR 0.72% 4,002,847 $16M $3.93 $13M +3,332,544 +497.2%
21 ATRA 0.47% 573,183 $10M $18.09 $2M — —
22 MNKD 0.43% 1,660,000 $9M $5.67 — +1,660,000 — NEW
23 NUVB-WT 0.39% 963,333 $9M $8.96 $5M — —
24 EOLS 0.20% 675,000 $4M $6.65 — +675,000 — NEW
25 IBIO 0.20% 2,228,000 $4M $1.93 — +2,228,000 — NEW
26 MREO 0.15% 7,856,466 $3M $0.42 — +7,856,466 — NEW
27 CAMP 0.09% 325,000 $2M $6.13 — +325,000 — NEW
28 SRZNW —% 4,444 $100K $22.60 -$759K -62,221 -93.3%
29 TNGX —% — — — -$89M -10,630,736 -100.0% SOLD
30 PEPG —% — — — -$4M -800,000 -100.0% SOLD
31 MDGL —% — — — -$34M -75,000 -100.0% SOLD
32 PRME —% — — — -$9M -1,543,326 -100.0% SOLD
33 APLS —% — — — -$78M -3,447,156 -100.0% SOLD
34 KURA —% — — — -$8M -872,500 -100.0% SOLD
35 ALKS —% — — — -$15M -500,000 -100.0% SOLD
36 CMPS —% — — — -$2M -265,137 -100.0% SOLD
37 MTSR —% — — — -$14M -271,529 -100.0% SOLD
38 RNAM —% — — — -$33M -765,000 -100.0% SOLD

New Positions

SymbolValue% Port
CGON $32M 1.46%
ZBIO $29M 1.31%
GPCR $23M 1.06%
PCVX $21M 0.95%
MNKD $9M 0.43%
EOLS $4M 0.20%
IBIO $4M 0.20%
MREO $3M 0.15%
CAMP $2M 0.09%

Sold Out Positions

SymbolValue% Port
MDGL — —%
ALKS — —%
CMPS — —%
KURA — —%
PRME — —%
PEPG — —%
TNGX — —%
APLS — —%
MTSR — —%
RNAM — —%
View SEC EDGAR Filings for EcoR1 Capital, LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms