— Know what they know.
Not Investment Advice
Asset Manager ← All Institutions

Opaleye Management Inc.

Q2 2026 · Filed 2026-08-14
Market Value
$1.1B
+43.4%
Holdings
64
+4
New Purchases
12
Added To
14
Closed
8
Reduced
13
Top 10 Concentration
65.3%
Turnover
31.2%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
LQDA 18.57% 12.12% +6.45% $195M
IMMX 2.30% 0.00% +2.30% $24M
IRON 5.95% 3.67% +2.28% $63M
MGTX 4.56% 2.51% +2.06% $48M
GLUE 1.72% 0.00% +1.72% $18M
REPL 1.46% 0.00% +1.46% $15M
VSTM 0.65% 0.00% +0.65% $7M
CABA 1.14% 0.51% +0.64% $12M
EDIT 1.19% 0.65% +0.54% $13M
RZLT 3.12% 2.62% +0.50% $33M
RVMD 1.78% 1.33% +0.46% $19M
APGE 4.93% 4.48% +0.45% $52M
BBOT 0.51% 0.07% +0.44% $5M
TGTX 2.80% 2.43% +0.37% $29M
MBX 1.37% 1.06% +0.31% $14M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
HROW 9.70% 13.63% -3.93% $102M
RYTM 1.29% 4.82% -3.53% $14M
CATX 0.00% 2.66% -2.66% $0
SNWV 0.29% 2.32% -2.02% $3M
SLGL 3.53% 5.41% -1.88% $37M
CBIO 2.26% 3.29% -1.03% $24M
STOK 2.18% 3.11% -0.93% $23M
ANNX 0.93% 1.76% -0.83% $10M
CGON 0.12% 0.88% -0.76% $1M
ASRT 0.00% 0.69% -0.69% $0
STRO 0.00% 0.65% -0.65% $0
TECX 0.00% 0.52% -0.52% $0
JBIO 0.31% 0.82% -0.51% $3M
DERM 0.24% 0.61% -0.38% $2M
RLMD 0.62% 0.89% -0.27% $6M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 1 $19M 1.8%
Mid Cap 9 $401M 38.1%
Small Cap 34 $512M 48.8%
Micro Cap 20 $119M 11.3%

Portfolio Analytics

Avg Market Cap
$2.0B
Median Market Cap
$529M
Avg P/E
29.9
Median P/E
14.2
Avg Dividend Yield
—%
Avg Beta
1.11
# Stocks
64
# ETFs / Funds
0

Top Holdings (64 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 LQDA 18.57% 2,447,500 $195M $79.73 $106M -97,500 -3.8%
2 ETON 9.85% 2,860,000 $104M $36.20 $33M — —
3 HROW 9.70% 2,400,000 $102M $42.47 $2M -432,230 -15.3%
4 IRON 5.95% 855,000 $63M $73.14 $36M +434,000 +103.1%
5 APGE 4.93% 390,000 $52M $132.73 $19M — —
6 MGTX 4.56% 3,550,000 $48M $13.51 $30M +1,426,741 +67.2%
7 SLGL 3.53% 500,000 $37M $74.14 -$3M — —
8 RZLT 3.12% 6,300,000 $33M $5.20 $14M — —
9 TGTX 2.80% 535,000 $29M $54.94 $12M — —
10 IMMX 2.30% 2,345,000 $24M $10.31 — +2,345,000 — NEW
11 CBIO 2.26% 1,319,351 $24M $18.00 -$364K +6,736 +0.5%
12 STOK 2.18% 700,000 $23M $32.72 $112K — —
13 ACOG 1.99% 2,895,467 $21M $7.22 $7M +333,517 +13.0%
14 EWTX 1.93% 500,000 $20M $40.63 $5M — —
15 RVMD 1.78% 100,000 $19M $187.28 $9M — —
16 GLUE 1.72% 745,000 $18M $24.20 — +745,000 — NEW
17 ALMS 1.47% 550,000 $15M $28.14 $3M — —
18 CDXS 1.46% 6,785,000 $15M $2.26 $4M — —
19 REPL 1.46% 1,384,993 $15M $11.07 — +1,384,993 — NEW
20 XOMA 1.37% 338,374 $14M $42.50 $5M +38,374 +12.8%
21 MBX 1.37% 260,000 $14M $55.20 $7M — —
22 RYTM 1.29% 122,500 $14M $111.03 -$22M -500 -0.4%
23 EDIT 1.19% 3,861,930 $13M $3.24 $8M +1,934,933 +100.4%
24 PTGX 1.17% 100,000 $12M $122.58 $2M — —
25 CABA 1.14% 3,863,800 $12M $3.11 $8M +2,483,800 +180.0%
26 QTTB 1.13% 931,000 $12M $12.74 $4M -325,228 -25.9%
27 ANNX 0.93% 1,714,451 $10M $5.71 -$3M -617,310 -26.5%
28 VSTM 0.65% 1,800,000 $7M $3.82 — +1,800,000 — NEW
29 ZNTL 0.65% 1,412,656 $7M $4.85 $4M — —
30 RLMD 0.62% 935,000 $6M $6.92 -$37K — —
31 OCUL 0.56% 600,000 $6M $9.82 $810K — —
32 TRVI 0.55% 310,000 $6M $18.65 $2M -35,100 -10.2%
33 BBOT 0.51% 700,000 $5M $7.62 $5M +646,718 +1213.8%
34 LYEL 0.46% 344,025 $5M $14.05 $3M +264,928 +334.9%
35 IRD 0.44% 1,125,000 $5M $4.11 $2M +5,000 +0.5%
36 FDMT 0.42% 334,437 $4M $13.30 $3M +222,146 +197.8%
37 NTLA 0.40% 250,000 $4M $16.92 $1M +5,000 +2.0%
38 VYGR 0.39% 1,185,000 $4M $3.50 -$292K +35,000 +3.0%
39 BDSX 0.39% 180,000 $4M $22.55 $607K -58,047 -24.4%
40 RCKT 0.33% 1,000,000 $3M $3.42 $1K +45,000 +4.7%
41 JBIO 0.31% 145,000 $3M $22.22 -$3M -282,608 -66.1%
42 SNWV 0.29% 306,140 $3M $10.00 -$14M -675,127 -68.8%
43 FBIO 0.26% 890,000 $3M $3.06 -$184K -152,000 -14.6%
44 DERM 0.24% 350,000 $2M $7.08 -$2M -610,000 -63.5%
45 PHAT 0.19% 185,589 $2M $10.85 — +185,589 — NEW
46 INBX 0.18% 20,291 $2M $94.75 — +20,291 — NEW
47 ENTA 0.17% 125,000 $2M $14.58 $244K — —
48 COAG 0.17% 47,652 $2M $36.73 — +47,652 — NEW
49 TRAX 0.12% 65,000 $1M $20.12 — +65,000 — NEW
50 CGON 0.12% 17,789 $1M $71.05 -$5M -77,011 -81.2%
51 BHVN 0.11% 77,915 $1M $14.88 — +77,915 — NEW
52 AVIR 0.10% 235,000 $1M $4.65 -$643K -87,600 -27.1%
53 KTTA 0.10% 2,050,000 $1M $0.52 — +2,050,000 — NEW
54 ADCT 0.07% 700,000 $749K $1.07 — +700,000 — NEW
55 PTN 0.02% 20,500 $221K $10.79 — +20,500 — NEW
56 ADGM —% 18,444 $13K $0.72 -$8K — —
57 NXTC —% — — — -$2M -141,181 -100.0% SOLD
58 STRO —% — — — -$5M -190,671 -100.0% SOLD
59 CATX —% — — — -$19M -4,675,000 -100.0% SOLD
60 TECX —% — — — -$4M -123,000 -100.0% SOLD
61 ASRT —% — — — -$5M -265,707 -100.0% SOLD
62 RIGL —% — — — -$2M -70,000 -100.0% SOLD
63 PLX —% — — — -$738K -340,000 -100.0% SOLD
64 LBRX —% — — — -$358K -14,506 -100.0% SOLD

New Positions

SymbolValue% Port
IMMX $24M 2.30%
GLUE $18M 1.72%
REPL $15M 1.46%
VSTM $7M 0.65%
PHAT $2M 0.19%
INBX $2M 0.18%
COAG $2M 0.17%
TRAX $1M 0.12%
BHVN $1M 0.11%
KTTA $1M 0.10%
ADCT $749K 0.07%
PTN $221K 0.02%

Sold Out Positions

SymbolValue% Port
LBRX — —%
NXTC — —%
RIGL — —%
CATX — —%
PLX — —%
STRO — —%
TECX — —%
ASRT — —%
View SEC EDGAR Filings for Opaleye Management Inc. →

Sign in to InsiderStreet

You'll also get our free weekly newsletter with
smart money signals, market insights, and alpha ideas.
Unsubscribe anytime.

For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms