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Opaleye Management Inc.

Q4 2025 · Filed 2026-04-13
Market Value
$663M
+2.2%
Holdings
55
+10
New Purchases
18
Added To
12
Closed
8
Reduced
8
Top 10 Concentration
70.8%
Turnover
47.3%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
LQDA 12.82% 9.17% +3.66% $85M
SLGL 2.88% 0.92% +1.96% $19M
KPTI 1.03% 0.00% +1.03% $7M
JBIO 1.00% 0.00% +1.00% $7M
URGN 0.95% 0.00% +0.95% $6M
RZLT 2.24% 1.31% +0.93% $15M
STOK 3.33% 2.47% +0.86% $22M
CATX 0.75% 0.00% +0.75% $5M
ANNX 1.97% 1.22% +0.75% $13M
VYGR 0.71% 0.00% +0.71% $5M
RLMD 0.68% 0.00% +0.68% $5M
TECX 0.68% 0.00% +0.68% $4M
EWTX 1.87% 1.25% +0.62% $12M
MBX 1.24% 0.68% +0.55% $8M
RCKT 0.51% 0.00% +0.51% $3M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
IMNM 0.00% 5.75% -5.75% $0
CDXS 1.67% 4.81% -3.14% $11M
ETON 7.30% 9.58% -2.28% $48M
RYTM 5.33% 7.19% -1.86% $35M
SRPT 0.00% 1.74% -1.74% $0
LRMR 0.00% 1.63% -1.63% $0
ARVN 0.00% 1.30% -1.30% $0
TMCI 0.00% 0.73% -0.73% $0
TGTX 2.41% 2.98% -0.57% $16M
ADCT 0.00% 0.42% -0.42% $0
XOMA 1.17% 1.52% -0.34% $8M
PLX 0.67% 0.88% -0.21% $4M
SYRE 0.00% 0.17% -0.17% $0
HROW 28.87% 29.00% -0.13% $191M
PEPG 0.00% 0.05% -0.05% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 2 $9M 1.4%
Mid Cap 12 $214M 32.3%
Small Cap 25 $370M 55.8%
Micro Cap 16 $70M 10.5%

Portfolio Analytics

Avg Market Cap
$2.2B
Median Market Cap
$549M
Avg P/E
43.8
Median P/E
13.9
Avg Dividend Yield
—%
Avg Beta
1.13
# Stocks
55
# ETFs / Funds
0

Top Holdings (55 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 HROW 28.87% 3,905,000 $191M $49.00 $3M
2 LQDA 12.82% 2,435,000 $85M $34.90 $26M -180,000 -6.9%
3 ETON 7.30% 2,860,000 $48M $16.91 -$14M
4 RYTM 5.33% 330,000 $35M $107.04 -$11M -131,700 -28.5%
5 STOK 3.33% 695,000 $22M $31.74 $6M +12,983 +1.9%
6 OCUL 2.92% 1,595,000 $19M $12.14 $718K
7 SLGL 2.88% 453,739 $19M $42.14 $13M +248,904 +121.5%
8 CGON 2.57% 410,000 $17M $41.52 $508K
9 TGTX 2.41% 535,000 $16M $29.81 -$3M
10 IRON 2.40% 200,000 $16M $79.41 $3M +6,227 +3.2%
11 RZLT 2.24% 6,287,156 $15M $2.36 $6M +5,383,714 +595.9%
12 ALKS 2.07% 490,000 $14M $27.98 $210K +40,000 +8.9%
13 ANNX 1.97% 2,600,000 $13M $5.02 $5M
14 EWTX 1.87% 500,000 $12M $24.82 $4M
15 CDXS 1.67% 6,789,738 $11M $1.63 -$20M -6,005,262 -46.9%
16 PTGX 1.38% 105,000 $9M $87.34 $2M
17 GOSS 1.27% 2,720,000 $8M $3.10 $1M -5,000 -0.2%
18 MBX 1.24% 260,000 $8M $31.54 $4M +7,000 +2.8%
19 RVMD 1.20% 100,000 $8M $79.65 $3M
20 XOMA 1.17% 292,590 $8M $26.59 -$2M +37,503 +14.7%
21 DERM 1.13% 975,000 $8M $7.71 $603K +3,936 +0.4%
22 KPTI 1.03% 930,000 $7M $7.36 +930,000 NEW
23 JBIO 1.00% 427,608 $7M $15.43 +427,608 NEW
24 URGN 0.95% 268,423 $6M $23.42 +268,423 NEW
25 ALMS 0.79% 535,000 $5M $9.76 $3M -130,000 -19.6%
26 CATX 0.75% 1,184,500 $5M $4.21 +1,184,500 NEW
27 VYGR 0.71% 1,196,904 $5M $3.93 +1,196,904 NEW
28 RLMD 0.68% 935,000 $5M $4.83 +935,000 NEW
29 TECX 0.68% 214,747 $4M $20.86 +214,747 NEW
30 PLX 0.67% 2,478,176 $4M $1.80 -$1M -102,380 -4.0%
31 TRVI 0.65% 345,100 $4M $12.52 $752K -44,900 -11.5%
32 RCKT 0.51% 955,000 $3M $3.51 +955,000 NEW
33 MGTX 0.47% 390,844 $3M $7.95 +390,844 NEW
34 RIGL 0.45% 70,000 $3M $42.83 $2M +32,213 +85.2%
35 ASRT 0.39% 285,000 $3M $9.07 +285,000 NEW
36 VTYX 0.34% 251,932 $2M $9.03 +251,932 NEW
37 IRD 0.34% 1,120,000 $2M $2.01 $436K +20,000 +1.8%
38 CABA 0.30% 900,000 $2M $2.19 $78K +91,118 +11.3%
39 ZNTL 0.29% 1,400,906 $2M $1.35 $1M +1,084,356 +342.6%
40 GBIO 0.27% 310,000 $2M $5.68 +310,000 NEW
41 BBIO 0.21% 18,319 $1M $76.49 +18,319 NEW
42 ENTA 0.18% 75,000 $1M $15.77 +75,000 NEW
43 QTTB 0.11% 213,363 $708K $3.32 +213,363 NEW
44 AVIR 0.10% 179,815 $642K $3.57 +179,815 NEW
45 SLN 0.07% 78,926 $480K $6.08 +78,926 NEW
46 RAPT 0.03% 150,000 $213K $1.42 +150,000 NEW
47 ADGM —% 18,444 $19K $1.04 -$195K -92,127 -83.3%
48 ARVN —% -$8M -987,818 -100.0% SOLD
49 SRPT —% -$11M -585,000 -100.0% SOLD
50 SYRE —% -$1M -65,000 -100.0% SOLD
51 IMNM —% -$37M -3,185,000 -100.0% SOLD
52 TMCI —% -$5M -702,245 -100.0% SOLD
53 LRMR —% -$11M -3,720,867 -100.0% SOLD
54 PEPG —% -$346K -75,000 -100.0% SOLD
55 ADCT —% -$3M -682,529 -100.0% SOLD

New Positions

SymbolValue% Port
KPTI $7M 1.03%
JBIO $7M 1.00%
URGN $6M 0.95%
CATX $5M 0.75%
VYGR $5M 0.71%
RLMD $5M 0.68%
TECX $4M 0.68%
RCKT $3M 0.51%
MGTX $3M 0.47%
ASRT $3M 0.39%
VTYX $2M 0.34%
GBIO $2M 0.27%
BBIO $1M 0.21%
ENTA $1M 0.18%
QTTB $708K 0.11%

Sold Out Positions

SymbolValue% Port
ADCT —%
ARVN —%
IMNM —%
LRMR —%
PEPG —%
SYRE —%
SRPT —%
TMCI —%
View SEC EDGAR Filings for Opaleye Management Inc. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms