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Opaleye Management Inc.

Q3 2025 · Filed 2025-11-14
Market Value
$649M
+44.6%
Holdings
45
+2
New Purchases
9
Added To
9
Closed
8
Reduced
10
Top 10 Concentration
76.4%
Turnover
37.8%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
HROW 29.00% 26.59% +2.41% $188M
LQDA 9.17% 6.88% +2.29% $59M
ALKS 2.08% 0.00% +2.08% $14M
ANNX 1.22% 0.00% +1.22% $8M
STOK 2.47% 1.42% +1.05% $16M
CGON 2.55% 1.54% +1.00% $17M
SLGL 0.92% 0.00% +0.92% $6M
DERM 1.07% 0.15% +0.91% $7M
PLX 0.88% 0.00% +0.88% $6M
TMCI 0.73% 0.00% +0.73% $5M
RYTM 7.19% 6.69% +0.49% $47M
ETON 9.58% 9.09% +0.49% $62M
ADCT 0.42% 0.00% +0.42% $3M
RZLT 1.31% 0.90% +0.41% $8M
CABA 0.29% 0.00% +0.29% $2M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
CDXS 4.81% 6.85% -2.04% $31M
VIGL 0.00% 1.77% -1.77% $0
IMNM 5.75% 7.32% -1.57% $37M
ARVN 1.30% 2.76% -1.46% $8M
ANIK 0.00% 1.39% -1.39% $0
TGTX 2.98% 4.29% -1.31% $19M
DNA 0.00% 1.25% -1.25% $0
LRMR 1.63% 2.65% -1.02% $11M
EPIX 0.00% 0.84% -0.84% $0
CRGX 0.00% 0.61% -0.61% $0
TARA 0.00% 0.58% -0.58% $0
RCEL 0.00% 0.46% -0.46% $0
OCUL 2.87% 3.30% -0.43% $19M
ZNTL 0.07% 0.50% -0.42% $478K
IRON 1.97% 2.20% -0.23% $13M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 1 $5M 0.7%
Mid Cap 12 $228M 35.1%
Small Cap 16 $343M 52.8%
Micro Cap 16 $73M 11.3%

Portfolio Analytics

Avg Market Cap
$2.2B
Median Market Cap
$537M
Avg P/E
49.7
Median P/E
15.7
Avg Dividend Yield
0.19%
Avg Beta
1.27
# Stocks
45
# ETFs / Funds
0

Top Holdings (45 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 HROW 29.00% 3,905,000 $188M $48.18 $69M
2 ETON 9.58% 2,860,000 $62M $21.73 $21M
3 LQDA 9.17% 2,615,000 $59M $22.74 $29M +140,000 +5.7%
4 RYTM 7.19% 461,700 $47M $100.99 $17M -13,300 -2.8%
5 IMNM 5.75% 3,185,000 $37M $11.71 $4M -344,581 -9.8%
6 CDXS 4.81% 12,795,000 $31M $2.44 $476K +195,000 +1.6%
7 TGTX 2.98% 535,000 $19M $36.13 $72K
8 OCUL 2.87% 1,595,000 $19M $11.69 $4M
9 CGON 2.55% 410,000 $17M $40.28 $10M +144,000 +54.1%
10 STOK 2.47% 682,017 $16M $23.50 $10M +119,897 +21.3%
11 ALKS 2.08% 450,000 $14M $30.00 +450,000 NEW
12 IRON 1.97% 193,773 $13M $66.08 $3M +7,355 +4.0%
13 SRPT 1.74% 585,000 $11M $19.27 $3M +85,000 +17.0%
14 LRMR 1.63% 3,720,867 $11M $2.84 -$1M -389,133 -9.5%
15 XOMA 1.52% 255,087 $10M $38.54 $3M
16 RZLT 1.31% 903,442 $8M $9.40 $4M
17 ARVN 1.30% 987,818 $8M $8.52 -$4M -692,182 -41.2%
18 EWTX 1.25% 500,000 $8M $16.22 $2M +10,000 +2.0%
19 ANNX 1.22% 2,600,000 $8M $3.05 +2,600,000 NEW
20 GOSS 1.10% 2,725,000 $7M $2.63 $3M -820,000 -23.1%
21 PTGX 1.08% 105,000 $7M $66.43 $1M
22 DERM 1.07% 971,064 $7M $7.12 $6M +876,064 +922.2%
23 SLGL 0.92% 204,835 $6M $29.15 +204,835 NEW
24 PLX 0.88% 2,580,556 $6M $2.22 +2,580,556 NEW
25 TMCI 0.73% 702,245 $5M $6.71 +702,245 NEW
26 RVMD 0.72% 100,000 $5M $46.70 $807K -5,000 -4.8%
27 MBX 0.68% 253,000 $4M $17.50 $2M +13,681 +5.7%
28 TRVI 0.55% 390,000 $4M $9.15 $1M
29 ADCT 0.42% 682,529 $3M $4.00 +682,529 NEW
30 ALMS 0.41% 665,000 $3M $3.99 $328K -110,000 -14.2%
31 CABA 0.29% 808,882 $2M $2.34 +808,882 NEW
32 IRD 0.28% 1,100,000 $2M $1.65 $666K -120,000 -9.8%
33 SYRE 0.17% 65,000 $1M $16.76 +65,000 NEW
34 RIGL 0.17% 37,787 $1M $28.33 +37,787 NEW
35 ZNTL 0.07% 316,550 $478K $1.51 -$2M -1,607,750 -83.5%
36 PEPG 0.05% 75,000 $346K $4.62 $80K -165,000 -68.8%
37 ADGM 0.03% 110,571 $215K $1.94 $71K
38 TARA —% -$3M -855,000 -100.0% SOLD
39 RCEL —% -$2M -389,519 -100.0% SOLD
40 ELEV —% -$529K -1,442,061 -100.0% SOLD
41 ANIK —% -$6M -588,797 -100.0% SOLD
42 VIGL —% -$8M -1,000,000 -100.0% SOLD
43 EPIX —% -$4M -2,209,998 -100.0% SOLD
44 CRGX —% -$3M -666,503 -100.0% SOLD
45 DNA —% -$6M -500,000 -100.0% SOLD

New Positions

SymbolValue% Port
ALKS $14M 2.08%
ANNX $8M 1.22%
SLGL $6M 0.92%
PLX $6M 0.88%
TMCI $5M 0.73%
ADCT $3M 0.42%
CABA $2M 0.29%
SYRE $1M 0.17%
RIGL $1M 0.17%

Sold Out Positions

SymbolValue% Port
DNA —%
TARA —%
ANIK —%
RCEL —%
CRGX —%
EPIX —%
VIGL —%
ELEV —%
View SEC EDGAR Filings for Opaleye Management Inc. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms