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Opaleye Management Inc.

Q2 2025 · Filed 2025-08-15
Market Value
$449M
+13.0%
Holdings
43
-2
New Purchases
5
Added To
13
Closed
7
Reduced
12
Top 10 Concentration
76.4%
Turnover
27.9%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
SRPT 1.91% 0.00% +1.91% $9M
VIGL 1.77% 0.00% +1.77% $8M
LRMR 2.65% 1.04% +1.61% $12M
IMNM 7.32% 6.02% +1.30% $33M
IRON 2.20% 1.06% +1.14% $10M
STOK 1.42% 0.50% +0.92% $6M
RVMD 0.86% 0.00% +0.86% $4M
RZLT 0.90% 0.34% +0.56% $4M
CGON 1.54% 1.01% +0.53% $7M
ALMS 0.52% 0.00% +0.52% $2M
CDXS 6.85% 6.44% +0.42% $31M
OCUL 3.30% 2.95% +0.35% $15M
XOMA 1.43% 1.27% +0.16% $6M
RYTM 6.69% 6.54% +0.15% $30M
MBX 0.61% 0.46% +0.14% $3M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
LQDA 6.88% 8.40% -1.52% $31M
TARA 0.58% 1.86% -1.28% $3M
PVLA 0.00% 1.22% -1.22% $0
ANAB 0.00% 1.18% -1.18% $0
TGTX 4.29% 5.31% -1.02% $19M
SLRN 0.00% 1.01% -1.01% $0
TRVI 0.48% 1.26% -0.78% $2M
EWTX 1.43% 2.19% -0.76% $6M
ARVN 2.76% 3.49% -0.74% $12M
DNA 1.25% 1.72% -0.46% $6M
OPTN 0.00% 0.45% -0.45% $0
RCEL 0.46% 0.90% -0.44% $2M
NRIX 0.00% 0.34% -0.34% $0
ZNTL 0.50% 0.80% -0.30% $2M
ETON 9.09% 9.33% -0.24% $41M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 1 $4M 0.9%
Mid Cap 11 $146M 32.6%
Small Cap 15 $230M 51.3%
Micro Cap 16 $68M 15.2%

Portfolio Analytics

Avg Market Cap
$2.2B
Median Market Cap
$586M
Avg P/E
73.9
Median P/E
21.4
Avg Dividend Yield
0.20%
Avg Beta
1.13
# Stocks
43
# ETFs / Funds
0

Top Holdings (43 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 HROW 26.59% 3,905,000 $119M $30.54 $14M -50,000 -1.3%
2 ETON 9.09% 2,860,000 $41M $14.25 $4M +7,930 +0.3%
3 IMNM 7.32% 3,529,581 $33M $9.30 $9M -20,419 -0.6%
4 LQDA 6.88% 2,475,000 $31M $12.46 -$2M +215,000 +9.5%
5 CDXS 6.85% 12,600,000 $31M $2.44 $5M +3,100,000 +32.6%
6 RYTM 6.69% 475,000 $30M $63.19 $4M -15,000 -3.1%
7 TGTX 4.29% 535,000 $19M $35.99 -$2M
8 OCUL 3.30% 1,595,000 $15M $9.28 $3M
9 ARVN 2.76% 1,680,000 $12M $7.36 -$1M -295,000 -14.9%
10 LRMR 2.65% 4,110,000 $12M $2.89 $8M +2,195,923 +114.7%
11 IRON 2.20% 186,418 $10M $52.96 $6M +101,418 +119.3%
12 SRPT 1.91% 500,000 $9M $17.10 +500,000 NEW
13 VIGL 1.77% 1,000,000 $8M $7.95 +1,000,000 NEW
14 CGON 1.54% 266,000 $7M $26.00 $3M +102,012 +62.2%
15 XOMA 1.43% 255,087 $6M $25.20 $1M +2,044 +0.8%
16 EWTX 1.43% 490,000 $6M $13.11 -$2M +95,000 +24.1%
17 STOK 1.42% 562,120 $6M $11.35 $4M +262,120 +87.4%
18 ANIK 1.39% 588,797 $6M $10.58 $293K +193,797 +49.1%
19 PTGX 1.29% 105,000 $6M $55.27 $726K
20 DNA 1.25% 500,000 $6M $11.25 -$1M -695,000 -58.2%
21 GOSS 0.97% 3,545,000 $4M $1.23 -$356K -742,415 -17.3%
22 RZLT 0.90% 903,442 $4M $4.46 $3M +438,442 +94.3%
23 RVMD 0.86% 105,000 $4M $36.79 +105,000 NEW
24 EPIX 0.84% 2,209,998 $4M $1.70 $265K
25 CRGX 0.61% 666,503 $3M $4.12 $33K
26 MBX 0.61% 239,319 $3M $11.41 $886K -10,681 -4.3%
27 TARA 0.58% 855,000 $3M $3.03 -$5M -875,000 -50.6%
28 ALMS 0.52% 775,000 $2M $3.00 +775,000 NEW
29 ZNTL 0.50% 1,924,300 $2M $1.16 -$924K -60,700 -3.1%
30 TRVI 0.48% 390,000 $2M $5.47 -$3M -405,000 -50.9%
31 RCEL 0.46% 389,519 $2M $5.29 -$2M -50,481 -11.5%
32 IRD 0.26% 1,220,000 $1M $0.94 -$397K +45,000 +3.8%
33 DERM 0.15% 95,000 $682K $7.18 $273K +25,677 +37.0%
34 ELEV 0.12% 1,442,061 $529K $0.37 +1,442,061 NEW
35 PEPG 0.06% 240,000 $266K $1.11 -$324K -180,000 -42.9%
36 ADGM 0.03% 110,571 $144K $1.30 $52K
37 SLRN —% -$4M -1,615,000 -100.0% SOLD
38 ANAB —% -$5M -250,933 -100.0% SOLD
39 PVLA —% -$5M -172,357 -100.0% SOLD
40 NRIX —% -$1M -115,000 -100.0% SOLD
41 VTYX —% -$218K -190,000 -100.0% SOLD
42 SGMO —% -$692K -1,055,000 -100.0% SOLD
43 OPTN —% -$2M -193,039 -100.0% SOLD

New Positions

SymbolValue% Port
SRPT $9M 1.91%
VIGL $8M 1.77%
RVMD $4M 0.86%
ALMS $2M 0.52%
ELEV $529K 0.12%

Sold Out Positions

SymbolValue% Port
ANAB —%
PVLA —%
NRIX —%
SGMO —%
SLRN —%
VTYX —%
OPTN —%
View SEC EDGAR Filings for Opaleye Management Inc. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms