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Ikarian Capital, LLC

Q3 2025 · Filed 2025-11-14
Market Value
$480M
+64.0%
Holdings
128
+5
New Purchases
37
Added To
22
Closed
22
Reduced
25
Top 10 Concentration
48.0%
Turnover
46.1%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
GMAB 11.05% 0.00% +11.05% $53M
ABVX 6.96% 0.00% +6.96% $33M
IONS 5.66% 0.00% +5.66% $27M
PTCT 3.59% 0.00% +3.59% $17M
RAPT 3.31% 0.00% +3.31% $16M
MAZE 4.00% 1.10% +2.90% $19M
DNTH 2.84% 0.00% +2.84% $14M
CTMX 2.24% 0.00% +2.24% $11M
ZURA 1.92% 0.00% +1.92% $9M
APLS 2.13% 0.44% +1.69% $10M
TENX 1.53% 0.00% +1.53% $7M
FULC 2.47% 1.01% +1.46% $12M
SNDX 1.07% 0.00% +1.07% $5M
AGIO 1.06% 0.00% +1.06% $5M
TVTX 0.95% 0.00% +0.95% $5M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ALNY 0.00% 6.31% -6.31% $0
INSM 0.41% 5.63% -5.22% $2M
VRNA 0.00% 4.75% -4.75% $0
PRAX 0.32% 3.98% -3.66% $2M
APGE 0.00% 3.44% -3.44% $0
CRNX 1.14% 4.26% -3.12% $5M
SRPT 0.00% 2.62% -2.62% $0
COGT 0.03% 2.54% -2.51% $162K
CDTX 5.54% 7.73% -2.19% $27M
AKRO 2.05% 4.01% -1.97% $10M
TARS 0.91% 2.72% -1.81% $4M
ARVN 0.40% 2.14% -1.74% $2M
ACOG 1.28% 2.93% -1.64% $6M
TGTX 1.32% 2.58% -1.27% $6M
FBRX 0.94% 2.11% -1.17% $4M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 9 $72M 15.1%
Mid Cap 33 $225M 46.9%
Small Cap 42 $120M 25.1%
Micro Cap 44 $62M 13.0%

Portfolio Analytics

Avg Market Cap
$3.9B
Median Market Cap
$779M
Avg P/E
26.9
Median P/E
27.1
Avg Dividend Yield
0.01%
Avg Beta
0.93
# Stocks
126
# ETFs / Funds
2

Top Holdings (128 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 GMAB 11.05% 175,000 $53M $302.98 — +175,000 — NEW
2 ABVX 6.96% 396,098 $33M $84.36 — +396,098 — NEW
3 IONS 5.66% 415,163 $27M $65.42 — +415,163 — NEW
4 CDTX 5.54% 277,704 $27M $95.76 $4M -186,784 -40.2%
5 MAZE 4.00% 740,825 $19M $25.93 $16M +478,085 +182.0%
6 PTCT 3.59% 280,551 $17M $61.37 — +280,551 — NEW
7 RAPT 3.31% 615,000 $16M $25.79 — +615,000 — NEW
8 DNTH 2.84% 346,001 $14M $39.35 — +346,001 — NEW
9 CYTK 2.55% 222,674 $12M $54.96 $5M -10,790 -4.6%
10 FULC 2.47% 1,289,225 $12M $9.20 $9M +860,704 +200.8%
11 PCVX 2.34% 311,682 $11M $36.02 $1M +6,682 +2.2%
12 CTMX 2.24% 3,372,616 $11M $3.19 — +3,372,616 — NEW
13 JAZZ 2.14% 77,800 $10M $131.80 $6M +37,800 +94.5%
14 APLS 2.13% 451,902 $10M $22.63 $9M +376,902 +502.5%
15 CGON 2.09% 249,473 $10M $40.28 $6M +94,473 +61.0%
16 AKRO 2.05% 206,854 $10M $47.48 -$2M -13,146 -6.0%
17 ZURA 1.92% 2,132,322 $9M $4.33 — +2,132,322 — NEW
18 TENX 1.53% 967,600 $7M $7.61 — +967,600 — NEW
19 KOD 1.41% 413,841 $7M $16.37 $5M -185,693 -31.0%
20 TGTX 1.32% 174,959 $6M $36.13 -$1M -34,979 -16.7%
21 ACOG 1.28% 946,259 $6M $6.51 -$2M +28,392 +3.1%
22 CRNX 1.14% 130,902 $5M $41.65 -$7M -302,529 -69.8%
23 VRDN 1.10% 245,518 $5M $21.58 -$1M -224,431 -47.8%
24 SNDX 1.07% 333,733 $5M $15.38 — +333,733 — NEW
25 AGIO 1.06% 126,979 $5M $40.14 — +126,979 — NEW
26 DCTH 0.97% 431,251 $5M $10.75 $251K +108,861 +33.8%
27 GPCR 0.95% 163,237 $5M $28.00 $773K -19,848 -10.8%
28 TVTX 0.95% 190,781 $5M $23.90 — +190,781 — NEW
29 FBRX 0.94% 300,000 $4M $15.00 -$2M -176,443 -37.0%
30 TARS 0.91% 73,619 $4M $59.43 -$4M -122,917 -62.5%
31 KRYS 0.90% 24,421 $4M $176.53 — +24,421 — NEW
32 ARGX 0.90% 5,942 $4M $724.19 — +5,942 — NEW
33 VTYX 0.85% 1,309,604 $4M $3.11 $2M +342,014 +35.4%
34 PVLA 0.85% 64,746 $4M $62.69 — +64,746 — NEW
35 SLNO 0.79% 55,946 $4M $67.60 — +55,946 — NEW
36 LXEO 0.79% 567,601 $4M $6.64 $2M +17,572 +3.2%
37 LABD 0.78% 91,959 $4M $40.44 — +91,959 — NEW
38 RLMD 0.77% 1,843,060 $4M $2.01 $4M +1,802,790 +4476.8%
39 VIR 0.71% 593,374 $3M $5.71 -$2M -474,688 -44.4%
40 MLTX 0.65% 435,839 $3M $7.17 — +435,839 — NEW
41 UPB 0.63% 161,113 $3M $18.81 — +161,113 — NEW
42 GUTS 0.60% 1,800,000 $3M $1.59 — +1,800,000 — NEW
43 BBOT 0.59% 245,231 $3M $11.58 — +245,231 — NEW
44 BBIO 0.56% 51,967 $3M $51.94 — +51,967 — NEW
45 PEPG 0.52% 535,967 $2M $4.62 $2M +385,967 +257.3%
46 STIM 0.52% 905,716 $2M $2.73 -$1M -193,984 -17.6%
47 RLAY 0.51% 467,362 $2M $5.22 -$132K -275,946 -37.1%
48 ADMA 0.49% 159,854 $2M $14.66 — +159,854 — NEW
49 CPRX 0.48% 116,388 $2M $19.70 -$2M -93,261 -44.5%
50 ADGI 0.48% 2,078,706 $2M $1.10 — +2,078,706 — NEW
51 ALEC 0.47% 760,000 $2M $2.96 $990K -140,000 -15.6%
52 VTGN 0.46% 620,869 $2M $3.55 $1M +19,166 +3.2%
53 AVTX 0.42% 159,777 $2M $12.71 $2M +124,477 +352.6%
54 INSM 0.41% 13,751 $2M $144.01 -$14M -150,000 -91.6%
55 ARVN 0.40% 226,257 $2M $8.52 -$4M -623,743 -73.4%
56 CAPR 0.40% 264,642 $2M $7.21 — +264,642 — NEW
57 PRQR 0.40% 892,229 $2M $2.13 $130K +24,160 +2.8%
58 PTHS 0.36% 62,451 $2M $28.00 — +62,451 — NEW
59 CPIX 0.36% 555,932 $2M $3.12 -$262K -40,000 -6.7%
60 PRAX 0.32% 28,571 $2M $53.00 -$10M -248,379 -89.7%
61 ANAB 0.31% 48,410 $1M $30.62 $1M +32,748 +209.1%
62 DYN 0.30% 113,837 $1M $12.65 -$2M -250,000 -68.7%
63 OVID 0.30% 1,095,574 $1M $1.30 — +1,095,574 — NEW
64 JANX 0.28% 54,691 $1M $24.44 -$2M -75,000 -57.8%
65 SLN 0.27% 900,784 $1M $1.45 -$92K +27,216 +3.1%
66 ZYME 0.26% 72,787 $1M $17.08 $929K +47,787 +191.2%
67 TERN 0.26% 164,202 $1M $7.51 $1M +105,711 +180.7%
68 SLDB 0.23% 176,690 $1M $6.17 — +176,690 — NEW
69 IFRX 0.20% 722,066 $968K $1.34 $411K +17,056 +2.4%
70 DRUG 0.20% 15,431 $936K $60.66 -$772K -50,000 -76.4%
71 0R1D.L 0.18% 1,294,652 $872K $0.67 $190K +34,473 +2.7%
72 MBX 0.18% 48,071 $841K $17.50 — +48,071 — NEW
73 PRME 0.17% 150,000 $831K $5.54 — +150,000 — NEW
74 HELP 0.17% 140,475 $827K $5.89 -$351K — —
75 LYEL 0.15% 43,799 $711K $16.24 $324K — —
76 SONN 0.14% 150,000 $687K $4.58 — +150,000 — NEW
77 IOBT 0.12% 1,525,893 $554K $0.36 — +1,525,893 — NEW
78 VERU 0.11% 142,523 $542K $3.80 — +142,523 — NEW
79 IBIO 0.11% 617,327 $511K $0.83 $53K +17,414 +2.9%
80 EQ 0.10% 332,297 $475K $1.43 — +332,297 — NEW
81 ABOS 0.09% 265,769 $454K $1.71 $146K — —
82 ANRO 0.09% 110,000 $442K $4.02 $200K — —
83 IMTX 0.09% 49,396 $421K $8.52 $155K — —
84 KZR 0.09% 106,901 $417K $3.90 -$73K — —
85 ANEB 0.08% 157,720 $394K $2.50 $167K — —
86 EVAX 0.06% 80,000 $301K $3.76 $105K — —
87 VKTX 0.05% 10,000 $263K $26.28 -$2M -90,000 -90.0%
88 VYGR 0.05% 55,766 $260K $4.67 $87K — —
89 LXRX 0.05% 176,479 $238K $1.35 $71K — —
90 RNAC 0.05% 22,166 $227K $10.22 -$4K — —
91 FTH 0.04% 22,497 $213K $9.45 $20K — —
92 ARCT 0.04% 10,721 $198K $18.43 -$2M -164,279 -93.9%
93 KPTI 0.04% 27,257 $178K $6.54 $61K — —
94 COGT 0.03% 11,280 $162K $14.36 -$7M -1,024,248 -98.9%
95 AIRS 0.03% 17,951 $144K $8.02 $57K — —
96 CMMB 0.03% 53,262 $140K $2.63 — +53,262 — NEW
97 LYRA 0.03% 21,161 $139K $6.59 -$50K — —
98 PMVP 0.03% 97,500 $136K $1.40 — +97,500 — NEW
99 MGNX 0.03% 80,071 $135K $1.68 $38K — —
100 SPRB 0.02% 13,332 $119K $8.95 — +13,332 — NEW

Options Breakdown

43 Calls $198M Call Value 16 Puts $242M Put Value 1.22 P/C Ratio

Top Calls

SymbolSharesValueStatus
SRRK 561,600 $21M
INSM 100,000 $14M NEW
HROW 289,700 $14M NEW
PTCT 213,000 $13M NEW
SLNO 176,100 $12M
CRNX 257,700 $11M NEW
NVO 150,000 $8M NEW
APLS 358,000 $8M NEW
CNTA 307,700 $7M
CYTK 110,900 $6M

Top Puts

SymbolSharesValueStatus
UTHR 209,800 $88M NEW
XBI 750,000 $75M NEW
BMY 800,000 $36M NEW
INSM 100,000 $14M NEW
ANAB 161,100 $5M NEW
MTSR 86,000 $5M NEW
SRRK 96,200 $4M NEW
MBX 200,000 $4M NEW
SLNO 50,000 $3M
MLTX 450,000 $3M

New Positions

SymbolValue% Port
GMAB $53M 11.05%
ABVX $33M 6.96%
IONS $27M 5.66%
PTCT $17M 3.59%
RAPT $16M 3.31%
DNTH $14M 2.84%
CTMX $11M 2.24%
ZURA $9M 1.92%
TENX $7M 1.53%
SNDX $5M 1.07%
AGIO $5M 1.06%
TVTX $5M 0.95%
KRYS $4M 0.90%
ARGX $4M 0.90%
PVLA $4M 0.85%

Sold Out Positions

SymbolValue% Port
RCUS — —%
NUVB — —%
GERN — —%
ELDN — —%
ALNY — —%
IBB — —%
BIIB — —%
TKNO — —%
VERA — —%
INBX — —%
ORKA — —%
SRRK — —%
TECX — —%
SGMT — —%
SRPT — —%
View SEC EDGAR Filings for Ikarian Capital, LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms