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Commodore Capital LP

Q4 2025 · Filed 2026-02-17
Market Value
$1.3B
-27.0%
Holdings
31
+2
New Purchases
5
Added To
4
Closed
6
Reduced
9
Top 10 Concentration
63.5%
Turnover
35.5%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
RLAY 10.89% 4.91% +5.98% $144M
TYRA 6.72% 2.61% +4.11% $89M
SYRE 5.92% 1.84% +4.08% $78M
ANRO 2.46% 0.00% +2.46% $32M
ALKS 7.52% 5.14% +2.38% $99M
ORKA 4.02% 1.86% +2.16% $53M
TERN 4.51% 2.37% +2.14% $60M
AMLX 5.17% 3.06% +2.10% $68M
KYMR 4.42% 2.35% +2.07% $58M
NRIX 3.27% 1.93% +1.34% $43M
LBRX 2.53% 1.31% +1.22% $33M
CTMX 2.48% 1.36% +1.12% $33M
PEPG 1.68% 0.60% +1.07% $22M
REPL 1.05% 0.00% +1.05% $14M
CLDX 5.27% 4.33% +0.94% $70M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MRUS 0.00% 18.34% -18.34% $0
AGIO 0.00% 5.19% -5.19% $0
VRDN 0.00% 3.82% -3.82% $0
CDTX 0.00% 3.10% -3.10% $0
NUVL 4.19% 6.69% -2.51% $55M
CNTA 1.89% 3.82% -1.93% $25M
PTGX 2.97% 3.76% -0.79% $39M
TNGX 0.00% 0.70% -0.70% $0
ENTA 0.00% 0.53% -0.53% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mid Cap 16 $913M 69.1%
Small Cap 13 $383M 29.0%
Micro Cap 2 $26M 1.9%

Portfolio Analytics

Avg Market Cap
$2.9B
Median Market Cap
$2.0B
Avg P/E
40.0
Median P/E
40.0
Avg Dividend Yield
—%
Avg Beta
0.98
# Stocks
31
# ETFs / Funds
0

Top Holdings (31 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 RLAY 10.89% 17,000,000 $144M $8.46 $55M
2 ALKS 7.52% 3,550,000 $99M $27.98 $6M +453,246 +14.6%
3 TYRA 6.72% 3,375,000 $89M $26.29 $42M
4 XENE 6.11% 1,800,000 $81M $44.82 -$28M -900,000 -33.3%
5 SYRE 5.92% 2,388,245 $78M $32.76 $45M +400,161 +20.1%
6 COGT 5.91% 2,196,845 $78M $35.52 -$26M -5,053,155 -69.7%
7 ELVN 5.47% 4,692,809 $72M $15.40 -$24M
8 CLDX 5.27% 2,565,000 $70M $27.16 -$9M -463,335 -15.3%
9 AMLX 5.17% 5,650,000 $68M $12.08 $13M +1,574,522 +38.6%
10 TERN 4.51% 1,475,000 $60M $40.40 $17M -4,225,000 -74.1%
11 KYMR 4.42% 750,000 $58M $77.81 $16M
12 NUVL 4.19% 550,000 $55M $100.59 -$66M -850,000 -60.7%
13 ORKA 4.02% 1,753,054 $53M $30.31 $19M
14 PHVS 3.97% 1,889,445 $52M $27.75 -$8M -529,031 -21.9%
15 NRIX 3.27% 2,275,000 $43M $18.97 $8M -1,505,055 -39.8%
16 PTGX 2.97% 450,000 $39M $87.34 -$29M -575,000 -56.1%
17 LBRX 2.53% 1,500,000 $33M $22.26 $10M
18 CTMX 2.48% 7,692,300 $33M $4.26 $8M
19 ANRO 2.46% 1,823,196 $32M $17.80 +1,823,196 NEW
20 CNTA 1.89% 1,000,000 $25M $25.01 -$44M -1,850,000 -64.9%
21 PEPG 1.68% 3,400,000 $22M $6.51 $11M +1,042,681 +44.2%
22 REPL 1.05% 1,425,000 $14M $9.72 +1,425,000 NEW
23 CTNM 0.71% 816,326 $9M $11.43 +816,326 NEW
24 RAPT 0.64% 250,000 $8M $33.87 +250,000 NEW
25 LONA 0.27% 464,398 $4M $7.57 +464,398 NEW
26 VRDN —% -$69M -3,200,000 -100.0% SOLD
27 TNGX —% -$13M -1,500,000 -100.0% SOLD
28 MRUS —% -$332M -3,525,000 -100.0% SOLD
29 AGIO —% -$94M -2,338,287 -100.0% SOLD
30 CDTX —% -$56M -585,000 -100.0% SOLD
31 ENTA —% -$10M -800,000 -100.0% SOLD

New Positions

SymbolValue% Port
ANRO $32M 2.46%
REPL $14M 1.05%
CTNM $9M 0.71%
RAPT $8M 0.64%
LONA $4M 0.27%

Sold Out Positions

SymbolValue% Port
ENTA —%
VRDN —%
TNGX —%
AGIO —%
MRUS —%
CDTX —%
View SEC EDGAR Filings for Commodore Capital LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms