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Paradigm Biocapital Advisors LP

Q1 2026 · Filed 2026-05-15
Market Value
$4.8B
+31.3%
Holdings
37
-2
New Purchases
10
Added To
12
Closed
4
Reduced
7
Top 10 Concentration
69.5%
Turnover
37.8%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
INSM 4.31% 0.00% +4.31% $205M
BLTE 3.73% 0.00% +3.73% $178M
ACLX 13.92% 10.29% +3.63% $663M
CNTA 2.98% 0.00% +2.98% $142M
ERAS 3.53% 1.45% +2.08% $168M
CYTK 2.05% 0.00% +2.05% $98M
TNGX 1.76% 0.00% +1.76% $84M
MAZE 1.72% 0.00% +1.72% $82M
TYRA 1.65% 0.00% +1.65% $79M
TERN 2.45% 0.90% +1.55% $117M
MIRM 1.21% 0.00% +1.21% $58M
ORKA 2.39% 1.43% +0.96% $114M
SYRE 2.07% 1.33% +0.75% $99M
MANE 0.70% 0.00% +0.70% $33M
PCVX 5.85% 5.17% +0.67% $279M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
CDTX 0.00% 4.63% -4.63% $0
ABVX 1.81% 5.27% -3.46% $86M
NUVL 11.45% 14.61% -3.16% $545M
CRNX 0.00% 2.84% -2.84% $0
OLMA 2.51% 5.20% -2.69% $120M
SRRK 1.27% 3.72% -2.45% $60M
URGN 0.64% 2.89% -2.24% $31M
TARS 3.77% 5.78% -2.01% $180M
GMAB 4.49% 5.98% -1.49% $214M
BBIO 0.00% 1.44% -1.44% $0
EYPT 0.85% 1.86% -1.01% $41M
RVMD 13.59% 14.59% -1.00% $647M
OCUL 0.00% 0.98% -0.98% $0
BBOT 0.16% 0.78% -0.62% $8M
LXEO 0.75% 1.30% -0.56% $35M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 4 $1.1B 22.4%
Mid Cap 20 $3.2B 66.4%
Small Cap 10 $478M 10.0%
Micro Cap 3 $57M 1.2%

Portfolio Analytics

Avg Market Cap
$5.4B
Median Market Cap
$3.5B
Avg P/E
6.3
Median P/E
6.3
Avg Dividend Yield
—%
Avg Beta
0.80
# Stocks
37
# ETFs / Funds
0

Top Holdings (37 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 ACLX 13.92% 5,774,016 $663M $114.82 $290M +50,000 +0.9%
2 RVMD 13.59% 6,655,703 $647M $97.25 $118M +11,300 +0.2%
3 NUVL 11.45% 5,324,433 $545M $102.45 $15M +55,000 +1.0%
4 PCVX 5.85% 4,793,020 $279M $58.11 $91M +725,000 +17.8%
5 EWTX 4.87% 7,365,038 $232M $31.50 $70M +823,828 +12.6%
6 GMAB 4.49% 7,967,836 $214M $26.83 -$3M +928,002 +13.2%
7 INSM 4.31% 1,254,488 $205M $163.52 +1,254,488 NEW
8 TARS 3.77% 2,562,154 $180M $70.15 -$30M
9 BLTE 3.73% 1,114,784 $178M $159.44 +1,114,784 NEW
10 ERAS 3.53% 10,392,702 $168M $16.18 $115M -3,766,393 -26.6%
11 CNTA 2.98% 3,574,048 $142M $39.72 +3,574,048 NEW
12 OLMA 2.51% 8,020,576 $120M $14.91 -$69M +476,404 +6.3%
13 TERN 2.45% 2,216,499 $117M $52.72 $84M +1,406,213 +173.6%
14 ORKA 2.39% 2,320,316 $114M $49.05 $62M +610,000 +35.7%
15 SYRE 2.07% 1,957,266 $99M $50.44 $51M +490,000 +33.4%
16 CYTK 2.05% 1,480,857 $98M $65.91 +1,480,857 NEW
17 ABVX 1.81% 772,473 $86M $111.35 -$105M -645,000 -45.5%
18 TNGX 1.76% 4,009,679 $84M $20.92 +4,009,679 NEW
19 MAZE 1.72% 2,744,399 $82M $29.85 +2,744,399 NEW
20 TYRA 1.65% 2,054,991 $79M $38.30 +2,054,991 NEW
21 VRDN 1.29% 3,148,893 $62M $19.56 $17M +1,705,791 +118.2%
22 SRRK 1.27% 1,226,080 $60M $49.16 -$75M -1,836,077 -60.0%
23 MIRM 1.21% 625,000 $58M $92.38 +625,000 NEW
24 EYPT 0.85% 3,142,437 $41M $12.89 -$27M -549,038 -14.9%
25 LXEO 0.75% 6,184,134 $35M $5.74 -$12M +1,420,936 +29.8%
26 MANE 0.70% 525,000 $33M $63.15 +525,000 NEW
27 VOR 0.66% 1,750,000 $31M $17.84 $8M
28 URGN 0.64% 1,703,949 $31M $17.98 -$74M -2,769,699 -61.9%
29 GPCR 0.55% 545,287 $26M $48.20 +545,287 NEW
30 IVA 0.47% 4,000,000 $22M $5.55 $4M
31 ORIC 0.45% 1,701,217 $22M $12.67 $2M -700,000 -29.1%
32 BBOT 0.16% 868,213 $8M $8.95 -$21M -1,393,536 -61.6%
33 KLRS 0.08% 700,000 $4M $5.77 -$2M
34 OCUL —% -$36M -2,935,284 -100.0% SOLD
35 BBIO —% -$52M -684,277 -100.0% SOLD
36 CDTX —% -$168M -759,565 -100.0% SOLD
37 CRNX —% -$103M -2,210,774 -100.0% SOLD

Options Breakdown

0 Calls $0 Call Value 1 Puts $0 Put Value

Top Puts

SymbolSharesValueStatus
XBI $0 SOLD

New Positions

SymbolValue% Port
INSM $205M 4.31%
BLTE $178M 3.73%
CNTA $142M 2.98%
CYTK $98M 2.05%
TNGX $84M 1.76%
MAZE $82M 1.72%
TYRA $79M 1.65%
MIRM $58M 1.21%
MANE $33M 0.70%
GPCR $26M 0.55%

Sold Out Positions

SymbolValue% Port
BBIO —%
OCUL —%
CRNX —%
CDTX —%
View SEC EDGAR Filings for Paradigm Biocapital Advisors LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms