Asset Manager
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Paradigm Biocapital Advisors LP
Market Value
$5.3B
+9.8%
Holdings
41
+3
New Purchases
7
Added To
12
Closed
13
Reduced
7
Top 10 Concentration
75.2%
Turnover
48.8%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| RVMD | 22.31% | 13.31% | +9.00% | $1.2B |
| SYRE | 6.38% | 2.03% | +4.35% | $341M |
| EWTX | 7.77% | 4.77% | +3.00% | $415M |
| ALNY | 2.71% | 0.00% | +2.71% | $144M |
| MBX | 2.59% | 0.00% | +2.59% | $138M |
| NUVL | 13.70% | 11.22% | +2.48% | $732M |
| GMAB | 6.76% | 4.40% | +2.36% | $361M |
| TNGX | 3.72% | 1.72% | +2.00% | $199M |
| APGE | 3.92% | 2.33% | +1.58% | $209M |
| ORKA | 3.82% | 2.34% | +1.48% | $204M |
| JBIO | 1.19% | 0.00% | +1.19% | $63M |
| VRDN | 2.31% | 1.27% | +1.05% | $124M |
| ACHV | 0.61% | 0.00% | +0.61% | $32M |
| MPLT | 0.46% | 0.00% | +0.46% | $25M |
| ASMB | 0.80% | 0.38% | +0.42% | $43M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ACLX | 0.00% | 13.63% | -13.63% | $0 |
| PCVX | 2.32% | 5.73% | -3.41% | $124M |
| CNTA | 0.00% | 2.92% | -2.92% | $0 |
| TERN | 0.00% | 2.40% | -2.40% | $0 |
| CYTK | 0.00% | 2.01% | -2.01% | $0 |
| ABVX | 0.00% | 1.77% | -1.77% | $0 |
| MAZE | 0.00% | 1.68% | -1.68% | $0 |
| INSM | 2.65% | 4.22% | -1.57% | $141M |
| SRRK | 0.00% | 1.24% | -1.24% | $0 |
| MIRM | 0.00% | 1.19% | -1.19% | $0 |
| MANE | 0.00% | 0.68% | -0.68% | $0 |
| GPCR | 0.00% | 0.54% | -0.54% | $0 |
| TYRA | 1.09% | 1.62% | -0.52% | $58M |
| ORIC | 0.00% | 0.44% | -0.44% | $0 |
| OLMA | 2.03% | 2.46% | -0.43% | $108M |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 4 | $1.8B | 34.4% |
| Mid Cap | 20 | $3.0B | 56.6% |
| Small Cap | 13 | $402M | 7.5% |
| Micro Cap | 4 | $76M | 1.4% |
Portfolio Analytics
Avg Market Cap
$6.0B
Median Market Cap
$3.8B
Avg P/E
34.5
Median P/E
36.0
Avg Dividend Yield
—%
Avg Beta
0.85
# Stocks
41
# ETFs / Funds
0
Top Holdings (41 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | RVMD | 22.31% | 6,361,323 | $1.2B | $187.28 | $544M | -294,380 | -4.4% | |
| 2 | NUVL | 13.70% | 5,924,433 | $732M | $123.50 | $186M | +600,000 | +11.3% | |
| 3 | EWTX | 7.77% | 10,215,455 | $415M | $40.63 | $183M | +2,850,417 | +38.7% | |
| 4 | GMAB | 6.76% | 13,133,131 | $361M | $27.47 | $147M | +5,165,295 | +64.8% | |
| 5 | SYRE | 6.38% | 3,840,778 | $341M | $88.78 | $242M | +1,883,512 | +96.2% | |
| 6 | APGE | 3.92% | 1,576,385 | $209M | $132.73 | $96M | +228,142 | +16.9% | |
| 7 | ORKA | 3.82% | 2,144,526 | $204M | $95.17 | $90M | -175,790 | -7.6% | |
| 8 | TNGX | 3.72% | 6,357,523 | $199M | $31.26 | $115M | +2,347,844 | +58.5% | |
| 9 | BLTE | 3.55% | 1,232,877 | $190M | $153.99 | $12M | +118,093 | +10.6% | |
| 10 | ERAS | 3.28% | 9,550,000 | $175M | $18.32 | $7M | -842,702 | -8.1% | |
| 11 | TARS | 3.27% | 2,775,649 | $175M | $62.94 | -$5M | +213,495 | +8.3% | |
| 12 | ALNY | 2.71% | 480,000 | $144M | $301.03 | — | +480,000 | — | NEW |
| 13 | INSM | 2.65% | 1,325,977 | $141M | $106.62 | -$64M | +71,489 | +5.7% | |
| 14 | MBX | 2.59% | 2,508,015 | $138M | $55.20 | — | +2,508,015 | — | NEW |
| 15 | PCVX | 2.32% | 2,127,852 | $124M | $58.13 | -$155M | -2,665,168 | -55.6% | |
| 16 | VRDN | 2.31% | 6,723,788 | $124M | $18.37 | $62M | +3,574,895 | +113.5% | |
| 17 | OLMA | 2.03% | 8,670,576 | $108M | $12.51 | -$11M | +650,000 | +8.1% | |
| 18 | JBIO | 1.19% | 2,857,405 | $63M | $22.22 | — | +2,857,405 | — | NEW |
| 19 | TYRA | 1.09% | 1,828,607 | $58M | $31.94 | -$20M | -226,384 | -11.0% | |
| 20 | ASMB | 0.80% | 1,553,748 | $43M | $27.48 | $24M | +888,497 | +133.6% | |
| 21 | EYPT | 0.77% | 2,890,397 | $41M | $14.30 | $827K | -252,040 | -8.0% | |
| 22 | ACHV | 0.61% | 4,951,856 | $32M | $6.53 | — | +4,951,856 | — | NEW |
| 23 | VOR | 0.60% | 1,750,000 | $32M | $18.41 | $998K | — | — | |
| 24 | MPLT | 0.46% | 685,852 | $25M | $35.84 | — | +685,852 | — | NEW |
| 25 | KARD | 0.40% | 900,000 | $21M | $23.85 | — | +900,000 | — | NEW |
| 26 | LXEO | 0.36% | 4,175,382 | $19M | $4.65 | -$16M | -2,008,752 | -32.5% | |
| 27 | EDIT | 0.34% | 5,586,625 | $18M | $3.24 | — | +5,586,625 | — | NEW |
| 28 | IVA | 0.28% | 4,000,000 | $15M | $3.78 | -$7M | — | — | |
| 29 | TERN | —% | — | — | — | -$117M | -2,216,499 | -100.0% | SOLD |
| 30 | GPCR | —% | — | — | — | -$26M | -545,287 | -100.0% | SOLD |
| 31 | ABVX | —% | — | — | — | -$86M | -772,473 | -100.0% | SOLD |
| 32 | MANE | —% | — | — | — | -$33M | -525,000 | -100.0% | SOLD |
| 33 | MIRM | —% | — | — | — | -$58M | -625,000 | -100.0% | SOLD |
| 34 | KLRS | —% | — | — | — | -$4M | -700,000 | -100.0% | SOLD |
| 35 | CNTA | —% | — | — | — | -$142M | -3,574,048 | -100.0% | SOLD |
| 36 | ACLX | —% | — | — | — | -$663M | -5,774,016 | -100.0% | SOLD |
| 37 | CYTK | —% | — | — | — | -$98M | -1,480,857 | -100.0% | SOLD |
| 38 | SRRK | —% | — | — | — | -$60M | -1,226,080 | -100.0% | SOLD |
| 39 | MAZE | —% | — | — | — | -$82M | -2,744,399 | -100.0% | SOLD |
| 40 | ORIC | —% | — | — | — | -$22M | -1,701,217 | -100.0% | SOLD |
| 41 | BBOT | —% | — | — | — | -$8M | -868,213 | -100.0% | SOLD |