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Paradigm Biocapital Advisors LP

Q4 2025 · Filed 2026-02-17
Market Value
$3.6B
+9.3%
Holdings
39
+3
New Purchases
7
Added To
11
Closed
12
Reduced
6
Top 10 Concentration
76.0%
Turnover
48.7%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
RVMD 14.59% 8.76% +5.83% $529M
OLMA 5.20% 2.00% +3.20% $189M
GMAB 5.98% 3.53% +2.45% $217M
CDTX 4.63% 2.77% +1.85% $168M
SRRK 3.72% 2.25% +1.46% $135M
EWTX 4.47% 3.02% +1.46% $162M
ORKA 1.43% 0.00% +1.43% $52M
LXEO 1.30% 0.00% +1.30% $47M
ABVX 5.27% 4.00% +1.27% $191M
PCVX 5.17% 4.11% +1.07% $188M
TARS 5.78% 4.77% +1.01% $210M
EYPT 1.86% 0.86% +1.00% $67M
TERN 0.90% 0.00% +0.90% $33M
NUVL 14.61% 13.73% +0.88% $530M
VOR 0.63% 0.00% +0.63% $23M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MRUS 0.00% 12.41% -12.41% $0
AGIO 0.00% 3.23% -3.23% $0
JANX 0.00% 2.15% -2.15% $0
ALKS 0.00% 1.55% -1.55% $0
LENZ 0.00% 1.51% -1.51% $0
PHVS 0.00% 1.38% -1.38% $0
COGT 0.00% 1.37% -1.37% $0
ACLX 10.29% 11.50% -1.21% $373M
TNGX 0.00% 0.78% -0.78% $0
AMLX 0.00% 0.78% -0.78% $0
DYN 0.00% 0.72% -0.72% $0
IRON 0.00% 0.49% -0.49% $0
VRDN 1.24% 1.70% -0.46% $45M
CRNX 2.84% 3.20% -0.36% $103M
GPCR 0.00% 0.31% -0.31% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 3 $798M 22.0%
Mid Cap 20 $2.2B 61.9%
Small Cap 12 $537M 14.8%
Micro Cap 4 $47M 1.3%

Portfolio Analytics

Avg Market Cap
$4.4B
Median Market Cap
$2.6B
Avg P/E
23.2
Median P/E
23.2
Avg Dividend Yield
—%
Avg Beta
0.82
# Stocks
39
# ETFs / Funds
0

Top Holdings (39 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 NUVL 14.61% 5,269,433 $530M $100.59 $74M
2 RVMD 14.59% 6,644,403 $529M $79.65 $239M +421,112 +6.8%
3 ACLX 10.29% 5,724,016 $373M $65.20 -$8M +1,075,000 +23.1%
4 GMAB 5.98% 7,039,834 $217M $30.80 $100M +3,222,983 +84.4%
5 TARS 5.78% 2,562,154 $210M $81.88 $51M -103,544 -3.9%
6 ABVX 5.27% 1,417,473 $191M $134.85 $58M -146,723 -9.4%
7 OLMA 5.20% 7,544,172 $189M $25.00 $122M +750,000 +11.0%
8 PCVX 5.17% 4,068,020 $188M $46.14 $51M +283,265 +7.5%
9 CDTX 4.63% 759,565 $168M $220.89 $76M -201,599 -21.0%
10 EWTX 4.47% 6,541,210 $162M $24.81 $62M +371,079 +6.0%
11 SRRK 3.72% 3,062,157 $135M $44.05 $60M +1,052,412 +52.4%
12 URGN 2.89% 4,473,648 $105M $23.42 $21M +257,564 +6.1%
13 CRNX 2.84% 2,210,774 $103M $46.55 -$3M -340,000 -13.3%
14 EYPT 1.86% 3,691,475 $67M $18.27 $39M +1,686,110 +84.1%
15 ERAS 1.45% 14,159,095 $53M $3.72 $23M +599,078 +4.4%
16 BBIO 1.44% 684,277 $52M $76.49 $17M
17 ORKA 1.43% 1,710,316 $52M $30.31 +1,710,316 NEW
18 SYRE 1.33% 1,467,266 $48M $32.76 $23M
19 LXEO 1.30% 4,763,198 $47M $9.93 +4,763,198 NEW
20 VRDN 1.24% 1,443,102 $45M $31.12 -$11M -1,166,251 -44.7%
21 OCUL 0.98% 2,935,284 $36M $12.14 -$5M -562,023 -16.1%
22 TERN 0.90% 810,286 $33M $40.40 +810,286 NEW
23 BBOT 0.78% 2,261,749 $28M $12.52 $7M +395,608 +21.2%
24 VOR 0.63% 1,750,000 $23M $13.08 +1,750,000 NEW
25 ORIC 0.54% 2,401,217 $20M $8.18 +2,401,217 NEW
26 IVA 0.51% 4,000,000 $19M $4.65 +4,000,000 NEW
27 KLRS 0.16% 700,000 $6M $8.44 +700,000 NEW
28 LENZ —% -$50M -1,073,461 -100.0% SOLD
29 GPCR —% -$10M -372,869 -100.0% SOLD
30 MRUS —% -$412M -4,373,770 -100.0% SOLD
31 AGIO —% -$107M -2,673,555 -100.0% SOLD
32 PHVS —% -$46M -1,835,494 -100.0% SOLD
33 DYN —% -$24M -1,898,950 -100.0% SOLD
34 TNGX —% -$26M -3,086,184 -100.0% SOLD
35 COGT —% -$45M -3,156,398 -100.0% SOLD
36 IRON —% -$16M -247,716 -100.0% SOLD
37 AMLX —% -$26M -1,900,000 -100.0% SOLD
38 ALKS —% -$52M -1,719,334 -100.0% SOLD
39 JANX —% -$71M -2,920,258 -100.0% SOLD

Options Breakdown

2 Calls $0 Call Value 1 Puts $183M Put Value

Top Calls

SymbolSharesValueStatus
MRUS $0 SOLD
AGIO $0 SOLD

Top Puts

SymbolSharesValueStatus
XBI 1,500,000 $183M

New Positions

SymbolValue% Port
ORKA $52M 1.43%
LXEO $47M 1.30%
TERN $33M 0.90%
VOR $23M 0.63%
ORIC $20M 0.54%
IVA $19M 0.51%
KLRS $6M 0.16%

Sold Out Positions

SymbolValue% Port
JANX —%
DYN —%
IRON —%
LENZ —%
AMLX —%
GPCR —%
COGT —%
ALKS —%
PHVS —%
TNGX —%
AGIO —%
MRUS —%
View SEC EDGAR Filings for Paradigm Biocapital Advisors LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms