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Paradigm Biocapital Advisors LP

Q2 2025 · Filed 2025-08-14
Market Value
$2.3B
+7.2%
Holdings
31
-1
New Purchases
5
Added To
14
Closed
5
Reduced
4
Top 10 Concentration
74.0%
Turnover
32.3%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MRUS 9.83% 6.64% +3.20% $225M
SRRK 2.48% 0.00% +2.48% $57M
BBIO 1.82% 0.00% +1.82% $42M
PCVX 4.79% 3.00% +1.79% $110M
ALKS 1.72% 0.00% +1.72% $39M
AGIO 1.66% 0.00% +1.66% $38M
OCUL 1.39% 0.45% +0.94% $32M
PHVS 0.82% 0.00% +0.82% $19M
COGT 3.25% 2.51% +0.73% $74M
MLTX 1.81% 1.15% +0.66% $41M
LENZ 2.20% 1.82% +0.38% $50M
VRDN 1.67% 1.32% +0.35% $38M
IMTX 0.74% 0.40% +0.34% $17M
OLMA 1.26% 1.19% +0.07% $29M
NUVL 17.56% 17.49% +0.06% $402M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ONC 3.68% 8.48% -4.81% $84M
ARGX 0.00% 1.65% -1.65% $0
CYTK 0.00% 1.62% -1.62% $0
INSM 0.00% 1.61% -1.61% $0
MTSR 0.00% 1.52% -1.52% $0
JANX 2.95% 4.21% -1.26% $67M
ARQT 0.00% 1.07% -1.07% $0
TARS 5.26% 6.28% -1.01% $121M
EWTX 3.52% 4.53% -1.01% $81M
RVMD 9.79% 10.23% -0.44% $224M
ACLX 13.37% 13.79% -0.42% $306M
SYRE 1.22% 1.61% -0.38% $28M
CRNX 2.94% 3.06% -0.11% $67M
YMAB 0.83% 0.88% -0.04% $19M
ERAS 0.66% 0.69% -0.03% $15M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 5 $350M 15.3%
Mid Cap 16 $1.6B 69.4%
Small Cap 9 $301M 13.1%
Micro Cap 1 $50M 2.2%

Portfolio Analytics

Avg Market Cap
$8.1B
Median Market Cap
$3.9B
Avg P/E
61.7
Median P/E
44.3
Avg Dividend Yield
—%
Avg Beta
0.93
# Stocks
31
# ETFs / Funds
0

Top Holdings (31 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 NUVL 17.56% 5,269,433 $402M $76.30 $28M
2 ACLX 13.37% 4,649,016 $306M $65.85 $11M +156,984 +3.5%
3 MRUS 9.83% 4,281,954 $225M $52.60 $83M +912,255 +27.1%
4 RVMD 9.79% 6,093,291 $224M $36.79 $6M -84,820 -1.4%
5 TARS 5.26% 2,976,099 $121M $40.51 -$14M +365,902 +14.0%
6 PCVX 4.79% 3,372,837 $110M $32.51 $46M +1,676,356 +98.8%
7 ONC 3.68% 347,787 $84M $242.07 -$97M -318,237 -47.8%
8 EWTX 3.52% 6,142,344 $81M $13.11 -$16M +1,747,788 +39.8%
9 COGT 3.25% 10,352,449 $74M $7.18 $21M +1,388,794 +15.5%
10 JANX 2.95% 2,920,258 $67M $23.10 -$22M -409,651 -12.3%
11 CRNX 2.94% 2,343,553 $67M $28.76 $2M +397,385 +20.4%
12 IRON 2.80% 1,210,971 $64M $52.96 $4M
13 SRRK 2.48% 1,600,554 $57M $35.42 +1,600,554 NEW
14 LENZ 2.20% 1,717,066 $50M $29.31 $11M +205,134 +13.6%
15 BBIO 1.82% 965,764 $42M $43.18 +965,764 NEW
16 MLTX 1.81% 878,323 $41M $47.20 $17M +250,900 +40.0%
17 ALKS 1.72% 1,375,569 $39M $28.61 +1,375,569 NEW
18 VRDN 1.67% 2,741,576 $38M $13.98 $10M +646,497 +30.9%
19 AGIO 1.66% 1,142,511 $38M $33.26 +1,142,511 NEW
20 OCUL 1.39% 3,420,340 $32M $9.28 $22M +2,106,322 +160.3%
21 OLMA 1.26% 6,764,172 $29M $4.26 $3M +23,000 +0.3%
22 SYRE 1.22% 1,870,445 $28M $14.97 -$6M -256,760 -12.1%
23 YMAB 0.83% 4,236,346 $19M $4.51 $339K
24 PHVS 0.82% 1,062,911 $19M $17.60 +1,062,911 NEW
25 IMTX 0.74% 3,144,157 $17M $5.38 $8M +1,237,049 +64.9%
26 ERAS 0.66% 11,907,182 $15M $1.27 $323K +1,104,828 +10.2%
27 CYTK —% -$35M -858,664 -100.0% SOLD
28 MTSR —% -$32M -1,191,462 -100.0% SOLD
29 ARQT —% -$23M -1,465,334 -100.0% SOLD
30 INSM —% -$34M -451,359 -100.0% SOLD
31 ARGX —% -$35M -59,679 -100.0% SOLD

Options Breakdown

1 Calls $0 Call Value 0 Puts $0 Put Value

Top Calls

SymbolSharesValueStatus
EWTX $0 SOLD

New Positions

SymbolValue% Port
SRRK $57M 2.48%
BBIO $42M 1.82%
ALKS $39M 1.72%
AGIO $38M 1.66%
PHVS $19M 0.82%

Sold Out Positions

SymbolValue% Port
ARGX —%
CYTK —%
ARQT —%
INSM —%
MTSR —%
View SEC EDGAR Filings for Paradigm Biocapital Advisors LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms