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Paradigm Biocapital Advisors LP

Q3 2025 · Filed 2025-11-14
Market Value
$3.3B
+44.9%
Holdings
36
+5
New Purchases
10
Added To
12
Closed
4
Reduced
7
Top 10 Concentration
69.2%
Turnover
38.9%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ABVX 4.00% 0.00% +4.00% $133M
GMAB 3.53% 0.00% +3.53% $117M
CDTX 2.77% 0.00% +2.77% $92M
MRUS 12.41% 9.83% +2.57% $412M
URGN 2.53% 0.00% +2.53% $84M
AGIO 3.23% 1.66% +1.57% $107M
EYPT 0.86% 0.00% +0.86% $29M
TNGX 0.78% 0.00% +0.78% $26M
AMLX 0.78% 0.00% +0.78% $26M
OLMA 2.00% 1.26% +0.75% $67M
DYN 0.72% 0.00% +0.72% $24M
BBOT 0.65% 0.00% +0.65% $22M
PHVS 1.38% 0.82% +0.56% $46M
GPCR 0.31% 0.00% +0.31% $10M
CRNX 3.20% 2.94% +0.26% $106M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
NUVL 13.73% 17.56% -3.83% $456M
ONC 0.00% 3.68% -3.68% $0
IRON 0.49% 2.80% -2.31% $16M
COGT 1.37% 3.25% -1.88% $45M
ACLX 11.50% 13.37% -1.87% $382M
MLTX 0.00% 1.81% -1.81% $0
RVMD 8.76% 9.79% -1.03% $291M
YMAB 0.00% 0.83% -0.83% $0
JANX 2.15% 2.95% -0.80% $71M
BBIO 1.07% 1.82% -0.75% $36M
IMTX 0.00% 0.74% -0.74% $0
LENZ 1.51% 2.20% -0.69% $50M
PCVX 4.11% 4.79% -0.68% $136M
EWTX 3.02% 3.52% -0.50% $100M
TARS 4.77% 5.26% -0.49% $158M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 4 $443M 13.4%
Mid Cap 18 $2.3B 68.6%
Small Cap 13 $548M 16.5%
Micro Cap 1 $50M 1.5%

Portfolio Analytics

Avg Market Cap
$5.5B
Median Market Cap
$2.8B
Avg P/E
49.0
Median P/E
40.0
Avg Dividend Yield
—%
Avg Beta
0.85
# Stocks
36
# ETFs / Funds
0

Top Holdings (36 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 NUVL 13.73% 5,269,433 $456M $86.48 $54M
2 MRUS 12.41% 4,373,770 $412M $94.15 $187M +91,816 +2.1%
3 ACLX 11.50% 4,649,016 $382M $82.10 $76M
4 RVMD 8.76% 6,223,291 $291M $46.70 $66M +130,000 +2.1%
5 TARS 4.77% 2,665,698 $158M $59.43 $38M -310,401 -10.4%
6 PCVX 4.11% 3,784,755 $136M $36.02 $27M +411,918 +12.2%
7 ABVX 4.00% 1,564,196 $133M $84.90 +1,564,196 NEW
8 GMAB 3.53% 3,816,851 $117M $30.67 +3,816,851 NEW
9 AGIO 3.23% 2,673,555 $107M $40.14 $69M +1,531,044 +134.0%
10 CRNX 3.20% 2,550,774 $106M $41.65 $39M +207,221 +8.8%
11 EWTX 3.02% 6,170,131 $100M $16.22 $20M +27,787 +0.5%
12 CDTX 2.77% 961,164 $92M $95.76 +961,164 NEW
13 URGN 2.53% 4,216,084 $84M $19.95 +4,216,084 NEW
14 SRRK 2.25% 2,009,745 $75M $37.24 $18M +409,191 +25.6%
15 JANX 2.15% 2,920,258 $71M $24.44 $4M
16 OLMA 2.00% 6,794,172 $67M $9.79 $38M +30,000 +0.4%
17 VRDN 1.70% 2,609,353 $56M $21.58 $18M -132,223 -4.8%
18 ALKS 1.55% 1,719,334 $52M $30.00 $12M +343,765 +25.0%
19 LENZ 1.51% 1,073,461 $50M $46.58 -$325K -643,605 -37.5%
20 PHVS 1.38% 1,835,494 $46M $24.95 $27M +772,583 +72.7%
21 COGT 1.37% 3,156,398 $45M $14.36 -$29M -7,196,051 -69.5%
22 OCUL 1.23% 3,497,307 $41M $11.69 $9M +76,967 +2.2%
23 BBIO 1.07% 684,277 $36M $51.94 -$6M -281,487 -29.1%
24 ERAS 0.89% 13,560,017 $30M $2.18 $14M +1,652,835 +13.9%
25 EYPT 0.86% 2,005,365 $29M $14.24 +2,005,365 NEW
26 TNGX 0.78% 3,086,184 $26M $8.40 +3,086,184 NEW
27 AMLX 0.78% 1,900,000 $26M $13.59 +1,900,000 NEW
28 SYRE 0.74% 1,467,266 $25M $16.76 -$3M -403,179 -21.6%
29 DYN 0.72% 1,898,950 $24M $12.65 +1,898,950 NEW
30 BBOT 0.65% 1,866,141 $22M $11.58 +1,866,141 NEW
31 IRON 0.49% 247,716 $16M $66.08 -$48M -963,255 -79.5%
32 GPCR 0.31% 372,869 $10M $28.00 +372,869 NEW
33 ONC —% -$84M -347,787 -100.0% SOLD
34 IMTX —% -$17M -3,144,157 -100.0% SOLD
35 MLTX —% -$41M -878,323 -100.0% SOLD
36 YMAB —% -$19M -4,236,346 -100.0% SOLD

Options Breakdown

2 Calls $36M Call Value 1 Puts $100M Put Value 2.76 P/C Ratio

Top Calls

SymbolSharesValueStatus
MRUS 300,000 $28M NEW
AGIO 200,000 $8M NEW

Top Puts

SymbolSharesValueStatus
XBI 1,000,000 $100M NEW

New Positions

SymbolValue% Port
ABVX $133M 4.00%
GMAB $117M 3.53%
CDTX $92M 2.77%
URGN $84M 2.53%
EYPT $29M 0.86%
TNGX $26M 0.78%
AMLX $26M 0.78%
DYN $24M 0.72%
BBOT $22M 0.65%
GPCR $10M 0.31%

Sold Out Positions

SymbolValue% Port
MLTX —%
IMTX —%
ONC —%
YMAB —%
View SEC EDGAR Filings for Paradigm Biocapital Advisors LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms