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Asset Manager ← All Institutions

Frazier Life Sciences Management, L.P.

Q3 2025 · Filed 2025-11-14
Market Value
$2.8B
+29.2%
Holdings
46
-3
New Purchases
2
Added To
8
Closed
6
Reduced
6
Top 10 Concentration
69.3%
Turnover
17.4%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MIRM 17.82% 15.98% +1.84% $498M
MAZE 4.24% 2.59% +1.65% $118M
ABVX 1.15% 0.00% +1.15% $32M
MBX 4.16% 3.16% +1.01% $116M
CYTK 1.75% 0.85% +0.90% $49M
PVLA 1.62% 0.75% +0.87% $45M
TRVI 3.36% 2.59% +0.76% $94M
VALN 1.00% 0.38% +0.62% $28M
DYN 1.23% 0.66% +0.57% $34M
ACAD 0.47% 0.00% +0.47% $13M
ERAS 1.77% 1.33% +0.44% $50M
ARQT 6.66% 6.40% +0.26% $186M
SVRA 1.46% 1.21% +0.26% $41M
LXEO 1.05% 0.82% +0.23% $29M
DSGN 0.53% 0.30% +0.22% $15M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
VRNA 12.92% 14.79% -1.88% $361M
HLVX 0.00% 0.98% -0.98% $0
CGON 0.00% 0.93% -0.93% $0
IRON 3.40% 4.05% -0.65% $95M
RARE 1.06% 1.65% -0.59% $30M
COGT 0.00% 0.58% -0.58% $0
ALKS 0.75% 1.32% -0.57% $21M
ORIC 0.00% 0.50% -0.50% $0
MREO 0.70% 1.18% -0.49% $19M
EOLS 0.58% 1.04% -0.46% $16M
BBIO 7.15% 7.59% -0.44% $200M
JBIO 0.44% 0.82% -0.38% $12M
KALV 2.20% 2.55% -0.36% $61M
TVTX 0.34% 0.69% -0.35% $9M
AURA 1.13% 1.48% -0.35% $32M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 4 $635M 22.7%
Mid Cap 20 $1.4B 49.8%
Small Cap 17 $739M 26.4%
Micro Cap 5 $30M 1.1%

Portfolio Analytics

Avg Market Cap
$5.1B
Median Market Cap
$2.0B
Avg P/E
29.5
Median P/E
39.0
Avg Dividend Yield
—%
Avg Beta
0.84
# Stocks
46
# ETFs / Funds
0

Top Holdings (46 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 MIRM 17.82% 6,795,121 $498M $73.31 $152M
2 VRNA 12.92% 3,383,950 $361M $106.71 $41M
3 BBIO 7.15% 3,845,457 $200M $51.94 $36M +45,000 +1.2%
4 ARQT 6.66% 9,874,511 $186M $18.85 $48M
5 PHAT 5.25% 12,466,489 $147M $11.77 $27M
6 KRYS 4.35% 688,460 $122M $176.53 $27M
7 MAZE 4.24% 4,567,274 $118M $25.93 $62M -1
8 MBX 4.16% 6,652,013 $116M $17.50 $48M +666,666 +11.1%
9 IRON 3.40% 1,438,534 $95M $66.08 $7M -216,300 -13.1%
10 TRVI 3.36% 10,259,409 $94M $9.15 $38M
11 TARS 2.48% 1,167,527 $69M $59.43 $13M -230,000 -16.5%
12 KALV 2.20% 5,039,867 $61M $12.18 $6M +152,000 +3.1%
13 ZLAB 1.97% 1,627,320 $55M $33.89 $9M +319,182 +24.4%
14 AGIO 1.84% 1,279,754 $51M $40.14 $9M
15 ERAS 1.77% 22,729,436 $50M $2.18 $21M
16 CYTK 1.75% 890,445 $49M $54.96 $31M +335,714 +60.5%
17 RVMD 1.67% 997,455 $47M $46.70 $10M
18 PVLA 1.62% 722,400 $45M $62.69 $29M
19 SVRA 1.46% 11,462,301 $41M $3.57 $15M
20 DYN 1.23% 2,718,105 $34M $12.65 $20M +1,212,121 +80.5%
21 ABVX 1.15% 378,300 $32M $84.90 +378,300 NEW
22 AURA 1.13% 5,100,000 $32M $6.18 -$408K
23 RARE 1.06% 983,715 $30M $30.08 -$6M
24 LXEO 1.05% 4,424,725 $29M $6.64 $12M
25 VALN 1.00% 2,291,666 $28M $12.20 $20M +833,333 +57.1%
26 RNAM 0.97% 625,000 $27M $43.57 $9M
27 ALKS 0.75% 700,647 $21M $30.00 -$8M -300,000 -30.0%
28 MREO 0.70% 9,440,112 $19M $2.06 -$6M
29 AKRO 0.62% 366,784 $17M $47.48 -$2M
30 PCVX 0.61% 474,405 $17M $36.02 $2M
31 EOLS 0.58% 2,630,665 $16M $6.14 -$6M +195,115 +8.0%
32 DSGN 0.53% 1,953,547 $15M $7.53 $8M
33 IMCR 0.50% 384,782 $14M $36.33 $2M
34 ACAD 0.47% 613,837 $13M $21.34 +613,837 NEW
35 JBIO 0.44% 1,413,280 $12M $8.63 -$6M -358,836 -20.2%
36 TVTX 0.34% 392,092 $9M $23.90 -$5M -610,000 -60.9%
37 AUTL 0.27% 4,623,324 $8M $1.63 -$3M
38 MGNX 0.19% 3,175,665 $5M $1.68 $1M
39 SLN 0.18% 970,130 $5M $5.19 -$592K
40 ALLO 0.17% 3,868,750 $5M $1.24 $426K
41 ORIC —% -$11M -1,065,334 -100.0% SOLD
42 HLVX —% -$21M -10,617,062 -100.0% SOLD
43 ELEV —% -$2M -5,993,579 -100.0% SOLD
44 ORKA —% -$7M -583,327 -100.0% SOLD
45 COGT —% -$12M -1,734,601 -100.0% SOLD
46 CGON —% -$20M -770,000 -100.0% SOLD

New Positions

SymbolValue% Port
ABVX $32M 1.15%
ACAD $13M 0.47%

Sold Out Positions

SymbolValue% Port
COGT —%
CGON —%
ORKA —%
ORIC —%
HLVX —%
ELEV —%
View SEC EDGAR Filings for Frazier Life Sciences Management, L.P. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms