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SR One Capital Management, LP

Q1 2026 · Filed 2026-05-14
Market Value
$893M
+30.1%
Holdings
12
+1
New Purchases
1
Added To
0
Closed
0
Reduced
0
Top 10 Concentration
98.9%
Turnover
8.3%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MANE 16.98% 0.00% +16.98% $152M
ACLX 30.16% 22.28% +7.89% $269M
ALMS 4.83% 2.79% +2.05% $43M
ORIC 6.55% 5.50% +1.05% $58M
ORKA 2.36% 1.90% +0.46% $21M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ZBIO 11.03% 26.63% -15.61% $98M
CRSP 10.86% 15.57% -4.71% $97M
MLYS 4.74% 8.26% -3.52% $42M
SPRY 3.61% 6.81% -3.20% $32M
DSGN 7.77% 8.91% -1.14% $69M
RARE 0.32% 0.46% -0.14% $3M
NKTX 0.79% 0.90% -0.11% $7M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mid Cap 6 $585M 65.5%
Small Cap 5 $301M 33.7%
Micro Cap 1 $7M 0.8%

Portfolio Analytics

Avg Market Cap
$2.4B
Median Market Cap
$2.1B
Avg P/E
Median P/E
Avg Dividend Yield
—%
Avg Beta
0.52
# Stocks
12
# ETFs / Funds
0

Top Holdings (12 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 ACLX 30.16% 2,346,630 $269M $114.82 $116M
2 MANE 16.98% 2,401,868 $152M $63.15 +2,401,868 NEW
3 ZBIO 11.03% 5,037,854 $98M $19.55 -$84M
4 CRSP 10.86% 2,038,763 $97M $47.57 -$10M
5 DSGN 7.77% 6,526,476 $69M $10.64 $8M
6 ORIC 6.55% 4,514,929 $58M $12.95 $21M
7 ALMS 4.83% 1,959,896 $43M $22.03 $24M
8 MLYS 4.74% 1,563,966 $42M $27.09 -$14M
9 SPRY 3.61% 4,012,903 $32M $8.03 -$15M
10 ORKA 2.36% 430,330 $21M $49.05 $8M
11 NKTX 0.79% 3,333,333 $7M $2.11 $867K
12 RARE 0.32% 137,753 $3M $20.95 -$282K

New Positions

SymbolValue% Port
MANE $152M 16.98%
View SEC EDGAR Filings for SR One Capital Management, LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms