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SR One Capital Management, LP

Q4 2025 · Filed 2026-02-12
Market Value
$687M
+0.9%
Holdings
11
+1
New Purchases
1
Added To
1
Closed
0
Reduced
1
Top 10 Concentration
99.5%
Turnover
9.1%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ZBIO 26.63% 16.02% +10.61% $183M
DSGN 8.91% 7.22% +1.69% $61M
ALMS 2.79% 1.15% +1.64% $19M
SPRY 6.81% 5.93% +0.88% $47M
ORKA 1.90% 1.22% +0.68% $13M
RARE 0.46% 0.00% +0.46% $3M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ACLX 22.28% 28.31% -6.03% $153M
CRSP 15.57% 19.41% -3.85% $107M
MLYS 8.26% 11.78% -3.51% $57M
ORIC 5.50% 7.96% -2.46% $38M
NKTX 0.90% 1.01% -0.12% $6M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mid Cap 5 $295M 43.0%
Small Cap 5 $385M 56.1%
Micro Cap 1 $6M 0.9%

Portfolio Analytics

Avg Market Cap
$2.2B
Median Market Cap
$2.0B
Avg P/E
Median P/E
Avg Dividend Yield
—%
Avg Beta
0.57
# Stocks
11
# ETFs / Funds
0

Top Holdings (11 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 ZBIO 26.63% 5,037,854 $183M $36.31 $74M +126,315 +2.6%
2 ACLX 22.28% 2,346,630 $153M $65.20 -$40M
3 CRSP 15.57% 2,038,763 $107M $52.44 -$25M
4 DSGN 8.91% 6,526,476 $61M $9.38 $12M
5 MLYS 8.26% 1,563,966 $57M $36.29 -$23M -549,967 -26.0%
6 SPRY 6.81% 4,012,903 $47M $11.65 $6M
7 ORIC 5.50% 4,514,929 $38M $8.36 -$16M
8 ALMS 2.79% 1,959,896 $19M $9.76 $11M
9 ORKA 1.90% 430,330 $13M $30.31 $5M
10 NKTX 0.90% 3,333,333 $6M $1.85 -$733K
11 RARE 0.46% 137,753 $3M $23.00 +137,753 NEW

New Positions

SymbolValue% Port
RARE $3M 0.46%
View SEC EDGAR Filings for SR One Capital Management, LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms