Also trades as: 0HB0.L (LSE) · $vol 0M

$31.80

-0.68 (-2.09%)

Weekly Expected Move ±4.6%

$29 $30 $32 $33 $35

NASDAQ · Healthcare · Biotechnology · Tech Score Sell · Power 38 · $1.9B mcap · 56M float · 1.97% daily turnover · Short 63% of daily vol

Edge Score

Quantitative competitive moat analysis scoring five pillars of durable advantage — cost leadership, brand intangibles, switching costs, network effects, and efficient scale — using industry percentile rankings on a 0–100 scale.

WEAK EDGE

45.2 / 100

NoneWeakNarrowWide

Primary source: Network Effects · ROIC: -82.5% · 5Y Avg: -72.2%

Cost Advantage

Intangibles

Switching Cost

Network Effect

Scale

The Edge Score quantifies a company's competitive moat using five pillars: Cost Advantage (20%, operating margin and SG&A efficiency vs industry peers), Intangible Assets (25%, gross margin premium, R&D intensity, brand pricing power), Switching Costs (25%, revenue stability, earnings consistency, customer retention proxied by operating leverage), Network Effects (15%, revenue growth with expanding margins, market share dominance), and Efficient Scale (15%, market concentration, ROIC sustainability). Each pillar is scored 0–100 using industry percentile rankings, then weighted into a composite. Wide ≥ 70, Narrow ≥ 55, Weak ≥ 40, None < 40. AGIO shows a Weak competitive edge (45.2/100) — limited structural advantages that may face competitive pressure. The primary source of advantage is Network Effects. Negative ROIC of -82.5% indicates the company is currently destroying value, though this may reflect a growth investment phase.

Analyst Insights

Wall Street analyst consensus based on price targets and buy/sell/hold recommendations from institutional research coverage over the trailing 12 months.

Analyst Price Targets

$55

Low

$55

Avg Target

$55

High

Based on 1 analyst since Jul 30, 2026 earnings

Analyst Recommendations

Strong Buy: 0Buy: 22Hold: 7Sell: 0Strong Sell: 0

Rating Summary

ConsensusBuy

Avg Target$45.00

Analysts4

Price Target Change History

Date	Firm	Analyst	Old	New	Change	Upside @ Call	Stock@Call
2026-07-30	H.C. Wainwright	—	$52	$55	+3	+67.0%	$32.92
2026-07-21	H.C. Wainwright	Emily Bodnar	$54	$52	-2	+37.7%	$37.77
2026-07-07	Truist Financial	—	$36	$41	+5	-2.5%	$42.07
2026-07-07	RBC Capital	—	$53	$32	-21	-14.4%	$37.39
2026-06-15	H.C. Wainwright	Emily Bodnar	$50	$54	+4	+83.3%	$29.46
2026-04-30	Truist Financial	—	$39	$36	-3	+28.3%	$28.05
2026-04-20	H.C. Wainwright	Emily Bodnar	$62	$50	-12	+85.7%	$26.93
2026-02-12	Truist Financial	Greg Renza	$38	$39	+1	+37.3%	$28.41
2025-12-26	Leerink Partners	—	$34	$40	+6	+37.1%	$29.17
2025-12-24	H.C. Wainwright	—	$56	$62	+6	+112.5%	$29.17
2025-12-24	Truist Financial	Gregory Renza	$32	$38	+6	+30.3%	$29.17
2025-11-24	Truist Financial	—	Initiated	$32	—	+26.8%	$25.24
2025-11-20	Goldman Sachs	—	$32	$25	-7	-2.2%	$25.55
2025-11-20	Leerink Partners	—	$56	$34	-22	+52.2%	$22.34
2025-10-20	H.C. Wainwright	Emily Bodnar	Initiated	$56	—	+32.3%	$42.33
2025-05-02	Scotiabank	Greg Harrison	Initiated	$71	—	+135.9%	$30.10
2024-10-31	Raymond James	Danielle Brill	$56	$51	-5	+14.8%	$44.43
2024-09-27	Leerink Partners	Andrew Berens	Initiated	$56	—	+22.8%	$45.61
2024-09-10	Raymond James	Chris Raymond	$55	$56	+1	+27.1%	$44.05
2024-06-17	Raymond James	Chris Raymond	$45	$55	+10	+26.7%	$43.42
2024-06-03	RBC Capital	Gregory Renza	Initiated	$53	—	+19.7%	$44.26
2024-05-28	Raymond James	Chris Raymond	Initiated	$45	—	+17.2%	$38.39
2023-02-03	Piper Sandler	—	Initiated	$41	—	+35.9%	$30.18
2022-12-01	J.P. Morgan	—	Initiated	$33	—	+12.0%	$29.46
2022-11-17	Goldman Sachs	—	Initiated	$32	—	+18.0%	$27.13
2021-04-29	Barclays	Peter Lawson	Initiated	$70	—	+25.4%	$55.80

Financial Rating

Composite financial health rating (A+ to F) based on discounted cash flow valuation, return on equity, return on assets, debt-to-equity leverage, and relative P/E and P/B multiples.

C-

Oct 02, 2026

DCF

ROE

ROA

D/E

P/E

P/B

The Financial Rating evaluates six fundamental factors — discounted cash flow (DCF) valuation, return on equity (ROE), return on assets (ROA), debt-to-equity leverage (D/E), and relative price-to-earnings (P/E) and price-to-book (P/B) multiples — each scored 1–5. AGIO receives an overall rating of C-. Areas of concern: DCF (1/5), ROE (1/5), ROA (1/5), D/E (2/5), P/E (1/5).

Rating Change History

Date	From	To
2026-10-01	C	C-
2026-04-01	C+	C
2026-03-20	C	C+

InsiderStreet Scorecard

Proprietary multi-factor scorecard rating companies across seven fundamental dimensions — profitability, balance sheet strength, earnings quality, growth, value, momentum, and safety — each scored 0–100.

★ ★ ★ ★ ★ 41 Grade D

Profitability

Balance Sheet

Earnings Quality

Growth

Value

Momentum

Safety

100

Cash Flow

The InsiderStreet Scorecard rates companies across eight dimensions: Profitability (margins, ROA, ROE), Balance Sheet (leverage, liquidity, coverage), Earnings Quality (accruals, cash conversion), Growth (revenue and earnings trajectory), Value (P/E, P/B, earnings yield, Graham criteria), Momentum (revenue and earnings acceleration), Safety (Altman Z-Score risk adjustment), and Cash Flow (operating cash flow quality, FCF conversion, cash coverage). The overall score blends 35% quality, 35% value, and 30% momentum, with a penalty for distress-zone Altman scores. AGIO scores highest in Safety (100/100) and lowest in Profitability (20/100). A grade of D flags significant fundamental concerns across multiple dimensions.

Risk & Quality Signals

Academic financial models used by institutional investors to assess bankruptcy risk, earnings manipulation, financial strength, and credit quality.

Altman Z-Score

14.65

Safe Zone

Piotroski F-Score

4/9

✗ ✗ ✗ ✓ ✓ ✗ ✗ ✓ ✓

Beneish M-Score

-0.25

Possible Manipulator

Ohlson O-Score

-0.77

Bankruptcy prob: 31.7%

Moderate

Credit Rating

A+

Score: 75.7/100

Trend: Stable

Earnings Quality

—

OCF/NI: 0.88x

Accruals: -3.9%

The Altman Z-Score (1968) combines five ratios — working capital, retained earnings, EBIT, market value of equity, and sales, all relative to total assets or liabilities — into a single bankruptcy predictor. AGIO scores 14.65, placing it in the Safe Zone (safe > 2.99, distress < 1.81). Bankruptcy is statistically unlikely within the next two years. The Piotroski F-Score (2000) is a 9-point binary checklist — four profitability tests (positive ROA, positive cash flow, improving ROA, cash flow exceeding net income), three leverage tests (declining debt ratio, improving current ratio, no share dilution), and two efficiency tests (improving gross margin, improving asset turnover). Each pass scores 1 point. AGIO scores 4/9, indicating moderate financial health — some areas of strength offset by weaknesses in others. The Beneish M-Score (1999) is an 8-variable model that detects earnings manipulation by comparing year-over-year changes in receivables, gross margins, asset quality, sales growth, depreciation, SG&A, leverage, and accruals. Scores above −1.78 statistically resemble past manipulators. AGIO's score of -0.25 exceeds the −1.78 red flag threshold — this does not confirm manipulation but indicates the earnings profile resembles past manipulators statistically. The Ohlson O-Score (1980) is a 9-variable logistic regression that estimates bankruptcy probability using firm size, leverage, working capital, current ratio, profitability (ROA), cash flow coverage, negative equity flag, consecutive losses flag, and earnings trajectory. The raw score is converted to a probability via logistic transformation. AGIO's implied 31.7% bankruptcy probability is elevated and warrants attention to the balance sheet. Our Credit Rating model scores companies on five weighted components — solvency (30%), earning power (25%), leverage (20%), liquidity (15%), and cash flow quality (10%) — then blends the absolute score with sector and industry peer rankings. For companies with large buyback programs, equity is adjusted by adding back cumulative 5-year repurchases (capped at 80% of FCF generated) to avoid penalizing shareholder-friendly capital allocation. AGIO receives an estimated rating of A+ (score: 75.7/100), with a stable trend.

Valuation

Key valuation multiples comparing the stock's market price to its earnings, revenue, book value, and cash flows. Lower multiples may indicate relative undervaluation versus peers.

P/E

-4.54x

PEG

0.03x

P/S

19.31x

P/B

1.84x

P/FCF

-6.04x

P/OCF

—

EV/EBITDA

-3.89x

EV/Revenue

16.49x

EV/EBIT

-3.84x

EV/FCF

-4.44x

Earnings Yield

-18.63%

FCF Yield

-16.54%

Shareholder Yield

0.00%

Graham Number

—

Equity-based multiples (P/E, P/B, P/FCF) compare the stock price to per-share fundamentals and are affected by capital structure. Enterprise value multiples (EV/EBITDA, EV/Revenue, EV/FCF) strip out debt and cash, making them more useful for cross-company comparisons regardless of how companies are financed. The Graham Number — √(22.5 × EPS × Book Value) — is Benjamin Graham's formula for the maximum price a defensive investor should pay. AGIO currently has negative earnings — the P/E ratio is not meaningful.

DuPont Decomposition (5-Factor)

The 5-factor DuPont framework breaks Return on Equity into its component drivers — tax efficiency, interest burden, operating profitability, asset utilization, and financial leverage — to reveal what truly drives shareholder returns.

Tax Burden

0.998

NI / EBT

Interest Burden

0.977

EBT / EBIT

EBIT Margin

-4.293

EBIT / Rev

Asset Turnover

0.076

Rev / Assets

Equity Multiplier

1.077

Assets / Equity

ROE

-34.3%

The 5-factor DuPont identity decomposes ROE as: Tax Burden × Interest Burden × EBIT Margin × Asset Turnover × Equity Multiplier = ROE. This reveals whether returns are driven by operating performance, financial leverage, or tax efficiency — three very different sources of profitability. AGIO's ROE of -34.3% is driven by Asset Turnover (0.076), indicating efficient use of assets to generate revenue. A tax burden ratio of 1.00 indicates minimal tax leakage — the company retains over 90% of pre-tax earnings.

Graham-Dodd Adjusted Valuation

Our adaptation of Graham's growth formula (Fair P/E = 8.5 + 2g) from The Intelligent Investor. The classic version relies on analyst growth projections, which can be unreliable. This adjusted model substitutes the company's realized 3-year EPS CAGR — a backward-looking, verifiable measure of actual earnings power — grounding the valuation in demonstrated performance rather than forecasts.

Two adjustments we make, and why. Growth is capped at 15%. Graham defined g as expected growth over the next seven to ten years, not last year's rate. Across US companies since 1994 the median realized 7-year EPS growth is 5–8% regardless of how fast a company grew beforehand, and of 4,457 company-quarters that grew faster than 200%, none sustained it. Uncapped, the formula assigned fair multiples in the hundreds to companies that had never held that rate — and scored worse than simply reading the P/E. Capped, it carries real information. The verdict has three states, not two. Tested over 377,249 stock-months, this ratio only separates outcomes at its extremes: below 0.25 beat the universe by 1.3 points a year, above 3.0 lagged by 2.7, and everything in between sat inside a one-point band. Rather than call two-thirds of the market "undervalued" on a threshold of 1.0, we say Neutral where the model cannot tell — which is most of the time.

Adj. Growth Rate

0.00%

Fair P/E

8.50x

Intrinsic Value

—

Price/Value

—

Margin of Safety

—

Premium

—

Profitability Trends

Historical profitability ratios tracking how efficiently the company converts revenue into returns for shareholders over time.

Leverage & Solvency Trends

Debt and liquidity metrics showing the company's financial leverage and ability to meet short-term and long-term obligations.

Efficiency & Working Capital Trends

Operating efficiency metrics measuring how quickly the company converts inventory to sales, collects receivables, and manages its cash conversion cycle.

Growth Trends (YoY %)

Year-over-year growth rates for key financial metrics, showing the trajectory of revenue, earnings, and cash flow generation.

Earnings Stability

R-squared of linear regression measuring how predictably revenue, earnings, and margins follow a trend over the trailing 5 years. 1.0 = perfectly predictable; lower values indicate erratic or cyclical behavior.

Monte Carlo Price Simulation

Geometric Brownian Motion with 1,000 antithetic paths over 1 year, seeded from 1800 days of historical volatility. Percentile bands show the range of statistically plausible outcomes — this is a statistical model, not a forecast.

Current Price

$31.80

Median 1Y

$25.68

5th Pctile

$9.81

95th Pctile

$67.21

Ann. Volatility

60.4%

Analyst Target

$45.00

25th–75th percentile 5th–95th percentile Median path Historical Analyst target

Executive Compensation

C-suite compensation breakdown including salary, stock awards, options, and incentive pay. The CEO-to-employee pay ratio and Gini coefficient measure pay distribution fairness.

C-Suite Compensation

Executive	Salary	Stock	Total
Brian Goff Chief Executive Officer	$846,864	$1,291,680	$5,370,389
Krishnan Viswanadhan, Pharm.D Chief Corporate Development & Strategy Officer	$433,125	$824,985	$2,805,026
Cecilia Jones Financial ancial Officer	$535,085	$924,379	$2,518,222
James Burns Legal Legal Officer	$527,275	$786,898	$2,369,416
Sarah Gheuens, M.D., Ph.D. Chief Medical Officer, Head of Research & Development	$601,060	$397,440	$2,086,680

CEO Pay Ratio

16:1

CEO-to-Employee Pay Ratio

CEO Total Comp: $5,370,389

Avg Employee Cost (SGA/emp): $334,471

Employees: 539

C-Suite Pay Equality (Gini)

CEO Compensation Mix

Workforce & Productivity

Workforce efficiency metrics measuring revenue, profit, and R&D spend per employee — key indicators of operational leverage and human capital productivity.

Employees

539

+10.9% YoY

Revenue / Employee

$100,237

Rev: $54,028,000

Profit / Employee

$-765,827

NI: $-412,781,000

SGA / Employee

$334,471

Avg labor cost proxy

R&D / Employee

$629,935

Innovation spend

Scaling Efficiency

All Ratios & Metrics

Complete fundamental data with up to 20 periods of history, sparkline trends, and current values across 13 categories and 130+ financial metrics.

Profitability

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
ROE	-41.3%	-45.5%	-20.6%	-26.0%	-29.7%	-19.4%	-19.4%	-20.1%	-22.7%	-36.8%	-39.6%	-44.9%	53.7%	57.3%	60.3%	64.0%	-27.6%	-30.2%	-32.8%	-34.3%	-34.34%
ROA	-31.6%	-33.6%	-18.9%	-23.6%	-26.7%	-17.3%	-17.5%	-18.0%	-20.1%	-32.4%	-35.2%	-39.3%	48.2%	51.8%	55.4%	57.9%	-25.3%	-27.9%	-30.8%	-31.9%	-31.89%
ROIC	-1.3%	-81.0%	-81.0%	-78.8%	-75.8%	-76.2%	-78.8%	-86.9%	-96.4%	-2.9%	-1.4%	-2.1%	-55.3%	-56.7%	-65.9%	-90.1%	-99.9%	-93.1%	-92.1%	-82.5%	-82.49%
ROCE	-23.6%	-25.9%	-27.9%	-30.7%	-32.6%	-19.7%	-19.7%	-20.4%	-24.2%	-42.8%	-48.0%	-57.0%	-24.3%	-26.9%	-29.3%	-31.9%	-34.1%	-35.5%	-37.6%	-40.7%	-40.66%
Gross Margin	—	—	-5.3%	6.7%	-42.5%	-11.1%	11.7%	17.0%	91.4%	72.0%	75.9%	64.2%	91.3%	88.3%	87.6%	76.2%	87.0%	84.2%	87.1%	93.3%	93.30%
Operating Margin	—	—	-121.6%	-17.5%	-25.9%	-23.0%	-16.2%	-14.0%	-13.6%	-15.0%	-11.2%	-12.3%	-11.5%	-11.7%	-12.2%	-10.2%	-9.1%	-6.1%	-5.3%	-2.5%	-2.47%
Net Margin	—	—	-113.9%	-16.4%	-23.2%	8.5%	-14.4%	-12.5%	-12.3%	-13.5%	-10.0%	-11.2%	105.7%	-9.0%	-10.2%	-9.0%	-8.0%	-5.4%	-4.8%	-2.3%	-2.25%
EBITDA Margin	—	—	-108.0%	-15.6%	-22.0%	9.5%	-13.7%	-11.8%	-13.4%	-14.8%	-11.1%	-12.1%	-11.3%	-11.5%	-12.1%	-8.9%	-7.9%	-5.4%	-4.7%	-2.4%	-2.44%
FCF Margin	-8.5%	—	-471.0%	-54.6%	-33.9%	-22.1%	-16.3%	-14.9%	-12.1%	-11.1%	-10.3%	-9.8%	-10.0%	-10.7%	-10.9%	-10.0%	-9.2%	-7.0%	-5.8%	-3.7%	-3.71%
OCF Margin	-8.5%	—	-461.9%	-53.2%	-33.0%	-21.7%	-16.1%	-14.9%	-12.1%	-11.0%	-10.2%	-9.8%	-10.0%	-10.7%	-10.8%	-9.9%	-9.2%	-6.9%	-5.8%	-3.7%	-3.67%
ROE 3Y Avg	snapshot only																				-15.96%
ROE 5Y Avg	snapshot only																				-20.50%
ROA 3Y Avg	snapshot only																				-13.38%
ROIC 3Y Avg	snapshot only																				-72.46%
ROIC Economic	snapshot only																				-34.37%
Cash ROA	snapshot only																				-32.53%
Cash ROIC	snapshot only																				-82.03%
CROIC	snapshot only																				-83.08%
NOPAT Margin	snapshot only																				-3.69%
Pretax Margin	snapshot only																				-4.19%
R&D / Revenue	snapshot only																				3.60%
SGA / Revenue	snapshot only																				1.96%
SBC / Revenue	snapshot only																				58.96%

Valuation

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
P/E Ratio	-6.80	-4.65	-4.40	-3.29	-4.27	-6.64	-5.82	-7.50	-6.29	-3.54	-4.68	-6.71	3.85	2.79	2.53	2.96	-5.82	-3.85	-4.71	-5.37	-4.536
P/S Ratio	59.77	—	1908.79	189.42	156.19	108.04	66.75	78.16	57.48	46.41	56.07	78.24	78.98	51.46	45.46	47.14	52.10	29.39	30.11	22.45	19.306
P/B Ratio	1.89	1.38	1.32	1.08	1.48	1.40	1.22	1.63	1.56	1.53	2.22	3.71	1.60	1.22	1.15	1.41	1.82	1.33	1.79	2.15	1.844
P/FCF	-7.03	-4.32	-4.05	-3.47	-4.61	-4.89	-4.10	-5.25	-4.75	-4.19	-5.47	-7.97	-7.86	-4.80	-4.17	-4.71	-5.64	-4.21	-5.17	-6.04	-6.044
P/OCF	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
EV/EBITDA	-4.41	-2.56	-2.22	-1.39	-2.62	-3.94	-3.06	-4.95	-3.78	-1.50	-2.99	-4.87	-4.12	-2.48	-1.94	-2.35	-3.23	-1.87	-3.08	-3.89	-3.890
EV/Revenue	33.28	—	912.49	75.89	91.87	59.06	32.21	47.21	33.67	20.13	38.06	62.10	50.26	28.53	22.77	25.36	31.82	14.72	19.49	16.49	16.486
EV/EBIT	-4.19	-2.42	-2.11	-1.32	-2.49	-3.63	-2.81	-4.53	-3.53	-1.45	-2.92	-4.80	-4.06	-2.45	-1.91	-2.32	-3.19	-1.84	-3.04	-3.84	-3.840
EV/FCF	-3.91	-2.09	-1.94	-1.39	-2.71	-2.68	-1.98	-3.17	-2.78	-1.82	-3.71	-6.32	-5.01	-2.66	-2.09	-2.53	-3.44	-2.11	-3.35	-4.44	-4.439
Earnings Yield	-14.7%	-21.5%	-22.7%	-30.4%	-23.4%	-15.1%	-17.2%	-13.3%	-15.9%	-28.3%	-21.4%	-14.9%	26.0%	35.9%	39.6%	33.7%	-17.2%	-26.0%	-21.3%	-18.6%	-18.63%
FCF Yield	-14.2%	-23.1%	-24.7%	-28.8%	-21.7%	-20.4%	-24.4%	-19.1%	-21.0%	-23.9%	-18.3%	-12.6%	-12.7%	-20.8%	-24.0%	-21.2%	-17.7%	-23.8%	-19.3%	-16.5%	-16.54%
PEG Ratio	snapshot only																				0.028
Price/Tangible Book	snapshot only																				2.152
EV/Gross Profit	snapshot only																				18.457
Shareholder Yield	snapshot only																				0.00%

Leverage & Solvency

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Current Ratio	22.55	17.79	21.30	17.98	14.65	13.30	17.55	13.73	12.06	12.27	12.84	10.09	8.99	11.90	18.50	14.48	13.82	11.46	14.19	10.22	10.221
Quick Ratio	22.55	17.79	21.24	17.89	14.55	13.16	17.30	13.45	11.76	11.99	12.39	9.71	8.77	11.56	17.93	14.04	13.39	11.06	13.59	9.79	9.791
Debt/Equity	0.07	0.08	0.08	0.08	0.08	0.08	0.08	0.08	0.09	0.09	0.09	0.10	0.04	0.04	0.04	0.04	0.03	0.05	0.03	0.03	0.030
Net Debt/Equity	-0.84	-0.71	-0.69	-0.65	-0.61	-0.63	-0.63	-0.65	-0.64	-0.87	-0.71	-0.76	-0.58	-0.54	-0.57	-0.65	-0.71	-0.66	-0.63	-0.57	-0.572
Debt/Assets	0.06	0.07	0.07	0.07	0.08	0.07	0.07	0.07	0.07	0.08	0.08	0.08	0.03	0.03	0.03	0.03	0.03	0.05	0.03	0.03	0.028
Debt/EBITDA	-0.30	-0.29	-0.28	-0.26	-0.26	-0.40	-0.41	-0.41	-0.35	-0.20	-0.18	-0.16	-0.15	-0.14	-0.12	-0.11	-0.10	-0.15	-0.09	-0.07	-0.075
Net Debt/EBITDA	3.51	2.73	2.43	2.08	1.83	3.27	3.28	3.24	2.67	1.96	1.42	1.27	2.35	1.99	1.93	2.02	2.06	1.86	1.68	1.41	1.407
Interest Coverage	-57.24	-3874.11	-3916.47	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Equity Multiplier	1.11	1.11	1.11	1.11	1.12	1.13	1.11	1.13	1.14	1.16	1.14	1.17	1.10	1.08	1.06	1.07	1.08	1.09	1.07	1.08	1.080
Cash Ratio	snapshot only																				8.795
Cash to Debt	snapshot only																				19.813
FCF to Debt	snapshot only																				-11.718
Defensive Interval	snapshot only																				425.6 days

Efficiency & Turnover

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Asset Turnover	0.04	0.00	0.00	0.00	0.01	0.01	0.02	0.02	0.02	0.02	0.03	0.03	0.02	0.03	0.03	0.04	0.03	0.04	0.05	0.08	0.076
Inventory Turnover	2.66	—	15.40	9.68	7.76	4.77	2.88	2.06	1.42	0.95	0.59	0.39	0.36	0.30	0.24	0.22	0.24	0.29	0.32	0.34	0.344
Receivables Turnover	3.11	0.00	3.08	1.32	2.25	4.33	16.41	10.47	16.05	10.69	11.24	10.41	15.31	10.55	10.90	9.34	11.00	7.36	6.78	7.84	7.836
Payables Turnover	1.31	1.09	0.61	2.54	1.94	1.15	1.98	2.09	1.35	0.93	1.03	0.71	0.52	0.54	0.50	0.44	0.38	0.51	0.76	0.62	0.620
DSO	117	—	118	277	162	84	22	35	23	34	32	35	24	35	33	39	33	50	54	47	46.6 days
DIO	137	0	24	38	47	76	127	177	257	383	618	941	1018	1199	1547	1642	1527	1246	1128	1060	1060.0 days
DPO	279	335	599	143	188	318	185	174	271	394	356	514	708	679	730	826	959	720	479	589	588.7 days
Cash Conversion Cycle	-25	—	-457	171	21	-157	-36	38	9	23	295	461	333	555	850	855	602	575	703	518	517.9 days
Fixed Asset Turnover	snapshot only																				9.887
Operating Cycle	snapshot only																				1106.6 days
Cash Velocity	snapshot only																				0.159
Capital Intensity	snapshot only																				11.272

Growth (YoY)

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Revenue	-77.4%	-1.0%	-99.3%	-91.9%	-77.5%	—	21.9%	2.1%	1.4%	88.4%	54.6%	55.4%	36.8%	36.1%	26.0%	30.6%	36.3%	48.0%	78.3%	1.4%	1.41%
Net Income	-16.7%	-17.4%	10.9%	7.3%	6.3%	39.7%	39.6%	43.1%	39.5%	-51.9%	-61.7%	-73.7%	4.1%	2.9%	2.9%	2.8%	-1.6%	-1.6%	-1.6%	-1.6%	-1.63%
EPS	-41.4%	-49.7%	-13.5%	-3.3%	2.6%	40.2%	40.4%	44.0%	40.5%	-48.9%	-58.5%	-70.1%	3.9%	2.9%	2.9%	2.7%	-1.6%	-1.6%	-1.6%	-1.6%	-1.62%
FCF	-5.4%	-35.5%	-23.6%	3.4%	10.1%	23.9%	21.0%	14.4%	13.7%	5.5%	2.6%	-2.5%	-13.6%	-31.8%	-33.9%	-33.0%	-25.4%	3.6%	4.7%	10.7%	10.70%
EBITDA	-5.7%	-12.7%	1.8%	-3.2%	-4.7%	36.8%	41.4%	45.1%	38.4%	-68.9%	-87.1%	-1.1%	-87.2%	-16.7%	-16.2%	-10.6%	-10.1%	-1.4%	3.8%	5.5%	5.54%
Op. Income	-11.0%	-19.7%	-6.6%	-8.1%	-7.8%	-2.8%	2.5%	5.1%	2.6%	-0.6%	-3.8%	-8.1%	-5.9%	-8.7%	-12.0%	-13.9%	-16.9%	-10.9%	-8.0%	0.5%	0.54%
OCF Growth	snapshot only																				11.18%
Asset Growth	snapshot only																				-24.66%
Equity Growth	snapshot only																				-25.08%
Debt Growth	snapshot only																				-36.07%
Shares Change	snapshot only																				2.69%

Growth (CAGR)

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Revenue 3Y	-15.9%	—	-80.7%	-60.2%	-55.5%	-50.6%	-52.3%	-52.3%	-50.2%	-49.1%	-36.7%	-26.5%	-9.3%	—	2.5%	85.4%	65.2%	56.0%	51.4%	69.6%	69.63%
Revenue 5Y	-3.8%	—	-55.8%	-34.6%	-29.2%	-19.8%	-14.4%	-22.1%	-20.2%	-22.2%	-24.0%	-21.0%	-21.8%	-20.9%	-26.7%	-26.1%	-25.5%	-23.3%	-10.7%	4.5%	4.54%
EPS 3Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
EPS 5Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Net Income 3Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Net Income 5Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
EBITDA 3Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
EBITDA 5Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Gross Profit 3Y	—	—	—	—	—	—	—	—	-65.2%	-59.1%	-43.9%	-29.6%	-4.7%	—	—	—	—	—	—	—	—
Gross Profit 5Y	—	—	—	—	—	—	—	—	—	—	-6.8%	-25.0%	-25.7%	-24.1%	-29.2%	-28.3%	-27.8%	-25.8%	-12.6%	5.4%	5.39%
Op. Income 3Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Op. Income 5Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
FCF 3Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
FCF 5Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
OCF 3Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
OCF 5Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Assets 3Y	18.4%	18.8%	17.6%	16.9%	19.1%	11.6%	12.9%	3.6%	3.5%	3.2%	-30.1%	-25.6%	5.1%	5.0%	5.2%	5.5%	5.5%	1.6%	1.0%	0.7%	0.71%
Assets 5Y	18.1%	18.4%	19.1%	10.5%	11.4%	15.1%	2.1%	1.7%	1.6%	1.8%	0.7%	-0.3%	20.7%	13.3%	14.2%	8.6%	8.8%	8.7%	-13.8%	-10.0%	-9.98%
Equity 3Y	22.4%	23.4%	24.9%	28.3%	32.8%	19.8%	18.3%	20.0%	22.7%	26.6%	-31.3%	-27.3%	5.3%	6.1%	6.7%	6.8%	6.9%	2.7%	2.3%	2.1%	2.09%
Book Value 3Y	23.1%	26.3%	27.8%	31.3%	35.9%	26.1%	27.2%	28.9%	31.8%	36.0%	-26.3%	-25.6%	4.4%	4.3%	4.9%	4.8%	4.9%	0.6%	0.2%	-0.2%	-0.18%
Dividend 3Y	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—

Growth Quality

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Revenue Stability	0.09	0.00	0.01	0.03	0.06	0.05	0.11	0.26	0.26	0.29	0.60	0.66	0.65	0.37	0.47	0.49	0.50	0.48	0.23	0.02	0.019
Earnings Stability	0.68	0.56	0.63	0.56	0.34	0.11	0.19	0.20	0.31	0.15	0.14	0.17	0.53	0.49	0.49	0.47	0.14	0.11	0.13	0.13	0.134
Margin Stability	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.38	0.43	0.429
Rev. Growth Consistency	0.00	0.00	0.00	0.00	0.00	0.50	0.50	0.50	0.50	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.000
Earn. Growth Consistency	0.00	0.00	0.50	0.50	0.50	0.50	1.00	1.00	1.00	0.00	0.00	0.00	1.00	0.50	0.50	0.50	0.00	0.00	0.00	0.00	0.000
FCF Positive Streak	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Earnings Persistence	0.93	0.93	0.96	0.97	0.97	0.84	0.84	0.83	0.84	0.50	0.50	0.50	0.20	0.20	0.20	0.20	0.20	0.20	0.20	0.20	0.200
Earnings Smoothness	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
ROE Trend	0.51	0.43	0.08	0.09	0.14	0.35	0.03	0.06	0.06	-0.18	-0.22	-0.28	0.71	0.76	0.80	0.86	-0.40	-0.35	-0.37	-0.36	-0.362
Gross Margin Trend	-0.33	—	-22.96	-2.99	-1.85	—	10.48	0.59	0.52	—	11.68	1.79	1.10	0.76	0.53	0.48	0.30	0.18	0.10	0.09	0.090
FCF Margin Trend	-6.00	—	-468.49	-51.34	-28.74	—	220.58	14.73	9.11	—	233.36	24.94	12.96	5.85	2.36	2.35	1.82	3.92	4.75	6.20	6.200
Sustainable Growth Rate	—	—	—	—	—	—	—	—	—	—	—	—	53.7%	57.3%	60.3%	64.0%	—	—	—	—	—
Internal Growth Rate	—	—	—	—	—	—	—	—	—	—	—	—	93.0%	1.1%	1.2%	1.4%	—	—	—	—	—

Cash Flow Quality

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
OCF/Net Income	0.96	1.06	1.06	0.92	0.90	1.34	1.41	1.43	1.32	0.84	0.85	0.84	-0.49	-0.58	-0.60	-0.62	1.02	0.90	0.90	0.88	0.877
FCF/OCF	1.00	1.01	1.02	1.03	1.03	1.02	1.01	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.01	1.01	1.01	1.01	1.01	1.01	1.013
FCF/Net Income	snapshot only																				0.888
CapEx/Revenue	4.1%	—	9.1%	1.4%	93.4%	34.3%	13.0%	2.7%	3.7%	3.7%	2.5%	2.9%	2.9%	4.6%	6.2%	7.4%	9.3%	8.0%	6.5%	4.7%	4.73%
CapEx/Depreciation	snapshot only																				0.870
Accruals Ratio	-0.01	0.02	0.01	-0.02	-0.03	0.06	0.07	0.08	0.06	-0.05	-0.05	-0.06	0.72	0.82	0.89	0.94	0.01	-0.03	-0.03	-0.04	-0.039
Sloan Accruals	snapshot only																				-0.238
Cash Flow Adequacy	snapshot only																				-77.448

Dividends & Buybacks

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Dividend Yield	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.00%
Dividend/Share	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00
Payout Ratio	—	—	—	—	—	—	—	—	—	—	—	—	0.0%	0.0%	0.0%	0.0%	—	—	—	—	—
FCF Payout Ratio	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Total Payout Ratio	—	—	—	—	—	—	—	—	—	—	—	—	0.0%	0.0%	0.0%	0.0%	—	—	—	—	—
Div. Increase Streak	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Chowder Number	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Buyback Yield	9.7%	15.3%	17.2%	22.5%	1.2%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.00%
Net Buyback Yield	9.4%	14.9%	17.2%	22.5%	1.2%	-0.0%	-0.2%	-0.2%	-0.3%	-0.4%	-0.5%	-0.4%	-0.4%	-0.8%	-0.6%	-0.5%	-0.5%	-0.5%	-0.5%	-0.3%	-0.32%
Total Shareholder Return	9.4%	14.9%	17.2%	22.5%	1.2%	-0.0%	-0.2%	-0.2%	-0.3%	-0.4%	-0.5%	-0.4%	-0.4%	-0.8%	-0.6%	-0.5%	-0.5%	-0.5%	-0.5%	-0.3%	-0.32%

DuPont Factors

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Tax Burden (NI/EBT)	1.09	1.08	1.00	1.00	0.99	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.93	0.94	0.94	0.94	0.98	1.00	1.00	1.00	0.998
Interest Burden (EBT/EBIT)	1.02	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.96	0.95	0.92	0.90	-1.79	-1.69	-1.61	-1.56	0.92	0.96	1.00	0.98	0.977
EBIT Margin	-7.93	—	-433.07	-57.60	-36.95	-16.28	-11.47	-10.43	-9.54	-13.87	-13.03	-12.94	-12.38	-11.66	-11.89	-10.92	-9.98	-7.98	-6.41	-4.29	-4.293
Asset Turnover	0.04	0.00	0.00	0.00	0.01	0.01	0.02	0.02	0.02	0.02	0.03	0.03	0.02	0.03	0.03	0.04	0.03	0.04	0.05	0.08	0.076
Equity Multiplier	1.31	1.35	1.09	1.10	1.11	1.12	1.11	1.12	1.13	1.14	1.12	1.14	1.11	1.11	1.09	1.11	1.09	1.08	1.06	1.08	1.077

Per Share

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
EPS (Diluted TTM)	$-6.79	$-7.07	$-6.62	$-6.74	$-6.62	$-4.23	$-3.95	$-3.78	$-3.94	$-6.30	$-6.25	$-6.42	$11.54	$11.79	$11.59	$11.22	$-6.90	$-7.08	$-7.19	$-6.91	$-6.91
Book Value/Share	$24.45	$23.78	$22.13	$20.51	$19.15	$20.09	$18.76	$17.34	$15.89	$14.51	$13.19	$11.63	$27.84	$26.96	$25.52	$23.64	$22.09	$20.45	$18.87	$17.25	$17.25
Tangible Book/Share	$24.45	$23.78	$22.13	$20.51	$19.15	$20.09	$18.76	$17.34	$15.89	$14.51	$13.19	$11.63	$27.84	$26.96	$25.52	$23.64	$22.09	$20.45	$18.87	$17.25	$17.25
Revenue/Share	$0.77	$0.00	$0.02	$0.12	$0.18	$0.26	$0.34	$0.36	$0.43	$0.48	$0.52	$0.55	$0.56	$0.64	$0.64	$0.71	$0.77	$0.93	$1.12	$1.65	$1.65
FCF/Share	$-6.56	$-7.60	$-7.18	$-6.40	$-6.14	$-5.74	$-5.60	$-5.40	$-5.21	$-5.31	$-5.35	$-5.41	$-5.65	$-6.85	$-7.03	$-7.06	$-7.12	$-6.47	$-6.54	$-6.14	$-6.14
OCF/Share	$-6.53	$-7.50	$-7.04	$-6.23	$-5.97	$-5.65	$-5.55	$-5.39	$-5.19	$-5.30	$-5.33	$-5.40	$-5.63	$-6.82	$-6.99	$-7.01	$-7.05	$-6.39	$-6.47	$-6.06	$-6.06
Cash/Share	$22.19	$18.77	$16.93	$14.95	$13.27	$14.29	$13.38	$12.64	$11.60	$13.90	$10.61	$10.03	$17.20	$15.64	$15.55	$16.21	$16.39	$14.65	$12.54	$10.38	$10.38
EBITDA/Share	$-5.83	$-6.21	$-6.26	$-6.40	$-6.35	$-3.89	$-3.62	$-3.46	$-3.84	$-6.44	$-6.64	$-7.03	$-6.87	$-7.35	$-7.57	$-7.62	$-7.60	$-7.30	$-7.12	$-7.01	$-7.01
Debt/Share	$1.74	$1.79	$1.73	$1.66	$1.62	$1.56	$1.49	$1.42	$1.35	$1.29	$1.21	$1.14	$1.04	$1.00	$0.92	$0.84	$0.77	$1.06	$0.61	$0.52	$0.52
Net Debt/Share	$-20.46	$-16.99	$-15.19	$-13.29	$-11.65	$-12.73	$-11.89	$-11.22	$-10.25	$-12.61	$-9.39	$-8.90	$-16.15	$-14.64	$-14.63	$-15.37	$-15.62	$-13.58	$-11.93	$-9.86	$-9.86

Academic Models

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Altman Z-Score	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	14.645
Altman Z-Prime	snapshot only																				27.163
Piotroski F-Score	5	4	1	2	2	2	3	4	4	3	3	3	3	4	5	5	4	2	3	4	4
Beneish M-Score	—	—	—	—	—	—	-22.16	-2.78	-2.78	-3.40	-2.75	-3.04	1.78	4.96	1.32	1.97	-2.13	-1.64	-0.58	-0.25	-0.253
Ohlson O-Score	snapshot only																				-0.767
ROIC (Greenblatt)	snapshot only																				-64.22%
Net-Net WC	snapshot only																				$10.68
EVA	snapshot only																				$-406590560.00

Credit

Metric	Q3'21	Q4'21	Q1'22	Q2'22	Q3'22	Q4'22	Q1'23	Q2'23	Q3'23	Q4'23	Q1'24	Q2'24	Q3'24	Q4'24	Q1'25	Q2'25	Q3'25	Q4'25	Q1'26	Q2'26	Current
Credit Rating	snapshot only																				A+
Credit Score	59.46	61.07	61.98	75.63	75.61	76.88	75.99	76.11	76.22	76.56	76.19	76.32	76.07	76.11	76.01	76.16	75.85	75.71	75.74	75.70	75.703
Credit Grade	snapshot only																				5
Credit Trend	snapshot only																				-0.460
Implied Spread (bps)	snapshot only																				125.000
Industry Credit Rank	snapshot only																				76
Sector Credit Rank	snapshot only																				71

AGIO NASDAQ

Edge Score

Analyst Insights

Financial Rating

InsiderStreet Scorecard

Risk & Quality Signals

Valuation

DuPont Decomposition (5-Factor)

Graham-Dodd Adjusted Valuation

Profitability Trends

Leverage & Solvency Trends

Efficiency & Working Capital Trends

Growth Trends (YoY %)

Earnings Stability

Monte Carlo Price Simulation

Executive Compensation

C-Suite Compensation

CEO Pay Ratio

C-Suite Pay Equality (Gini)

CEO Compensation Mix

Workforce & Productivity

Scaling Efficiency

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