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Asset Manager ← All Institutions

PERCEPTIVE ADVISORS LLC

Q4 2025 · Filed 2026-02-17
Market Value
$5.1B
+60.3%
Holdings
118
+27
New Purchases
34
Added To
31
Closed
12
Reduced
19
Top 10 Concentration
43.0%
Turnover
39.0%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
PRAX 11.44% 2.59% +8.86% $588M
APGE 3.42% 1.67% +1.75% $176M
CELC 6.13% 4.55% +1.58% $315M
EXAS 2.37% 0.79% +1.58% $122M
SYRE 1.96% 0.64% +1.31% $101M
BLTE 1.29% 0.11% +1.17% $66M
DYN 1.32% 0.21% +1.11% $68M
ADGI 1.05% 0.00% +1.05% $54M
NRIX 1.31% 0.41% +0.90% $67M
DHR 0.89% 0.00% +0.89% $46M
BSX 1.82% 0.94% +0.87% $93M
VRDN 1.84% 0.98% +0.86% $95M
INBX 2.23% 1.39% +0.84% $115M
CDTX 0.71% 0.00% +0.71% $36M
IRON 0.70% 0.00% +0.70% $36M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ACLX 1.86% 6.32% -4.46% $96M
MRUS 0.00% 3.97% -3.97% $0
RYTM 5.30% 8.99% -3.69% $273M
INSM 0.00% 3.15% -3.15% $0
AMLX 1.95% 3.79% -1.85% $100M
VRNA 0.00% 1.74% -1.74% $0
AKRO 0.00% 1.68% -1.68% $0
MGTX 1.60% 3.24% -1.64% $82M
AORT 1.53% 2.67% -1.14% $79M
PEN 0.67% 1.74% -1.07% $34M
NBIX 0.91% 1.97% -1.06% $47M
SLDB 1.30% 2.28% -0.98% $67M
NUVL 3.26% 4.21% -0.95% $167M
CNTA 1.42% 2.34% -0.93% $73M
OMDA 0.74% 1.65% -0.92% $38M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 18 $718M 14.0%
Mid Cap 45 $3.2B 61.8%
Small Cap 32 $1.0B 20.2%
Micro Cap 23 $208M 4.1%

Portfolio Analytics

Avg Market Cap
$9.4B
Median Market Cap
$2.3B
Avg P/E
68.7
Median P/E
38.7
Avg Dividend Yield
0.00%
Avg Beta
1.05
# Stocks
118
# ETFs / Funds
0

Top Holdings (118 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 PRAX 11.44% 1,995,986 $588M $294.74 $505M +431,432 +27.6%
2 CELC 6.13% 3,160,200 $315M $99.74 $169M +203,881 +6.9%
3 RYTM 5.30% 2,546,391 $273M $107.04 -$16M -416,558,578 -99.4%
4 APGE 3.42% 2,330,651 $176M $75.48 $122M +978,662 +72.4%
5 ROIV 3.37% 7,985,461 $173M $21.70 $62M +617,000 +8.4%
6 NUVL 3.26% 1,665,105 $167M $100.59 $32M +102,769 +6.6%
7 TVTX 3.18% 4,278,180 $163M $38.21 $73M +483,565 +12.7%
8 EXAS 2.37% 1,200,487 $122M $101.56 $96M +735,000 +157.9%
9 PTGX 2.29% 1,350,425 $118M $87.34 $50M +320,291 +31.1%
10 INBX 2.23% 1,452,707 $115M $79.00 $70M +125,000 +9.4%
11 EWTX 2.15% 4,457,974 $111M $24.82 $49M +662,080 +17.4%
12 IMTX 2.12% 10,383,456 $109M $10.50 $29M +1,000,000 +10.7%
13 SYRE 1.96% 3,069,225 $101M $32.76 $80M +1,839,780 +149.6%
14 AMLX 1.95% 8,284,882 $100M $12.08 -$22M -667,483 -7.5%
15 ACLX 1.86% 1,466,071 $96M $65.20 -$107M -1,002,282 -40.6%
16 VRDN 1.84% 3,042,703 $95M $31.12 $63M +1,580,303 +108.1%
17 BSX 1.82% 979,000 $93M $95.35 $63M +669,000 +215.8%
18 FOLD 1.76% 6,370,851 $91M $14.24 $41M — —
19 ZYME 1.67% 3,261,850 $86M $26.33 $50M +1,171,187 +56.0%
20 ATXS 1.65% 6,485,420 $85M $13.09 $38M — —
21 MGTX 1.60% 10,326,103 $82M $7.95 -$22M -2,300,000 -18.2%
22 AORT 1.53% 1,722,290 $79M $45.61 -$7M -297,710 -14.7%
23 CNTA 1.42% 2,917,634 $73M $25.01 -$2M -183,268 -5.9%
24 DYN 1.32% 3,478,944 $68M $19.56 $61M +2,938,500 +543.7%
25 NRIX 1.31% 3,555,877 $67M $18.97 $54M +2,139,728 +151.1%
26 SLDB 1.30% 11,833,539 $67M $5.64 -$6M — —
27 BLTE 1.29% 414,239 $66M $159.96 $63M +364,451 +732.0%
28 ABVX 1.20% 458,343 $62M $134.85 $29M +69,735 +17.9%
29 ADGI 1.05% 21,785,166 $54M $2.47 — +21,785,166 — NEW
30 RGEN 1.01% 315,541 $52M $163.86 $16M +45,113 +16.7%
31 IMVT 0.99% 1,994,890 $51M $25.42 $25M +407,000 +25.6%
32 ISRG 0.97% 87,919 $50M $566.36 $26M +35,800 +68.7%
33 SION 0.94% 1,179,098 $49M $41.14 $14M — —
34 NBIX 0.91% 331,050 $47M $141.83 -$16M -119,000 -26.4%
35 DHR 0.89% 200,000 $46M $228.92 — +200,000 — NEW
36 ORKA 0.87% 1,476,501 $45M $30.31 $20M +208,480 +16.4%
37 CTMX 0.80% 9,680,185 $41M $4.26 $10M — —
38 OMDA 0.74% 2,396,330 $38M $15.78 -$15M — —
39 CDTX 0.71% 165,131 $36M $220.89 — +165,131 — NEW
40 IRON 0.70% 450,743 $36M $79.41 — +450,743 — NEW
41 DRUG 0.68% 449,290 $35M $78.04 $8M — —
42 PEN 0.67% 110,529 $34M $310.91 -$22M -110,018 -49.9%
43 ANRO 0.62% 1,784,393 $32M $17.80 $31M +1,629,027 +1048.5%
44 CAI 0.60% 1,136,206 $31M $26.98 -$3M +38,043 +3.5%
45 JAZZ 0.56% 170,000 $29M $170.00 — +170,000 — NEW
46 PALI 0.55% 12,050,000 $28M $2.35 — +12,050,000 — NEW
47 RAPT 0.54% 825,890 $28M $33.87 $23M +642,000 +349.1%
48 PVLA 0.54% 266,287 $28M $104.67 $3M -128,806 -32.6%
49 AXSM 0.53% 148,900 $27M $182.64 $9M — —
50 AXGN 0.50% 784,140 $26M $32.73 — +784,140 — NEW
51 XFOR 0.49% 6,314,452 $25M $4.00 — +6,314,452 — NEW
52 BCRX 0.48% 3,162,529 $25M $7.80 — +3,162,529 — NEW
53 NAUT 0.48% 12,594,211 $25M $1.95 $14M — —
54 KOD 0.46% 848,900 $24M $27.96 $13M +214,323 +33.8%
55 BIIB 0.42% 124,000 $22M $175.99 — +124,000 — NEW
56 ALDX 0.42% 4,185,632 $22M $5.18 -$6M -1,036,679 -19.9%
57 OBIO 0.41% 5,127,256 $21M $4.15 $8M -165,300 -3.1%
58 MIRM 0.40% 259,545 $21M $78.99 — +259,545 — NEW
59 RAPP 0.40% 673,923 $20M $30.34 $8M +270,000 +66.8%
60 GRAL 0.40% 237,342 $20M $85.59 — +237,342 — NEW
61 IRTC 0.37% 108,000 $19M $177.44 -$2M -15,000 -12.2%
62 BBNX 0.36% 602,944 $18M $30.47 $13M +325,000 +116.9%
63 CVS 0.34% 220,000 $17M $79.36 — +220,000 — NEW
64 CTNM 0.33% 1,464,592 $17M $11.43 $8M +750,000 +105.0%
65 GH 0.32% 160,000 $16M $102.14 — +160,000 — NEW
66 ADMA 0.31% 883,468 $16M $18.24 -$795K -270,000 -23.4%
67 RLAY 0.31% 1,903,245 $16M $8.46 — +1,903,245 — NEW
68 GKOS 0.31% 140,000 $16M $112.91 — +140,000 — NEW
69 DXCM 0.29% 225,758 $15M $66.37 — +225,758 — NEW
70 SVRA 0.28% 2,400,000 $14M $6.03 — +2,400,000 — NEW
71 ATHA 0.27% 1,859,322 $14M $7.57 $12M +1,319,026 +244.1%
72 SEPN 0.23% 433,160 $12M $27.88 $2M -108,290 -20.0%
73 IKT 0.22% 5,421,568 $11M $2.05 $2M — —
74 ADGM 0.20% 9,876,576 $10M $1.04 -$9M — —
75 MPLT 0.19% 550,000 $10M $17.57 — +550,000 — NEW
76 XENE 0.18% 200,791 $9M $44.82 $938K — —
77 IRD 0.17% 4,325,000 $9M $2.01 $2M — —
78 AVR 0.16% 1,675,476 $8M $4.99 $688K -29,654 -1.7%
79 KMTS 0.15% 285,000 $8M $26.52 — +285,000 — NEW
80 BLLN 0.12% 72,812 $6M $81.84 — +72,812 — NEW
81 KYMR 0.11% 69,935 $5M $77.81 -$4M -99,861 -58.8%
82 PEPG 0.11% 829,870 $5M $6.51 $2M — —
83 CBIO 0.10% 453,686 $5M $11.86 -$14K — —
84 TENX 0.10% 439,142 $5M $12.19 — +439,142 — NEW
85 CRVS 0.10% 692,441 $5M $7.70 -$5M -746,154 -51.9%
86 AQST 0.09% 747,193 $5M $6.46 -$16M -3,012,906 -80.1%
87 TNGX 0.09% 513,035 $5M $8.86 — +513,035 — NEW
88 KRYS 0.08% 17,500 $4M $246.54 -$2M -17,500 -50.0%
89 COGT 0.08% 121,082 $4M $35.52 — +121,082 — NEW
90 OLMA 0.08% 165,713 $4M $25.00 — +165,713 — NEW
91 SDGR 0.07% 202,400 $4M $17.88 — +202,400 — NEW
92 OM 0.06% 833,333 $3M $3.71 -$9M — —
93 SABS 0.06% 803,210 $3M $3.74 — +803,210 — NEW
94 AVTX 0.05% 139,667 $3M $18.16 $761K — —
95 CNTB 0.04% 792,696 $2M $2.82 — +792,696 — NEW
96 IMMX 0.03% 338,941 $2M $5.23 — +338,941 — NEW
97 LXEO 0.03% 139,835 $1M $9.93 $460K — —
98 CPIX 0.03% 341,087 $1M $3.98 — +341,087 — NEW
99 MDLN 0.02% 28,000 $1M $42.00 — +28,000 — NEW
100 PTN 0.02% 70,000 $1M $15.38 — +70,000 — NEW

Options Breakdown

3 Calls $18M Call Value 2 Puts $134M Put Value 7.52 P/C Ratio

Top Calls

SymbolSharesValueStatus
CAPR 242,100 $7M NEW
BHVN 500,000 $6M NEW
TECX 250,000 $5M NEW

Top Puts

SymbolSharesValueStatus
XBI 1,100,000 $134M NEW
SBTX — $0 SOLD

New Positions

SymbolValue% Port
ADGI $54M 1.05%
DHR $46M 0.89%
CDTX $36M 0.71%
IRON $36M 0.70%
JAZZ $29M 0.56%
PALI $28M 0.55%
AXGN $26M 0.50%
XFOR $25M 0.49%
BCRX $25M 0.48%
BIIB $22M 0.42%
MIRM $21M 0.40%
GRAL $20M 0.40%
CVS $17M 0.34%
GH $16M 0.32%
RLAY $16M 0.31%

Sold Out Positions

SymbolValue% Port
APYX — —%
HTFL — —%
INSM — —%
JANX — —%
VKTX — —%
TEM — —%
PYXS — —%
LYRA — —%
AKRO — —%
SCPH — —%
VRNA — —%
MRUS — —%
View SEC EDGAR Filings for PERCEPTIVE ADVISORS LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms