— Know what they know.
Not Investment Advice
Asset Manager ← All Institutions

TANG CAPITAL MANAGEMENT LLC

Q4 2025 · Filed 2026-02-17
Market Value
$1.9B
-21.1%
Holdings
193
-8
New Purchases
8
Added To
12
Closed
121
Reduced
36
Top 10 Concentration
54.5%
Turnover
66.8%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
AUPH 9.45% 5.16% +4.28% $181M
RNAM 3.39% 0.00% +3.39% $65M
CELC 5.48% 2.34% +3.13% $105M
CAPR 2.57% 0.00% +2.57% $49M
CMPX 4.71% 2.43% +2.29% $90M
PTCT 5.96% 3.80% +2.16% $114M
ANAB 3.38% 1.68% +1.69% $65M
MIRM 5.10% 3.74% +1.37% $98M
KALV 3.86% 2.53% +1.33% $74M
IMCR 4.77% 3.45% +1.32% $91M
BNTX 2.34% 1.10% +1.24% $45M
NUVB 1.81% 0.64% +1.17% $35M
SPY 1.07% 0.00% +1.07% $20M
SYRE 3.24% 2.21% +1.03% $62M
VTYX 1.33% 0.40% +0.93% $25M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MRUS 0.00% 2.33% -2.33% $0
RLAY 0.00% 1.74% -1.74% $0
VERA 0.00% 1.62% -1.62% $0
NKE 0.00% 1.49% -1.49% $0
IONS 0.00% 1.48% -1.48% $0
CTMX 0.00% 1.46% -1.46% $0
LEGN 0.00% 1.12% -1.12% $0
LQDA 0.00% 1.07% -1.07% $0
JAZZ 0.00% 1.03% -1.03% $0
LENZ 0.72% 1.72% -1.00% $14M
EOLS 0.43% 1.39% -0.96% $8M
TARS 5.09% 6.02% -0.93% $97M
KROS 0.00% 0.93% -0.93% $0
ACAD 0.42% 1.32% -0.90% $8M
NBIX 0.00% 0.87% -0.87% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 24 $60M 3.1%
Large Cap 37 $226M 11.8%
Mid Cap 47 $852M 44.5%
Small Cap 47 $614M 32.1%
Micro Cap 38 $161M 8.4%

Portfolio Analytics

Avg Market Cap
$141.2B
Median Market Cap
$2.8B
Avg P/E
26.6
Median P/E
20.8
Avg Dividend Yield
0.01%
Avg Beta
0.96
# Stocks
192
# ETFs / Funds
1

Top Holdings (193 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 AUPH 9.45% 11,329,500 $181M $15.95 $56M — —
2 LKFT 6.70% 3,921,219 $128M $32.70 -$16M -229,975 -5.5%
3 PTCT 5.96% 1,500,000 $114M $75.96 $22M — —
4 CELC 5.48% 1,050,000 $105M $99.74 $48M -100,000 -8.7%
5 MIRM 5.10% 1,236,027 $98M $78.99 $7M — —
6 TARS 5.09% 1,188,624 $97M $81.88 -$49M -1,266,173 -51.6%
7 IMCR 4.77% 2,628,538 $91M $34.71 $7M +322,930 +14.0%
8 CMPX 4.71% 16,790,809 $90M $5.37 $31M -21,154 -0.1%
9 KALV 3.86% 4,573,530 $74M $16.15 $12M -468,268 -9.3%
10 RNAM 3.39% 900,000 $65M $72.13 — +900,000 — NEW
11 ANAB 3.38% 1,332,087 $65M $48.48 $24M -1,552 -0.1%
12 SYRE 3.24% 1,892,200 $62M $32.76 $8M -1,307,800 -40.9%
13 VRDN 2.92% 1,792,626 $56M $31.12 -$6M -1,050,299 -36.9%
14 CAPR 2.57% 1,700,000 $49M $28.86 — +1,700,000 — NEW
15 BNTX 2.34% 470,000 $45M $95.20 $18M +200,000 +74.1%
16 ANIP 1.99% 481,437 $38M $78.94 $9M +163,937 +51.6%
17 VRTX 1.90% 80,000 $36M $453.36 $5M — —
18 NUVB 1.81% 3,857,457 $35M $8.96 $19M -342,543 -8.2%
19 TVTX 1.40% 700,000 $27M $38.21 $10M — —
20 VTYX 1.33% 2,814,000 $25M $9.03 $16M -286,000 -9.2%
21 NVDA 1.25% 127,788 $24M $186.50 -$518K -2,721 -2.1%
22 PGEN 1.23% 5,617,500 $23M $4.18 -$17M -6,782,500 -54.7%
23 SPY 1.07% 30,000 $20M $681.92 — +30,000 — NEW
24 MRNA 1.07% 692,820 $20M $29.49 $13M +387,520 +126.9%
25 VKTX 0.92% 500,000 $18M $35.18 -$5M -370,000 -42.5%
26 AVIR 0.90% 4,814,700 $17M $3.57 $3M -11,500 -0.2%
27 STOK 0.83% 500,000 $16M $31.74 $4M — —
28 IDYA 0.81% 450,000 $16M $34.57 $5M +50,000 +12.5%
29 META 0.81% 23,331 $15M $660.09 -$4M -2,677 -10.3%
30 GSK 0.77% 300,000 $15M $49.04 -$3M -100,000 -25.0%
31 DERM 0.75% 1,854,596 $14M $7.71 $1M — —
32 LENZ 0.72% 865,169 $14M $16.00 -$28M -32,447 -3.6%
33 PCVX 0.66% 275,000 $13M $46.14 $2M -25,000 -8.3%
34 DNTH 0.57% 264,692 $11M $41.21 $492K — —
35 HRMY 0.57% 290,292 $11M $37.42 $3M +9,092 +3.2%
36 BMY 0.56% 200,000 $11M $53.94 — +200,000 — NEW
37 INSM 0.55% 60,000 $10M $174.04 -$18M -140,000 -70.0%
38 CBIO 0.54% 872,398 $10M $11.86 $2M +192,574 +28.3%
39 TDOC 0.51% 1,400,000 $10M $7.00 -$1M — —
40 DVAX 0.45% 556,359 $9M $15.38 -$11M -1,393,141 -71.5%
41 EOLS 0.43% 1,245,692 $8M $6.65 -$25M -4,242,607 -77.3%
42 VSTM 0.43% 1,069,810 $8M $7.72 $1M +280,000 +35.5%
43 HRTX 0.42% 6,250,000 $8M $1.30 $4M +2,800,000 +81.2%
44 ACAD 0.42% 300,000 $8M $26.71 -$24M -1,200,000 -80.0%
45 ALT 0.40% 2,131,307 $8M $3.61 -$341K — —
46 SRPT 0.39% 349,220 $8M $21.52 -$4M -250,780 -41.8%
47 PLRX 0.39% 6,143,132 $7M $1.22 -$1M +139,686 +2.3%
48 ARVN 0.35% 569,698 $7M $11.86 -$5M -824,102 -59.1%
49 TBPH 0.34% 351,252 $7M $18.71 $3M +86,944 +32.9%
50 BCRX 0.33% 800,000 $6M $7.80 $168K — —
51 PMVP 0.32% 4,940,000 $6M $1.25 -$524K +154,799 +3.2%
52 REGN 0.32% 8,000 $6M $771.87 $552K -2,000 -20.0%
53 BIIB 0.32% 35,000 $6M $175.99 $1M — —
54 CORT 0.29% 156,764 $5M $34.80 — +156,764 — NEW
55 ABEO 0.28% 1,000,000 $5M $5.27 — +1,000,000 — NEW
56 IBRX 0.24% 2,333,333 $5M $1.98 -$1M — —
57 KZR 0.22% 664,314 $4M $6.29 $1M -55,686 -7.7%
58 CHRS 0.20% 2,724,509 $4M $1.42 -$4M -2,372,853 -46.5%
59 ERAS 0.18% 900,000 $3M $3.72 $72K -602,915 -40.1%
60 NKTX 0.14% 1,480,823 $3M $1.85 -$12M -5,574,753 -79.0%
61 NUVL 0.12% 21,880 $2M $100.59 -$2M -28,120 -56.2%
62 ARE 0.10% 40,000 $2M $48.94 -$1M — —
63 NMRA 0.09% 967,235 $2M $1.79 -$817K -432,765 -30.9%
64 STRO 0.08% 139,617 $2M $11.57 — +139,617 — NEW
65 BHVN 0.08% 140,000 $2M $11.29 -$521K — —
66 RVMD 0.07% 15,640 $1M $79.65 -$3M -84,360 -84.4%
67 FATE 0.06% 1,167,773 $1M $0.98 -$1M -700,000 -37.5%
68 ZYME 0.05% 34,631 $912K $26.33 -$18M -1,065,369 -96.8%
69 RCKT 0.02% 100,000 $351K $3.51 -$2M -750,000 -88.2%
70 ACET —% 6,158 $52K $8.42 — +6,158 — NEW
71 TCRX —% 46,131 $46K $1.00 -$1M -553,869 -92.3%
72 SAVA —% 7,073 $14K $1.98 -$7K — —
73 KOD —% — — — -$2M -100,000 -100.0% SOLD
74 JAZZ —% — — — -$25M -190,000 -100.0% SOLD
75 AMLX —% — — — -$1M -100,000 -100.0% SOLD
76 ENTA —% — — — -$2M -126,655 -100.0% SOLD
77 WHR —% — — — -$341K -4,335 -100.0% SOLD
78 BDTX —% — — — -$8M -2,070,209 -100.0% SOLD
79 UNH —% — — — -$940K -2,721 -100.0% SOLD
80 MTD —% — — — -$2M -1,969 -100.0% SOLD
81 GEV —% — — — -$847K -1,378 -100.0% SOLD
82 GE —% — — — -$901K -2,994 -100.0% SOLD
83 BABA —% — — — -$13M -70,000 -100.0% SOLD
84 ALL —% — — — -$580K -2,700 -100.0% SOLD
85 AMZN —% — — — -$567K -2,583 -100.0% SOLD
86 CGON —% — — — -$4M -87,500 -100.0% SOLD
87 HD —% — — — -$1M -3,646 -100.0% SOLD
88 MLYS —% — — — -$8M -200,000 -100.0% SOLD
89 BLCO —% — — — -$7M -444,467 -100.0% SOLD
90 CDNA —% — — — -$1M -100,000 -100.0% SOLD
91 BEAM —% — — — -$6M -255,000 -100.0% SOLD
92 LQDA —% — — — -$26M -1,143,759 -100.0% SOLD
93 FTRE —% — — — -$842K -100,000 -100.0% SOLD
94 BIOA —% — — — -$9M -1,600,000 -100.0% SOLD
95 JNJ —% — — — -$2M -9,472 -100.0% SOLD
96 KO —% — — — -$2M -22,712 -100.0% SOLD
97 ALMS —% — — — -$5M -1,167,009 -100.0% SOLD
98 WMT —% — — — -$2M -17,242 -100.0% SOLD
99 GMAB —% — — — -$6M -200,000 -100.0% SOLD
100 NKE —% — — — -$36M -519,399 -100.0% SOLD

New Positions

SymbolValue% Port
RNAM $65M 3.39%
CAPR $49M 2.57%
SPY $20M 1.07%
BMY $11M 0.56%
CORT $5M 0.29%
ABEO $5M 0.28%
STRO $2M 0.08%
ACET $52K —%

Sold Out Positions

SymbolValue% Port
F — —%
AAT — —%
FDX — —%
NKE — —%
PFE — —%
DIS — —%
AXP — —%
BABA — —%
ALL — —%
BRK-B — —%
V — —%
HRL — —%
BLCO — —%
KO — —%
GEV — —%
View SEC EDGAR Filings for TANG CAPITAL MANAGEMENT LLC →

Sign in to InsiderStreet

You'll also get our free weekly newsletter with
smart money signals, market insights, and alpha ideas.
Unsubscribe anytime.

For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms