Asset Manager
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BAKER BROS. ADVISORS LP
Market Value
$19.7B
+14.6%
Holdings
87
New Purchases
8
Added To
15
Closed
7
Reduced
7
Top 10 Concentration
73.8%
Turnover
17.2%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| RVMD | 10.88% | 5.41% | +5.47% | $2.1B |
| INCY | 17.70% | 16.84% | +0.87% | $3.5B |
| KYMR | 5.04% | 4.20% | +0.84% | $993M |
| ABCL | 1.32% | 0.61% | +0.70% | $259M |
| ALKS | 2.66% | 2.06% | +0.60% | $525M |
| RYTM | 3.16% | 2.84% | +0.32% | $622M |
| IMVT | 1.06% | 0.79% | +0.27% | $209M |
| RLAY | 0.27% | 0.07% | +0.20% | $53M |
| GRAL | 1.40% | 1.21% | +0.18% | $275M |
| IDYA | 0.95% | 0.77% | +0.18% | $187M |
| FTH | 0.16% | 0.00% | +0.16% | $32M |
| NRIX | 0.57% | 0.42% | +0.15% | $113M |
| REPL | 0.62% | 0.49% | +0.13% | $122M |
| GLUE | 0.53% | 0.42% | +0.12% | $105M |
| CLDX | 0.22% | 0.12% | +0.10% | $44M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ONC | 12.73% | 15.20% | -2.47% | $2.5B |
| INSM | 4.76% | 7.06% | -2.30% | $938M |
| SMMT | 2.42% | 4.01% | -1.59% | $478M |
| CELC | 4.20% | 5.26% | -1.05% | $828M |
| MDGL | 5.84% | 6.52% | -0.68% | $1.2B |
| ABVX | 0.00% | 0.57% | -0.57% | $0 |
| KOD | 3.94% | 4.42% | -0.48% | $776M |
| EWTX | 0.76% | 1.21% | -0.44% | $150M |
| PRAX | 2.98% | 3.29% | -0.31% | $587M |
| SYRE | 0.00% | 0.29% | -0.29% | $0 |
| TRDA | 0.19% | 0.37% | -0.18% | $37M |
| CNTA | 0.00% | 0.16% | -0.16% | $0 |
| IMTX | 0.49% | 0.63% | -0.14% | $96M |
| IMCR | 0.00% | 0.13% | -0.13% | $0 |
| CTNM | 0.00% | 0.11% | -0.11% | $0 |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 9 | $10.9B | 55.2% |
| Mid Cap | 33 | $7.6B | 38.5% |
| Small Cap | 32 | $1.0B | 5.2% |
| Micro Cap | 13 | $220M | 1.1% |
Portfolio Analytics
Avg Market Cap
$5.4B
Median Market Cap
$1.9B
Avg P/E
37.2
Median P/E
26.3
Avg Dividend Yield
—%
Avg Beta
0.98
# Stocks
87
# ETFs / Funds
0
Top Holdings (87 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | INCY | 17.70% | 30,762,330 | $3.5B | $113.36 | $594M | +17,918 | +0.1% | |
| 2 | ONC | 12.73% | 8,801,567 | $2.5B | $284.97 | -$105M | +2,514 | +0.0% | |
| 3 | RVMD | 10.88% | 11,443,357 | $2.1B | $187.28 | $1.2B | +1,888,000 | +19.8% | |
| 4 | MDGL | 5.84% | 2,143,131 | $1.2B | $536.95 | $30M | +1,430 | +0.1% | |
| 5 | ACAD | 5.51% | 42,912,904 | $1.1B | $25.30 | $131M | +16,214 | +0.0% | |
| 6 | KYMR | 5.04% | 8,657,242 | $993M | $114.67 | $272M | — | — | |
| 7 | INSM | 4.76% | 8,796,111 | $938M | $106.62 | -$276M | +1,375,000 | +18.5% | |
| 8 | CELC | 4.20% | 7,915,792 | $828M | $104.62 | -$75M | — | — | |
| 9 | KOD | 3.94% | 19,919,186 | $776M | $38.96 | $17M | — | — | |
| 10 | RYTM | 3.16% | 5,604,483 | $622M | $111.03 | $135M | — | — | |
| 11 | PRAX | 2.98% | 1,753,198 | $587M | $334.79 | $22M | — | — | |
| 12 | ALKS | 2.66% | 10,012,267 | $525M | $52.39 | $171M | — | — | |
| 13 | SMMT | 2.42% | 32,786,348 | $478M | $14.57 | -$212M | -3,604,715 | -9.9% | |
| 14 | GRAL | 1.40% | 4,028,614 | $275M | $68.27 | $67M | — | — | |
| 15 | ABCL | 1.32% | 33,012,138 | $259M | $7.85 | $153M | +2,736,200 | +9.0% | |
| 16 | IMVT | 1.06% | 5,435,220 | $209M | $38.53 | $74M | -22,661 | -0.4% | |
| 17 | IDYA | 0.95% | 5,010,030 | $187M | $37.27 | $55M | +1,063,515 | +26.9% | |
| 18 | ROIV | 0.85% | 4,716,831 | $167M | $35.39 | $32M | -150,892 | -3.1% | |
| 19 | ARWR | 0.82% | 1,992,783 | $162M | $81.51 | $37M | — | — | |
| 20 | IONS | 0.82% | 2,047,727 | $162M | $79.29 | $9M | — | — | |
| 21 | EWTX | 0.76% | 3,701,719 | $150M | $40.63 | -$57M | -2,874,221 | -43.7% | |
| 22 | REPL | 0.62% | 11,045,336 | $122M | $11.07 | $38M | — | — | |
| 23 | NRIX | 0.57% | 4,658,556 | $113M | $24.26 | $41M | — | — | |
| 24 | STOK | 0.55% | 3,336,697 | $109M | $32.72 | $534K | — | — | |
| 25 | GLUE | 0.53% | 4,345,736 | $105M | $24.20 | $34M | — | — | |
| 26 | IMTX | 0.49% | 9,508,565 | $96M | $10.13 | -$11M | -1,408,128 | -12.9% | |
| 27 | DNLI | 0.49% | 3,734,336 | $96M | $25.72 | $24M | +2,641 | +0.1% | |
| 28 | CRNX | 0.45% | 2,351,465 | $88M | $37.42 | $3M | — | — | |
| 29 | DNTH | 0.42% | 852,164 | $83M | $97.48 | $12M | — | — | |
| 30 | GPCR | 0.39% | 1,432,529 | $77M | $53.67 | $8M | — | — | |
| 31 | RAPP | 0.33% | 1,547,090 | $64M | $41.67 | $16M | — | — | |
| 32 | ALMS | 0.29% | 2,012,500 | $57M | $28.14 | $12M | — | — | |
| 33 | PRLD | 0.27% | 10,123,824 | $54M | $5.33 | $19M | — | — | |
| 34 | RLAY | 0.27% | 2,826,783 | $53M | $18.71 | $41M | +1,666,666 | +143.7% | |
| 35 | MIRM | 0.27% | 445,975 | $52M | $117.07 | $11M | — | — | |
| 36 | BCYC | 0.23% | 10,885,357 | $46M | $4.24 | -$4M | — | — | |
| 37 | ELVN | 0.23% | 905,191 | $46M | $50.75 | $10M | — | — | |
| 38 | CLDX | 0.22% | 1,182,611 | $44M | $37.21 | $23M | +517,241 | +77.7% | |
| 39 | VRDN | 0.22% | 2,383,025 | $44M | $18.37 | $5M | +411,347 | +20.9% | |
| 40 | DSGN | 0.20% | 2,678,430 | $39M | $14.47 | $11M | +92,452 | +3.6% | |
| 41 | TRDA | 0.19% | 5,072,730 | $37M | $7.36 | -$27M | — | — | |
| 42 | FTH | 0.16% | 1,286,411 | $32M | $25.00 | — | +1,286,411 | — | NEW |
| 43 | AKTS | 0.16% | 996,351 | $32M | $32.23 | $14M | — | — | |
| 44 | NGNE | 0.16% | 991,691 | $31M | $31.45 | $11M | — | — | |
| 45 | JBIO | 0.14% | 1,230,426 | $27M | $22.22 | $4M | -410,711 | -25.0% | |
| 46 | TSHA | 0.14% | 4,004,756 | $27M | $6.81 | $9M | — | — | |
| 47 | RCUS | 0.13% | 844,816 | $26M | $30.83 | $17M | +429,195 | +103.3% | |
| 48 | IRON | 0.13% | 349,657 | $26M | $73.14 | $3M | — | — | |
| 49 | ABSI | 0.13% | 2,134,803 | $25M | $11.59 | $18M | — | — | |
| 50 | GENB | 0.12% | 1,423,602 | $24M | $16.87 | $6M | — | — | |
| 51 | DBVT | 0.12% | 1,461,425 | $24M | $16.40 | -$7M | — | — | |
| 52 | XENE | 0.11% | 370,208 | $22M | $60.36 | $818K | — | — | |
| 53 | TECX | 0.11% | 607,788 | $21M | $34.38 | $2M | — | — | |
| 54 | CERS | 0.09% | 6,395,431 | $19M | $2.92 | $459K | -3,612,914 | -36.1% | |
| 55 | CTMX | 0.09% | 4,975,826 | $19M | $3.75 | -$5M | — | — | |
| 56 | DYN | 0.09% | 813,449 | $18M | $22.21 | $3M | — | — | |
| 57 | CYTK | 0.09% | 211,267 | $18M | $85.19 | — | +211,267 | — | NEW |
| 58 | XNCR | 0.09% | 1,102,106 | $18M | $16.10 | $4M | — | — | |
| 59 | SION | 0.09% | 400,000 | $18M | $43.99 | $2M | — | — | |
| 60 | NTLA | 0.08% | 930,232 | $16M | $16.92 | — | +930,232 | — | NEW |
| 61 | PBLS | 0.07% | 500,000 | $14M | $27.37 | — | +500,000 | — | NEW |
| 62 | MPLT | 0.07% | 364,705 | $13M | $35.84 | $6M | — | — | |
| 63 | AVLN | 0.06% | 350,000 | $12M | $32.92 | — | +350,000 | — | NEW |
| 64 | EVMN | 0.06% | 847,390 | $11M | $13.29 | -$8M | — | — | |
| 65 | BNTX | 0.06% | 119,743 | $11M | $93.05 | $499K | — | — | |
| 66 | TNGX | 0.05% | 333,333 | $10M | $31.26 | — | +333,333 | — | NEW |
| 67 | AVTX | 0.05% | 550,000 | $10M | $18.48 | — | +550,000 | — | NEW |
| 68 | SERA | 0.05% | 5,498,170 | $10M | $1.82 | -$1M | — | — | |
| 69 | VSTM | 0.05% | 2,499,338 | $10M | $3.82 | $6M | +1,914,581 | +327.4% | |
| 70 | SGMT | 0.04% | 952,996 | $7M | $7.73 | $2M | — | — | |
| 71 | EIKN | 0.04% | 555,555 | $7M | $13.05 | $1M | — | — | |
| 72 | LBRX | 0.03% | 200,000 | $6M | $32.46 | $2M | — | — | |
| 73 | VTVT | 0.03% | 148,314 | $6M | $37.65 | -$298K | — | — | |
| 74 | TARA | 0.02% | 971,614 | $4M | $3.82 | -$1M | — | — | |
| 75 | TCRX | 0.01% | 2,784,792 | $3M | $0.98 | -$83K | — | — | |
| 76 | IMNM | 0.01% | 55,306 | $1M | $21.19 | — | +55,306 | — | NEW |
| 77 | SANA | 0.01% | 310,483 | $1M | $3.49 | $189K | — | — | |
| 78 | ALGS | —% | 83,055 | $479K | $5.77 | -$138K | — | — | |
| 79 | TYRA | —% | 10,607 | $339K | $31.94 | -$67K | — | — | |
| 80 | SRZNW | —% | 833,333 | $14K | $0.02 | $417 | — | — | |
| 81 | CNTA | —% | — | — | — | -$27M | -670,751 | -100.0% | SOLD |
| 82 | ABVX | —% | — | — | — | -$98M | -875,796 | -100.0% | SOLD |
| 83 | SYRE | —% | — | — | — | -$50M | -1,000,000 | -100.0% | SOLD |
| 84 | CMPS | —% | — | — | — | -$13M | -2,344,720 | -100.0% | SOLD |
| 85 | IMCR | —% | — | — | — | -$22M | -734,397 | -100.0% | SOLD |
| 86 | CTNM | —% | — | — | — | -$19M | -1,420,838 | -100.0% | SOLD |
| 87 | ARGX | —% | — | — | — | -$18M | -25,174 | -100.0% | SOLD |