Asset Manager
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BAKER BROS. ADVISORS LP
Market Value
$17.2B
+1.8%
Holdings
87
-6
New Purchases
7
Added To
16
Closed
8
Reduced
6
Top 10 Concentration
74.5%
Turnover
17.2%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| PRAX | 3.29% | 1.97% | +1.32% | $565M |
| KOD | 4.42% | 3.30% | +1.12% | $759M |
| RVMD | 5.41% | 4.46% | +0.94% | $929M |
| CELC | 5.26% | 4.68% | +0.58% | $904M |
| ALKS | 2.06% | 1.66% | +0.40% | $354M |
| INSM | 7.06% | 6.80% | +0.26% | $1.2B |
| SMMT | 4.01% | 3.77% | +0.24% | $690M |
| MIRM | 0.24% | 0.00% | +0.24% | $41M |
| EWTX | 1.21% | 0.97% | +0.24% | $207M |
| DNTH | 0.42% | 0.19% | +0.22% | $72M |
| KYMR | 4.20% | 3.99% | +0.20% | $721M |
| ELVN | 0.21% | 0.02% | +0.18% | $35M |
| ALMS | 0.26% | 0.09% | +0.17% | $44M |
| GRAL | 1.21% | 1.06% | +0.15% | $208M |
| EVMN | 0.11% | 0.00% | +0.11% | $19M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ACAD | 5.56% | 6.79% | -1.23% | $955M |
| INCY | 16.84% | 17.99% | -1.16% | $2.9B |
| MDGL | 6.52% | 7.39% | -0.87% | $1.1B |
| RYTM | 2.84% | 3.55% | -0.72% | $487M |
| ONC | 15.20% | 15.84% | -0.64% | $2.6B |
| RARE | 0.00% | 0.38% | -0.38% | $0 |
| IMCR | 0.13% | 0.48% | -0.35% | $22M |
| TERN | 0.00% | 0.23% | -0.23% | $0 |
| GPCR | 0.40% | 0.59% | -0.19% | $69M |
| BCYC | 0.29% | 0.46% | -0.16% | $51M |
| BNTX | 0.06% | 0.21% | -0.15% | $11M |
| REPL | 0.49% | 0.64% | -0.14% | $84M |
| VRDN | 0.22% | 0.36% | -0.14% | $39M |
| ABVX | 0.57% | 0.70% | -0.13% | $98M |
| BCRX | 0.00% | 0.13% | -0.13% | $0 |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 9 | $9.6B | 56.0% |
| Mid Cap | 33 | $6.5B | 37.8% |
| Small Cap | 31 | $814M | 4.7% |
| Micro Cap | 14 | $246M | 1.4% |
Portfolio Analytics
Avg Market Cap
$5.4B
Median Market Cap
$1.9B
Avg P/E
37.2
Median P/E
26.3
Avg Dividend Yield
—%
Avg Beta
1.03
# Stocks
87
# ETFs / Funds
0
Top Holdings (87 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | INCY | 16.84% | 30,744,412 | $2.9B | $94.12 | -$143M | +421 | — | |
| 2 | ONC | 15.20% | 8,799,053 | $2.6B | $296.97 | -$60M | — | — | |
| 3 | INSM | 7.06% | 7,421,111 | $1.2B | $163.52 | $66M | +828,365 | +12.6% | |
| 4 | MDGL | 6.52% | 2,141,701 | $1.1B | $523.47 | -$126M | — | — | |
| 5 | ACAD | 5.56% | 42,896,690 | $955M | $22.26 | -$191M | — | — | |
| 6 | RVMD | 5.41% | 9,555,357 | $929M | $97.25 | $176M | +100,000 | +1.1% | |
| 7 | CELC | 5.26% | 7,915,792 | $904M | $114.14 | $114M | — | — | |
| 8 | KOD | 4.42% | 19,919,186 | $759M | $38.12 | $202M | — | — | |
| 9 | KYMR | 4.20% | 8,657,242 | $721M | $83.29 | $47M | — | — | |
| 10 | SMMT | 4.01% | 36,391,063 | $690M | $18.96 | $53M | — | — | |
| 11 | PRAX | 3.29% | 1,753,198 | $565M | $322.19 | $233M | +626,710 | +55.6% | |
| 12 | RYTM | 2.84% | 5,604,483 | $487M | $86.97 | -$112M | — | — | |
| 13 | ALKS | 2.06% | 10,012,267 | $354M | $35.36 | $74M | — | — | |
| 14 | GRAL | 1.21% | 4,028,614 | $208M | $51.68 | $30M | +1,943,281 | +93.2% | |
| 15 | EWTX | 1.21% | 6,575,940 | $207M | $31.50 | $44M | — | — | |
| 16 | IONS | 0.89% | 2,047,727 | $154M | $75.09 | $12M | +255,886 | +14.3% | |
| 17 | IMVT | 0.79% | 5,457,881 | $136M | $24.84 | -$3M | — | — | |
| 18 | ROIV | 0.78% | 4,867,723 | $135M | $27.70 | $14M | -687,294 | -12.4% | |
| 19 | IDYA | 0.77% | 3,946,515 | $131M | $33.32 | $6M | +327,689 | +9.1% | |
| 20 | ARWR | 0.73% | 1,992,783 | $125M | $62.70 | -$19M | -182,862 | -8.4% | |
| 21 | STOK | 0.63% | 3,336,697 | $109M | $32.56 | $3M | — | — | |
| 22 | IMTX | 0.63% | 10,916,693 | $107M | $9.84 | -$20M | -1,177,401 | -9.7% | |
| 23 | ABCL | 0.61% | 30,275,938 | $106M | $3.49 | $12M | +2,750,298 | +10.0% | |
| 24 | ABVX | 0.57% | 875,796 | $98M | $111.35 | -$21M | — | — | |
| 25 | CRNX | 0.50% | 2,351,465 | $85M | $36.32 | $9M | +702,596 | +42.6% | |
| 26 | REPL | 0.49% | 11,045,336 | $84M | $7.65 | -$23M | — | — | |
| 27 | NRIX | 0.42% | 4,658,556 | $72M | $15.50 | -$16M | — | — | |
| 28 | DNLI | 0.42% | 3,731,695 | $72M | $19.20 | $10M | — | — | |
| 29 | DNTH | 0.42% | 852,164 | $72M | $83.92 | $39M | +62,405 | +7.9% | |
| 30 | GLUE | 0.42% | 4,345,736 | $71M | $16.45 | $3M | — | — | |
| 31 | GPCR | 0.40% | 1,432,529 | $69M | $48.20 | -$31M | — | — | |
| 32 | TRDA | 0.37% | 5,072,730 | $64M | $12.62 | $12M | — | — | |
| 33 | BCYC | 0.29% | 10,885,357 | $51M | $4.64 | -$27M | — | — | |
| 34 | SYRE | 0.29% | 1,000,000 | $50M | $50.44 | $18M | — | — | |
| 35 | RAPP | 0.28% | 1,547,090 | $48M | $31.29 | $1M | — | — | |
| 36 | ALMS | 0.26% | 2,012,500 | $44M | $22.03 | $29M | +450,000 | +28.8% | |
| 37 | MIRM | 0.24% | 445,975 | $41M | $92.38 | — | +445,975 | — | NEW |
| 38 | VRDN | 0.22% | 1,971,678 | $39M | $19.56 | -$23M | — | — | |
| 39 | ELVN | 0.21% | 905,191 | $35M | $39.20 | $31M | +633,785 | +233.5% | |
| 40 | PRLD | 0.20% | 10,123,824 | $35M | $3.42 | $5M | — | — | |
| 41 | DBVT | 0.18% | 1,461,425 | $31M | $20.89 | $3M | — | — | |
| 42 | DSGN | 0.16% | 2,585,978 | $28M | $10.64 | $7M | +352,879 | +15.8% | |
| 43 | CNTA | 0.16% | 670,751 | $27M | $39.72 | $10M | — | — | |
| 44 | CTMX | 0.14% | 4,975,826 | $23M | $4.70 | $5M | +725,000 | +17.1% | |
| 45 | JBIO | 0.13% | 1,641,137 | $23M | $14.05 | -$2M | — | — | |
| 46 | IRON | 0.13% | 349,657 | $22M | $63.94 | -$4M | +12,607 | +3.7% | |
| 47 | IMCR | 0.13% | 734,397 | $22M | $30.15 | -$58M | -1,588,259 | -68.4% | |
| 48 | XENE | 0.13% | 370,208 | $22M | $58.15 | $5M | — | — | |
| 49 | CLDX | 0.12% | 665,370 | $21M | $31.72 | $3M | — | — | |
| 50 | NGNE | 0.12% | 991,691 | $20M | $20.16 | -$436K | — | — | |
| 51 | EVMN | 0.11% | 847,390 | $19M | $22.99 | — | +847,390 | — | NEW |
| 52 | TECX | 0.11% | 607,788 | $19M | $30.91 | -$58K | -295,612 | -32.7% | |
| 53 | CTNM | 0.11% | 1,420,838 | $19M | $13.06 | $2M | — | — | |
| 54 | ARGX | 0.11% | 25,174 | $18M | $730.25 | -$3M | — | — | |
| 55 | CERS | 0.11% | 10,008,345 | $18M | $1.82 | -$2M | — | — | |
| 56 | TSHA | 0.10% | 4,004,756 | $18M | $4.47 | -$4M | — | — | |
| 57 | AKTS | 0.10% | 996,351 | $18M | $17.89 | — | +996,351 | — | NEW |
| 58 | GENB | 0.10% | 1,423,602 | $18M | $12.50 | — | +1,423,602 | — | NEW |
| 59 | SION | 0.09% | 400,000 | $16M | $40.09 | -$420K | — | — | |
| 60 | DYN | 0.09% | 813,449 | $15M | $18.13 | -$1M | — | — | |
| 61 | XNCR | 0.08% | 1,102,106 | $13M | $12.06 | -$4M | — | — | |
| 62 | CMPS | 0.08% | 2,344,720 | $13M | $5.53 | — | +2,344,720 | — | NEW |
| 63 | RLAY | 0.07% | 1,160,117 | $12M | $9.95 | $2M | — | — | |
| 64 | SERA | 0.06% | 5,498,170 | $11M | $2.03 | -$5M | — | — | |
| 65 | BNTX | 0.06% | 119,743 | $11M | $88.88 | -$24M | -249,180 | -67.5% | |
| 66 | RCUS | 0.05% | 415,621 | $9M | $21.60 | $3M | +145,621 | +53.9% | |
| 67 | MPLT | 0.04% | 364,705 | $7M | $20.33 | $1M | — | — | |
| 68 | ABSI | 0.04% | 2,134,803 | $6M | $3.00 | -$1M | — | — | |
| 69 | VTVT | 0.03% | 148,314 | $6M | $39.66 | -$49K | — | — | |
| 70 | EIKN | 0.03% | 555,555 | $6M | $10.58 | — | +555,555 | — | NEW |
| 71 | TARA | 0.03% | 971,614 | $5M | $5.21 | -$117K | — | — | |
| 72 | SGMT | 0.03% | 952,996 | $5M | $5.22 | -$662K | — | — | |
| 73 | LBRX | 0.03% | 200,000 | $5M | $24.66 | $480K | — | — | |
| 74 | VSTM | 0.02% | 584,757 | $3M | $5.30 | — | +584,757 | — | NEW |
| 75 | TCRX | 0.02% | 2,784,792 | $3M | $1.01 | $28K | — | — | |
| 76 | SANA | 0.01% | 310,483 | $894K | $2.88 | -$369K | — | — | |
| 77 | ALGS | —% | 83,055 | $617K | $7.43 | -$157K | — | — | |
| 78 | TYRA | —% | 10,607 | $406K | $38.30 | $127K | — | — | |
| 79 | SRZNW | —% | 833,333 | $13K | $0.02 | -$3K | — | — | |
| 80 | ACRV | —% | — | — | — | -$55K | -22,809 | -100.0% | SOLD |
| 81 | TERN | —% | — | — | — | -$38M | -950,000 | -100.0% | SOLD |
| 82 | FDMT | —% | — | — | — | -$4M | -475,737 | -100.0% | SOLD |
| 83 | BCRX | —% | — | — | — | -$22M | -2,822,727 | -100.0% | SOLD |
| 84 | VIR | —% | — | — | — | -$3M | -542,539 | -100.0% | SOLD |
| 85 | NUVL | —% | — | — | — | -$14M | -143,937 | -100.0% | SOLD |
| 86 | VTYX | —% | — | — | — | -$21M | -2,349,280 | -100.0% | SOLD |
| 87 | RARE | —% | — | — | — | -$64M | -2,772,692 | -100.0% | SOLD |