Asset Manager
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BAKER BROS. ADVISORS LP
Market Value
$16.9B
+23.5%
Holdings
93
New Purchases
9
Added To
21
Closed
13
Reduced
7
Top 10 Concentration
75.3%
Turnover
23.7%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| CELC | 4.68% | 2.86% | +1.82% | $790M |
| PRAX | 1.97% | 0.27% | +1.70% | $332M |
| KYMR | 3.99% | 2.75% | +1.24% | $674M |
| RVMD | 4.46% | 3.23% | +1.23% | $753M |
| KOD | 3.30% | 2.07% | +1.23% | $557M |
| IONS | 0.84% | 0.27% | +0.57% | $142M |
| ARWR | 0.86% | 0.42% | +0.43% | $144M |
| CRNX | 0.45% | 0.09% | +0.37% | $77M |
| GRAL | 1.06% | 0.71% | +0.35% | $178M |
| REPL | 0.64% | 0.34% | +0.30% | $107M |
| ROIV | 0.71% | 0.42% | +0.30% | $121M |
| GPCR | 0.59% | 0.32% | +0.27% | $100M |
| NRIX | 0.52% | 0.26% | +0.26% | $88M |
| TERN | 0.23% | 0.00% | +0.23% | $38M |
| MDGL | 7.39% | 7.19% | +0.20% | $1.2B |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ONC | 15.84% | 21.93% | -6.09% | $2.7B |
| SMMT | 3.77% | 5.10% | -1.33% | $636M |
| INCY | 17.99% | 19.07% | -1.08% | $3.0B |
| RYTM | 3.55% | 4.14% | -0.59% | $600M |
| ABCL | 0.56% | 1.01% | -0.46% | $94M |
| MRUS | 0.00% | 0.40% | -0.40% | $0 |
| NTLA | 0.00% | 0.35% | -0.35% | $0 |
| INSM | 6.80% | 7.06% | -0.26% | $1.1B |
| RARE | 0.38% | 0.61% | -0.23% | $64M |
| RNAM | 0.00% | 0.20% | -0.20% | $0 |
| STOK | 0.63% | 0.80% | -0.17% | $106M |
| PCVX | 0.00% | 0.17% | -0.17% | $0 |
| BCYC | 0.46% | 0.62% | -0.16% | $77M |
| CDTX | 0.00% | 0.16% | -0.16% | $0 |
| IMCR | 0.48% | 0.62% | -0.14% | $81M |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 10 | $9.7B | 57.3% |
| Mid Cap | 39 | $6.0B | 35.7% |
| Small Cap | 28 | $942M | 5.6% |
| Micro Cap | 16 | $240M | 1.4% |
Portfolio Analytics
Avg Market Cap
$5.5B
Median Market Cap
$2.2B
Avg P/E
37.2
Median P/E
26.3
Avg Dividend Yield
0.01%
Avg Beta
1.05
# Stocks
93
# ETFs / Funds
0
Top Holdings (93 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | INCY | 17.99% | 30,743,991 | $3.0B | $98.77 | $429M | +328 | — | |
| 2 | ONC | 15.84% | 8,799,053 | $2.7B | $303.81 | -$325M | — | — | |
| 3 | MDGL | 7.39% | 2,141,701 | $1.2B | $582.34 | $265M | — | — | |
| 4 | INSM | 6.80% | 6,592,746 | $1.1B | $174.04 | $182M | -110,738 | -1.6% | |
| 5 | ACAD | 6.79% | 42,896,690 | $1.1B | $26.71 | $230M | — | — | |
| 6 | CELC | 4.68% | 7,915,792 | $790M | $99.74 | $398M | — | — | |
| 7 | RVMD | 4.46% | 9,455,357 | $753M | $79.65 | $312M | — | — | |
| 8 | KYMR | 3.99% | 8,657,242 | $674M | $77.81 | $297M | +2,005,813 | +30.2% | |
| 9 | SMMT | 3.77% | 36,391,063 | $636M | $17.49 | -$60M | +2,668,089 | +7.9% | |
| 10 | RYTM | 3.55% | 5,604,483 | $600M | $107.04 | $34M | — | — | |
| 11 | KOD | 3.30% | 19,919,186 | $557M | $27.96 | $274M | +2,608,696 | +15.1% | |
| 12 | PRAX | 1.97% | 1,126,488 | $332M | $294.74 | $295M | +437,000 | +63.4% | |
| 13 | ALKS | 1.66% | 10,012,267 | $280M | $27.98 | $37M | +1,920,916 | +23.7% | |
| 14 | GRAL | 1.06% | 2,085,333 | $178M | $85.59 | $82M | +455,208 | +27.9% | |
| 15 | EWTX | 0.97% | 6,575,940 | $163M | $24.81 | $45M | -730,000 | -10.0% | |
| 16 | ARWR | 0.86% | 2,175,645 | $144M | $66.39 | $87M | +504,883 | +30.2% | |
| 17 | IONS | 0.84% | 1,791,841 | $142M | $79.11 | $105M | +1,225,043 | +216.1% | |
| 18 | IMVT | 0.82% | 5,457,881 | $139M | $25.42 | $51M | — | — | |
| 19 | IMTX | 0.75% | 12,094,094 | $127M | $10.50 | $24M | — | — | |
| 20 | IDYA | 0.74% | 3,618,826 | $125M | $34.57 | $36M | +343,382 | +10.5% | |
| 21 | ROIV | 0.71% | 5,555,017 | $121M | $21.70 | $64M | +1,787,244 | +47.4% | |
| 22 | ABVX | 0.70% | 875,796 | $118M | $134.86 | $44M | — | — | |
| 23 | REPL | 0.64% | 11,045,336 | $107M | $9.72 | $61M | — | — | |
| 24 | STOK | 0.63% | 3,336,697 | $106M | $31.74 | -$3M | -1,297,141 | -28.0% | |
| 25 | GPCR | 0.59% | 1,432,529 | $100M | $69.55 | $56M | -123,580 | -7.9% | |
| 26 | ABCL | 0.56% | 27,525,640 | $94M | $3.42 | -$44M | — | — | |
| 27 | NRIX | 0.52% | 4,658,556 | $88M | $18.97 | $53M | +776,431 | +20.0% | |
| 28 | IMCR | 0.48% | 2,322,656 | $81M | $34.71 | -$4M | — | — | |
| 29 | BCYC | 0.46% | 10,885,357 | $77M | $7.08 | -$7M | — | — | |
| 30 | CRNX | 0.45% | 1,648,869 | $77M | $46.55 | $65M | +1,368,869 | +488.9% | |
| 31 | GLUE | 0.40% | 4,345,736 | $68M | $15.68 | $32M | -570,359 | -11.6% | |
| 32 | RARE | 0.38% | 2,772,692 | $64M | $23.00 | -$20M | — | — | |
| 33 | DNLI | 0.37% | 3,731,695 | $62M | $16.51 | $7M | — | — | |
| 34 | VRDN | 0.36% | 1,971,678 | $61M | $31.12 | $24M | +227,272 | +13.0% | |
| 35 | TRDA | 0.31% | 5,072,730 | $52M | $10.28 | $24M | +206,911 | +4.2% | |
| 36 | RAPP | 0.28% | 1,547,090 | $47M | $30.34 | $990K | — | — | |
| 37 | TERN | 0.23% | 950,000 | $38M | $40.40 | — | +950,000 | — | NEW |
| 38 | BNTX | 0.21% | 368,923 | $35M | $95.20 | -$1M | — | — | |
| 39 | SYRE | 0.19% | 1,000,000 | $33M | $32.76 | $16M | — | — | |
| 40 | DNTH | 0.19% | 789,759 | $33M | $41.21 | $1M | — | — | |
| 41 | PRLD | 0.17% | 10,123,824 | $29M | $2.90 | $15M | — | — | |
| 42 | DBVT | 0.17% | 1,461,425 | $28M | $19.17 | $13M | — | — | |
| 43 | IRON | 0.16% | 337,050 | $27M | $79.41 | $4M | — | — | |
| 44 | JBIO | 0.15% | 1,641,137 | $25M | $15.43 | — | +1,641,137 | — | NEW |
| 45 | TSHA | 0.13% | 4,004,756 | $22M | $5.50 | $9M | — | — | |
| 46 | BCRX | 0.13% | 2,822,727 | $22M | $7.80 | — | +2,822,727 | — | NEW |
| 47 | VTYX | 0.13% | 2,349,280 | $21M | $9.03 | $18M | +1,326,150 | +129.6% | |
| 48 | ARGX | 0.13% | 25,174 | $21M | $840.95 | -$7M | -12,586 | -33.3% | |
| 49 | DSGN | 0.12% | 2,233,099 | $21M | $9.38 | $8M | +520,217 | +30.4% | |
| 50 | CERS | 0.12% | 10,008,345 | $21M | $2.06 | $5M | — | — | |
| 51 | NGNE | 0.12% | 991,691 | $20M | $20.60 | $3M | — | — | |
| 52 | TECX | 0.11% | 903,400 | $19M | $20.86 | $17M | +803,400 | +803.4% | |
| 53 | CTMX | 0.11% | 4,250,826 | $18M | $4.26 | $5M | — | — | |
| 54 | CLDX | 0.11% | 665,370 | $18M | $27.16 | $858K | — | — | |
| 55 | XNCR | 0.10% | 1,102,106 | $17M | $15.31 | $4M | — | — | |
| 56 | CNTA | 0.10% | 670,751 | $17M | $25.01 | — | +670,751 | — | NEW |
| 57 | XENE | 0.10% | 370,208 | $17M | $44.82 | $2M | — | — | |
| 58 | SION | 0.10% | 400,000 | $16M | $41.14 | $5M | — | — | |
| 59 | CTNM | 0.10% | 1,420,838 | $16M | $11.43 | $15M | +1,343,168 | +1729.3% | |
| 60 | SERA | 0.10% | 5,498,170 | $16M | $2.95 | -$605K | — | — | |
| 61 | DYN | 0.09% | 813,449 | $16M | $19.56 | — | +813,449 | — | NEW |
| 62 | ALMS | 0.09% | 1,562,500 | $15M | $9.76 | $9M | — | — | |
| 63 | NUVL | 0.09% | 143,937 | $14M | $100.59 | $2M | — | — | |
| 64 | RLAY | 0.06% | 1,160,117 | $10M | $8.46 | $4M | — | — | |
| 65 | ABSI | 0.04% | 2,134,803 | $7M | $3.49 | — | +2,134,803 | — | NEW |
| 66 | RCUS | 0.04% | 270,000 | $6M | $23.83 | — | +270,000 | — | NEW |
| 67 | MPLT | 0.04% | 364,705 | $6M | $17.56 | — | +364,705 | — | NEW |
| 68 | VTVT | 0.04% | 148,314 | $6M | $39.99 | $2M | — | — | |
| 69 | SGMT | 0.03% | 952,996 | $6M | $5.92 | -$896K | — | — | |
| 70 | TARA | 0.03% | 971,614 | $5M | $5.33 | $3M | +434,782 | +81.0% | |
| 71 | LBRX | 0.03% | 200,000 | $4M | $22.26 | $1M | — | — | |
| 72 | ELVN | 0.02% | 271,406 | $4M | $15.40 | $2M | +156,573 | +136.3% | |
| 73 | FDMT | 0.02% | 475,737 | $4M | $7.50 | — | +475,737 | — | NEW |
| 74 | VIR | 0.02% | 542,539 | $3M | $6.03 | $174K | — | — | |
| 75 | TCRX | 0.02% | 2,784,792 | $3M | $1.00 | -$2M | — | — | |
| 76 | SANA | 0.01% | 310,483 | $1M | $4.07 | -$6M | -1,720,466 | -84.7% | |
| 77 | ALGS | —% | 83,055 | $774K | $9.32 | -$40K | — | — | |
| 78 | TYRA | —% | 10,607 | $279K | $26.29 | $130K | — | — | |
| 79 | ACRV | —% | 22,809 | $55K | $2.41 | $14K | — | — | |
| 80 | SRZNW | —% | 833,333 | $17K | $0.02 | $2K | — | — | |
| 81 | AGIO | —% | — | — | — | -$8M | -189,866 | -100.0% | SOLD |
| 82 | CDTX | —% | — | — | — | -$22M | -227,272 | -100.0% | SOLD |
| 83 | RNAM | —% | — | — | — | -$27M | -625,000 | -100.0% | SOLD |
| 84 | HRTX | —% | — | — | — | -$5M | -4,251,951 | -100.0% | SOLD |
| 85 | PCVX | —% | — | — | — | -$23M | -640,885 | -100.0% | SOLD |
| 86 | MBX | —% | — | — | — | -$5M | -277,777 | -100.0% | SOLD |
| 87 | MRUS | —% | — | — | — | -$54M | -574,377 | -100.0% | SOLD |
| 88 | AKRO | —% | — | — | — | -$15M | -324,630 | -100.0% | SOLD |
| 89 | GBIO | —% | — | — | — | -$1M | -194,493 | -100.0% | SOLD |
| 90 | NTLA | —% | — | — | — | -$47M | -2,746,674 | -100.0% | SOLD |
| 91 | VKTX | —% | — | — | — | -$10M | -366,083 | -100.0% | SOLD |
| 92 | VYNE | —% | — | — | — | -$285K | -851,353 | -100.0% | SOLD |
| 93 | ACLX | —% | — | — | — | -$14M | -166,825 | -100.0% | SOLD |