Asset Manager
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Palo Alto Investors LP
Market Value
$783M
+22.0%
Holdings
52
+2
New Purchases
3
Added To
5
Closed
2
Reduced
14
Top 10 Concentration
62.1%
Turnover
9.6%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ACHC | 9.26% | 0.00% | +9.26% | $72M |
| TRAX | 1.55% | 0.00% | +1.55% | $12M |
| RARE | 2.55% | 1.95% | +0.60% | $20M |
| MIRM | 5.22% | 4.68% | +0.54% | $41M |
| CDNA | 1.94% | 1.44% | +0.50% | $15M |
| CLDX | 1.90% | 1.47% | +0.44% | $15M |
| CMPX | 1.63% | 1.25% | +0.38% | $13M |
| BCAX | 2.09% | 1.71% | +0.38% | $16M |
| NVCR | 2.48% | 2.18% | +0.30% | $19M |
| ALKS | 1.62% | 1.34% | +0.29% | $13M |
| SGMT | 0.25% | 0.00% | +0.25% | $2M |
| TSHA | 1.21% | 0.97% | +0.24% | $9M |
| TVTX | 1.22% | 1.07% | +0.15% | $10M |
| ACRS | 1.09% | 0.94% | +0.15% | $9M |
| CMPS | 0.21% | 0.10% | +0.11% | $2M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| INSM | 5.64% | 10.58% | -4.94% | $44M |
| FOLD | 0.00% | 2.51% | -2.51% | $0 |
| UTHR | 4.33% | 5.80% | -1.47% | $34M |
| BMRN | 4.99% | 6.03% | -1.04% | $39M |
| SNDX | 2.42% | 3.15% | -0.73% | $19M |
| ACAD | 9.26% | 9.97% | -0.71% | $72M |
| DNLI | 0.00% | 0.70% | -0.70% | $0 |
| IOVA | 2.82% | 3.47% | -0.66% | $22M |
| ALGN | 0.68% | 1.11% | -0.43% | $5M |
| ANNX | 2.15% | 2.55% | -0.39% | $17M |
| CAPR | 0.71% | 1.09% | -0.38% | $6M |
| ANAB | 5.21% | 5.52% | -0.31% | $41M |
| PTCT | 9.58% | 9.79% | -0.21% | $75M |
| BIIB | 3.87% | 4.02% | -0.15% | $30M |
| AGIO | 1.01% | 1.13% | -0.11% | $8M |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 10 | $163M | 20.9% |
| Mid Cap | 18 | $414M | 52.9% |
| Small Cap | 16 | $184M | 23.5% |
| Micro Cap | 8 | $22M | 2.8% |
Portfolio Analytics
Avg Market Cap
$6.7B
Median Market Cap
$2.3B
Avg P/E
42.0
Median P/E
28.1
Avg Dividend Yield
0.00%
Avg Beta
0.92
# Stocks
52
# ETFs / Funds
0
Top Holdings (52 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | PTCT | 9.58% | 918,846 | $75M | $81.57 | $12M | -2,761 | -0.3% | |
| 2 | ACAD | 9.26% | 2,864,096 | $72M | $25.30 | $9M | -8,599 | -0.3% | |
| 3 | ACHC | 9.26% | 2,864,096 | $72M | $25.30 | — | +2,864,096 | — | NEW |
| 4 | INSM | 5.64% | 413,980 | $44M | $106.62 | -$24M | -1,289 | -0.3% | |
| 5 | MIRM | 5.22% | 348,808 | $41M | $117.07 | $11M | +23,633 | +7.3% | |
| 6 | ANAB | 5.21% | 603,489 | $41M | $67.50 | $5M | -34,672 | -5.4% | |
| 7 | BMRN | 4.99% | 682,777 | $39M | $57.22 | $363K | -2,405 | -0.3% | |
| 8 | DYN | 4.68% | 1,647,521 | $37M | $22.21 | $7M | -5,451 | -0.3% | |
| 9 | UTHR | 4.33% | 62,587 | $34M | $541.83 | -$3M | -222 | -0.3% | |
| 10 | IRON | 3.89% | 416,646 | $30M | $73.14 | $5M | +14,927 | +3.7% | |
| 11 | BIIB | 3.87% | 140,279 | $30M | $216.06 | $5M | -440 | -0.3% | |
| 12 | IOVA | 2.82% | 5,296,209 | $22M | $4.16 | -$255K | -1,053,354 | -16.6% | |
| 13 | RARE | 2.55% | 596,495 | $20M | $33.39 | $7M | — | — | |
| 14 | NVCR | 2.48% | 1,280,439 | $19M | $15.15 | $5M | — | — | |
| 15 | SNDX | 2.42% | 864,986 | $19M | $21.86 | -$1M | — | — | |
| 16 | ANNX | 2.15% | 2,948,090 | $17M | $5.71 | $501K | — | — | |
| 17 | BCAX | 2.09% | 550,408 | $16M | $29.69 | $5M | — | — | |
| 18 | CDNA | 1.94% | 531,870 | $15M | $28.50 | $6M | — | — | |
| 19 | CLDX | 1.90% | 399,856 | $15M | $37.21 | $5M | +103,448 | +34.9% | |
| 20 | CMPX | 1.63% | 5,831,813 | $13M | $2.19 | $5M | +4,317,309 | +285.1% | |
| 21 | ALKS | 1.62% | 242,560 | $13M | $52.39 | $4M | — | — | |
| 22 | TRAX | 1.55% | 603,489 | $12M | $20.12 | — | +603,489 | — | NEW |
| 23 | TVTX | 1.22% | 167,525 | $10M | $56.81 | $3M | -62,928 | -27.3% | |
| 24 | TSHA | 1.21% | 1,391,382 | $9M | $6.81 | $3M | — | — | |
| 25 | ACRS | 1.09% | 1,613,430 | $9M | $5.29 | $2M | — | — | |
| 26 | AGIO | 1.01% | 213,601 | $8M | $37.11 | $701K | — | — | |
| 27 | CAPR | 0.71% | 229,763 | $6M | $24.08 | -$1M | — | — | |
| 28 | ALGN | 0.68% | 31,389 | $5M | $168.66 | -$2M | -10,131 | -24.4% | |
| 29 | ORKA | 0.41% | 33,546 | $3M | $95.17 | $250K | -26,439 | -44.1% | |
| 30 | XENE | 0.40% | 51,345 | $3M | $60.36 | $113K | — | — | |
| 31 | NBIX | 0.39% | 18,117 | $3M | $168.54 | $667K | — | — | |
| 32 | EW | 0.39% | 33,640 | $3M | $90.46 | $349K | — | — | |
| 33 | STOK | 0.35% | 84,631 | $3M | $32.72 | $14K | — | — | |
| 34 | CYTK | 0.35% | 32,195 | $3M | $85.19 | $621K | — | — | |
| 35 | PYXS | 0.33% | 864,277 | $3M | $3.01 | $1M | -146,233 | -14.5% | |
| 36 | EHTH | 0.28% | 1,482,797 | $2M | $1.49 | $297K | — | — | |
| 37 | CRSP | 0.28% | 39,605 | $2M | $54.54 | $276K | — | — | |
| 38 | SGMT | 0.25% | 250,000 | $2M | $7.73 | — | +250,000 | — | NEW |
| 39 | NUVB | 0.24% | 326,609 | $2M | $5.68 | -$328K | -182,237 | -35.8% | |
| 40 | BNTX | 0.23% | 19,614 | $2M | $93.05 | $82K | — | — | |
| 41 | CMPS | 0.21% | 115,616 | $2M | $14.15 | $997K | — | — | |
| 42 | HUM | 0.20% | 3,985 | $2M | $397.22 | $892K | — | — | |
| 43 | VSTM | 0.15% | 309,685 | $1M | $3.82 | -$121K | +63,592 | +25.8% | |
| 44 | MDGL | 0.12% | 1,787 | $960K | $536.95 | $24K | — | — | |
| 45 | BCYC | 0.11% | 201,890 | $856K | $4.24 | -$81K | — | — | |
| 46 | XERS | 0.11% | 104,410 | $827K | $7.92 | $221K | — | — | |
| 47 | ABEO | 0.09% | 108,865 | $673K | $6.18 | $185K | — | — | |
| 48 | INSP | 0.05% | 8,772 | $391K | $44.61 | -$61K | — | — | |
| 49 | PRQR | 0.04% | 188,807 | $351K | $1.86 | $45K | — | — | |
| 50 | ALDX | 0.04% | 155,709 | $332K | $2.13 | $69K | — | — | |
| 51 | FOLD | —% | — | — | — | -$16M | -1,113,045 | -100.0% | SOLD |
| 52 | DNLI | —% | — | — | — | -$5M | -234,582 | -100.0% | SOLD |