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Palo Alto Investors LP

Q4 2025 · Filed 2026-02-17
Market Value
$718M
+33.0%
Holdings
50
+5
New Purchases
8
Added To
12
Closed
2
Reduced
13
Top 10 Concentration
67.8%
Turnover
20.0%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
FOLD 10.32% 7.83% +2.49% $74M
CMPX 1.89% 0.00% +1.89% $14M
ANNX 1.67% 0.00% +1.67% $12M
DYN 4.01% 2.96% +1.05% $29M
CAPR 0.91% 0.00% +0.91% $7M
MIRM 1.72% 0.88% +0.84% $12M
ANAB 4.66% 3.82% +0.84% $33M
IRON 3.51% 2.74% +0.77% $25M
BCAX 0.70% 0.00% +0.70% $5M
XENE 0.60% 0.00% +0.60% $4M
SNDX 2.32% 1.87% +0.46% $17M
CDNA 1.25% 0.85% +0.40% $9M
DNLI 1.47% 1.10% +0.38% $11M
TSHA 0.91% 0.75% +0.15% $7M
INSP 0.11% 0.00% +0.11% $809K

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ALNY 0.00% 2.73% -2.73% $0
BMRN 6.17% 7.56% -1.39% $44M
INSM 11.86% 13.11% -1.25% $85M
AGIO 0.81% 1.97% -1.17% $6M
RNAM 0.00% 0.89% -0.89% $0
GOSS 1.93% 2.66% -0.73% $14M
NVCR 2.34% 3.00% -0.67% $17M
PRTA 1.76% 2.39% -0.64% $13M
RARE 1.48% 2.06% -0.58% $11M
UTHR 3.95% 4.52% -0.57% $28M
ACAD 9.24% 9.75% -0.51% $66M
IOVA 2.70% 3.06% -0.36% $19M
BIIB 4.50% 4.81% -0.32% $32M
PYXS 0.17% 0.43% -0.26% $1M
EHTH 0.98% 1.23% -0.25% $7M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 11 $205M 28.5%
Mid Cap 15 $366M 51.0%
Small Cap 16 $109M 15.2%
Micro Cap 8 $38M 5.3%

Portfolio Analytics

Avg Market Cap
$7.0B
Median Market Cap
$2.2B
Avg P/E
26.3
Median P/E
23.6
Avg Dividend Yield
0.00%
Avg Beta
0.93
# Stocks
50
# ETFs / Funds
0

Top Holdings (50 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 INSM 11.86% 489,482 $85M $174.04 $14M -2,323 -0.5%
2 FOLD 10.32% 5,205,767 $74M $14.24 $32M -162,031 -3.0%
3 PTCT 9.56% 903,916 $69M $75.96 $16M +41,303 +4.8%
4 ACAD 9.24% 2,484,031 $66M $26.71 $14M +17,347 +0.7%
5 BMRN 6.17% 746,256 $44M $59.43 $4M -7,751 -1.0%
6 ANAB 4.66% 690,032 $33M $48.48 $13M +16,512 +2.5%
7 BIIB 4.50% 183,571 $32M $175.99 $6M -2,090 -1.1%
8 DYN 4.01% 1,472,197 $29M $19.56 $13M +209,523 +16.6%
9 UTHR 3.95% 58,186 $28M $487.25 $4M
10 IRON 3.51% 317,456 $25M $79.41 $10M +93,156 +41.5%
11 IOVA 2.70% 7,116,676 $19M $2.73 $3M -501,456 -6.6%
12 NVCR 2.34% 1,298,964 $17M $12.93 $566K +42,805 +3.4%
13 SNDX 2.32% 794,507 $17M $21.01 $7M +139,577 +21.3%
14 GOSS 1.93% 4,471,592 $14M $3.10 -$509K -992,757 -18.2%
15 CMPX 1.89% 2,532,419 $14M $5.37 +2,532,419 NEW
16 PRTA 1.76% 1,320,510 $13M $9.55 -$312K -3,518 -0.3%
17 MIRM 1.72% 156,421 $12M $78.99 $8M +91,721 +141.8%
18 ANNX 1.67% 2,384,192 $12M $5.02 +2,384,192 NEW
19 RARE 1.48% 461,294 $11M $23.00 -$506K +91,763 +24.8%
20 DNLI 1.47% 641,239 $11M $16.51 $5M +233,233 +57.2%
21 CDNA 1.25% 478,220 $9M $18.84 $4M +162,016 +51.2%
22 EHTH 0.98% 1,531,429 $7M $4.60 $387K -13,190 -0.8%
23 ALKS 0.94% 242,560 $7M $27.98 $1M +58,622 +31.9%
24 CAPR 0.91% 226,304 $7M $28.86 +226,304 NEW
25 TSHA 0.91% 1,183,195 $7M $5.50 $2M -62,838 -5.0%
26 ALGN 0.90% 41,520 $6M $156.15 $756K -4,215 -9.2%
27 AGIO 0.81% 212,499 $6M $27.22 -$5M -52,998 -20.0%
28 BCAX 0.70% 298,575 $5M $16.83 +298,575 NEW
29 NUVB 0.67% 538,079 $5M $8.96 $1M -482,468 -47.3%
30 ACRS 0.66% 1,566,840 $5M $3.01 $2M
31 XENE 0.60% 96,519 $4M $44.82 +96,519 NEW
32 TVTX 0.59% 110,719 $4M $38.21 $2M
33 EW 0.40% 33,640 $3M $85.25 $252K
34 NBIX 0.36% 18,117 $3M $141.83 $26K
35 STOK 0.32% 72,022 $2M $31.74 -$192K -33,405 -31.7%
36 CRSP 0.30% 41,226 $2M $52.44 -$510K
37 BNTX 0.26% 19,614 $2M $95.20 -$67K
38 ORKA 0.25% 59,985 $2M $30.31 $1M
39 BCYC 0.22% 221,071 $2M $7.08 -$146K
40 PYXS 0.17% 1,037,421 $1M $1.15 -$1M
41 ALDX 0.16% 225,465 $1M $5.18 -$9K
42 HUM 0.14% 3,985 $1M $256.13 -$16K
43 INSP 0.11% 8,772 $809K $92.23 +8,772 NEW
44 CMPS 0.11% 115,616 $798K $6.90 +115,616 NEW
45 URGN 0.08% 24,500 $574K $23.42 $85K
46 0H7R.L 0.08% 108,865 $574K $5.27 -$1K
47 PRQR 0.05% 188,807 $381K $2.02 -$21K
48 GBIO 0.01% 15,047 $85K $5.68 +15,047 NEW
49 ALNY —% -$15M -32,320 -100.0% SOLD
50 RNAM —% -$5M -109,831 -100.0% SOLD

New Positions

SymbolValue% Port
CMPX $14M 1.89%
ANNX $12M 1.67%
CAPR $7M 0.91%
BCAX $5M 0.70%
XENE $4M 0.60%
INSP $809K 0.11%
CMPS $798K 0.11%
GBIO $85K 0.01%

Sold Out Positions

SymbolValue% Port
ALNY —%
RNAM —%
View SEC EDGAR Filings for Palo Alto Investors LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms