Asset Manager
← All Institutions
Palo Alto Investors LP
Market Value
$691M
+34.9%
Holdings
47
+4
New Purchases
8
Added To
12
Closed
2
Reduced
11
Top 10 Concentration
70.4%
Turnover
21.3%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| FOLD | 10.72% | 8.26% | +2.47% | $74M |
| CMPX | 1.97% | 0.00% | +1.97% | $14M |
| ANNX | 1.73% | 0.00% | +1.73% | $12M |
| DYN | 4.17% | 3.12% | +1.05% | $29M |
| CAPR | 0.94% | 0.00% | +0.94% | $7M |
| MIRM | 1.79% | 0.93% | +0.86% | $12M |
| ANAB | 4.84% | 4.03% | +0.81% | $33M |
| IRON | 3.65% | 2.89% | +0.75% | $25M |
| BCAX | 0.73% | 0.00% | +0.73% | $5M |
| XENE | 0.63% | 0.00% | +0.63% | $4M |
| SNDX | 2.41% | 1.97% | +0.45% | $17M |
| CDNA | 1.30% | 0.90% | +0.41% | $9M |
| DNLI | 1.53% | 1.16% | +0.38% | $11M |
| TSHA | 0.94% | 0.80% | +0.15% | $7M |
| INSP | 0.12% | 0.00% | +0.12% | $809K |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| ALNY | 0.00% | 2.88% | -2.88% | $0 |
| BMRN | 6.42% | 7.97% | -1.55% | $44M |
| INSM | 12.32% | 13.82% | -1.50% | $85M |
| AGIO | 0.84% | 2.08% | -1.24% | $6M |
| RNAM | 0.00% | 0.93% | -0.93% | $0 |
| NVCR | 2.43% | 3.17% | -0.74% | $17M |
| ACAD | 9.60% | 10.27% | -0.68% | $66M |
| UTHR | 4.10% | 4.76% | -0.66% | $28M |
| RARE | 1.53% | 2.17% | -0.63% | $11M |
| IOVA | 2.81% | 3.23% | -0.42% | $19M |
| BIIB | 4.67% | 5.08% | -0.40% | $32M |
| PTCT | 9.93% | 10.33% | -0.40% | $69M |
| EHTH | 1.02% | 1.30% | -0.28% | $7M |
| PYXS | 0.17% | 0.45% | -0.28% | $1M |
| CRSP | 0.31% | 0.52% | -0.21% | $2M |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 11 | $205M | 29.7% |
| Mid Cap | 15 | $335M | 48.4% |
| Small Cap | 13 | $126M | 18.2% |
| Micro Cap | 8 | $26M | 3.7% |
Portfolio Analytics
Avg Market Cap
$7.7B
Median Market Cap
$2.8B
Avg P/E
41.5
Median P/E
31.2
Avg Dividend Yield
0.00%
Avg Beta
0.90
# Stocks
47
# ETFs / Funds
0
Top Holdings (47 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | INSM | 12.32% | 489,482 | $85M | $174.04 | $14M | -2,323 | -0.5% | |
| 2 | FOLD | 10.72% | 5,205,767 | $74M | $14.24 | $32M | -162,031 | -3.0% | |
| 3 | PTCT | 9.93% | 903,916 | $69M | $75.96 | $16M | +41,303 | +4.8% | |
| 4 | ACAD | 9.60% | 2,484,031 | $66M | $26.71 | $14M | +17,347 | +0.7% | |
| 5 | BMRN | 6.42% | 746,256 | $44M | $59.43 | $4M | -7,751 | -1.0% | |
| 6 | ANAB | 4.84% | 690,032 | $33M | $48.48 | $13M | +16,512 | +2.5% | |
| 7 | BIIB | 4.67% | 183,571 | $32M | $175.99 | $6M | -2,090 | -1.1% | |
| 8 | DYN | 4.17% | 1,472,197 | $29M | $19.56 | $13M | +209,523 | +16.6% | |
| 9 | UTHR | 4.10% | 58,186 | $28M | $487.25 | $4M | — | — | |
| 10 | IRON | 3.65% | 317,456 | $25M | $79.41 | $10M | +93,156 | +41.5% | |
| 11 | IOVA | 2.81% | 7,116,676 | $19M | $2.73 | $3M | -501,456 | -6.6% | |
| 12 | NVCR | 2.43% | 1,298,964 | $17M | $12.93 | $566K | +42,805 | +3.4% | |
| 13 | SNDX | 2.41% | 794,507 | $17M | $21.01 | $7M | +139,577 | +21.3% | |
| 14 | CMPX | 1.97% | 2,532,419 | $14M | $5.37 | — | +2,532,419 | — | NEW |
| 15 | MIRM | 1.79% | 156,421 | $12M | $78.99 | $8M | +91,721 | +141.8% | |
| 16 | ANNX | 1.73% | 2,384,192 | $12M | $5.02 | — | +2,384,192 | — | NEW |
| 17 | RARE | 1.53% | 461,294 | $11M | $23.00 | -$506K | +91,763 | +24.8% | |
| 18 | DNLI | 1.53% | 641,239 | $11M | $16.51 | $5M | +233,233 | +57.2% | |
| 19 | CDNA | 1.30% | 478,220 | $9M | $18.84 | $4M | +162,016 | +51.2% | |
| 20 | EHTH | 1.02% | 1,531,429 | $7M | $4.60 | $387K | -13,190 | -0.8% | |
| 21 | ALKS | 0.98% | 242,560 | $7M | $27.98 | $1M | +58,622 | +31.9% | |
| 22 | CAPR | 0.94% | 226,304 | $7M | $28.86 | — | +226,304 | — | NEW |
| 23 | TSHA | 0.94% | 1,183,195 | $7M | $5.50 | $2M | -62,838 | -5.0% | |
| 24 | ALGN | 0.94% | 41,520 | $6M | $156.15 | $756K | -4,215 | -9.2% | |
| 25 | AGIO | 0.84% | 212,499 | $6M | $27.22 | -$5M | -52,998 | -20.0% | |
| 26 | BCAX | 0.73% | 298,575 | $5M | $16.83 | — | +298,575 | — | NEW |
| 27 | NUVB | 0.70% | 538,079 | $5M | $8.96 | $1M | -482,468 | -47.3% | |
| 28 | ACRS | 0.68% | 1,566,840 | $5M | $3.01 | $2M | — | — | |
| 29 | XENE | 0.63% | 96,519 | $4M | $44.82 | — | +96,519 | — | NEW |
| 30 | TVTX | 0.61% | 110,719 | $4M | $38.21 | $2M | — | — | |
| 31 | EW | 0.41% | 33,640 | $3M | $85.25 | $252K | — | — | |
| 32 | NBIX | 0.37% | 18,117 | $3M | $141.83 | $26K | — | — | |
| 33 | STOK | 0.33% | 72,022 | $2M | $31.74 | -$192K | -33,405 | -31.7% | |
| 34 | CRSP | 0.31% | 41,226 | $2M | $52.44 | -$510K | — | — | |
| 35 | BNTX | 0.27% | 19,614 | $2M | $95.20 | -$67K | — | — | |
| 36 | ORKA | 0.26% | 59,985 | $2M | $30.31 | $1M | — | — | |
| 37 | BCYC | 0.23% | 221,071 | $2M | $7.08 | -$146K | — | — | |
| 38 | PYXS | 0.17% | 1,037,421 | $1M | $1.15 | -$1M | — | — | |
| 39 | ALDX | 0.17% | 225,465 | $1M | $5.18 | -$9K | — | — | |
| 40 | HUM | 0.15% | 3,985 | $1M | $256.13 | -$16K | — | — | |
| 41 | INSP | 0.12% | 8,772 | $809K | $92.23 | — | +8,772 | — | NEW |
| 42 | CMPS | 0.12% | 115,616 | $798K | $6.90 | — | +115,616 | — | NEW |
| 43 | ABEO | 0.08% | 108,865 | $574K | $5.27 | -$1K | — | — | |
| 44 | PRQR | 0.06% | 188,807 | $381K | $2.02 | -$21K | — | — | |
| 45 | GBIO | 0.01% | 15,047 | $85K | $5.68 | — | +15,047 | — | NEW |
| 46 | RNAM | —% | — | — | — | -$5M | -109,831 | -100.0% | SOLD |
| 47 | ALNY | —% | — | — | — | -$15M | -32,320 | -100.0% | SOLD |