Asset Manager
← All Institutions
Palo Alto Investors LP
Market Value
$642M
-7.2%
Holdings
50
+3
New Purchases
5
Added To
17
Closed
1
Reduced
16
Top 10 Concentration
65.1%
Turnover
12.0%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| MIRM | 4.68% | 1.79% | +2.89% | $30M |
| UTHR | 5.80% | 4.10% | +1.70% | $37M |
| CLDX | 1.47% | 0.00% | +1.47% | $9M |
| BCAX | 1.71% | 0.73% | +0.98% | $11M |
| ANNX | 2.55% | 1.73% | +0.81% | $16M |
| SNDX | 3.15% | 2.41% | +0.73% | $20M |
| ANAB | 5.52% | 4.84% | +0.68% | $35M |
| IOVA | 3.47% | 2.81% | +0.66% | $22M |
| DYN | 4.67% | 4.17% | +0.50% | $30M |
| TVTX | 1.07% | 0.61% | +0.46% | $7M |
| RARE | 1.95% | 1.53% | +0.41% | $12M |
| ACAD | 9.97% | 9.60% | +0.37% | $64M |
| IRON | 4.00% | 3.65% | +0.36% | $26M |
| ALKS | 1.34% | 0.98% | +0.35% | $9M |
| CYTK | 0.33% | 0.00% | +0.33% | $2M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| FOLD | 2.51% | 10.72% | -8.22% | $16M |
| INSM | 10.58% | 12.32% | -1.74% | $68M |
| DNLI | 0.70% | 1.53% | -0.83% | $5M |
| EHTH | 0.30% | 1.02% | -0.72% | $2M |
| CMPX | 1.25% | 1.97% | -0.72% | $8M |
| BIIB | 4.02% | 4.67% | -0.65% | $26M |
| BMRN | 6.03% | 6.42% | -0.38% | $39M |
| NUVB | 0.34% | 0.70% | -0.36% | $2M |
| NVCR | 2.18% | 2.43% | -0.25% | $14M |
| XENE | 0.47% | 0.63% | -0.16% | $3M |
| PTCT | 9.79% | 9.93% | -0.15% | $63M |
| ALDX | 0.04% | 0.17% | -0.13% | $263K |
| BCYC | 0.15% | 0.23% | -0.08% | $937K |
| INSP | 0.07% | 0.12% | -0.05% | $452K |
| HUM | 0.11% | 0.15% | -0.04% | $691K |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 10 | $185M | 28.9% |
| Mid Cap | 17 | $300M | 46.7% |
| Small Cap | 15 | $143M | 22.3% |
| Micro Cap | 8 | $13M | 2.1% |
Portfolio Analytics
Avg Market Cap
$6.9B
Median Market Cap
$2.3B
Avg P/E
42.0
Median P/E
28.1
Avg Dividend Yield
0.00%
Avg Beta
0.85
# Stocks
50
# ETFs / Funds
0
Top Holdings (50 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | INSM | 10.58% | 415,269 | $68M | $163.52 | -$17M | -74,213 | -15.2% | |
| 2 | ACAD | 9.97% | 2,872,695 | $64M | $22.26 | -$2M | +388,664 | +15.7% | |
| 3 | PTCT | 9.79% | 921,607 | $63M | $68.13 | -$6M | +17,691 | +2.0% | |
| 4 | BMRN | 6.03% | 685,182 | $39M | $56.49 | -$6M | -61,074 | -8.2% | |
| 5 | UTHR | 5.80% | 62,809 | $37M | $592.98 | $9M | +4,623 | +8.0% | |
| 6 | ANAB | 5.52% | 638,161 | $35M | $55.46 | $2M | -51,871 | -7.5% | |
| 7 | MIRM | 4.68% | 325,175 | $30M | $92.38 | $18M | +168,754 | +107.9% | |
| 8 | DYN | 4.67% | 1,652,972 | $30M | $18.13 | $1M | +180,775 | +12.3% | |
| 9 | BIIB | 4.02% | 140,719 | $26M | $183.33 | -$7M | -42,852 | -23.3% | |
| 10 | IRON | 4.00% | 401,719 | $26M | $63.94 | $477K | +84,263 | +26.5% | |
| 11 | IOVA | 3.47% | 6,349,563 | $22M | $3.51 | $3M | -767,113 | -10.8% | |
| 12 | SNDX | 3.15% | 864,986 | $20M | $23.36 | $4M | +70,479 | +8.9% | |
| 13 | ANNX | 2.55% | 2,948,090 | $16M | $5.54 | $4M | +563,898 | +23.6% | |
| 14 | FOLD | 2.51% | 1,113,045 | $16M | $14.46 | -$58M | -4,092,722 | -78.6% | |
| 15 | NVCR | 2.18% | 1,280,439 | $14M | $10.90 | -$3M | -18,525 | -1.4% | |
| 16 | RARE | 1.95% | 596,495 | $12M | $20.95 | $2M | +135,201 | +29.3% | |
| 17 | BCAX | 1.71% | 550,408 | $11M | $19.89 | $6M | +251,833 | +84.3% | |
| 18 | CLDX | 1.47% | 296,408 | $9M | $31.72 | — | +296,408 | — | NEW |
| 19 | CDNA | 1.44% | 531,870 | $9M | $17.36 | $224K | +53,650 | +11.2% | |
| 20 | ALKS | 1.34% | 242,560 | $9M | $35.36 | $2M | — | — | |
| 21 | CMPX | 1.25% | 1,514,504 | $8M | $5.29 | -$6M | -1,017,915 | -40.2% | |
| 22 | AGIO | 1.13% | 213,601 | $7M | $33.83 | $1M | +1,102 | +0.5% | |
| 23 | ALGN | 1.11% | 41,520 | $7M | $171.43 | $634K | — | — | |
| 24 | CAPR | 1.09% | 229,763 | $7M | $30.40 | $454K | +3,459 | +1.5% | |
| 25 | TVTX | 1.07% | 230,453 | $7M | $29.71 | $3M | +119,734 | +108.1% | |
| 26 | TSHA | 0.97% | 1,391,382 | $6M | $4.47 | -$288K | +208,187 | +17.6% | |
| 27 | ACRS | 0.94% | 1,613,430 | $6M | $3.75 | $1M | +46,590 | +3.0% | |
| 28 | DNLI | 0.70% | 234,582 | $5M | $19.20 | -$6M | -406,657 | -63.4% | |
| 29 | XENE | 0.47% | 51,345 | $3M | $58.15 | -$1M | -45,174 | -46.8% | |
| 30 | ORKA | 0.46% | 59,985 | $3M | $49.05 | $1M | — | — | |
| 31 | STOK | 0.43% | 84,631 | $3M | $32.56 | $470K | +12,609 | +17.5% | |
| 32 | EW | 0.42% | 33,640 | $3M | $80.08 | -$174K | — | — | |
| 33 | NBIX | 0.37% | 18,117 | $2M | $131.74 | -$183K | — | — | |
| 34 | NUVB | 0.34% | 508,846 | $2M | $4.29 | -$3M | -29,233 | -5.4% | |
| 35 | CYTK | 0.33% | 32,195 | $2M | $65.91 | — | +32,195 | — | NEW |
| 36 | EHTH | 0.30% | 1,482,797 | $2M | $1.29 | -$5M | -48,632 | -3.2% | |
| 37 | CRSP | 0.29% | 39,605 | $2M | $47.57 | -$278K | -1,621 | -3.9% | |
| 38 | BNTX | 0.27% | 19,614 | $2M | $88.88 | -$124K | — | — | |
| 39 | PYXS | 0.23% | 1,010,510 | $1M | $1.46 | $282K | -26,911 | -2.6% | |
| 40 | VSTM | 0.20% | 246,093 | $1M | $5.30 | — | +246,093 | — | NEW |
| 41 | BCYC | 0.15% | 201,890 | $937K | $4.64 | -$628K | -19,181 | -8.7% | |
| 42 | MDGL | 0.15% | 1,787 | $935K | $523.47 | — | +1,787 | — | NEW |
| 43 | HUM | 0.11% | 3,985 | $691K | $173.39 | -$330K | — | — | |
| 44 | CMPS | 0.10% | 115,616 | $639K | $5.53 | -$158K | — | — | |
| 45 | XERS | 0.09% | 104,410 | $606K | $5.80 | — | +104,410 | — | NEW |
| 46 | ABEO | 0.08% | 108,865 | $488K | $4.48 | -$86K | — | — | |
| 47 | INSP | 0.07% | 8,772 | $452K | $51.58 | -$357K | — | — | |
| 48 | PRQR | 0.05% | 188,807 | $306K | $1.62 | -$76K | — | — | |
| 49 | ALDX | 0.04% | 155,709 | $263K | $1.69 | -$905K | -69,756 | -30.9% | |
| 50 | GBIO | —% | — | — | — | -$85K | -15,047 | -100.0% | SOLD |