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Palo Alto Investors LP

Q1 2026 · Filed 2026-05-15
Market Value
$654M
-9.0%
Holdings
53
+3
New Purchases
5
Added To
17
Closed
2
Reduced
17
Top 10 Concentration
63.8%
Turnover
13.2%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MIRM 4.59% 1.72% +2.87% $30M
UTHR 5.70% 3.95% +1.75% $37M
CLDX 1.44% 0.00% +1.44% $9M
BCAX 1.67% 0.70% +0.97% $11M
ANNX 2.50% 1.67% +0.83% $16M
SNDX 3.09% 2.32% +0.77% $20M
ANAB 5.41% 4.66% +0.76% $35M
IOVA 3.41% 2.70% +0.70% $22M
DYN 4.58% 4.01% +0.57% $30M
ACAD 9.78% 9.24% +0.54% $64M
TVTX 1.05% 0.59% +0.46% $7M
RARE 1.91% 1.48% +0.43% $12M
IRON 3.93% 3.51% +0.42% $26M
ALKS 1.31% 0.94% +0.37% $9M
CYTK 0.32% 0.00% +0.32% $2M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
FOLD 2.46% 10.32% -7.86% $16M
GOSS 0.00% 1.93% -1.93% $0
INSM 10.39% 11.86% -1.47% $68M
DNLI 0.69% 1.47% -0.79% $5M
EHTH 0.29% 0.98% -0.69% $2M
CMPX 1.23% 1.89% -0.67% $8M
BIIB 3.95% 4.50% -0.55% $26M
NUVB 0.33% 0.67% -0.34% $2M
BMRN 5.92% 6.17% -0.25% $39M
NVCR 2.13% 2.34% -0.20% $14M
XENE 0.46% 0.60% -0.15% $3M
ALDX 0.04% 0.16% -0.12% $263K
BCYC 0.14% 0.22% -0.07% $937K
INSP 0.07% 0.11% -0.04% $452K
HUM 0.11% 0.14% -0.04% $691K

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 10 $185M 28.3%
Mid Cap 17 $330M 50.4%
Small Cap 18 $127M 19.4%
Micro Cap 8 $12M 1.9%

Portfolio Analytics

Avg Market Cap
$6.1B
Median Market Cap
$2.0B
Avg P/E
27.8
Median P/E
23.6
Avg Dividend Yield
0.00%
Avg Beta
0.89
# Stocks
53
# ETFs / Funds
0

Top Holdings (53 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 INSM 10.39% 415,269 $68M $163.52 -$17M -74,213 -15.2%
2 ACAD 9.78% 2,872,695 $64M $22.26 -$2M +388,664 +15.7%
3 PTCT 9.60% 921,607 $63M $68.13 -$6M +17,691 +2.0%
4 BMRN 5.92% 685,182 $39M $56.49 -$6M -61,074 -8.2%
5 UTHR 5.70% 62,809 $37M $592.98 $9M +4,623 +8.0%
6 ANAB 5.41% 638,161 $35M $55.46 $2M -51,871 -7.5%
7 MIRM 4.59% 325,175 $30M $92.38 $18M +168,754 +107.9%
8 DYN 4.58% 1,652,972 $30M $18.13 $1M +180,775 +12.3%
9 BIIB 3.95% 140,719 $26M $183.33 -$7M -42,852 -23.3%
10 IRON 3.93% 401,719 $26M $63.94 $477K +84,263 +26.5%
11 IOVA 3.41% 6,349,563 $22M $3.51 $3M -767,113 -10.8%
12 SNDX 3.09% 864,986 $20M $23.36 $4M +70,479 +8.9%
13 ANNX 2.50% 2,948,090 $16M $5.54 $4M +563,898 +23.6%
14 FOLD 2.46% 1,113,045 $16M $14.46 -$58M -4,092,722 -78.6%
15 NVCR 2.13% 1,280,439 $14M $10.90 -$3M -18,525 -1.4%
16 RARE 1.91% 596,495 $12M $20.95 $2M +135,201 +29.3%
17 PRTA 1.80% 1,208,568 $12M $9.72 -$864K -111,942 -8.5%
18 BCAX 1.67% 550,408 $11M $19.89 $6M +251,833 +84.3%
19 CLDX 1.44% 296,408 $9M $31.72 +296,408 NEW
20 CDNA 1.41% 531,870 $9M $17.36 $224K +53,650 +11.2%
21 ALKS 1.31% 242,560 $9M $35.36 $2M
22 CMPX 1.23% 1,514,504 $8M $5.29 -$6M -1,017,915 -40.2%
23 AGIO 1.11% 213,601 $7M $33.83 $1M +1,102 +0.5%
24 ALGN 1.09% 41,520 $7M $171.43 $634K
25 CAPR 1.07% 229,763 $7M $30.40 $454K +3,459 +1.5%
26 TVTX 1.05% 230,453 $7M $29.71 $3M +119,734 +108.1%
27 TSHA 0.95% 1,391,382 $6M $4.47 -$288K +208,187 +17.6%
28 ACRS 0.93% 1,613,430 $6M $3.75 $1M +46,590 +3.0%
29 DNLI 0.69% 234,582 $5M $19.20 -$6M -406,657 -63.4%
30 XENE 0.46% 51,345 $3M $58.15 -$1M -45,174 -46.8%
31 ORKA 0.45% 59,985 $3M $49.05 $1M
32 STOK 0.42% 84,631 $3M $32.56 $470K +12,609 +17.5%
33 EW 0.41% 33,640 $3M $80.08 -$174K
34 NBIX 0.37% 18,117 $2M $131.74 -$183K
35 NUVB 0.33% 508,846 $2M $4.29 -$3M -29,233 -5.4%
36 CYTK 0.32% 32,195 $2M $65.91 +32,195 NEW
37 EHTH 0.29% 1,482,797 $2M $1.29 -$5M -48,632 -3.2%
38 CRSP 0.29% 39,605 $2M $47.57 -$278K -1,621 -3.9%
39 BNTX 0.27% 19,614 $2M $88.88 -$124K
40 PYXS 0.23% 1,010,510 $1M $1.46 $282K -26,911 -2.6%
41 0LOV.L 0.20% 246,093 $1M $5.30 +246,093 NEW
42 BCYC 0.14% 201,890 $937K $4.64 -$628K -19,181 -8.7%
43 MDGL 0.14% 1,787 $935K $523.47 +1,787 NEW
44 HUM 0.11% 3,985 $691K $173.39 -$330K
45 CMPS 0.10% 115,616 $639K $5.53 -$158K
46 XERS 0.09% 104,410 $606K $5.80 +104,410 NEW
47 0H7R.L 0.07% 108,865 $488K $4.48 -$86K
48 INSP 0.07% 8,772 $452K $51.58 -$357K
49 URGN 0.07% 24,500 $441K $17.98 -$133K
50 PRQR 0.05% 188,807 $306K $1.62 -$76K
51 ALDX 0.04% 155,709 $263K $1.69 -$905K -69,756 -30.9%
52 GOSS —% -$14M -4,471,592 -100.0% SOLD
53 GBIO —% -$85K -15,047 -100.0% SOLD

New Positions

SymbolValue% Port
CLDX $9M 1.44%
CYTK $2M 0.32%
0LOV.L $1M 0.20%
MDGL $935K 0.14%
XERS $606K 0.09%

Sold Out Positions

SymbolValue% Port
GOSS —%
GBIO —%
View SEC EDGAR Filings for Palo Alto Investors LP →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms