Asset Manager
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Palo Alto Investors LP
Market Value
$512M
+12.7%
Holdings
43
-2
New Purchases
3
Added To
12
Closed
4
Reduced
17
Top 10 Concentration
70.9%
Turnover
16.3%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| PTCT | 10.33% | 4.37% | +5.97% | $53M |
| DYN | 3.12% | 0.55% | +2.56% | $16M |
| IOVA | 3.23% | 1.30% | +1.93% | $17M |
| RARE | 2.17% | 0.39% | +1.78% | $11M |
| IRON | 2.89% | 1.70% | +1.20% | $15M |
| FOLD | 8.26% | 7.07% | +1.18% | $42M |
| SNDX | 1.97% | 0.92% | +1.05% | $10M |
| CDNA | 0.90% | 0.00% | +0.90% | $5M |
| DNLI | 1.16% | 0.74% | +0.42% | $6M |
| NUVB | 0.74% | 0.33% | +0.41% | $4M |
| MIRM | 0.93% | 0.72% | +0.20% | $5M |
| PYXS | 0.45% | 0.25% | +0.20% | $2M |
| RNAM | 0.93% | 0.74% | +0.19% | $5M |
| STOK | 0.48% | 0.31% | +0.17% | $2M |
| TSHA | 0.80% | 0.63% | +0.16% | $4M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| INSM | 13.82% | 19.15% | -5.33% | $71M |
| STAA | 0.00% | 2.92% | -2.92% | $0 |
| ALNY | 2.88% | 5.42% | -2.54% | $15M |
| BMRN | 7.97% | 10.16% | -2.19% | $41M |
| ACAD | 10.27% | 12.16% | -1.89% | $53M |
| UTHR | 4.76% | 6.03% | -1.27% | $24M |
| BIIB | 5.08% | 5.68% | -0.61% | $26M |
| NVCR | 3.17% | 3.77% | -0.60% | $16M |
| ALGN | 1.12% | 1.57% | -0.46% | $6M |
| ALKS | 1.08% | 1.39% | -0.31% | $6M |
| BNTX | 0.38% | 0.59% | -0.21% | $2M |
| EHTH | 1.30% | 1.51% | -0.21% | $7M |
| KPTI | 0.00% | 0.18% | -0.18% | $0 |
| EW | 0.51% | 0.68% | -0.17% | $3M |
| VYNE | 0.00% | 0.16% | -0.16% | $0 |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Large Cap | 11 | $195M | 38.1% |
| Mid Cap | 13 | $222M | 43.3% |
| Small Cap | 11 | $82M | 16.0% |
| Micro Cap | 8 | $13M | 2.5% |
Portfolio Analytics
Avg Market Cap
$8.2B
Median Market Cap
$3.2B
Avg P/E
62.0
Median P/E
36.0
Avg Dividend Yield
0.02%
Avg Beta
0.89
# Stocks
43
# ETFs / Funds
0
Top Holdings (43 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | INSM | 13.82% | 491,805 | $71M | $144.01 | -$16M | -373,308 | -43.1% | |
| 2 | PTCT | 10.33% | 862,613 | $53M | $61.37 | $33M | +456,144 | +112.2% | |
| 3 | ACAD | 10.27% | 2,466,684 | $53M | $21.34 | -$3M | -96,525 | -3.8% | |
| 4 | FOLD | 8.26% | 5,367,798 | $42M | $7.88 | $10M | -242,715 | -4.3% | |
| 5 | BMRN | 7.97% | 754,007 | $41M | $54.16 | -$5M | -86,463 | -10.3% | |
| 6 | BIIB | 5.08% | 185,661 | $26M | $140.08 | $166K | -20,098 | -9.8% | |
| 7 | UTHR | 4.76% | 58,186 | $24M | $419.21 | -$3M | -37,296 | -39.1% | |
| 8 | ANAB | 4.03% | 673,520 | $21M | $30.62 | $3M | -139,301 | -17.1% | |
| 9 | IOVA | 3.23% | 7,618,132 | $17M | $2.17 | $11M | +4,188,803 | +122.2% | |
| 10 | NVCR | 3.17% | 1,256,159 | $16M | $12.92 | -$901K | +293,763 | +30.5% | |
| 11 | DYN | 3.12% | 1,262,674 | $16M | $12.65 | $13M | +997,698 | +376.5% | |
| 12 | IRON | 2.89% | 224,300 | $15M | $66.08 | $7M | +78,609 | +54.0% | |
| 13 | ALNY | 2.88% | 32,320 | $15M | $456.00 | -$10M | -43,215 | -57.2% | |
| 14 | RARE | 2.17% | 369,531 | $11M | $30.08 | $9M | +320,781 | +658.0% | |
| 15 | AGIO | 2.08% | 265,497 | $11M | $40.14 | $2M | -3,286 | -1.2% | |
| 16 | SNDX | 1.97% | 654,930 | $10M | $15.38 | $6M | +210,563 | +47.4% | |
| 17 | EHTH | 1.30% | 1,544,619 | $7M | $4.31 | -$206K | -33,231 | -2.1% | |
| 18 | DNLI | 1.16% | 408,006 | $6M | $14.52 | $3M | +168,197 | +70.1% | |
| 19 | ALGN | 1.12% | 45,735 | $6M | $125.22 | -$1M | +7,963 | +21.1% | |
| 20 | ALKS | 1.08% | 183,938 | $6M | $30.00 | -$805K | -37,083 | -16.8% | |
| 21 | RNAM | 0.93% | 109,831 | $5M | $43.57 | $1M | -9,055 | -7.6% | |
| 22 | MIRM | 0.93% | 64,700 | $5M | $73.31 | $1M | — | — | |
| 23 | CDNA | 0.90% | 316,204 | $5M | $14.54 | — | +316,204 | — | NEW |
| 24 | TSHA | 0.80% | 1,246,033 | $4M | $3.27 | $1M | — | — | |
| 25 | NUVB | 0.74% | 1,020,547 | $4M | $3.70 | $2M | +247,895 | +32.1% | |
| 26 | ACRS | 0.58% | 1,566,840 | $3M | $1.90 | $1M | +176,812 | +12.7% | |
| 27 | CRSP | 0.52% | 41,226 | $3M | $64.81 | $501K | -3,399 | -7.6% | |
| 28 | TVTX | 0.52% | 110,719 | $3M | $23.90 | $1M | — | — | |
| 29 | EW | 0.51% | 33,640 | $3M | $77.77 | -$471K | -5,833 | -14.8% | |
| 30 | NBIX | 0.50% | 18,117 | $3M | $140.38 | $867K | +4,783 | +35.9% | |
| 31 | STOK | 0.48% | 105,427 | $2M | $23.50 | $1M | -20,434 | -16.2% | |
| 32 | PYXS | 0.45% | 1,037,421 | $2M | $2.22 | $1M | — | — | |
| 33 | BNTX | 0.38% | 19,614 | $2M | $98.62 | -$749K | -5,592 | -22.2% | |
| 34 | BCYC | 0.33% | 221,071 | $2M | $7.74 | -$19K | -27,863 | -11.2% | |
| 35 | ALDX | 0.23% | 225,465 | $1M | $5.22 | $313K | — | — | |
| 36 | HUM | 0.20% | 3,985 | $1M | $260.17 | $63K | — | — | |
| 37 | ORKA | 0.15% | 59,985 | $791K | $13.19 | — | +59,985 | — | NEW |
| 38 | ABEO | 0.11% | 108,865 | $575K | $5.28 | -$44K | — | — | |
| 39 | PRQR | 0.08% | 188,807 | $402K | $2.13 | — | +188,807 | — | NEW |
| 40 | KPTI | —% | — | — | — | -$810K | -187,911 | -100.0% | SOLD |
| 41 | ALMS | —% | — | — | — | -$430K | -143,437 | -100.0% | SOLD |
| 42 | VYNE | —% | — | — | — | -$735K | -445,434 | -100.0% | SOLD |
| 43 | STAA | —% | — | — | — | -$13M | -791,879 | -100.0% | SOLD |