— Know what they know.
Not Investment Advice
Asset Manager ← All Institutions

Palo Alto Investors LP

Q3 2025 · Filed 2025-11-14
Market Value
$540M
+15.2%
Holdings
45
-1
New Purchases
3
Added To
13
Closed
3
Reduced
18
Top 10 Concentration
67.3%
Turnover
13.3%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
PTCT 9.80% 4.23% +5.57% $53M
DYN 2.96% 0.54% +2.42% $16M
IOVA 3.06% 1.26% +1.80% $17M
RARE 2.06% 0.38% +1.68% $11M
GOSS 2.66% 1.50% +1.16% $14M
IRON 2.74% 1.65% +1.10% $15M
SNDX 1.87% 0.89% +0.98% $10M
FOLD 7.83% 6.85% +0.98% $42M
CDNA 0.85% 0.00% +0.85% $5M
PRTA 2.39% 1.65% +0.74% $13M
DNLI 1.10% 0.72% +0.38% $6M
NUVB 0.70% 0.32% +0.38% $4M
PYXS 0.43% 0.24% +0.18% $2M
MIRM 0.88% 0.70% +0.18% $5M
RNAM 0.89% 0.72% +0.17% $5M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
INSM 13.11% 18.56% -5.45% $71M
STAA 0.00% 2.83% -2.83% $0
ALNY 2.73% 5.25% -2.52% $15M
BMRN 7.56% 9.85% -2.29% $41M
ACAD 9.75% 11.79% -2.04% $53M
UTHR 4.52% 5.85% -1.33% $24M
BIIB 4.81% 5.51% -0.69% $26M
NVCR 3.00% 3.65% -0.65% $16M
ALGN 1.06% 1.52% -0.46% $6M
ALKS 1.02% 1.35% -0.33% $6M
EHTH 1.23% 1.46% -0.23% $7M
BNTX 0.36% 0.57% -0.21% $2M
EW 0.48% 0.66% -0.17% $3M
KPTI 0.00% 0.17% -0.17% $0
ALMS 0.00% 0.09% -0.09% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Large Cap 11 $195M 36.2%
Mid Cap 15 $249M 46.1%
Small Cap 12 $70M 13.0%
Micro Cap 7 $25M 4.7%

Portfolio Analytics

Avg Market Cap
$7.7B
Median Market Cap
$2.6B
Avg P/E
27.7
Median P/E
25.4
Avg Dividend Yield
0.00%
Avg Beta
0.90
# Stocks
45
# ETFs / Funds
0

Top Holdings (45 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 INSM 13.11% 491,805 $71M $144.01 -$16M -373,308 -43.1%
2 PTCT 9.80% 862,613 $53M $61.37 $33M +456,144 +112.2%
3 ACAD 9.75% 2,466,684 $53M $21.34 -$3M -96,525 -3.8%
4 FOLD 7.83% 5,367,798 $42M $7.88 $10M -242,715 -4.3%
5 BMRN 7.56% 754,007 $41M $54.16 -$5M -86,463 -10.3%
6 BIIB 4.81% 185,661 $26M $140.08 $166K -20,098 -9.8%
7 UTHR 4.52% 58,186 $24M $419.21 -$3M -37,296 -39.1%
8 ANAB 3.82% 673,520 $21M $30.62 $3M -139,301 -17.1%
9 IOVA 3.06% 7,618,132 $17M $2.17 $11M +4,188,803 +122.2%
10 NVCR 3.00% 1,256,159 $16M $12.92 -$901K +293,763 +30.5%
11 DYN 2.96% 1,262,674 $16M $12.65 $13M +997,698 +376.5%
12 IRON 2.74% 224,300 $15M $66.08 $7M +78,609 +54.0%
13 ALNY 2.73% 32,320 $15M $456.00 -$10M -43,215 -57.2%
14 GOSS 2.66% 5,464,349 $14M $2.63 $7M -274,664 -4.8%
15 PRTA 2.39% 1,324,028 $13M $9.76 $5M +49,275 +3.9%
16 RARE 2.06% 369,531 $11M $30.08 $9M +320,781 +658.0%
17 AGIO 1.97% 265,497 $11M $40.14 $2M -3,286 -1.2%
18 SNDX 1.87% 654,930 $10M $15.38 $6M +210,563 +47.4%
19 EHTH 1.23% 1,544,619 $7M $4.31 -$206K -33,231 -2.1%
20 DNLI 1.10% 408,006 $6M $14.52 $3M +168,197 +70.1%
21 ALGN 1.06% 45,735 $6M $125.22 -$1M +7,963 +21.1%
22 ALKS 1.02% 183,938 $6M $30.00 -$805K -37,083 -16.8%
23 RNAM 0.89% 109,831 $5M $43.57 $1M -9,055 -7.6%
24 MIRM 0.88% 64,700 $5M $73.31 $1M
25 CDNA 0.85% 316,204 $5M $14.54 +316,204 NEW
26 TSHA 0.75% 1,246,033 $4M $3.27 $1M
27 NUVB 0.70% 1,020,547 $4M $3.70 $2M +247,895 +32.1%
28 ACRS 0.55% 1,566,840 $3M $1.90 $1M +176,812 +12.7%
29 CRSP 0.49% 41,226 $3M $64.81 $501K -3,399 -7.6%
30 TVTX 0.49% 110,719 $3M $23.90 $1M
31 EW 0.48% 33,640 $3M $77.77 -$471K -5,833 -14.8%
32 NBIX 0.47% 18,117 $3M $140.38 $867K +4,783 +35.9%
33 STOK 0.46% 105,427 $2M $23.50 $1M -20,434 -16.2%
34 PYXS 0.43% 1,037,421 $2M $2.22 $1M
35 BNTX 0.36% 19,614 $2M $98.62 -$749K -5,592 -22.2%
36 BCYC 0.32% 221,071 $2M $7.74 -$19K -27,863 -11.2%
37 ALDX 0.22% 225,465 $1M $5.22 $313K
38 HUM 0.19% 3,985 $1M $260.17 $63K
39 ORKA 0.15% 59,985 $791K $13.19 +59,985 NEW
40 0H7R.L 0.11% 108,865 $575K $5.28 -$44K
41 URGN 0.09% 24,500 $489K $19.95 $153K
42 PRQR 0.07% 188,807 $402K $2.13 +188,807 NEW
43 STAA —% -$13M -791,879 -100.0% SOLD
44 KPTI —% -$810K -187,911 -100.0% SOLD
45 ALMS —% -$430K -143,437 -100.0% SOLD

New Positions

SymbolValue% Port
CDNA $5M 0.85%
ORKA $791K 0.15%
PRQR $402K 0.07%

Sold Out Positions

SymbolValue% Port
ALMS —%
KPTI —%
STAA —%
View SEC EDGAR Filings for Palo Alto Investors LP →

Sign in to InsiderStreet

You'll also get our free weekly newsletter with
smart money signals, market insights, and alpha ideas.
Unsubscribe anytime.

For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms