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Asset Manager ← All Institutions

HighVista Strategies LLC

Q3 2025 · Filed 2025-11-14
Market Value
$401M
+48.9%
Holdings
168
-2
New Purchases
27
Added To
74
Closed
26
Reduced
38
Top 10 Concentration
29.6%
Turnover
31.5%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
ABVX 3.91% 0.15% +3.76% $16M
CDTX 1.69% 0.00% +1.69% $7M
MRUS 3.13% 1.75% +1.38% $13M
INSM 1.79% 0.43% +1.36% $7M
MLYS 1.98% 0.75% +1.23% $8M
RVMD 2.04% 0.93% +1.11% $8M
ACLX 1.97% 0.87% +1.10% $8M
AGIO 1.96% 0.87% +1.09% $8M
GPCR 1.65% 0.67% +0.98% $7M
CYTK 1.82% 0.84% +0.98% $7M
COGT 1.66% 0.75% +0.90% $7M
PTGX 2.02% 1.19% +0.83% $8M
SNDK 1.33% 0.67% +0.66% $5M
OLMA 1.07% 0.44% +0.63% $4M
GHRS 0.86% 0.24% +0.63% $3M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
DBC 8.07% 11.63% -3.56% $32M
ANSS 0.00% 2.23% -2.23% $0
JNPR 0.00% 1.70% -1.70% $0
HES 0.00% 1.49% -1.49% $0
AMED 0.00% 1.43% -1.43% $0
VRNA 0.00% 1.01% -1.01% $0
CORZ 0.34% 1.14% -0.80% $1M
STX 0.41% 1.18% -0.78% $2M
WDC 0.43% 1.20% -0.78% $2M
SNPS 0.00% 0.74% -0.74% $0
LYFT 0.00% 0.74% -0.74% $0
CLF 0.00% 0.72% -0.72% $0
MSFT 1.22% 1.89% -0.67% $5M
INTU 0.37% 0.95% -0.59% $1M
DAL 0.00% 0.56% -0.56% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 16 $42M 10.5%
Large Cap 69 $107M 26.7%
Mid Cap 60 $212M 52.9%
Small Cap 21 $37M 9.3%
Micro Cap 2 $3M 0.7%

Portfolio Analytics

Avg Market Cap
$170.6B
Median Market Cap
$10.7B
Avg P/E
33.7
Median P/E
25.6
Avg Dividend Yield
0.01%
Avg Beta
1.09
# Stocks
167
# ETFs / Funds
1

Top Holdings (168 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 DBC 8.07% 1,436,136 $32M $22.53 $1M — —
2 ABVX 3.91% 184,468 $16M $84.90 $15M +133,312 +260.6%
3 MRUS 3.13% 133,321 $13M $94.15 $8M +43,559 +48.5%
4 VRDN 2.53% 469,335 $10M $21.58 $3M -15,224 -3.1%
5 RVMD 2.04% 175,448 $8M $46.70 $6M +107,400 +157.8%
6 PTGX 2.02% 121,682 $8M $66.43 $5M +63,831 +110.3%
7 NUVL 2.01% 93,294 $8M $86.48 $4M +42,834 +84.9%
8 MLYS 1.98% 209,829 $8M $37.92 $6M +59,691 +39.8%
9 ACLX 1.97% 96,177 $8M $82.10 $6M +60,463 +169.3%
10 AGIO 1.96% 195,298 $8M $40.14 $6M +125,171 +178.5%
11 CYTK 1.82% 132,930 $7M $54.96 $5M +64,278 +93.6%
12 INSM 1.79% 49,949 $7M $144.01 $6M +38,354 +330.8%
13 CDTX 1.69% 70,904 $7M $95.76 — +70,904 — NEW
14 COGT 1.66% 462,405 $7M $14.36 $5M +179,219 +63.3%
15 GPCR 1.65% 236,236 $7M $28.00 $5M +149,615 +172.7%
16 AMZN 1.45% 26,393 $6M $219.57 $2M +7,500 +39.7%
17 SNDK 1.33% 47,451 $5M $112.20 $4M +7,851 +19.8%
18 ELVN 1.32% 259,135 $5M $20.47 $2M +117,619 +83.1%
19 AKRO 1.30% 110,079 $5M $47.48 $2M +50,086 +83.5%
20 PRAX 1.26% 95,002 $5M $53.00 $2M +27,714 +41.2%
21 MSFT 1.22% 9,458 $5M $517.95 -$204K -800 -7.8%
22 OLMA 1.07% 437,179 $4M $9.79 $3M +158,749 +57.0%
23 BBIO 1.06% 81,959 $4M $51.94 $1M +14,460 +21.4%
24 APGE 1.06% 107,107 $4M $39.73 $2M +62,055 +137.7%
25 IMVT 1.02% 253,127 $4M $16.12 $1M +70,319 +38.5%
26 XOMA 1.02% 105,714 $4M $38.54 $1M -8,834 -7.7%
27 GH 1.01% 64,583 $4M $62.48 $3M +36,318 +128.5%
28 LQDA 1.00% 176,485 $4M $22.74 $3M +55,844 +46.3%
29 RYTM 0.94% 37,482 $4M $100.99 $2M +9,414 +33.5%
30 SYRE 0.90% 215,746 $4M $16.76 $2M +102,941 +91.3%
31 CLDX 0.87% 135,258 $3M $25.87 $1M +28,705 +26.9%
32 GHRS 0.86% 241,894 $3M $14.30 $3M +189,647 +363.0%
33 EWTX 0.84% 208,101 $3M $16.22 $2M +138,378 +198.5%
34 AVGO 0.84% 10,200 $3M $329.91 -$163K -2,600 -20.3%
35 META 0.82% 4,500 $3M $734.38 $1M +1,400 +45.2%
36 XENE 0.82% 82,190 $3M $40.15 $2M +36,570 +80.2%
37 APLS 0.82% 145,729 $3M $22.63 $2M +59,066 +68.2%
38 PCVX 0.78% 86,802 $3M $36.02 $2M +53,345 +159.4%
39 CRM 0.76% 12,885 $3M $237.00 $4K +1,700 +15.2%
40 ARGX 0.75% 4,068 $3M $737.56 $2M +1,653 +68.5%
41 RNAM 0.71% 65,580 $3M $43.57 $2M +24,716 +60.5%
42 AMD 0.69% 17,200 $3M $161.79 $598K +1,800 +11.7%
43 XPO 0.68% 21,080 $3M $129.27 $63K — —
44 U 0.67% 67,229 $3M $40.04 $1M +10,129 +17.7%
45 V 0.67% 7,861 $3M $341.38 $402K +1,434 +22.3%
46 VERA 0.66% 91,189 $3M $29.06 $2M +50,716 +125.3%
47 CEG 0.62% 7,600 $3M $329.07 -$178K -700 -8.4%
48 NVDA 0.62% 13,400 $3M $186.58 $20K -2,300 -14.7%
49 HPE 0.60% 98,700 $2M $24.56 $661K +12,500 +14.5%
50 MA 0.60% 4,205 $2M $568.81 $144K +205 +5.1%
51 GOOG 0.60% 9,800 $2M $243.55 — +9,800 — NEW
52 SRRK 0.55% 59,573 $2M $37.24 $1M +28,343 +90.8%
53 FERG 0.54% 9,678 $2M $224.58 $23K -200 -2.0%
54 TLN 0.54% 5,100 $2M $425.38 $454K -800 -13.6%
55 PWR 0.54% 5,200 $2M $414.42 -$265K -1,200 -18.8%
56 AVTR 0.54% 172,400 $2M $12.48 — +172,400 — NEW
57 DNTH 0.53% 54,225 $2M $39.35 $2M +38,364 +241.9%
58 CLH 0.53% 9,106 $2M $232.22 — +9,106 — NEW
59 LITE 0.52% 12,927 $2M $162.71 — +12,927 — NEW
60 FLS 0.52% 38,975 $2M $53.14 — +38,975 — NEW
61 COF 0.51% 9,674 $2M $212.58 — +9,674 — NEW
62 BVN 0.50% 82,931 $2M $24.33 $773K +7,100 +9.4%
63 WDAY 0.49% 8,191 $2M $240.73 $508K +2,091 +34.3%
64 PTC 0.48% 9,522 $2M $203.02 $189K -600 -5.9%
65 AGX 0.48% 7,100 $2M $270.05 $661K +1,400 +24.6%
66 DVAX 0.48% 192,849 $2M $9.93 $722K +72,578 +60.4%
67 APH 0.48% 15,400 $2M $123.75 $30K -3,600 -18.9%
68 FN 0.46% 5,100 $2M $364.62 — +5,100 — NEW
69 BBD 0.44% 520,100 $2M $3.38 $387K +76,500 +17.2%
70 NU 0.44% 109,337 $2M $16.01 $371K +8,800 +8.8%
71 QXO 0.43% 90,200 $2M $19.06 -$101K +5,700 +6.8%
72 WDC 0.43% 14,242 $2M $120.06 -$2M -36,358 -71.8%
73 P 0.43% 20,400 $2M $83.81 — +20,400 — NEW
74 KBR 0.42% 35,500 $2M $47.29 — +35,500 — NEW
75 PBR-A 0.41% 138,200 $2M $11.82 $422K +33,200 +31.6%
76 STX 0.41% 6,898 $2M $236.06 -$2M -15,202 -68.8%
77 APG 0.41% 47,350 $2M $34.37 $344K +22,200 +88.3%
78 MDGL 0.40% 3,537 $2M $458.66 $925K +1,232 +53.5%
79 CNTA 0.38% 63,301 $2M $24.25 $1M +22,617 +55.6%
80 CNM 0.37% 27,900 $2M $53.83 — +27,900 — NEW
81 ROIV 0.37% 98,858 $1M $15.13 $805K +37,590 +61.4%
82 CRBP 0.37% 118,027 $1M $12.65 $974K +42,735 +56.8%
83 CSCO 0.37% 21,800 $1M $68.42 -$146K -1,800 -7.6%
84 INTU 0.37% 2,163 $1M $682.91 -$1M -1,100 -33.7%
85 TARS 0.37% 24,854 $1M $59.43 $1M +13,174 +112.8%
86 ENTG 0.36% 15,700 $1M $92.46 -$234K -5,200 -24.9%
87 RDDT 0.36% 6,300 $1M $229.99 — +6,300 — NEW
88 MTZ 0.36% 6,700 $1M $212.81 -$449K -4,300 -39.1%
89 BAC 0.35% 27,500 $1M $51.59 -$124K -5,100 -15.6%
90 ADMA 0.35% 95,112 $1M $14.66 — +95,112 — NEW
91 EOLS 0.35% 226,025 $1M $6.14 $853K +167,983 +289.4%
92 RBC 0.34% 3,500 $1M $390.29 -$58K -200 -5.4%
93 OFIX 0.34% 93,200 $1M $14.64 $177K -13,300 -12.5%
94 PGR 0.34% 5,500 $1M $246.95 -$216K -400 -6.8%
95 JANX 0.34% 55,250 $1M $24.44 -$92K -7,186 -11.5%
96 CORZ 0.34% 75,163 $1M $17.94 -$2M -104,737 -58.2%
97 SCHW 0.34% 14,100 $1M $95.47 -$141K -2,200 -13.5%
98 ALKS 0.33% 44,081 $1M $30.00 -$192K -8,863 -16.7%
99 KROS 0.33% 83,050 $1M $15.82 $611K +30,432 +57.8%
100 SLNO 0.32% 18,700 $1M $67.60 $180K +5,759 +44.5%

New Positions

SymbolValue% Port
CDTX $7M 1.69%
GOOG $2M 0.60%
AVTR $2M 0.54%
CLH $2M 0.53%
LITE $2M 0.52%
FLS $2M 0.52%
COF $2M 0.51%
FN $2M 0.46%
P $2M 0.43%
KBR $2M 0.42%
CNM $2M 0.37%
RDDT $1M 0.36%
ADMA $1M 0.35%
JCI $1M 0.30%
RBLX $1M 0.30%

Sold Out Positions

SymbolValue% Port
REXR — —%
CLF — —%
PM — —%
HCA — —%
DAL — —%
KGS — —%
TKO — —%
CME — —%
CGEM — —%
DYN — —%
GERN — —%
LYFT — —%
IRON — —%
LKQ — —%
SNPS — —%
View SEC EDGAR Filings for HighVista Strategies LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms