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Asset Manager ← All Institutions

HighVista Strategies LLC

Q1 2026 · Filed 2026-05-15
Market Value
$334M
-7.0%
Holdings
168
-3
New Purchases
32
Added To
42
Closed
23
Reduced
67
Top 10 Concentration
28.6%
Turnover
32.7%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
DBC 9.17% 6.59% +2.58% $31M
TYRA 1.51% 0.26% +1.25% $5M
ORKA 1.16% 0.00% +1.16% $4M
MLTX 1.08% 0.00% +1.08% $4M
ABVX 3.78% 2.71% +1.07% $13M
DFTX 1.05% 0.00% +1.05% $4M
NRIX 1.05% 0.00% +1.05% $4M
IVA 1.02% 0.00% +1.02% $3M
ERAS 0.88% 0.00% +0.88% $3M
XENE 0.85% 0.00% +0.85% $3M
VERA 0.83% 0.00% +0.83% $3M
ALMS 0.75% 0.00% +0.75% $2M
EYPT 0.71% 0.00% +0.71% $2M
PCVX 2.17% 1.47% +0.70% $7M
DYN 0.99% 0.33% +0.67% $3M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
VRDN 0.79% 3.23% -2.44% $3M
GPCR 1.79% 3.74% -1.95% $6M
CDTX 0.00% 1.41% -1.41% $0
ACLX 0.00% 1.36% -1.36% $0
OLMA 0.53% 1.68% -1.16% $2M
AGIO 0.00% 1.12% -1.12% $0
MAZE 0.89% 1.97% -1.07% $3M
COGT 2.27% 3.33% -1.06% $8M
APLS 0.00% 1.06% -1.06% $0
MLYS 0.38% 1.26% -0.88% $1M
CYTK 1.16% 2.03% -0.87% $4M
RYTM 0.44% 1.28% -0.84% $1M
RNAM 0.00% 0.80% -0.80% $0
PTGX 1.07% 1.79% -0.72% $4M
INSM 1.19% 1.91% -0.72% $4M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 11 $21M 6.4%
Large Cap 63 $80M 23.9%
Mid Cap 61 $141M 42.1%
Small Cap 31 $89M 26.6%
Micro Cap 2 $3M 1.0%

Portfolio Analytics

Avg Market Cap
$155.2B
Median Market Cap
$7.5B
Avg P/E
45.9
Median P/E
28.4
Avg Dividend Yield
0.00%
Avg Beta
1.06
# Stocks
167
# ETFs / Funds
1

Top Holdings (168 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 DBC 9.17% 1,057,238 $31M $28.95 $7M
2 ABVX 3.78% 113,254 $13M $111.35 $3M +41,069 +56.9%
3 COGT 2.27% 197,051 $8M $38.49 -$4M -139,616 -41.5%
4 SYRE 2.21% 146,264 $7M $50.44 $1M -41,942 -22.3%
5 PCVX 2.17% 124,647 $7M $58.11 $2M +10,598 +9.3%
6 RVMD 2.02% 69,309 $7M $97.25 -$3M -50,931 -42.4%
7 TERN 1.81% 114,307 $6M $52.72 -$1M -61,155 -34.9%
8 GPCR 1.79% 123,909 $6M $48.20 -$7M -69,092 -35.8%
9 NUVL 1.74% 56,602 $6M $102.45 -$2M -16,685 -22.8%
10 IMVT 1.68% 225,139 $6M $24.84 -$48K +3,256 +1.5%
11 TYRA 1.51% 131,304 $5M $38.30 $4M +96,218 +274.2%
12 AMLX 1.47% 352,085 $5M $13.90 $2M +113,273 +47.4%
13 AMZN 1.40% 22,397 $5M $208.27 $649K +5,000 +28.7%
14 LBRX 1.28% 173,595 $4M $24.66 $1M +33,488 +23.9%
15 RLAY 1.26% 421,881 $4M $9.95 -$414K -123,198 -22.6%
16 INSM 1.19% 24,316 $4M $163.52 -$3M -15,084 -38.3%
17 NVDA 1.17% 22,420 $4M $174.40 $1M +8,200 +57.7%
18 ORKA 1.16% 78,911 $4M $49.05 +78,911 NEW
19 CYTK 1.16% 58,643 $4M $65.91 -$3M -55,921 -48.8%
20 LQDA 1.13% 99,744 $4M $37.74 -$2M -56,259 -36.1%
21 OCUL 1.12% 441,573 $4M $8.47 -$437K +97,506 +28.3%
22 TARS 1.10% 52,464 $4M $70.15 -$705K -1,100 -2.0%
23 BBIO 1.10% 49,560 $4M $74.26 -$2M -30,645 -38.2%
24 MLTX 1.08% 193,955 $4M $18.64 +193,955 NEW
25 ARGX 1.08% 4,918 $4M $730.25 $574K +1,330 +37.1%
26 PTGX 1.07% 33,852 $4M $105.40 -$3M -39,693 -54.0%
27 DFTX 1.05% 185,856 $4M $18.90 +185,856 NEW
28 NRIX 1.05% 226,546 $4M $15.50 +226,546 NEW
29 AXSM 1.04% 20,437 $3M $169.02 $1M +9,306 +83.6%
30 IVA 1.02% 615,666 $3M $5.55 +615,666 NEW
31 DYN 0.99% 182,929 $3M $18.13 $2M +123,286 +206.7%
32 GHRS 0.90% 213,212 $3M $14.06 -$57K -27,312 -11.4%
33 DNTH 0.90% 35,587 $3M $83.92 $988K -12,897 -26.6%
34 MAZE 0.89% 99,850 $3M $29.85 -$4M -70,503 -41.4%
35 ERAS 0.88% 181,069 $3M $16.18 +181,069 NEW
36 EWTX 0.87% 91,931 $3M $31.50 -$1M -79,206 -46.3%
37 ELVN 0.86% 73,102 $3M $39.20 $2M -9,434 -11.4%
38 XENE 0.85% 49,050 $3M $58.15 +49,050 NEW
39 CLDX 0.85% 89,397 $3M $31.72 $1M +37,592 +72.6%
40 VERA 0.83% 69,241 $3M $40.23 +69,241 NEW
41 PHVS 0.83% 97,866 $3M $28.25 -$2M -64,504 -39.7%
42 VRDN 0.79% 134,229 $3M $19.56 -$9M -238,243 -64.0%
43 ALKS 0.78% 73,189 $3M $35.36 $2M +46,788 +177.2%
44 ALMS 0.75% 112,929 $2M $22.03 +112,929 NEW
45 MSFT 0.72% 6,457 $2M $370.17 -$771K -80 -1.2%
46 EYPT 0.71% 183,037 $2M $12.89 +183,037 NEW
47 LITE 0.66% 3,117 $2M $702.76 $599K -1,200 -27.8%
48 TNGX 0.65% 104,193 $2M $20.92 +104,193 NEW
49 V 0.65% 7,141 $2M $302.24 -$48K +850 +13.5%
50 GH 0.65% 23,357 $2M $92.37 -$2M -13,401 -36.5%
51 HPE 0.64% 89,981 $2M $23.81 $313K +13,800 +18.1%
52 CIEN 0.61% 5,285 $2M $388.23 $839K +100 +1.9%
53 JAZZ 0.61% 10,838 $2M $189.05 +10,838 NEW
54 STOK 0.61% 62,617 $2M $32.56 -$2M -52,922 -45.8%
55 CMPS 0.60% 364,360 $2M $5.53 -$1M -134,573 -27.0%
56 FLS 0.55% 24,958 $2M $73.51 $103K
57 IMCR 0.53% 58,697 $2M $30.15 $624K +25,699 +77.9%
58 OLMA 0.53% 117,601 $2M $14.91 -$4M -123,888 -51.3%
59 NATL 0.52% 40,100 $2M $43.58 +40,100 NEW
60 XPO 0.52% 8,923 $2M $194.55 $7K -3,800 -29.9%
61 ON 0.52% 28,000 $2M $61.92 +28,000 NEW
62 AVGO 0.52% 5,599 $2M $309.51 -$219K -40 -0.7%
63 KOD 0.50% 43,569 $2M $38.12 +43,569 NEW
64 CEG 0.48% 5,752 $2M $279.25 -$94K +940 +19.5%
65 CLH 0.48% 5,543 $2M $286.73 $125K -700 -11.2%
66 GOOG 0.47% 5,477 $2M $286.86 -$399K -800 -12.7%
67 CRM 0.47% 8,313 $2M $186.67 -$730K -300 -3.5%
68 CORZ 0.46% 103,412 $2M $14.96 $622K +39,900 +62.8%
69 ETR 0.46% 13,528 $2M $112.36 $565K +3,200 +31.0%
70 CELC 0.45% 13,105 $1M $114.14 -$154K -3,438 -20.8%
71 XOMA 0.44% 46,814 $1M $31.37 -$2M -66,103 -58.5%
72 AVTR 0.44% 186,500 $1M $7.84 +186,500 NEW
73 MA 0.44% 2,924 $1M $499.66 -$128K +140 +5.0%
74 RYTM 0.44% 16,796 $1M $86.97 -$3M -26,071 -60.8%
75 KBR 0.44% 39,406 $1M $36.86 $246K +9,400 +31.3%
76 RBC 0.43% 2,663 $1M $543.12 $234K -40 -1.5%
77 MIRM 0.43% 15,563 $1M $92.38 +15,563 NEW
78 U 0.41% 62,763 $1M $21.94 $111K +34,100 +119.0%
79 SVRA 0.41% 250,999 $1M $5.46 +250,999 NEW
80 MDGL 0.41% 2,598 $1M $523.47 -$293K -241 -8.5%
81 CTMX 0.41% 288,057 $1M $4.70 $528K +94,116 +48.5%
82 CGON 0.40% 19,914 $1M $67.68 $130K -9,411 -32.1%
83 TDG 0.40% 1,145 $1M $1,158.96 -$2M -1,030 -47.4%
84 KNX 0.40% 22,900 $1M $57.58 +22,900 NEW
85 RKT 0.39% 92,430 $1M $14.25 -$569K -5,000 -5.1%
86 INTU 0.39% 3,003 $1M $432.38 $97K +1,190 +65.6%
87 MU 0.38% 3,800 $1M $337.84 +3,800 NEW
88 BLTE 0.38% 8,033 $1M $159.44 +8,033 NEW
89 MLYS 0.38% 46,778 $1M $27.09 -$3M -77,766 -62.4%
90 APH 0.37% 9,781 $1M $126.35 $279K +2,700 +38.1%
91 BKNG 0.36% 283 $1M $4,210.32 -$110K +40 +16.5%
92 KRC 0.36% 41,997 $1M $28.21 +41,997 NEW
93 MTZ 0.35% 3,627 $1M $321.74 $74K -1,400 -27.9%
94 EQT 0.35% 18,290 $1M $63.64 -$288K -8,800 -32.5%
95 STX 0.34% 2,900 $1M $391.76 +2,900 NEW
96 PBR-A 0.33% 59,400 $1M $18.75 $492K +4,200 +7.6%
97 WDC 0.33% 4,100 $1M $270.49 +4,100 NEW
98 FERG 0.33% 4,673 $1M $233.26 -$462K -2,300 -33.0%
99 APG 0.32% 26,658 $1M $40.52 -$104K -4,300 -13.9%
100 TVTX 0.32% 36,325 $1M $29.71 +36,325 NEW

New Positions

SymbolValue% Port
ORKA $4M 1.16%
MLTX $4M 1.08%
DFTX $4M 1.05%
NRIX $4M 1.05%
IVA $3M 1.02%
ERAS $3M 0.88%
XENE $3M 0.85%
VERA $3M 0.83%
ALMS $2M 0.75%
EYPT $2M 0.71%
TNGX $2M 0.65%
JAZZ $2M 0.61%
NATL $2M 0.52%
ON $2M 0.52%
KOD $2M 0.50%

Sold Out Positions

SymbolValue% Port
ALV —%
FOUR —%
VST —%
UNF —%
ALC —%
BVN —%
SCHW —%
CNX —%
TMO —%
AFRM —%
APP —%
ACHC —%
GTLB —%
CMPX —%
SNDK —%
View SEC EDGAR Filings for HighVista Strategies LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms