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Asset Manager ← All Institutions

HighVista Strategies LLC

Q4 2025 · Filed 2026-02-17
Market Value
$378M
-5.6%
Holdings
173
+5
New Purchases
31
Added To
25
Closed
34
Reduced
83
Top 10 Concentration
28.9%
Turnover
37.6%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
GPCR 3.55% 1.65% +1.90% $13M
TERN 1.87% 0.00% +1.87% $7M
MAZE 1.87% 0.00% +1.87% $7M
COGT 3.16% 1.66% +1.50% $12M
SLNO 1.65% 0.32% +1.34% $6M
STOK 0.97% 0.00% +0.97% $4M
CMPS 0.91% 0.00% +0.91% $3M
RLAY 1.22% 0.31% +0.91% $5M
LBRX 0.82% 0.00% +0.82% $3M
PALI 0.81% 0.00% +0.81% $3M
OCUL 1.10% 0.31% +0.79% $4M
TARS 1.16% 0.37% +0.79% $4M
TDG 0.76% 0.00% +0.76% $3M
AMLX 0.76% 0.00% +0.76% $3M
BBOT 0.76% 0.00% +0.76% $3M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MRUS 0.00% 3.13% -3.13% $0
DBC 6.25% 8.07% -1.82% $24M
ABVX 2.57% 3.91% -1.33% $10M
AKRO 0.00% 1.30% -1.30% $0
SNDK 0.27% 1.33% -1.05% $1M
ELVN 0.34% 1.32% -0.99% $1M
AGIO 1.06% 1.96% -0.89% $4M
XENE 0.00% 0.82% -0.82% $0
MLYS 1.19% 1.98% -0.79% $5M
AMD 0.00% 0.69% -0.69% $0
ACLX 1.29% 1.97% -0.68% $5M
VERA 0.00% 0.66% -0.66% $0
SRRK 0.00% 0.55% -0.55% $0
PWR 0.00% 0.54% -0.54% $0
AVTR 0.00% 0.54% -0.54% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 16 $24M 6.3%
Large Cap 66 $89M 23.5%
Mid Cap 60 $197M 52.0%
Small Cap 26 $64M 17.0%
Micro Cap 5 $5M 1.2%

Portfolio Analytics

Avg Market Cap
$164.6B
Median Market Cap
$8.8B
Avg P/E
32.9
Median P/E
25.5
Avg Dividend Yield
0.01%
Avg Beta
1.08
# Stocks
172
# ETFs / Funds
1

Top Holdings (173 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 DBC 6.25% 1,057,238 $24M $22.36 -$9M -378,898 -26.4%
2 GPCR 3.55% 193,001 $13M $69.55 $7M -43,235 -18.3%
3 COGT 3.16% 336,667 $12M $35.52 $5M -125,738 -27.2%
4 VRDN 3.06% 372,472 $12M $31.12 $1M -96,863 -20.6%
5 ABVX 2.57% 72,185 $10M $134.85 -$6M -112,283 -60.9%
6 RVMD 2.53% 120,240 $10M $79.65 $1M -55,208 -31.5%
7 PRAX 2.01% 25,841 $8M $294.74 $3M -69,161 -72.8%
8 NUVL 1.95% 73,287 $7M $100.59 -$696K -20,007 -21.4%
9 CYTK 1.92% 114,564 $7M $63.54 -$26K -18,366 -13.8%
10 TERN 1.87% 175,462 $7M $40.40 — +175,462 — NEW
11 MAZE 1.87% 170,353 $7M $41.43 — +170,353 — NEW
12 INSM 1.81% 39,400 $7M $174.04 -$336K -10,549 -21.1%
13 APGE 1.78% 89,229 $7M $75.48 $2M -17,878 -16.7%
14 PTGX 1.70% 73,545 $6M $87.34 -$2M -48,137 -39.6%
15 SLNO 1.65% 135,069 $6M $46.30 $5M +116,369 +622.3%
16 SYRE 1.63% 188,206 $6M $32.76 $3M -27,540 -12.8%
17 BBIO 1.62% 80,205 $6M $76.49 $2M -1,754 -2.1%
18 OLMA 1.60% 241,489 $6M $25.00 $2M -195,690 -44.8%
19 IMVT 1.49% 221,883 $6M $25.42 $2M -31,244 -12.3%
20 LQDA 1.42% 156,003 $5M $34.49 $1M -20,482 -11.6%
21 PCVX 1.39% 114,049 $5M $46.14 $2M +27,247 +31.4%
22 CDTX 1.34% 22,928 $5M $220.89 -$2M -47,976 -67.7%
23 ACLX 1.29% 75,002 $5M $65.20 -$3M -21,175 -22.0%
24 RLAY 1.22% 545,079 $5M $8.46 $3M +304,620 +126.7%
25 RYTM 1.21% 42,867 $5M $107.04 $803K +5,385 +14.4%
26 MLYS 1.19% 124,544 $5M $36.29 -$3M -85,285 -40.6%
27 TARS 1.16% 53,564 $4M $81.88 $3M +28,710 +115.5%
28 EWTX 1.12% 171,137 $4M $24.82 $871K -36,964 -17.8%
29 OCUL 1.10% 344,067 $4M $12.14 $3M +237,456 +222.7%
30 AGIO 1.06% 147,662 $4M $27.22 -$4M -47,636 -24.4%
31 AMZN 1.06% 17,397 $4M $230.82 -$2M -8,996 -34.1%
32 APLS 1.00% 150,776 $4M $25.12 $490K +5,047 +3.5%
33 GH 0.99% 36,758 $4M $102.14 -$281K -27,825 -43.1%
34 STOK 0.97% 115,539 $4M $31.74 — +115,539 — NEW
35 CMPS 0.91% 498,933 $3M $6.90 — +498,933 — NEW
36 MSFT 0.84% 6,537 $3M $483.62 -$2M -2,921 -30.9%
37 LBRX 0.82% 140,107 $3M $22.26 — +140,107 — NEW
38 PALI 0.81% 1,300,031 $3M $2.35 — +1,300,031 — NEW
39 GHRS 0.81% 240,524 $3M $12.70 -$404K -1,370 -0.6%
40 ARGX 0.80% 3,588 $3M $840.95 $17K -480 -11.8%
41 XOMA 0.79% 112,917 $3M $26.59 -$1M +7,203 +6.8%
42 TDG 0.76% 2,175 $3M $1,329.85 — +2,175 — NEW
43 RNAM 0.76% 40,020 $3M $72.13 $29K -25,560 -39.0%
44 AMLX 0.76% 238,812 $3M $12.08 — +238,812 — NEW
45 BBOT 0.76% 229,263 $3M $12.52 — +229,263 — NEW
46 NVDA 0.70% 14,220 $3M $186.50 $152K +820 +6.1%
47 CRM 0.60% 8,613 $2M $264.91 -$772K -4,272 -33.1%
48 V 0.58% 6,291 $2M $350.71 -$477K -1,570 -20.0%
49 SEPN 0.58% 78,682 $2M $27.88 — +78,682 — NEW
50 AXSM 0.54% 11,131 $2M $182.64 $898K +1,783 +19.1%
51 DNTH 0.53% 48,484 $2M $41.21 -$136K -5,741 -10.6%
52 GOOG 0.52% 6,277 $2M $313.80 -$417K -3,523 -36.0%
53 AVGO 0.52% 5,639 $2M $346.10 -$1M -4,561 -44.7%
54 RKT 0.50% 97,430 $2M $19.36 — +97,430 — NEW
55 UNP 0.49% 8,058 $2M $231.32 — +8,058 — NEW
56 HPE 0.48% 76,181 $2M $24.02 -$594K -22,519 -22.8%
57 AVTX 0.46% 95,631 $2M $18.16 $1M +67,853 +244.3%
58 FLS 0.46% 24,958 $2M $69.38 -$340K -14,017 -36.0%
59 XPO 0.46% 12,723 $2M $135.91 -$996K -8,357 -39.6%
60 CEG 0.45% 4,812 $2M $353.27 -$801K -2,788 -36.7%
61 META 0.45% 2,562 $2M $660.09 -$2M -1,938 -43.1%
62 APP 0.44% 2,482 $2M $673.82 — +2,482 — NEW
63 MDGL 0.44% 2,839 $2M $582.34 $31K -698 -19.7%
64 CELC 0.44% 16,543 $2M $99.74 $974K +2,863 +20.9%
65 LITE 0.42% 4,317 $2M $368.59 -$512K -8,610 -66.6%
66 MA 0.42% 2,784 $2M $570.88 -$803K -1,421 -33.8%
67 CLF 0.42% 118,574 $2M $13.28 — +118,574 — NEW
68 FERG 0.41% 6,973 $2M $222.63 -$621K -2,705 -27.9%
69 NEE 0.41% 19,285 $2M $80.28 $359K +3,533 +22.4%
70 UNF 0.39% 7,727 $1M $192.90 — +7,727 — NEW
71 CLH 0.39% 6,243 $1M $234.48 -$651K -2,863 -31.4%
72 EQT 0.38% 27,090 $1M $53.60 — +27,090 — NEW
73 CLDX 0.37% 51,805 $1M $27.16 -$2M -83,453 -61.7%
74 WDAY 0.37% 6,486 $1M $214.78 -$579K -1,705 -20.8%
75 TRVI 0.35% 106,159 $1M $12.52 — +106,159 — NEW
76 CMPX 0.35% 245,532 $1M $5.37 — +245,532 — NEW
77 TMO 0.35% 2,269 $1M $579.45 — +2,269 — NEW
78 TLN 0.35% 3,488 $1M $374.84 -$862K -1,612 -31.6%
79 BKNG 0.34% 243 $1M $5,355.33 $454K +86 +54.8%
80 OFIX 0.34% 85,049 $1M $15.16 -$75K -8,151 -8.8%
81 ELVN 0.34% 82,536 $1M $15.40 -$4M -176,599 -68.2%
82 U 0.33% 28,663 $1M $44.17 -$1M -38,566 -57.4%
83 RDDT 0.32% 5,300 $1M $229.87 -$231K -1,000 -15.9%
84 CGON 0.32% 29,325 $1M $41.52 $169K +3,285 +12.6%
85 CIEN 0.32% 5,185 $1M $233.87 — +5,185 — NEW
86 RBC 0.32% 2,703 $1M $448.43 -$154K -797 -22.8%
87 KBR 0.32% 30,006 $1M $40.20 -$473K -5,494 -15.5%
88 INTU 0.32% 1,813 $1M $662.42 -$276K -350 -16.2%
89 APG 0.31% 30,958 $1M $38.26 -$443K -16,392 -34.6%
90 DYN 0.31% 59,643 $1M $19.56 — +59,643 — NEW
91 P 0.31% 17,409 $1M $67.01 -$543K -2,991 -14.7%
92 ACHC 0.31% 81,630 $1M $14.19 — +81,630 — NEW
93 GEV 0.31% 1,768 $1M $653.57 $141K +118 +7.2%
94 RXO 0.30% 90,938 $1M $12.64 -$95K +10,038 +12.4%
95 IMCR 0.30% 32,998 $1M $34.71 — +32,998 — NEW
96 UTHR 0.30% 2,330 $1M $487.25 — +2,330 — NEW
97 QXO 0.30% 58,720 $1M $19.29 -$587K -31,480 -34.9%
98 CNTA 0.29% 44,490 $1M $25.01 -$422K -18,811 -29.7%
99 PTC 0.29% 6,374 $1M $174.21 -$823K -3,148 -33.1%
100 MTZ 0.29% 5,027 $1M $217.37 -$333K -1,673 -25.0%

New Positions

SymbolValue% Port
TERN $7M 1.87%
MAZE $7M 1.87%
STOK $4M 0.97%
CMPS $3M 0.91%
LBRX $3M 0.82%
PALI $3M 0.81%
TDG $3M 0.76%
AMLX $3M 0.76%
BBOT $3M 0.76%
SEPN $2M 0.58%
RKT $2M 0.50%
UNP $2M 0.49%
APP $2M 0.44%
CLF $2M 0.42%
UNF $1M 0.39%

Sold Out Positions

SymbolValue% Port
BABA — —%
BEKE — —%
PWR — —%
BAC — —%
AVTR — —%
JCI — —%
FN — —%
CNM — —%
TAL — —%
COF — —%
PGR — —%
MAGN — —%
EOLS — —%
AMD — —%
CSCO — —%
View SEC EDGAR Filings for HighVista Strategies LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms