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Asset Manager ← All Institutions

HighVista Strategies LLC

Q4 2025 · Filed 2026-02-17
Market Value
$359M
-9.1%
Holdings
171
+3
New Purchases
30
Added To
23
Closed
35
Reduced
83
Top 10 Concentration
30.3%
Turnover
38.0%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
GPCR 3.74% 1.68% +2.06% $13M
TERN 1.98% 0.00% +1.98% $7M
MAZE 1.97% 0.00% +1.97% $7M
COGT 3.33% 1.68% +1.65% $12M
PHVS 1.26% 0.00% +1.26% $5M
STOK 1.02% 0.00% +1.02% $4M
RLAY 1.29% 0.32% +0.97% $5M
CMPS 0.96% 0.00% +0.96% $3M
LBRX 0.87% 0.00% +0.87% $3M
OCUL 1.16% 0.32% +0.85% $4M
TARS 1.22% 0.37% +0.85% $4M
TDG 0.81% 0.00% +0.81% $3M
AMLX 0.80% 0.00% +0.80% $3M
SYRE 1.72% 0.92% +0.80% $6M
BBOT 0.80% 0.00% +0.80% $3M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
MRUS 0.00% 3.18% -3.18% $0
DBC 6.59% 8.20% -1.61% $24M
AKRO 0.00% 1.32% -1.32% $0
ABVX 2.71% 3.97% -1.26% $10M
SNDK 0.29% 1.35% -1.06% $1M
ELVN 0.35% 1.34% -0.99% $1M
AGIO 1.12% 1.99% -0.87% $4M
XENE 0.00% 0.84% -0.84% $0
MLYS 1.26% 2.02% -0.76% $5M
AMD 0.00% 0.71% -0.71% $0
VERA 0.00% 0.67% -0.67% $0
ACLX 1.36% 2.00% -0.64% $5M
CRH.L 0.00% 0.59% -0.59% $0
SRRK 0.00% 0.56% -0.56% $0
PWR 0.00% 0.55% -0.55% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 14 $21M 6.0%
Large Cap 69 $93M 25.9%
Mid Cap 55 $147M 41.0%
Small Cap 31 $96M 26.7%
Micro Cap 2 $1M 0.4%

Portfolio Analytics

Avg Market Cap
$160.6B
Median Market Cap
$9.2B
Avg P/E
42.6
Median P/E
28.4
Avg Dividend Yield
0.01%
Avg Beta
1.05
# Stocks
170
# ETFs / Funds
1

Top Holdings (171 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 DBC 6.59% 1,057,238 $24M $22.36 -$9M -378,898 -26.4%
2 GPCR 3.74% 193,001 $13M $69.55 $7M -43,235 -18.3%
3 COGT 3.33% 336,667 $12M $35.52 $5M -125,738 -27.2%
4 VRDN 3.23% 372,472 $12M $31.12 $1M -96,863 -20.6%
5 ABVX 2.71% 72,185 $10M $134.85 -$6M -112,283 -60.9%
6 RVMD 2.67% 120,240 $10M $79.65 $1M -55,208 -31.5%
7 NUVL 2.05% 73,287 $7M $100.59 -$696K -20,007 -21.4%
8 CYTK 2.03% 114,564 $7M $63.54 -$26K -18,366 -13.8%
9 TERN 1.98% 175,462 $7M $40.40 +175,462 NEW
10 MAZE 1.97% 170,353 $7M $41.43 +170,353 NEW
11 INSM 1.91% 39,400 $7M $174.04 -$336K -10,549 -21.1%
12 PTGX 1.79% 73,545 $6M $87.34 -$2M -48,137 -39.6%
13 SYRE 1.72% 188,206 $6M $32.76 $3M -27,540 -12.8%
14 BBIO 1.71% 80,205 $6M $76.49 $2M -1,754 -2.1%
15 OLMA 1.68% 241,489 $6M $25.00 $2M -195,690 -44.8%
16 IMVT 1.57% 221,883 $6M $25.42 $2M -31,244 -12.3%
17 LQDA 1.50% 156,003 $5M $34.49 $1M -20,482 -11.6%
18 PCVX 1.47% 114,049 $5M $46.14 $2M +27,247 +31.4%
19 CDTX 1.41% 22,928 $5M $220.89 -$2M -47,976 -67.7%
20 ACLX 1.36% 75,002 $5M $65.20 -$3M -21,175 -22.0%
21 RLAY 1.29% 545,079 $5M $8.46 $3M +304,620 +126.7%
22 RYTM 1.28% 42,867 $5M $107.04 $803K +5,385 +14.4%
23 MLYS 1.26% 124,544 $5M $36.29 -$3M -85,285 -40.6%
24 PHVS 1.26% 162,370 $5M $27.75 +162,370 NEW
25 TARS 1.22% 53,564 $4M $81.88 $3M +28,710 +115.5%
26 EWTX 1.18% 171,137 $4M $24.82 $871K -36,964 -17.8%
27 OCUL 1.16% 344,067 $4M $12.14 $3M +237,456 +222.7%
28 AGIO 1.12% 147,662 $4M $27.22 -$4M -47,636 -24.4%
29 AMZN 1.12% 17,397 $4M $230.82 -$2M -8,996 -34.1%
30 APLS 1.06% 150,776 $4M $25.12 $490K +5,047 +3.5%
31 GH 1.05% 36,758 $4M $102.14 -$281K -27,825 -43.1%
32 STOK 1.02% 115,539 $4M $31.74 +115,539 NEW
33 CMPS 0.96% 498,933 $3M $6.90 +498,933 NEW
34 MSFT 0.88% 6,537 $3M $483.62 -$2M -2,921 -30.9%
35 LBRX 0.87% 140,107 $3M $22.26 +140,107 NEW
36 GHRS 0.85% 240,524 $3M $12.70 -$404K -1,370 -0.6%
37 ARGX 0.84% 3,588 $3M $840.95 $17K -480 -11.8%
38 XOMA 0.84% 112,917 $3M $26.59 -$1M +7,203 +6.8%
39 TDG 0.81% 2,175 $3M $1,329.85 +2,175 NEW
40 RNAM 0.80% 40,020 $3M $72.13 $29K -25,560 -39.0%
41 AMLX 0.80% 238,812 $3M $12.08 +238,812 NEW
42 BBOT 0.80% 229,263 $3M $12.52 +229,263 NEW
43 NVDA 0.74% 14,220 $3M $186.50 $152K +820 +6.1%
44 CRM 0.64% 8,613 $2M $264.91 -$772K -4,272 -33.1%
45 V 0.61% 6,291 $2M $350.71 -$477K -1,570 -20.0%
46 SEPN 0.61% 78,682 $2M $27.88 +78,682 NEW
47 AXSM 0.57% 11,131 $2M $182.64 $898K +1,783 +19.1%
48 DNTH 0.56% 48,484 $2M $41.21 -$136K -5,741 -10.6%
49 GOOG 0.55% 6,277 $2M $313.80 -$417K -3,523 -36.0%
50 AVGO 0.54% 5,639 $2M $346.10 -$1M -4,561 -44.7%
51 RKT 0.53% 97,430 $2M $19.36 +97,430 NEW
52 UNP 0.52% 8,058 $2M $231.32 +8,058 NEW
53 HPE 0.51% 76,181 $2M $24.02 -$594K -22,519 -22.8%
54 FLS 0.48% 24,958 $2M $69.38 -$340K -14,017 -36.0%
55 XPO 0.48% 12,723 $2M $135.91 -$996K -8,357 -39.6%
56 CEG 0.47% 4,812 $2M $353.27 -$801K -2,788 -36.7%
57 META 0.47% 2,562 $2M $660.09 -$2M -1,938 -43.1%
58 APP 0.47% 2,482 $2M $673.82 +2,482 NEW
59 MDGL 0.46% 2,839 $2M $582.34 $31K -698 -19.7%
60 CELC 0.46% 16,543 $2M $99.74 $974K +2,863 +20.9%
61 LITE 0.44% 4,317 $2M $368.59 -$512K -8,610 -66.6%
62 MA 0.44% 2,784 $2M $570.88 -$803K -1,421 -33.8%
63 CLF 0.44% 118,574 $2M $13.28 +118,574 NEW
64 FERG 0.43% 6,973 $2M $222.63 -$621K -2,705 -27.9%
65 NEE 0.43% 19,285 $2M $80.28 $359K +3,533 +22.4%
66 UNF 0.42% 7,727 $1M $192.90 +7,727 NEW
67 CLH 0.41% 6,243 $1M $234.48 -$651K -2,863 -31.4%
68 EQT 0.40% 27,090 $1M $53.60 +27,090 NEW
69 CLDX 0.39% 51,805 $1M $27.16 -$2M -83,453 -61.7%
70 WDAY 0.39% 6,486 $1M $214.78 -$579K -1,705 -20.8%
71 TRVI 0.37% 106,159 $1M $12.52 +106,159 NEW
72 CMPX 0.37% 245,532 $1M $5.37 +245,532 NEW
73 TMO 0.37% 2,269 $1M $579.45 +2,269 NEW
74 TLN 0.36% 3,488 $1M $374.84 -$862K -1,612 -31.6%
75 BKNG 0.36% 243 $1M $5,355.33 $454K +86 +54.8%
76 OFIX 0.36% 85,049 $1M $15.16 -$75K -8,151 -8.8%
77 ELVN 0.35% 82,536 $1M $15.40 -$4M -176,599 -68.2%
78 U 0.35% 28,663 $1M $44.17 -$1M -38,566 -57.4%
79 RDDT 0.34% 5,300 $1M $229.87 -$231K -1,000 -15.9%
80 CGON 0.34% 29,325 $1M $41.52 $169K +3,285 +12.6%
81 CIEN 0.34% 5,185 $1M $233.87 +5,185 NEW
82 RBC 0.34% 2,703 $1M $448.43 -$154K -797 -22.8%
83 KBR 0.34% 30,006 $1M $40.20 -$473K -5,494 -15.5%
84 INTU 0.33% 1,813 $1M $662.42 -$276K -350 -16.2%
85 APG 0.33% 30,958 $1M $38.26 -$443K -16,392 -34.6%
86 DYN 0.33% 59,643 $1M $19.56 +59,643 NEW
87 P 0.33% 17,409 $1M $67.01 -$543K -2,991 -14.7%
88 ACHC 0.32% 81,630 $1M $14.19 +81,630 NEW
89 GEV 0.32% 1,768 $1M $653.57 $141K +118 +7.2%
90 RXO 0.32% 90,938 $1M $12.64 -$95K +10,038 +12.4%
91 IMCR 0.32% 32,998 $1M $34.71 +32,998 NEW
92 UTHR 0.32% 2,330 $1M $487.25 +2,330 NEW
93 QXO 0.32% 58,720 $1M $19.29 -$587K -31,480 -34.9%
94 CNTA 0.31% 44,490 $1M $25.01 -$422K -18,811 -29.7%
95 PTC 0.31% 6,374 $1M $174.21 -$823K -3,148 -33.1%
96 MTZ 0.30% 5,027 $1M $217.37 -$333K -1,673 -25.0%
97 SCHW 0.30% 10,601 $1M $99.91 -$287K -3,499 -24.8%
98 NU 0.29% 62,570 $1M $16.74 -$703K -46,767 -42.8%
99 SNDK 0.29% 4,378 $1M $237.38 -$4M -43,073 -90.8%
100 PFSI 0.29% 7,806 $1M $131.84 -$4K -531 -6.4%

New Positions

SymbolValue% Port
TERN $7M 1.98%
MAZE $7M 1.97%
PHVS $5M 1.26%
STOK $4M 1.02%
CMPS $3M 0.96%
LBRX $3M 0.87%
TDG $3M 0.81%
AMLX $3M 0.80%
BBOT $3M 0.80%
SEPN $2M 0.61%
RKT $2M 0.53%
UNP $2M 0.52%
APP $2M 0.47%
CLF $2M 0.44%
UNF $1M 0.42%

Sold Out Positions

SymbolValue% Port
AVTR —%
BAC —%
BEKE —%
CNM —%
PWR —%
FN —%
JCI —%
COF —%
TAL —%
MAGN —%
PGR —%
CSCO —%
AMD —%
EOLS —%
ENTG —%
View SEC EDGAR Filings for HighVista Strategies LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms