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Asset Manager ← All Institutions

Sofinnova Investments, Inc.

Q1 2026 · Filed 2026-05-15
Market Value
$1.9B
-5.3%
Holdings
70
+9
New Purchases
15
Added To
23
Closed
14
Reduced
9
Top 10 Concentration
56.8%
Turnover
41.4%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
AZN 4.62% 0.00% +4.62% $90M
RARE 3.39% 0.09% +3.29% $66M
BMY 6.20% 3.97% +2.23% $121M
BIIB 2.16% 0.00% +2.16% $42M
AXSM 1.85% 0.11% +1.74% $36M
INSM 2.91% 1.33% +1.58% $57M
ALC 2.83% 1.28% +1.55% $55M
SUPN 2.53% 1.34% +1.20% $49M
UTHR 4.88% 3.74% +1.14% $95M
GMAB 1.04% 0.00% +1.04% $20M
NKTR 1.88% 0.90% +0.98% $37M
XENE 0.91% 0.13% +0.78% $18M
COGT 4.18% 3.41% +0.77% $81M
SYK 0.75% 0.00% +0.75% $15M
CELC 2.15% 1.45% +0.69% $42M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
VRTX 0.00% 3.63% -3.63% $0
ABBV 0.00% 3.53% -3.53% $0
ISRG 0.00% 3.50% -3.50% $0
LLY 0.00% 3.22% -3.22% $0
RNAM 0.00% 2.61% -2.61% $0
JAZZ 5.81% 7.94% -2.13% $113M
CDTX 0.00% 1.94% -1.94% $0
GKOS 0.00% 1.58% -1.58% $0
NTRA 15.93% 17.28% -1.35% $310M
CNTA 0.00% 1.34% -1.34% $0
BBIO 1.56% 2.68% -1.12% $30M
VERA 5.78% 6.88% -1.11% $112M
GEHC 0.00% 0.64% -0.64% $0
DYN 1.52% 2.15% -0.62% $30M
EXAS 0.00% 0.50% -0.50% $0

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 3 $90M 4.6%
Large Cap 19 $976M 50.1%
Mid Cap 27 $605M 31.1%
Small Cap 16 $261M 13.4%
Micro Cap 5 $15M 0.7%

Portfolio Analytics

Avg Market Cap
$37.6B
Median Market Cap
$3.6B
Avg P/E
36.5
Median P/E
27.7
Avg Dividend Yield
0.00%
Avg Beta
0.81
# Stocks
70
# ETFs / Funds
0

Top Holdings (70 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 NTRA 15.93% 1,550,280 $310M $199.99 -$45M
2 BMY 6.20% 1,988,721 $121M $60.65 $39M +475,727 +31.4%
3 JAZZ 5.81% 598,327 $113M $189.05 -$50M -361,533 -37.7%
4 VERA 5.78% 2,793,987 $112M $40.23 -$29M
5 UTHR 4.88% 160,070 $95M $592.98 $18M +2,429 +1.5%
6 AZN 4.62% 456,031 $90M $197.22 +456,031 NEW
7 COGT 4.18% 2,113,551 $81M $38.49 $11M +139,926 +7.1%
8 RARE 3.39% 3,145,888 $66M $20.95 $64M +3,062,588 +3676.6%
9 RAPP 3.06% 1,904,408 $60M $31.29 $2M
10 INSM 2.91% 346,075 $57M $163.52 $29M +189,274 +120.7%
11 ALC 2.83% 729,972 $55M $75.35 $29M +397,452 +119.5%
12 SUPN 2.53% 954,309 $49M $51.69 $22M +401,214 +72.5%
13 BMRN 2.27% 781,982 $44M $56.49 $3M +84,849 +12.2%
14 BIIB 2.16% 229,521 $42M $183.33 +229,521 NEW
15 CELC 2.15% 366,175 $42M $114.14 $12M +66,758 +22.3%
16 BIOA 2.06% 2,293,788 $40M $17.49 $10M
17 RYTM 2.01% 450,096 $39M $86.97 $10M +178,702 +65.8%
18 AVBP 2.01% 1,696,752 $39M $23.07 $5M
19 IDYA 1.94% 1,131,786 $38M $33.32 $7M +246,665 +27.9%
20 IMNM 1.91% 1,701,904 $37M $21.87 $2M +83,427 +5.2%
21 NKTR 1.88% 509,546 $37M $71.95 $18M +70,916 +16.2%
22 AXSM 1.85% 212,747 $36M $169.02 $34M +200,481 +1634.4%
23 IMTX 1.84% 3,630,454 $36M $9.84 -$350K +194,912 +5.7%
24 BBIO 1.56% 409,183 $30M $74.26 -$25M -311,265 -43.2%
25 DYN 1.52% 1,633,897 $30M $18.13 -$14M -620,264 -27.5%
26 DXCM 1.27% 393,576 $25M $62.80 -$386K +15,357 +4.1%
27 PHVS 1.19% 818,328 $23M $28.25 $2M +73,159 +9.8%
28 GMAB 1.04% 752,261 $20M $26.83 +752,261 NEW
29 RCUS 1.02% 923,086 $20M $21.60 -$6M -173,619 -15.8%
30 XENE 0.91% 305,216 $18M $58.15 $15M +245,316 +409.5%
31 SYK 0.75% 44,480 $15M $328.59 +44,480 NEW
32 ANAB 0.71% 248,253 $14M $55.46 -$179K -39,437 -13.7%
33 ROIV 0.68% 477,995 $13M $27.70 -$3M -256,587 -34.9%
34 EWTX 0.63% 386,498 $12M $31.50 $1M -51,321 -11.7%
35 CMPX 0.56% 2,056,161 $11M $5.29 -$7M -1,309,285 -38.9%
36 ORIC 0.44% 679,578 $9M $12.67 +679,578 NEW
37 TNGX 0.42% 395,081 $8M $20.92 +395,081 NEW
38 TYRA 0.40% 204,015 $8M $38.30 +204,015 NEW
39 AXGN 0.36% 210,665 $7M $33.13 +210,665 NEW
40 DFTX 0.33% 344,166 $7M $18.90 +344,166 NEW
41 CYTK 0.31% 91,791 $6M $65.91 +91,791 NEW
42 IRON 0.26% 78,320 $5M $63.94 -$4M -32,690 -29.4%
43 MANE 0.24% 73,315 $5M $63.15 +73,315 NEW
44 HRMY 0.22% 152,695 $4M $28.01 +152,695 NEW
45 PCVX 0.15% 50,600 $3M $58.11 +50,600 NEW
46 MIRM 0.13% 27,591 $3M $92.38 $724K +4,491 +19.4%
47 NXTC 0.12% 222,654 $2M $10.68 -$782K
48 SVRA 0.10% 364,763 $2M $5.46 $154K +59,993 +19.7%
49 ESTA 0.10% 33,930 $2M $56.78 -$141K +5,564 +19.6%
50 ACAD 0.09% 78,551 $2M $22.26 -$3K +12,984 +19.8%
51 JBIO 0.08% 107,391 $2M $14.05 -$148K
52 WVE 0.07% 189,253 $1M $7.25 -$1M +31,071 +19.6%
53 SEPN 0.06% 47,506 $1M $24.03 +47,506 NEW
54 OKUR 0.03% 141,700 $587K $4.14 +141,700 NEW
55 BOLT 0.03% 137,721 $556K $4.04 -$197K
56 IMA 0.01% 31,884 $159K $5.00 -$61K
57 CNTA —% -$28M -1,104,274 -100.0% SOLD
58 EVMN —% -$3M -153,320 -100.0% SOLD
59 GEHC —% -$13M -160,876 -100.0% SOLD
60 GKOS —% -$33M -288,128 -100.0% SOLD
61 ISRG —% -$72M -126,968 -100.0% SOLD
62 AMLX —% -$6M -527,099 -100.0% SOLD
63 MASI —% -$6M -46,201 -100.0% SOLD
64 RNAM —% -$54M -745,116 -100.0% SOLD
65 VRTX —% -$75M -164,594 -100.0% SOLD
66 QURE —% -$4M -176,513 -100.0% SOLD
67 CDTX —% -$40M -180,265 -100.0% SOLD
68 EXAS —% -$10M -101,443 -100.0% SOLD
69 ABBV —% -$73M -317,783 -100.0% SOLD
70 LLY —% -$66M -61,652 -100.0% SOLD

Options Breakdown

4 Calls $40M Call Value 9 Puts $595M Put Value 14.8 P/C Ratio

Top Calls

SymbolSharesValueStatus
PFE 800,000 $22M NEW
REPL 1,015,400 $8M NEW
RARE 350,000 $7M NEW
CMPX 500,000 $3M NEW

Top Puts

SymbolSharesValueStatus
IWM 600,000 $149M NEW
XBI 1,050,000 $134M NEW
QQQ 150,000 $87M NEW
IBB 475,000 $80M NEW
UTHR 80,300 $48M NEW
CELC 300,000 $34M NEW
AXSM 200,000 $34M NEW
LQDA 500,000 $19M NEW
EXEL 251,500 $11M NEW

New Positions

SymbolValue% Port
AZN $90M 4.62%
BIIB $42M 2.16%
GMAB $20M 1.04%
SYK $15M 0.75%
ORIC $9M 0.44%
TNGX $8M 0.42%
TYRA $8M 0.40%
AXGN $7M 0.36%
DFTX $7M 0.33%
CYTK $6M 0.31%
MANE $5M 0.24%
HRMY $4M 0.22%
PCVX $3M 0.15%
SEPN $1M 0.06%
OKUR $587K 0.03%

Sold Out Positions

SymbolValue% Port
ABBV —%
LLY —%
GKOS —%
EVMN —%
MASI —%
CNTA —%
AMLX —%
GEHC —%
ISRG —%
QURE —%
VRTX —%
RNAM —%
EXAS —%
CDTX —%
View SEC EDGAR Filings for Sofinnova Investments, Inc. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms