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Asset Manager ← All Institutions

Sofinnova Investments, Inc.

Q4 2025 · Filed 2026-02-13
Market Value
$2.1B
+39.1%
Holdings
62
+3
New Purchases
11
Added To
20
Closed
6
Reduced
17
Top 10 Concentration
54.8%
Turnover
27.4%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
BMY 3.81% 0.00% +3.81% $82M
LLY 3.09% 0.00% +3.09% $66M
JAZZ 7.62% 5.04% +2.58% $163M
BMRN 1.93% 0.00% +1.93% $41M
CDTX 1.86% 0.34% +1.52% $40M
VERA 6.61% 5.27% +1.33% $141M
IMNM 1.62% 0.33% +1.29% $35M
CNTA 1.29% 0.00% +1.29% $28M
COGT 3.27% 1.99% +1.29% $70M
DYN 2.06% 0.81% +1.25% $44M
ALC 1.22% 0.00% +1.22% $26M
PRAX 1.73% 0.60% +1.14% $37M
ABBV 3.39% 2.27% +1.12% $73M
INBX 1.68% 0.96% +0.71% $36M
CELC 1.39% 0.81% +0.58% $30M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
GILD 0.00% 9.03% -9.03% $0
BSX 0.00% 3.61% -3.61% $0
AXSM 0.10% 3.10% -3.00% $2M
ROIV 0.74% 3.10% -2.35% $16M
DXCM 1.17% 3.41% -2.24% $25M
UTHR 3.59% 5.19% -1.61% $77M
AKRO 0.00% 1.46% -1.46% $0
RAPP 2.70% 3.76% -1.06% $58M
MRUS 0.00% 1.02% -1.02% $0
EXAS 0.48% 1.30% -0.82% $10M
PTCT 0.00% 0.75% -0.75% $0
SLNO 0.03% 0.73% -0.70% $575K
SVRA 0.09% 0.56% -0.48% $2M
AVBP 1.59% 2.03% -0.44% $34M
RYTM 1.36% 1.62% -0.26% $29M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 2 $139M 6.5%
Large Cap 17 $1.1B 51.0%
Mid Cap 26 $617M 28.8%
Small Cap 11 $239M 11.1%
Micro Cap 6 $55M 2.6%

Portfolio Analytics

Avg Market Cap
$42.2B
Median Market Cap
$5.2B
Avg P/E
41.8
Median P/E
28.1
Avg Dividend Yield
0.00%
Avg Beta
0.85
# Stocks
62
# ETFs / Funds
0

Top Holdings (62 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 NTRA 16.58% 1,550,280 $355M $229.09 $106M — —
2 JAZZ 7.62% 959,860 $163M $170.00 $86M +371,032 +63.0%
3 VERA 6.61% 2,793,987 $141M $50.64 $60M — —
4 BMY 3.81% 1,512,994 $82M $53.94 — +1,512,994 — NEW
5 UTHR 3.59% 157,641 $77M $487.25 -$3M -32,985 -17.3%
6 VRTX 3.48% 164,594 $75M $453.36 $28M +46,719 +39.6%
7 ABBV 3.39% 317,783 $73M $228.49 $38M +166,817 +110.5%
8 ISRG 3.36% 126,968 $72M $566.36 $22M +16,072 +14.5%
9 COGT 3.27% 1,973,625 $70M $35.52 $40M -154,316 -7.2%
10 LLY 3.09% 61,652 $66M $1,074.68 — +61,652 — NEW
11 RAPP 2.70% 1,904,408 $58M $30.34 -$63K -43,171 -2.2%
12 BBIO 2.57% 720,448 $55M $76.49 $12M -111,399 -13.4%
13 RNAM 2.51% 745,116 $54M $72.13 $16M -130,809 -14.9%
14 DYN 2.06% 2,254,161 $44M $19.56 $32M +1,268,333 +128.7%
15 BMRN 1.93% 697,133 $41M $59.43 — +697,133 — NEW
16 APGE 1.89% 534,845 $40M $75.48 $18M -30,572 -5.4%
17 CDTX 1.86% 180,265 $40M $220.89 $35M +126,068 +232.6%
18 PRAX 1.73% 125,722 $37M $294.74 $28M -47,111 -27.3%
19 IMTX 1.68% 3,435,542 $36M $10.50 $17M +1,207,705 +54.2%
20 INBX 1.68% 454,657 $36M $79.00 $21M +14,565 +3.3%
21 IMNM 1.62% 1,618,477 $35M $21.48 $30M +1,182,426 +271.2%
22 AVBP 1.59% 1,696,752 $34M $20.12 $3M — —
23 GKOS 1.52% 288,128 $33M $112.91 $7M -24,866 -7.9%
24 IDYA 1.43% 885,121 $31M $34.57 $5M -37,574 -4.1%
25 BIOA 1.42% 2,293,788 $30M $13.23 $17M — —
26 CELC 1.39% 299,417 $30M $99.74 $17M +46,042 +18.2%
27 RYTM 1.36% 271,394 $29M $107.04 $4M +24,428 +9.9%
28 CNTA 1.29% 1,104,274 $28M $25.01 — +1,104,274 — NEW
29 SUPN 1.28% 553,095 $27M $49.70 $9M +176,029 +46.7%
30 INSM 1.27% 156,801 $27M $174.04 $12M +52,462 +50.3%
31 ALC 1.22% 332,520 $26M $78.81 — +332,520 — NEW
32 RCUS 1.22% 1,096,705 $26M $23.83 $10M -125,558 -10.3%
33 DXCM 1.17% 378,219 $25M $66.37 -$27M -401,397 -51.5%
34 NKTR 0.87% 438,630 $19M $42.28 $12M +320,211 +270.4%
35 CMPX 0.84% 3,365,446 $18M $5.37 $11M +1,336,560 +65.9%
36 ROIV 0.74% 734,582 $16M $21.70 -$32M -2,414,688 -76.7%
37 ANAB 0.65% 287,690 $14M $48.48 $6M +33,422 +13.1%
38 GEHC 0.62% 160,876 $13M $82.02 $2M +9,791 +6.5%
39 EWTX 0.51% 437,819 $11M $24.81 $2M -82,421 -15.8%
40 EXAS 0.48% 101,443 $10M $101.56 -$10M -263,557 -72.2%
41 IRON 0.41% 111,010 $9M $79.41 $8M +97,457 +719.1%
42 AMLX 0.30% 527,099 $6M $12.08 — +527,099 — NEW
43 MASI 0.28% 46,201 $6M $130.06 — +46,201 — NEW
44 NXTC 0.15% 222,654 $3M $14.19 $2M — —
45 XENE 0.13% 59,900 $3M $44.82 — +59,900 — NEW
46 EVMN 0.12% 153,320 $3M $17.12 — +153,320 — NEW
47 AXSM 0.10% 12,266 $2M $182.64 -$46M -381,233 -96.9%
48 ESTA 0.10% 28,366 $2M $72.88 $2M +17,579 +163.0%
49 RARE 0.09% 83,300 $2M $23.00 — +83,300 — NEW
50 SVRA 0.09% 304,770 $2M $6.03 -$7M -2,122,954 -87.5%
51 MIRM 0.09% 23,100 $2M $78.99 — +23,100 — NEW
52 ACAD 0.08% 65,567 $2M $26.71 $1M +38,767 +144.7%
53 JBIO 0.08% 107,391 $2M $15.43 $730K — —
54 BOLT 0.04% 137,721 $753K $5.47 $20K — —
55 SLNO 0.03% 12,414 $575K $46.30 -$11M -153,867 -92.5%
56 IMA 0.01% 31,884 $220K $6.90 -$40K — —
57 SRRK —% — — — -$1M -31,410 -100.0% SOLD
58 MRUS —% — — — -$16M -166,729 -100.0% SOLD
59 GILD —% — — — -$139M -1,252,312 -100.0% SOLD
60 BSX —% — — — -$56M -569,427 -100.0% SOLD
61 PTCT —% — — — -$11M -186,932 -100.0% SOLD
62 AKRO —% — — — -$22M -473,625 -100.0% SOLD

Options Breakdown

1 Calls $0 Call Value 4 Puts $0 Put Value

Top Calls

SymbolSharesValueStatus
SMMT — $0 SOLD

Top Puts

SymbolSharesValueStatus
IBB — $0 SOLD
LQDA — $0 SOLD
UTHR — $0 SOLD
XBI — $0 SOLD

New Positions

SymbolValue% Port
BMY $82M 3.81%
LLY $66M 3.09%
BMRN $41M 1.93%
CNTA $28M 1.29%
ALC $26M 1.22%
AMLX $6M 0.30%
MASI $6M 0.28%
XENE $3M 0.13%
EVMN $3M 0.12%
RARE $2M 0.09%
MIRM $2M 0.09%

Sold Out Positions

SymbolValue% Port
BSX — —%
GILD — —%
PTCT — —%
SRRK — —%
AKRO — —%
MRUS — —%
View SEC EDGAR Filings for Sofinnova Investments, Inc. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms