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Sofinnova Investments, Inc.

Q4 2025 · Filed 2026-02-13
Market Value
$2.1B
+36.2%
Holdings
61
+3
New Purchases
11
Added To
21
Closed
6
Reduced
15
Top 10 Concentration
57.1%
Turnover
27.9%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
BMY 3.97% 0.00% +3.97% $82M
LLY 3.22% 0.00% +3.22% $66M
JAZZ 7.94% 5.14% +2.80% $163M
BMRN 2.02% 0.00% +2.02% $41M
CDTX 1.94% 0.34% +1.59% $40M
VERA 6.88% 5.38% +1.50% $141M
COGT 3.41% 2.02% +1.39% $70M
IMNM 1.69% 0.34% +1.35% $35M
CNTA 1.34% 0.00% +1.34% $28M
DYN 2.15% 0.83% +1.32% $44M
ALC 1.28% 0.00% +1.28% $26M
ABBV 3.53% 2.32% +1.22% $73M
NTRA 17.28% 16.53% +0.75% $355M
CELC 1.45% 0.83% +0.62% $30M
BIOA 1.48% 0.89% +0.58% $30M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
GILD 0.00% 9.21% -9.21% $0
BSX 0.00% 3.68% -3.68% $0
AXSM 0.11% 3.17% -3.06% $2M
ROIV 0.78% 3.16% -2.38% $16M
DXCM 1.22% 3.48% -2.25% $25M
UTHR 3.74% 5.29% -1.56% $77M
AKRO 0.00% 1.49% -1.49% $0
MRUS 0.00% 1.04% -1.04% $0
RAPP 2.81% 3.83% -1.02% $58M
EXAS 0.50% 1.32% -0.82% $10M
PTCT 0.00% 0.76% -0.76% $0
SVRA 0.09% 0.57% -0.48% $2M
AVBP 1.66% 2.07% -0.41% $34M
QURE 0.21% 0.53% -0.32% $4M
RYTM 1.41% 1.65% -0.24% $29M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 2 $139M 6.8%
Large Cap 18 $1.1B 53.2%
Mid Cap 25 $583M 28.4%
Small Cap 12 $217M 10.6%
Micro Cap 4 $22M 1.1%

Portfolio Analytics

Avg Market Cap
$39.7B
Median Market Cap
$5.0B
Avg P/E
39.9
Median P/E
27.6
Avg Dividend Yield
0.00%
Avg Beta
0.75
# Stocks
61
# ETFs / Funds
0

Top Holdings (61 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 NTRA 17.28% 1,550,280 $355M $229.09 $106M
2 JAZZ 7.94% 959,860 $163M $170.00 $86M +371,032 +63.0%
3 VERA 6.88% 2,793,987 $141M $50.64 $60M
4 BMY 3.97% 1,512,994 $82M $53.94 +1,512,994 NEW
5 UTHR 3.74% 157,641 $77M $487.25 -$3M -32,985 -17.3%
6 VRTX 3.63% 164,594 $75M $453.36 $28M +46,719 +39.6%
7 ABBV 3.53% 317,783 $73M $228.49 $38M +166,817 +110.5%
8 ISRG 3.50% 126,968 $72M $566.36 $22M +16,072 +14.5%
9 COGT 3.41% 1,973,625 $70M $35.52 $40M -154,316 -7.2%
10 LLY 3.22% 61,652 $66M $1,074.68 +61,652 NEW
11 RAPP 2.81% 1,904,408 $58M $30.34 -$63K -43,171 -2.2%
12 BBIO 2.68% 720,448 $55M $76.49 $12M -111,399 -13.4%
13 RNAM 2.61% 745,116 $54M $72.13 $16M -130,809 -14.9%
14 DYN 2.15% 2,254,161 $44M $19.56 $32M +1,268,333 +128.7%
15 BMRN 2.02% 697,133 $41M $59.43 +697,133 NEW
16 CDTX 1.94% 180,265 $40M $220.89 $35M +126,068 +232.6%
17 IMTX 1.76% 3,435,542 $36M $10.50 $17M +1,207,705 +54.2%
18 IMNM 1.69% 1,618,477 $35M $21.48 $30M +1,182,426 +271.2%
19 AVBP 1.66% 1,696,752 $34M $20.12 $3M
20 GKOS 1.58% 288,128 $33M $112.91 $7M -24,866 -7.9%
21 IDYA 1.49% 885,121 $31M $34.57 $5M -37,574 -4.1%
22 BIOA 1.48% 2,293,788 $30M $13.23 $17M
23 CELC 1.45% 299,417 $30M $99.74 $17M +46,042 +18.2%
24 RYTM 1.41% 271,394 $29M $107.04 $4M +24,428 +9.9%
25 CNTA 1.34% 1,104,274 $28M $25.01 +1,104,274 NEW
26 SUPN 1.34% 553,095 $27M $49.70 $9M +176,029 +46.7%
27 INSM 1.33% 156,801 $27M $174.04 $12M +52,462 +50.3%
28 ALC 1.28% 332,520 $26M $78.81 +332,520 NEW
29 RCUS 1.27% 1,096,705 $26M $23.83 $10M -125,558 -10.3%
30 DXCM 1.22% 378,219 $25M $66.37 -$27M -401,397 -51.5%
31 PHVS 1.01% 745,169 $21M $27.75 $2M +5,293 +0.7%
32 NKTR 0.90% 438,630 $19M $42.28 $12M +320,211 +270.4%
33 CMPX 0.88% 3,365,446 $18M $5.37 $11M +1,336,560 +65.9%
34 ROIV 0.78% 734,582 $16M $21.70 -$32M -2,414,688 -76.7%
35 ANAB 0.68% 287,690 $14M $48.48 $6M +33,422 +13.1%
36 GEHC 0.64% 160,876 $13M $82.02 $2M +9,791 +6.5%
37 EWTX 0.53% 437,819 $11M $24.81 $2M -82,421 -15.8%
38 EXAS 0.50% 101,443 $10M $101.56 -$10M -263,557 -72.2%
39 IRON 0.43% 111,010 $9M $79.41 $8M +97,457 +719.1%
40 AMLX 0.31% 527,099 $6M $12.08 +527,099 NEW
41 MASI 0.29% 46,201 $6M $130.06 +46,201 NEW
42 QURE 0.21% 176,513 $4M $23.93 -$4M +39,651 +29.0%
43 NXTC 0.15% 222,654 $3M $14.19 $2M
44 WVE 0.13% 158,182 $3M $17.00 $1M -12,761 -7.5%
45 XENE 0.13% 59,900 $3M $44.82 +59,900 NEW
46 EVMN 0.13% 153,320 $3M $17.12 +153,320 NEW
47 AXSM 0.11% 12,266 $2M $182.64 -$46M -381,233 -96.9%
48 ESTA 0.10% 28,366 $2M $72.88 $2M +17,579 +163.0%
49 RARE 0.09% 83,300 $2M $23.00 +83,300 NEW
50 SVRA 0.09% 304,770 $2M $6.03 -$7M -2,122,954 -87.5%
51 MIRM 0.09% 23,100 $2M $78.99 +23,100 NEW
52 ACAD 0.09% 65,567 $2M $26.71 $1M +38,767 +144.7%
53 JBIO 0.08% 107,391 $2M $15.43 $730K
54 BOLT 0.04% 137,721 $753K $5.47 $20K
55 IMA 0.01% 31,884 $220K $6.90 -$40K
56 MRUS —% -$16M -166,729 -100.0% SOLD
57 SRRK —% -$1M -31,410 -100.0% SOLD
58 PTCT —% -$11M -186,932 -100.0% SOLD
59 AKRO —% -$22M -473,625 -100.0% SOLD
60 GILD —% -$139M -1,252,312 -100.0% SOLD
61 BSX —% -$56M -569,427 -100.0% SOLD

Options Breakdown

2 Calls $0 Call Value 5 Puts $0 Put Value

Top Calls

SymbolSharesValueStatus
QURE $0 SOLD
SMMT $0 SOLD

Top Puts

SymbolSharesValueStatus
QURE $0 SOLD
IBB $0 SOLD
UTHR $0 SOLD
LQDA $0 SOLD
XBI $0 SOLD

New Positions

SymbolValue% Port
BMY $82M 3.97%
LLY $66M 3.22%
BMRN $41M 2.02%
CNTA $28M 1.34%
ALC $26M 1.28%
AMLX $6M 0.31%
MASI $6M 0.29%
XENE $3M 0.13%
EVMN $3M 0.13%
RARE $2M 0.09%
MIRM $2M 0.09%

Sold Out Positions

SymbolValue% Port
BSX —%
GILD —%
PTCT —%
SRRK —%
AKRO —%
MRUS —%
View SEC EDGAR Filings for Sofinnova Investments, Inc. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms