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Asset Manager ← All Institutions

Sofinnova Investments, Inc.

Q2 2025 · Filed 2025-08-14
Market Value
$1.4B
+9.9%
Holdings
63
-5
New Purchases
9
Added To
17
Closed
14
Reduced
15
Top 10 Concentration
58.8%
Turnover
36.5%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
GILD 8.32% 3.69% +4.64% $116M
ABBV 3.53% 0.00% +3.53% $49M
BSX 3.31% 0.00% +3.31% $46M
UTHR 2.43% 0.00% +2.43% $34M
ISRG 2.74% 0.47% +2.28% $38M
LLY 5.41% 3.42% +1.98% $76M
MRUS 1.52% 0.00% +1.52% $21M
NTRA 18.72% 17.22% +1.50% $262M
ROIV 2.49% 1.01% +1.47% $35M
DXCM 3.27% 2.12% +1.14% $46M
QURE 1.55% 0.45% +1.10% $22M
BBIO 3.06% 1.99% +1.07% $43M
INZY 1.22% 0.31% +0.92% $17M
CDTX 0.87% 0.00% +0.87% $12M
EXAS 0.79% 0.00% +0.79% $11M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
SYK 0.00% 8.73% -8.73% $0
MDT 0.00% 3.97% -3.97% $0
ALNY 0.00% 3.74% -3.74% $0
BPMC 0.00% 1.81% -1.81% $0
BMY 0.00% 1.78% -1.78% $0
INCY 0.00% 1.70% -1.70% $0
SRPT 0.00% 1.64% -1.64% $0
SNDX 1.02% 2.20% -1.17% $14M
PTCT 1.31% 2.32% -1.01% $18M
DHR 0.00% 0.94% -0.94% $0
AXSM 0.70% 1.61% -0.91% $10M
PEN 0.00% 0.90% -0.90% $0
SVRA 0.40% 1.19% -0.79% $6M
AVTE 0.00% 0.74% -0.74% $0
REPL 1.20% 1.90% -0.70% $17M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 2 $125M 8.9%
Large Cap 20 $763M 54.6%
Mid Cap 22 $331M 23.6%
Small Cap 16 $162M 11.6%
Micro Cap 3 $18M 1.3%

Portfolio Analytics

Avg Market Cap
$41.8B
Median Market Cap
$3.5B
Avg P/E
38.6
Median P/E
29.8
Avg Dividend Yield
0.00%
Avg Beta
0.74
# Stocks
63
# ETFs / Funds
0

Top Holdings (63 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 NTRA 18.72% 1,550,280 $262M $168.94 $43M
2 GILD 8.32% 1,050,308 $116M $110.87 $70M +631,408 +150.7%
3 LLY 5.41% 97,018 $76M $779.53 $32M +44,218 +83.8%
4 JAZZ 5.26% 694,096 $74M $106.12 $10M +184,046 +36.1%
5 VERA 4.70% 2,793,987 $66M $23.56 -$1M
6 ABBV 3.53% 265,850 $49M $185.62 +265,850 NEW
7 BSX 3.31% 431,200 $46M $107.41 +431,200 NEW
8 DXCM 3.27% 523,694 $46M $87.29 $19M +127,719 +32.2%
9 IDYA 3.23% 2,147,795 $45M $21.02 $2M -474,397 -18.1%
10 BBIO 3.06% 993,093 $43M $43.18 $17M +258,866 +35.3%
11 ISRG 2.74% 70,642 $38M $543.41 $32M +58,658 +489.5%
12 RYTM 2.65% 586,010 $37M $63.19 $13M +139,171 +31.1%
13 AVBP 2.64% 1,696,752 $37M $21.77 $6M
14 ROIV 2.49% 3,088,814 $35M $11.27 $22M +1,809,304 +141.4%
15 UTHR 2.43% 118,513 $34M $287.35 +118,513 NEW
16 INSM 2.26% 313,923 $32M $100.64 $8M +9,669 +3.2%
17 AKRO 2.09% 548,788 $29M $53.36 $9M +38,768 +7.6%
18 SUPN 1.80% 799,253 $25M $31.52 $8M +278,575 +53.5%
19 ANAB 1.64% 1,032,362 $23M $22.20 $1M -127,671 -11.0%
20 RAPP 1.62% 1,995,594 $23M $11.37 $3M
21 QURE 1.55% 1,558,356 $22M $13.94 $16M +1,012,585 +185.5%
22 MRUS 1.52% 404,562 $21M $52.60 +404,562 NEW
23 PTCT 1.31% 375,939 $18M $48.84 -$11M -203,400 -35.1%
24 INZY 1.22% 4,280,308 $17M $4.00 $13M
25 COGT 1.21% 2,355,505 $17M $7.18 $4M +173,384 +8.0%
26 REPL 1.20% 1,806,529 $17M $9.29 -$7M -673,410 -27.1%
27 RNAM 1.19% 584,801 $17M $28.40 $5M +204,870 +53.9%
28 SNDX 1.02% 1,524,440 $14M $9.37 -$14M -750,783 -33.0%
29 CDTX 0.87% 251,031 $12M $48.71 +251,031 NEW
30 IMTX 0.86% 2,240,528 $12M $5.38 $5M +686,224 +44.1%
31 EXAS 0.79% 208,300 $11M $53.14 +208,300 NEW
32 PHVS 0.74% 585,532 $10M $17.60 $989K -7,871 -1.3%
33 RCUS 0.71% 1,216,016 $10M $8.14 $2M +178,240 +17.2%
34 YMAB 0.71% 2,194,278 $10M $4.51 $176K
35 AXSM 0.70% 93,610 $10M $104.39 -$11M -81,707 -46.6%
36 BIOA 0.68% 2,304,901 $10M $4.13 $853K
37 EWTX 0.67% 716,873 $9M $13.11 $2M +374,655 +109.5%
38 IMNM 0.52% 778,476 $7M $9.30 $2M -10,190 -1.3%
39 DYN 0.42% 614,865 $6M $9.52 -$2M -102,031 -14.2%
40 SVRA 0.40% 2,457,352 $6M $2.28 -$10M -3,024,314 -55.2%
41 ESTA 0.09% 28,120 $1M $42.71 $31K -555 -1.9%
42 JBIO 0.08% 107,391 $1M $9.99 +107,391 NEW
43 MTSR 0.07% 36,191 $1M $28.45 $28K -609 -1.6%
44 SRRK 0.07% 26,440 $937K $35.42 -$3M -89,677 -77.2%
45 BOLT 0.06% 137,721 $795K $5.77 +137,721 NEW
46 WVE 0.05% 117,903 $766K $6.50 +117,903 NEW
47 GPCR 0.05% 34,353 $712K $20.74 $107K -599 -1.7%
48 IKNA 0.04% 382,616 $513K $1.34 $23K
49 IRON 0.03% 7,312 $387K $52.96 $16K -173 -2.3%
50 SYK —% -$111M -298,567 -100.0% SOLD
51 ALNY —% -$48M -176,181 -100.0% SOLD
52 BMY —% -$23M -371,497 -100.0% SOLD
53 AVTE —% -$9M -3,758,686 -100.0% SOLD
54 PEN —% -$11M -42,936 -100.0% SOLD
55 ERAS —% -$3M -1,877,085 -100.0% SOLD
56 ELVN —% -$660K -33,547 -100.0% SOLD
57 DHR —% -$12M -58,606 -100.0% SOLD
58 BPMC —% -$23M -261,039 -100.0% SOLD
59 KURA —% -$5M -791,667 -100.0% SOLD
60 VIR —% -$538K -83,010 -100.0% SOLD
61 MDT —% -$51M -562,992 -100.0% SOLD
62 INCY —% -$22M -357,800 -100.0% SOLD
63 SRPT —% -$21M -327,618 -100.0% SOLD

Options Breakdown

5 Calls $36M Call Value 6 Puts $130M Put Value 3.62 P/C Ratio

Top Calls

SymbolSharesValueStatus
SMMT 700,000 $15M NEW
ROIV 1,000,000 $11M NEW
CDTX 100,000 $5M NEW
COGT 660,000 $5M NEW
ACAD $0 SOLD

Top Puts

SymbolSharesValueStatus
IWM 250,000 $54M
IBB 375,000 $47M NEW
RYTM 225,000 $14M NEW
REPL 1,500,000 $14M NEW
QQQ $0 SOLD
EWTX $0 SOLD

New Positions

SymbolValue% Port
ABBV $49M 3.53%
BSX $46M 3.31%
UTHR $34M 2.43%
MRUS $21M 1.52%
CDTX $12M 0.87%
EXAS $11M 0.79%
JBIO $1M 0.08%
BOLT $795K 0.06%
WVE $766K 0.05%

Sold Out Positions

SymbolValue% Port
BMY —%
DHR —%
PEN —%
SYK —%
MDT —%
ERAS —%
ELVN —%
KURA —%
ALNY —%
INCY —%
VIR —%
SRPT —%
BPMC —%
AVTE —%
View SEC EDGAR Filings for Sofinnova Investments, Inc. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms