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Sofinnova Investments, Inc.

Q3 2025 · Filed 2025-11-14
Market Value
$1.5B
+7.9%
Holdings
58
-5
New Purchases
9
Added To
15
Closed
8
Reduced
21
Top 10 Concentration
59.0%
Turnover
29.3%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
VRTX 3.06% 0.00% +3.06% $46M
UTHR 5.29% 2.43% +2.86% $80M
AXSM 3.17% 0.70% +2.47% $48M
RAPP 3.83% 1.62% +2.21% $58M
GKOS 1.69% 0.00% +1.69% $26M
RNAM 2.53% 1.19% +1.34% $38M
GILD 9.21% 8.32% +0.89% $139M
CELC 0.83% 0.00% +0.83% $13M
COGT 2.02% 1.21% +0.82% $31M
GEHC 0.75% 0.00% +0.75% $11M
VERA 5.38% 4.70% +0.67% $81M
ROIV 3.16% 2.49% +0.67% $48M
ISRG 3.29% 2.74% +0.54% $50M
EXAS 1.32% 0.79% +0.53% $20M
PHVS 1.22% 0.74% +0.49% $18M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
LLY 0.00% 5.41% -5.41% $0
NTRA 16.53% 18.72% -2.19% $250M
IDYA 1.66% 3.23% -1.56% $25M
INSM 1.00% 2.26% -1.26% $15M
INZY 0.00% 1.22% -1.22% $0
ABBV 2.32% 3.53% -1.21% $35M
REPL 0.00% 1.20% -1.20% $0
ANAB 0.52% 1.64% -1.12% $8M
QURE 0.53% 1.55% -1.02% $8M
SNDX 0.00% 1.02% -1.02% $0
RYTM 1.65% 2.65% -0.99% $25M
YMAB 0.00% 0.71% -0.71% $0
SUPN 1.19% 1.80% -0.61% $18M
AKRO 1.49% 2.09% -0.60% $22M
AVBP 2.07% 2.64% -0.57% $31M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 2 $35M 2.3%
Large Cap 15 $973M 64.5%
Mid Cap 22 $326M 21.6%
Small Cap 14 $166M 11.0%
Micro Cap 5 $9M 0.6%

Portfolio Analytics

Avg Market Cap
$38.6B
Median Market Cap
$3.2B
Avg P/E
34.1
Median P/E
24.8
Avg Dividend Yield
0.00%
Avg Beta
0.77
# Stocks
58
# ETFs / Funds
0

Top Holdings (58 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 NTRA 16.53% 1,550,280 $250M $160.97 -$12M
2 GILD 9.21% 1,252,312 $139M $111.00 $23M +202,004 +19.2%
3 VERA 5.38% 2,793,987 $81M $29.06 $15M
4 UTHR 5.29% 190,626 $80M $419.21 $46M +72,113 +60.9%
5 JAZZ 5.14% 588,828 $78M $131.80 $4M -105,268 -15.2%
6 RAPP 3.83% 1,947,579 $58M $29.70 $35M -48,015 -2.4%
7 BSX 3.68% 569,427 $56M $97.63 $9M +138,227 +32.1%
8 DXCM 3.48% 779,616 $52M $67.29 $7M +255,922 +48.9%
9 ISRG 3.29% 110,896 $50M $447.23 $11M +40,254 +57.0%
10 AXSM 3.17% 393,499 $48M $121.45 $38M +299,889 +320.4%
11 ROIV 3.16% 3,149,270 $48M $15.13 $13M +60,456 +2.0%
12 VRTX 3.06% 117,875 $46M $391.64 +117,875 NEW
13 BBIO 2.86% 831,847 $43M $51.94 $324K -161,246 -16.2%
14 RNAM 2.53% 875,925 $38M $43.57 $22M +291,124 +49.8%
15 ABBV 2.32% 150,966 $35M $231.54 -$14M -114,884 -43.2%
16 AVBP 2.07% 1,696,752 $31M $18.45 -$6M
17 COGT 2.02% 2,127,941 $31M $14.36 $14M -227,564 -9.7%
18 GKOS 1.69% 312,994 $26M $81.55 +312,994 NEW
19 IDYA 1.66% 922,695 $25M $27.21 -$20M -1,225,100 -57.0%
20 RYTM 1.65% 246,966 $25M $100.99 -$12M -339,044 -57.9%
21 AKRO 1.49% 473,625 $22M $47.48 -$7M -75,163 -13.7%
22 EXAS 1.32% 365,000 $20M $54.71 $9M +156,700 +75.2%
23 IMTX 1.26% 2,227,837 $19M $8.52 $7M -12,691 -0.6%
24 PHVS 1.22% 739,876 $18M $24.95 $8M +154,344 +26.4%
25 SUPN 1.19% 377,066 $18M $47.79 -$7M -422,187 -52.8%
26 RCUS 1.10% 1,222,263 $17M $13.60 $7M +6,247 +0.5%
27 MRUS 1.04% 166,729 $16M $94.15 -$6M -237,833 -58.8%
28 INSM 1.00% 104,339 $15M $144.01 -$17M -209,584 -66.8%
29 BIOA 0.89% 2,293,788 $13M $5.88 $4M -11,113 -0.5%
30 CELC 0.83% 253,375 $13M $49.40 +253,375 NEW
31 DYN 0.83% 985,828 $12M $12.65 $7M +370,963 +60.3%
32 PTCT 0.76% 186,932 $11M $61.37 -$7M -189,007 -50.3%
33 GEHC 0.75% 151,085 $11M $75.10 +151,085 NEW
34 SVRA 0.57% 2,427,724 $9M $3.57 $3M -29,628 -1.2%
35 EWTX 0.56% 520,240 $8M $16.22 -$960K -196,633 -27.4%
36 QURE 0.53% 136,862 $8M $58.37 -$14M -1,421,494 -91.2%
37 ANAB 0.52% 254,268 $8M $30.62 -$15M -778,094 -75.4%
38 CMPX 0.47% 2,028,886 $7M $3.50 +2,028,886 NEW
39 NKTR 0.45% 118,419 $7M $56.90 +118,419 NEW
40 CDTX 0.34% 54,197 $5M $95.76 -$7M -196,834 -78.4%
41 IMNM 0.34% 436,051 $5M $11.71 -$2M -342,425 -44.0%
42 NXTC 0.09% 222,654 $1M $5.86 +222,654 NEW
43 WVE 0.08% 170,943 $1M $7.32 $485K +53,040 +45.0%
44 SRRK 0.08% 31,410 $1M $37.24 $233K +4,970 +18.8%
45 JBIO 0.06% 107,391 $927K $8.63 -$146K
46 IRON 0.06% 13,553 $896K $66.08 $508K +6,241 +85.3%
47 BOLT 0.05% 137,721 $733K $5.32 -$62K
48 ACAD 0.04% 26,800 $572K $21.34 +26,800 NEW
49 ESTA 0.03% 10,787 $442K $40.99 -$759K -17,333 -61.6%
50 IMA 0.02% 31,884 $260K $8.15 +31,884 NEW
51 INZY —% -$17M -4,280,308 -100.0% SOLD
52 LLY —% -$76M -97,018 -100.0% SOLD
53 YMAB —% -$10M -2,194,278 -100.0% SOLD
54 SNDX —% -$14M -1,524,440 -100.0% SOLD
55 REPL —% -$17M -1,806,529 -100.0% SOLD
56 GPCR —% -$712K -34,353 -100.0% SOLD
57 MTSR —% -$1M -36,191 -100.0% SOLD
58 IKNA —% -$513K -382,616 -100.0% SOLD

Options Breakdown

5 Calls $36M Call Value 8 Puts $163M Put Value 4.5 P/C Ratio

Top Calls

SymbolSharesValueStatus
SMMT 900,000 $19M
QURE 300,000 $18M NEW
ROIV $0 SOLD
CDTX $0 SOLD
COGT $0 SOLD

Top Puts

SymbolSharesValueStatus
IBB 325,000 $47M
UTHR 97,100 $41M NEW
XBI 400,000 $40M NEW
QURE 500,000 $29M NEW
LQDA 250,000 $6M NEW
IWM $0 SOLD
REPL $0 SOLD
RYTM $0 SOLD

New Positions

SymbolValue% Port
VRTX $46M 3.06%
GKOS $26M 1.69%
CELC $13M 0.83%
GEHC $11M 0.75%
CMPX $7M 0.47%
NKTR $7M 0.45%
NXTC $1M 0.09%
ACAD $572K 0.04%
IMA $260K 0.02%

Sold Out Positions

SymbolValue% Port
LLY —%
GPCR —%
SNDX —%
REPL —%
MTSR —%
IKNA —%
INZY —%
YMAB —%
View SEC EDGAR Filings for Sofinnova Investments, Inc. →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms