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Asset Manager ← All Institutions

Affinity Asset Advisors, LLC

Q4 2025 · Filed 2026-02-13
Market Value
$1.1B
+19.8%
Holdings
83
+4
New Purchases
16
Added To
19
Closed
18
Reduced
18
Top 10 Concentration
47.3%
Turnover
41.0%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
VTYX 5.33% 1.33% +4.00% $59M
ABVX 6.20% 3.33% +2.86% $68M
CYTK 4.63% 2.10% +2.53% $51M
WVE 4.18% 1.68% +2.50% $46M
ROIV 3.36% 1.32% +2.04% $37M
TERN 2.02% 0.00% +2.02% $22M
ANAB 1.96% 0.00% +1.96% $22M
BBIO 2.23% 0.37% +1.86% $24M
SYRE 4.27% 2.59% +1.68% $47M
CGEM 1.82% 0.17% +1.65% $20M
PTGX 1.37% 0.00% +1.37% $15M
COGT 1.13% 0.00% +1.13% $12M
SVRA 1.53% 0.58% +0.95% $17M
JBIO 1.00% 0.06% +0.94% $11M
TEVA 3.98% 3.08% +0.89% $44M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
VRNA 0.00% 7.27% -7.27% $0
SPY 0.00% 6.14% -6.14% $0
MDGL 1.65% 5.75% -4.10% $18M
MRUS 0.00% 2.93% -2.93% $0
QURE 0.11% 1.91% -1.80% $1M
RZLT 0.50% 2.15% -1.65% $6M
CNTA 1.37% 2.93% -1.56% $15M
ALKS 2.55% 4.09% -1.54% $28M
ACLX 3.11% 4.48% -1.37% $34M
XENE 5.10% 6.13% -1.03% $56M
TARS 0.00% 0.81% -0.81% $0
AKBA 0.00% 0.73% -0.73% $0
DNTH 0.43% 1.12% -0.69% $5M
MLYS 2.41% 3.10% -0.69% $26M
NUVL 2.95% 3.63% -0.67% $32M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 1 $0 0.0%
Large Cap 11 $217M 19.8%
Mid Cap 29 $551M 50.1%
Small Cap 26 $296M 26.9%
Micro Cap 16 $34M 3.1%

Portfolio Analytics

Avg Market Cap
$16.6B
Median Market Cap
$2.0B
Avg P/E
20.0
Median P/E
21.3
Avg Dividend Yield
0.00%
Avg Beta
0.79
# Stocks
82
# ETFs / Funds
1

Top Holdings (83 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 INSM 7.13% 450,000 $78M $174.04 $14M
2 ABVX 6.20% 505,000 $68M $134.85 $38M +145,000 +40.3%
3 VTYX 5.33% 6,484,558 $59M $9.03 $46M +2,560,143 +65.2%
4 XENE 5.10% 1,250,000 $56M $44.82 -$185K -150,000 -10.7%
5 CYTK 4.63% 800,000 $51M $63.54 $32M +450,000 +128.6%
6 SYRE 4.27% 1,432,591 $47M $32.76 $23M +13,292 +0.9%
7 WVE 4.18% 2,700,000 $46M $17.00 $31M +600,000 +28.6%
8 TEVA 3.98% 1,400,000 $44M $31.21 $15M
9 ROIV 3.36% 1,700,000 $37M $21.70 $25M +900,000 +112.5%
10 ACLX 3.11% 523,725 $34M $65.20 -$7M +23,725 +4.8%
11 NUVL 2.95% 322,633 $32M $100.59 -$791K -61,784 -16.1%
12 LXEO 2.89% 3,200,000 $32M $9.93 $6M -670,527 -17.3%
13 ALKS 2.55% 1,000,000 $28M $27.98 -$10M -250,000 -20.0%
14 TRVI 2.45% 2,150,172 $27M $12.52 $1M -649,828 -23.2%
15 MLYS 2.41% 730,000 $26M $36.29 -$2M -20,000 -2.7%
16 BBIO 2.23% 320,000 $24M $76.49 $21M +255,000 +392.3%
17 ORKA 2.21% 802,342 $24M $30.31 $6M -156,838 -16.4%
18 TERN 2.02% 550,000 $22M $40.40 +550,000 NEW
19 ANAB 1.96% 444,692 $22M $48.48 +444,692 NEW
20 CGEM 1.82% 1,932,106 $20M $10.35 $18M +1,668,289 +632.4%
21 NRIX 1.67% 967,620 $18M $18.97 $9M
22 TSHA 1.65% 3,300,000 $18M $5.50 $8M +300,000 +10.0%
23 MDGL 1.65% 31,131 $18M $582.34 -$35M -83,869 -72.9%
24 SVRA 1.53% 2,797,153 $17M $6.03 $12M +1,297,153 +86.5%
25 PTGX 1.37% 172,125 $15M $87.34 +172,125 NEW
26 CNTA 1.37% 600,552 $15M $25.01 -$12M -506,610 -45.8%
27 ESTA 1.33% 200,000 $15M $72.88 $2M -110,000 -35.5%
28 ERAS 1.32% 3,900,000 $15M $3.72 $5M -385,787 -9.0%
29 VERA 1.15% 250,000 $13M $50.64 $4M -53,330 -17.6%
30 COGT 1.13% 350,000 $12M $35.52 +350,000 NEW
31 OVID 1.06% 7,150,000 $12M $1.63 $8M +4,500,000 +169.8%
32 TVTX 1.04% 300,000 $11M $38.21 -$487K -200,000 -40.0%
33 JBIO 1.00% 714,956 $11M $15.43 $10M +649,639 +994.6%
34 CLDX 0.87% 350,000 $10M $27.16 $2M +50,000 +16.7%
35 TNGX 0.81% 1,000,000 $9M $8.86 +1,000,000 NEW
36 RVMD 0.72% 100,000 $8M $79.65 $3M
37 MBX 0.72% 250,000 $8M $31.54 $5M +85,000 +51.5%
38 VRDN 0.71% 250,000 $8M $31.12 $2M
39 RCUS 0.65% 300,000 $7M $23.83 +300,000 NEW
40 SGMT 0.62% 1,148,245 $7M $5.92 $4M +798,245 +228.1%
41 KPTI 0.60% 889,575 $7M $7.36 +889,575 NEW
42 VRCA 0.53% 707,338 $6M $8.31 +707,338 NEW
43 RZLT 0.50% 2,351,144 $6M $2.36 -$14M +251,144 +12.0%
44 CLYM 0.47% 1,300,000 $5M $4.00 $3M
45 IMVT 0.46% 200,000 $5M $25.42 $248K -100,000 -33.3%
46 PRQR 0.45% 2,454,278 $5M $2.02 -$3M -1,145,722 -31.8%
47 DNTH 0.43% 115,000 $5M $41.21 -$6M -147,100 -56.1%
48 ARWR 0.42% 70,000 $5M $66.39 +70,000 NEW
49 NXTC 0.32% 247,294 $4M $14.19 $2M +55,412 +28.9%
50 CRNX 0.32% 75,000 $3M $46.55 $368K
51 AMGN 0.30% 10,000 $3M $327.31 +10,000 NEW
52 BLTE 0.29% 20,000 $3M $159.96 +20,000 NEW
53 AVBP 0.27% 150,000 $3M $20.12 +150,000 NEW
54 MRSN 0.26% 100,000 $3M $28.93 +100,000 NEW
55 AVR 0.22% 486,684 $2M $4.99 $404K +36,684 +8.2%
56 OBIO 0.22% 572,804 $2M $4.15 $574K -154,468 -21.2%
57 GERN 0.18% 1,500,000 $2M $1.32 -$75K
58 RARE 0.16% 75,000 $2M $23.00 +75,000 NEW
59 CMPS 0.13% 200,000 $1M $6.90 $234K
60 QURE 0.11% 50,000 $1M $23.93 -$16M -250,000 -83.3%
61 CATX 0.08% 300,000 $825K $2.75 -$204K
62 MGNX 0.07% 484,308 $780K $1.61 +484,308 NEW
63 XFOR 0.05% 145,000 $580K $4.00 +145,000 NEW
64 QTTB 0.01% 27,777 $92K $3.32 $37K
65 ADGM 0.01% 80,000 $83K $1.04 -$72K
66 SPRY —% -$25K -2,500 -100.0% SOLD
67 JAZZ —% -$3M -25,000 -100.0% SOLD
68 OCUL —% -$3M -239,000 -100.0% SOLD
69 OLMA —% -$2M -250,000 -100.0% SOLD
70 STRO —% -$654K -752,722 -100.0% SOLD
71 AUTL —% -$3M -1,750,000 -100.0% SOLD
72 MIST —% -$1M -666,666 -100.0% SOLD
73 INSP —% -$4M -50,000 -100.0% SOLD
74 UTHR —% -$2M -5,000 -100.0% SOLD
75 MRUS —% -$27M -285,769 -100.0% SOLD
76 CNTX —% -$390K -402,653 -100.0% SOLD
77 AKBA —% -$7M -2,450,000 -100.0% SOLD
78 ATXS —% -$2M -300,000 -100.0% SOLD
79 RPTX —% -$352K -200,000 -100.0% SOLD
80 VRNA —% -$67M -625,000 -100.0% SOLD
81 PCVX —% -$5M -125,000 -100.0% SOLD
82 TARS —% -$7M -125,000 -100.0% SOLD
83 SPY —% -$56M -84,490 -100.0% SOLD

Options Breakdown

10 Calls $172M Call Value 6 Puts $191M Put Value 1.11 P/C Ratio

Top Calls

SymbolSharesValueStatus
IBB 400,000 $68M NEW
AMGN 135,000 $44M NEW
XLV 250,000 $39M NEW
QURE 800,000 $19M NEW
ABUS 521,900 $3M
OLMA $0 SOLD
NTLA $0 SOLD
INSM $0 SOLD
EXEL $0 SOLD
KPTI $0 SOLD

Top Puts

SymbolSharesValueStatus
XBI 1,500,000 $183M NEW
SMMT 350,000 $6M
LENZ 100,000 $2M NEW
EXEL $0 SOLD
OMER $0 SOLD
ATYR $0 SOLD

New Positions

SymbolValue% Port
TERN $22M 2.02%
ANAB $22M 1.96%
PTGX $15M 1.37%
COGT $12M 1.13%
TNGX $9M 0.81%
RCUS $7M 0.65%
KPTI $7M 0.60%
VRCA $6M 0.53%
ARWR $5M 0.42%
AMGN $3M 0.30%
BLTE $3M 0.29%
AVBP $3M 0.27%
MRSN $3M 0.26%
RARE $2M 0.16%
MGNX $780K 0.07%

Sold Out Positions

SymbolValue% Port
INSP —%
AUTL —%
JAZZ —%
MIST —%
AKBA —%
OCUL —%
PCVX —%
TARS —%
UTHR —%
SPY —%
STRO —%
CNTX —%
OLMA —%
SPRY —%
MRUS —%
View SEC EDGAR Filings for Affinity Asset Advisors, LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms