KPTI Institutional Ownership
Karyopharm Therapeutics Inc.
1W: -50.5%
1M: -55.2%
3M: -91.7%
YTD: -88.8%
1Y: -87.1%
3Y: -96.1%
5Y: -99.1%
$0.80
-0.06 (-7.45%)
Weekly Expected Move ±20.4%
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Institutional Ownership — KPTI
119
Institutional Holders
+23 vs prior quarter
0.0%
Ownership
+0.00pp
$196M
Total Invested
36
New Positions
31
Increased
27
Reduced
14
Closed
0.65
Put/Call Ratio
Ownership Trends
Top Institutional Holders (122 total)
| # | Holder | Shares | Value | Change | Change % | Holding Period | Filing |
|---|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 1,917,354 | $$2M | — | +0.0% | 2Q | SEC ↗ |
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,521,322 | $$1M | -285,000 | -15.8% | 6Q | SEC ↗ |
| 3 | ACORN CAPITAL ADVISORS, LLC | 1,518,113 | $$1M | +1,230,287 | +427.4% | 2Q | SEC ↗ |
| 4 | GOLDMAN SACHS GROUP INC | 1,424,658 | $$1M | +477,079 | +50.3% | 2Q | SEC ↗ |
| 5 | BlackRock, Inc. | 1,418,799 | $$1M | +1,173,900 | +479.3% | 6Q | SEC ↗ |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 958,979 | $$769K | +219,234 | +29.6% | 2Q | SEC ↗ |
| 7 | Catalio Capital Management, LP | 940,855 | $$755K | +43,146 | +4.8% | 6Q | SEC ↗ |
| 8 | Avidity Partners Management LP | 924,487 | $$742K | +460,746 | +99.4% | 6Q | SEC ↗ |
| 9 | T. Rowe Price Investment Management, I | 786,309 | $$631K | -755,781 | -49.0% | 6Q | SEC ↗ |
| 10 | TWO SIGMA INVESTMENTS, LP | 695,264 | $$558K | +544,032 | +359.7% | 3Q | SEC ↗ |
| 11 | Kalehua Capital Management LLC NEW | 685,644 | $$550K | — | +0.0% | 1Q | SEC ↗ |
| 12 | NEA Management Company, LLC NEW | 576,780 | $$463K | — | +0.0% | 1Q | SEC ↗ |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 531,231 | $$426K | +325,098 | +157.7% | 6Q | SEC ↗ |
| 14 | Ghisallo Capital Management LLC NEW | 500,000 | $$401K | — | +0.0% | 1Q | SEC ↗ |
| 15 | Soleus Capital Management, L.P. | 440,000 | $$353K | — | +0.0% | 3Q | SEC ↗ |
| 16 | UBS Group AG | 353,545 | $$284K | +159,528 | +82.2% | 6Q | SEC ↗ |
| 17 | STATE STREET CORP | 325,991 | $$262K | +245,249 | +303.7% | 6Q | SEC ↗ |
| 18 | Affinity Asset Advisors, LLC | 312,500 | $$251K | -187,500 | -37.5% | 3Q | SEC ↗ |
| 19 | Brevan Howard Capital Management LP | 309,817 | $$249K | +97,450 | +45.9% | 2Q | SEC ↗ |
| 20 | MILLENNIUM MANAGEMENT LLC | 305,676 | $$245K | -114,895 | -27.3% | 2Q | SEC ↗ |
| 21 | Boxer Capital Management, LLC | 302,536 | $$243K | — | +0.0% | 3Q | SEC ↗ |
| 22 | Davidson Kempner Capital Management LP | 300,000 | $$241K | — | +0.0% | 3Q | SEC ↗ |
| 23 | ACADIAN ASSET MANAGEMENT LLC | 298,997 | $$240K | +50,040 | +20.1% | 3Q | SEC ↗ |
| 24 | SILVERARC CAPITAL MANAGEMENT, LLC NEW | 297,460 | $$239K | — | +0.0% | 1Q | SEC ↗ |
| 25 | Eversept Partners, LP | 276,174 | $$222K | — | +0.0% | 2Q | SEC ↗ |
| 26 | JPMORGAN CHASE & CO | 207,609 | $$167K | +207,138 | +43978.3% | 6Q | SEC ↗ |
| 27 | MORGAN STANLEY | 202,506 | $$162K | +183,936 | +990.5% | 6Q | SEC ↗ |
| 28 | Trexquant Investment LP | 188,368 | $$151K | -69,535 | -27.0% | 3Q | SEC ↗ |
| 29 | BNP PARIBAS FINANCIAL MARKETS | 188,038 | $$151K | +187,954 | +223754.8% | 6Q | SEC ↗ |
| 30 | BARCLAYS PLC | 165,904 | $$133K | +158,480 | +2134.7% | 6Q | SEC ↗ |
| 31 | NORTHERN TRUST CORP | 160,006 | $$128K | +121,450 | +315.0% | 6Q | SEC ↗ |
| 32 | VANGUARD FIDUCIARY TRUST CO | 145,401 | $$117K | +30,467 | +26.5% | 2Q | SEC ↗ |
| 33 | VANGUARD PORTFOLIO MANAGEMENT LLC NEW | 134,818 | $$108K | — | +0.0% | 1Q | SEC ↗ |
| 34 | MARSHALL WACE, LLP | 128,451 | $$103K | — | +0.0% | 6Q | SEC ↗ |
| 35 | RENAISSANCE TECHNOLOGIES LLC | 108,214 | $$87K | +2,800 | +2.7% | 6Q | SEC ↗ |
| 36 | C WorldWide Group Holding A/S | 100,000 | $$80K | — | +0.0% | 6Q | SEC ↗ |
| 37 | Jump Financial, LLC | 94,000 | $$75K | -168,146 | -64.1% | 3Q | SEC ↗ |
| 38 | Invesco Ltd. | 90,304 | $$72K | +73,566 | +439.5% | 2Q | SEC ↗ |
| 39 | Connor, Clark & Lunn Investment Manage | 76,397 | $$61K | -2,684 | -3.4% | 3Q | SEC ↗ |
| 40 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 71,873 | $$58K | — | +0.0% | 5Q | SEC ↗ |
| 41 | J. Goldman & Co LP NEW | 67,500 | $$54K | — | +0.0% | 1Q | SEC ↗ |
| 42 | Squarepoint Ops LLC NEW | 63,801 | $$51K | — | +0.0% | 1Q | SEC ↗ |
| 43 | Sixth Street Partners Management Compa NEW | 61,943 | $$50K | — | +0.0% | 1Q | SEC ↗ |
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT I | 61,943 | $$50K | +48,514 | +361.3% | 2Q | SEC ↗ |
| 45 | ROYAL BANK OF CANADA | 60,430 | $$48K | +57 | +0.1% | 6Q | SEC ↗ |
| 46 | Bank of New York Mellon Corp | 57,262 | $$46K | +45,863 | +402.3% | 6Q | SEC ↗ |
| 47 | Susquehanna Portfolio Strategies, LLC | 54,545 | $$44K | +29,524 | +118.0% | 2Q | SEC ↗ |
| 48 | XTX Topco Ltd | 53,272 | $$43K | -111,171 | -67.6% | 5Q | SEC ↗ |
| 49 | CITADEL ADVISORS LLC NEW | 52,069 | $$42K | — | +0.0% | 1Q | SEC ↗ |
| 50 | BANK OF AMERICA CORP /DE | 49,924 | $$40K | +30,452 | +156.4% | 6Q | SEC ↗ |
Recent Activity
New Positions (20)
| Holder | Shares | Value |
|---|---|---|
| Kalehua Capital Management LLC | 685,644 | $$550K |
| NEA Management Company, LLC | 576,780 | $$463K |
| Ghisallo Capital Management LLC | 500,000 | $$401K |
| SILVERARC CAPITAL MANAGEMENT, LLC | 297,460 | $$239K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 134,818 | $$108K |
| J. Goldman & Co LP | 67,500 | $$54K |
| Squarepoint Ops LLC | 63,801 | $$51K |
| Sixth Street Partners Management Co | 61,943 | $$50K |
| CITADEL ADVISORS LLC | 52,069 | $$42K |
| Nuveen, LLC | 37,868 | $$30K |
| NOMURA ASSET MANAGEMENT INTERNATION | 33,333 | $$27K |
| TORONTO DOMINION BANK | 30,930 | $$25K |
| ExodusPoint Capital Management, LP | 26,582 | $$21K |
| SIMPLEX TRADING, LLC | 24,086 | $$19K |
| RHUMBLINE ADVISERS | 23,467 | $$19K |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS | 23,265 | $$19K |
| DEUTSCHE BANK AG | 19,425 | $$16K |
| WELLS FARGO & COMPANY/MN | 16,903 | $$14K |
| SEI INVESTMENTS CO | 15,083 | $$12K |
| Headlands Technologies LLC | 12,113 | $$10K |
Sold Out (20)
| Holder | Prev Shares | Prev Value |
|---|---|---|
| Commodore Capital LP | 1,950,000 | $$2M |
| Opaleye Management Inc. | 930,000 | $$746K |
| Ikarian Capital, LLC | 733,435 | $$588K |
| BRAIDWELL LP | 303,370 | $$243K |
| Exome Asset Management LLC | 295,541 | $$237K |
| AMERIPRISE FINANCIAL INC | 276,881 | $$222K |
| BOOTHBAY FUND MANAGEMENT, LLC | 213,810 | $$172K |
| GROUP ONE TRADING LLC | 191,527 | $$154K |
| ADAR1 Capital Management, LLC | 136,736 | $$110K |
| Walleye Capital LLC | 95,672 | $$77K |
| Balyasny Asset Management L.P. | 70,748 | $$57K |
| Context Capital Management, LLC | 62,995 | $$51K |
| Tetragon Partners GP Ltd | 52,984 | $$43K |
| DAFNA Capital Management LLC | 45,800 | $$37K |
| Zimmer Partners, LP | 37,500 | $$30K |
| Centiva Capital, LP | 30,210 | $$24K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,723 | $$23K |
| SUSQUEHANNA INTERNATIONAL GROUP, LL | 24,138 | $$19K |
| OMERS ADMINISTRATION Corp | 19,400 | $$16K |
| TUDOR INVESTMENT CORP ET AL | 12,922 | $$10K |
Biggest Increases (20)
| Holder | Added | Change % | Total Shares |
|---|---|---|---|
| ACORN CAPITAL ADVISORS, LLC | +1,230,287 | +427.4% | 1,518,113 |
| BlackRock, Inc. | +1,173,900 | +479.3% | 1,418,799 |
| TWO SIGMA INVESTMENTS, LP | +544,032 | +359.7% | 695,264 |
| GOLDMAN SACHS GROUP INC | +477,079 | +50.3% | 1,424,658 |
| Avidity Partners Management LP | +460,746 | +99.4% | 924,487 |
| GEODE CAPITAL MANAGEMENT, LLC | +325,098 | +157.7% | 531,231 |
| STATE STREET CORP | +245,249 | +303.7% | 325,991 |
| VANGUARD CAPITAL MANAGEMENT LLC | +219,234 | +29.6% | 958,979 |
| JPMORGAN CHASE & CO | +207,138 | +43978.3% | 207,609 |
| BNP PARIBAS FINANCIAL MARKETS | +187,954 | +223754.8% | 188,038 |
| MORGAN STANLEY | +183,936 | +990.5% | 202,506 |
| UBS Group AG | +159,528 | +82.2% | 353,545 |
| BARCLAYS PLC | +158,480 | +2134.7% | 165,904 |
| NORTHERN TRUST CORP | +121,450 | +315.0% | 160,006 |
| Brevan Howard Capital Management LP | +97,450 | +45.9% | 309,817 |
| Invesco Ltd. | +73,566 | +439.5% | 90,304 |
| ACADIAN ASSET MANAGEMENT LLC | +50,040 | +20.1% | 298,997 |
| CHARLES SCHWAB INVESTMENT MANAGEMEN | +48,514 | +361.3% | 61,943 |
| Bank of New York Mellon Corp | +45,863 | +402.3% | 57,262 |
| Catalio Capital Management, LP | +43,146 | +4.8% | 940,855 |
Biggest Decreases (13)
| Holder | Reduced | Change % | Total Shares |
|---|---|---|---|
| T. Rowe Price Investment Management | -755,781 | -49.0% | 786,309 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | -285,000 | -15.8% | 1,521,322 |
| Affinity Asset Advisors, LLC | -187,500 | -37.5% | 312,500 |
| Jump Financial, LLC | -168,146 | -64.1% | 94,000 |
| MILLENNIUM MANAGEMENT LLC | -114,895 | -27.3% | 305,676 |
| XTX Topco Ltd | -111,171 | -67.6% | 53,272 |
| Engineers Gate Manager LP | -78,466 | -69.8% | 33,966 |
| JANE STREET GROUP, LLC | -72,728 | -68.7% | 33,173 |
| Trexquant Investment LP | -69,535 | -27.0% | 188,368 |
| SILVERBACK ASSET MANAGEMENT LLC | -35,000 | -53.8% | 30,000 |
| China Universal Asset Management Co | -5,000 | -16.7% | 25,000 |
| Connor, Clark & Lunn Investment Man | -2,684 | -3.4% | 76,397 |
| Quent Capital, LLC | -69 | -29.4% | 166 |