Asset Manager
← All Institutions
ORBIMED ADVISORS LLC
Market Value
$5.1B
+14.3%
Holdings
132
+12
New Purchases
32
Added To
31
Closed
20
Reduced
23
Top 10 Concentration
44.6%
Turnover
39.4%
Top Buys (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| EWTX | 12.38% | 10.97% | +1.40% | $631M |
| UNH | 1.31% | 0.00% | +1.31% | $67M |
| ASND | 1.28% | 0.00% | +1.28% | $65M |
| HUM | 1.28% | 0.00% | +1.28% | $65M |
| MBX | 3.72% | 2.44% | +1.28% | $189M |
| LLY | 6.07% | 4.89% | +1.18% | $309M |
| ODTX | 1.10% | 0.00% | +1.10% | $56M |
| ARQT | 1.05% | 0.00% | +1.05% | $54M |
| COGT | 1.28% | 0.28% | +1.00% | $65M |
| GH | 1.72% | 0.90% | +0.82% | $88M |
| GPCR | 2.33% | 1.60% | +0.73% | $119M |
| QTTB | 1.03% | 0.32% | +0.71% | $53M |
| PRLD | 1.44% | 0.84% | +0.60% | $73M |
| PVLA | 0.88% | 0.38% | +0.50% | $45M |
| WST | 0.50% | 0.00% | +0.50% | $25M |
Top Sells (by % of Portfolio)
| Symbol | Cur % | Prior % | Chg % | Value |
|---|---|---|---|---|
| MYGN | 0.00% | 2.76% | -2.76% | $0 |
| BSX | 1.24% | 3.36% | -2.11% | $63M |
| PFE | 0.00% | 1.23% | -1.23% | $0 |
| CMPX | 0.65% | 1.81% | -1.15% | $33M |
| DHR | 0.00% | 1.13% | -1.13% | $0 |
| IRON | 0.51% | 1.53% | -1.02% | $26M |
| SION | 2.21% | 3.18% | -0.97% | $112M |
| RCEL | 0.00% | 0.95% | -0.95% | $0 |
| ISRG | 1.23% | 2.16% | -0.93% | $63M |
| ALNY | 0.10% | 0.88% | -0.78% | $5M |
| EW | 1.48% | 2.21% | -0.73% | $76M |
| ESPR | 0.00% | 0.65% | -0.65% | $0 |
| ARGX | 1.69% | 2.24% | -0.55% | $86M |
| SVA | 3.62% | 4.14% | -0.52% | $184M |
| BTSG | 0.00% | 0.48% | -0.48% | $0 |
Sector Allocation Over Time
Market Cap Concentration
| Tier | Holdings | Value | Weight |
|---|---|---|---|
| Mega Cap | 6 | $678M | 13.3% |
| Large Cap | 21 | $797M | 15.6% |
| Mid Cap | 33 | $2.0B | 39.9% |
| Small Cap | 44 | $1.1B | 21.4% |
| Micro Cap | 28 | $496M | 9.7% |
Portfolio Analytics
Avg Market Cap
$32.1B
Median Market Cap
$1.6B
Avg P/E
43.5
Median P/E
36.7
Avg Dividend Yield
0.01%
Avg Beta
0.94
# Stocks
132
# ETFs / Funds
0
Top Holdings (132 total)
| # | Symbol | % Port | Shares | Value | Avg Price | Q/Q Value Chg | Share Chg | Chg % | Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | EWTX | 12.38% | 15,518,492 | $631M | $40.63 | $142M | — | — | |
| 2 | ELVN | 6.75% | 6,776,632 | $344M | $50.75 | $32M | -1,182,906 | -14.9% | |
| 3 | LLY | 6.07% | 257,900 | $309M | $1,199.43 | $92M | +21,100 | +8.9% | |
| 4 | MBX | 3.72% | 3,428,736 | $189M | $55.20 | $81M | -209,151 | -5.8% | |
| 5 | SVA | 3.62% | 2,718,735 | $184M | $67.85 | — | — | — | |
| 6 | AZN | 3.36% | 915,700 | $171M | $186.83 | $39M | +245,500 | +36.6% | |
| 7 | GPCR | 2.33% | 2,209,400 | $119M | $53.67 | $47M | +733,997 | +49.8% | |
| 8 | SION | 2.21% | 2,555,877 | $112M | $43.99 | -$29M | -974,825 | -27.6% | |
| 9 | CRVS | 2.10% | 7,165,006 | $107M | $14.94 | $2M | — | — | |
| 10 | AVBP | 2.06% | 3,027,328 | $105M | $34.74 | $35M | — | — | |
| 11 | GH | 1.72% | 583,700 | $88M | $150.03 | $47M | +148,500 | +34.1% | |
| 12 | ARGX | 1.69% | 92,880 | $86M | $927.77 | -$14M | -44,020 | -32.1% | |
| 13 | MRK | 1.67% | 663,400 | $85M | $128.50 | $5M | — | — | |
| 14 | PRAX | 1.51% | 230,100 | $77M | $334.79 | $21M | +57,600 | +33.4% | |
| 15 | EW | 1.48% | 834,900 | $76M | $90.46 | -$23M | -395,700 | -32.2% | |
| 16 | PRLD | 1.44% | 13,724,571 | $73M | $5.33 | $36M | +2,815,315 | +25.8% | |
| 17 | ABVX | 1.43% | 546,522 | $73M | $133.26 | $21M | +80,822 | +17.4% | |
| 18 | DYN | 1.41% | 3,235,684 | $72M | $22.21 | $19M | +317,800 | +10.9% | |
| 19 | NTRA | 1.40% | 262,000 | $71M | $271.45 | $19M | — | — | |
| 20 | CGON | 1.36% | 972,800 | $69M | $71.05 | $5M | +24,533 | +2.6% | |
| 21 | UNH | 1.31% | 161,100 | $67M | $415.63 | — | +161,100 | — | NEW |
| 22 | SBTX | 1.30% | 8,288,510 | $66M | $8.01 | -$166K | — | — | |
| 23 | ASND | 1.28% | 244,456 | $65M | $266.72 | — | +244,456 | — | NEW |
| 24 | HUM | 1.28% | 164,100 | $65M | $397.22 | — | +164,100 | — | NEW |
| 25 | COGT | 1.28% | 1,681,300 | $65M | $38.70 | $53M | +1,359,200 | +422.0% | |
| 26 | BSX | 1.24% | 1,483,200 | $63M | $42.68 | -$86M | -898,900 | -37.7% | |
| 27 | ISRG | 1.23% | 157,900 | $63M | $397.68 | -$33M | -50,800 | -24.3% | |
| 28 | MLYS | 1.12% | 2,110,300 | $57M | $26.98 | $1M | +57,400 | +2.8% | |
| 29 | ODTX | 1.10% | 3,001,198 | $56M | $18.71 | — | +3,001,198 | — | NEW |
| 30 | XENE | 1.06% | 892,471 | $54M | $60.36 | -$8M | -167,500 | -15.8% | |
| 31 | ARQT | 1.05% | 2,042,000 | $54M | $26.22 | — | +2,042,000 | — | NEW |
| 32 | BMY | 1.05% | 925,000 | $53M | $57.62 | -$3M | — | — | |
| 33 | QTTB | 1.03% | 4,127,987 | $53M | $12.74 | $38M | +1,875,000 | +83.2% | |
| 34 | SYK | 0.98% | 159,100 | $50M | $314.84 | -$10M | -23,400 | -12.8% | |
| 35 | CAI | 0.98% | 2,806,811 | $50M | $17.82 | -$168K | — | — | |
| 36 | TMO | 0.89% | 90,700 | $45M | $501.36 | $23M | +44,200 | +95.0% | |
| 37 | PVLA | 0.88% | 292,360 | $45M | $152.82 | $28M | +157,760 | +117.2% | |
| 38 | ANTM | 0.87% | 114,700 | $44M | $386.73 | $11M | — | — | |
| 39 | STTK | 0.86% | 6,306,127 | $44M | $6.94 | $3M | — | — | |
| 40 | UPB | 0.77% | 5,693,589 | $39M | $6.92 | -$12M | — | — | |
| 41 | CRNX | 0.73% | 999,000 | $37M | $37.42 | $1M | — | — | |
| 42 | RYTM | 0.70% | 322,900 | $36M | $111.03 | $9M | +8,800 | +2.8% | |
| 43 | SNDX | 0.66% | 1,542,000 | $34M | $21.86 | $11M | +579,700 | +60.2% | |
| 44 | FBRX | 0.66% | 1,577,705 | $34M | $21.25 | $3M | +380,750 | +31.8% | |
| 45 | CMPX | 0.65% | 15,219,994 | $33M | $2.19 | -$47M | — | — | |
| 46 | NKTR | 0.64% | 465,346 | $32M | $69.81 | $13M | +190,346 | +69.2% | |
| 47 | KRYS | 0.61% | 83,200 | $31M | $371.67 | $13M | +14,100 | +20.4% | |
| 48 | AXSM | 0.56% | 117,578 | $29M | $244.77 | -$7M | -96,343 | -45.0% | |
| 49 | TRVI | 0.52% | 1,430,293 | $27M | $18.65 | -$3M | -1,024,107 | -41.7% | |
| 50 | IRON | 0.51% | 357,535 | $26M | $73.14 | -$42M | -710,015 | -66.5% | |
| 51 | WST | 0.50% | 70,600 | $25M | $359.00 | — | +70,600 | — | NEW |
| 52 | RLMD | 0.49% | 3,631,195 | $25M | $6.92 | -$8M | -1,084,669 | -23.0% | |
| 53 | STRO | 0.48% | 743,944 | $25M | $33.20 | $5M | -57,200 | -7.1% | |
| 54 | SVRA | 0.48% | 3,959,900 | $24M | $6.16 | $21M | +3,324,900 | +523.6% | |
| 55 | NPCE | 0.47% | 1,505,125 | $24M | $15.89 | -$4M | -591,402 | -28.2% | |
| 56 | AURA | 0.46% | 3,333,333 | $24M | $7.10 | — | +3,333,333 | — | NEW |
| 57 | ORIC | 0.43% | 2,015,000 | $22M | $10.83 | -$12M | -678,929 | -25.2% | |
| 58 | HELP | 0.42% | 3,271,400 | $22M | $6.61 | $3M | -561,443 | -14.7% | |
| 59 | BCRX | 0.36% | 1,852,000 | $19M | $10.00 | $5M | +426,800 | +29.9% | |
| 60 | BIOA | 0.36% | 752,153 | $18M | $24.51 | $6M | +40,342 | +5.7% | |
| 61 | LXEO | 0.36% | 3,947,850 | $18M | $4.66 | -$2M | +345,400 | +9.6% | |
| 62 | WHWK | 0.35% | 3,934,296 | $18M | $4.58 | $4M | -231,704 | -5.6% | |
| 63 | DFTX | 0.34% | 365,400 | $17M | $47.04 | $2M | -438,600 | -54.5% | |
| 64 | SYRE | 0.32% | 186,145 | $17M | $88.78 | — | +186,145 | — | NEW |
| 65 | CRBP | 0.32% | 1,737,287 | $16M | $9.38 | -$17K | — | — | |
| 66 | VERA | 0.31% | 369,596 | $16M | $42.91 | $991K | — | — | |
| 67 | ALMS | 0.30% | 548,163 | $15M | $28.14 | $3M | — | — | |
| 68 | EYPT | 0.30% | 1,069,147 | $15M | $14.30 | $2M | — | — | |
| 69 | WAT | 0.30% | 40,300 | $15M | $375.04 | — | +40,300 | — | NEW |
| 70 | MNPR | 0.29% | 157,423 | $15M | $92.59 | — | +157,423 | — | NEW |
| 71 | TVTX | 0.28% | 253,000 | $14M | $56.81 | — | +253,000 | — | NEW |
| 72 | TSHA | 0.27% | 2,000,000 | $14M | $6.81 | — | +2,000,000 | — | NEW |
| 73 | BIIB | 0.26% | 61,600 | $13M | $216.06 | $2M | — | — | |
| 74 | RVMD | 0.26% | 70,500 | $13M | $187.28 | $8M | +18,500 | +35.6% | |
| 75 | DNTH | 0.22% | 115,000 | $11M | $97.48 | — | +115,000 | — | NEW |
| 76 | SPRB | 0.21% | 200,000 | $11M | $54.00 | — | +200,000 | — | NEW |
| 77 | LFST | 0.20% | 947,400 | $10M | $10.71 | $7M | +447,400 | +89.5% | |
| 78 | ERAS | 0.18% | 495,900 | $9M | $18.32 | — | +495,900 | — | NEW |
| 79 | TARA | 0.17% | 2,220,000 | $8M | $3.82 | — | +2,220,000 | — | NEW |
| 80 | KROS | 0.16% | 759,155 | $8M | $10.70 | -$258K | — | — | |
| 81 | JANX | 0.16% | 524,700 | $8M | $15.36 | -$6M | -458,900 | -46.7% | |
| 82 | TECX | 0.15% | 226,600 | $8M | $34.38 | $785K | — | — | |
| 83 | ACET | 0.14% | 844,787 | $7M | $8.64 | $299K | -183,157 | -17.8% | |
| 84 | ANRO | 0.13% | 257,852 | $7M | $26.39 | $3M | +90,352 | +53.9% | |
| 85 | ZNTL | 0.13% | 1,390,576 | $7M | $4.85 | — | +1,390,576 | — | NEW |
| 86 | DRUG | 0.13% | 93,000 | $7M | $70.20 | $4M | +53,000 | +132.5% | |
| 87 | ALXO | 0.12% | 2,866,256 | $6M | $2.07 | $186K | — | — | |
| 88 | XLO | 0.11% | 592,300 | $6M | $9.58 | — | +592,300 | — | NEW |
| 89 | BCAX | 0.11% | 191,100 | $6M | $29.69 | -$8M | -476,200 | -71.4% | |
| 90 | IMA | 0.11% | 909,269 | $5M | $5.90 | $3M | +530,713 | +140.2% | |
| 91 | PTGX | 0.10% | 42,100 | $5M | $122.58 | $723K | — | — | |
| 92 | ALNY | 0.10% | 17,000 | $5M | $301.03 | -$34M | -102,000 | -85.7% | |
| 93 | PALI | 0.10% | 2,333,000 | $5M | $2.09 | $793K | — | — | |
| 94 | ATAI | 0.08% | 797,500 | $4M | $5.27 | $3M | +450,500 | +129.8% | |
| 95 | PTCT | 0.08% | 49,100 | $4M | $81.57 | $660K | — | — | |
| 96 | AORT | 0.08% | 175,000 | $4M | $22.47 | -$2M | +24,000 | +15.9% | |
| 97 | NMRA | 0.07% | 2,139,882 | $4M | $1.70 | — | +2,139,882 | — | NEW |
| 98 | ACAD | 0.07% | 137,000 | $3M | $25.30 | — | +137,000 | — | NEW |
| 99 | AMLX | 0.06% | 183,400 | $3M | $17.96 | — | +183,400 | — | NEW |
| 100 | TYRA | 0.06% | 102,000 | $3M | $31.94 | — | +102,000 | — | NEW |
Options Breakdown
8 Calls
$69M Call Value
2 Puts
$49M Put Value
0.71 P/C Ratio