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Asset Manager ← All Institutions

ORBIMED ADVISORS LLC

Q2 2025 · Filed 2025-08-14
Market Value
$3.6B
-4.7%
Holdings
103
-3
New Purchases
12
Added To
18
Closed
18
Reduced
20
Top 10 Concentration
48.3%
Turnover
29.1%

Top Buys (by % of Portfolio)

SymbolCur %Prior %Chg %Value
CAI 2.26% 0.00% +2.26% $81M
SPRY 4.03% 2.77% +1.26% $145M
BSX 8.42% 7.53% +0.89% $302M
ROIV 0.87% 0.00% +0.87% $31M
UPB 1.74% 0.92% +0.82% $63M
EW 3.72% 2.95% +0.77% $134M
SION 1.79% 1.03% +0.76% $64M
NTRA 2.79% 2.05% +0.74% $100M
ALNY 3.11% 2.48% +0.63% $111M
THC 2.28% 1.66% +0.62% $82M
ISRG 4.41% 3.82% +0.58% $158M
VRTX 2.61% 2.06% +0.55% $94M
CTMX 0.54% 0.00% +0.54% $19M
MBX 1.27% 0.78% +0.49% $46M
SYK 3.96% 3.55% +0.41% $142M

Top Sells (by % of Portfolio)

SymbolCur %Prior %Chg %Value
EWTX 5.67% 8.77% -3.10% $203M
PFE 0.00% 2.59% -2.59% $0
IONS 0.00% 2.03% -2.03% $0
NBIX 1.54% 2.74% -1.21% $55M
TMO 0.53% 1.70% -1.18% $19M
SWTX 0.00% 1.11% -1.11% $0
XTNT 0.00% 0.91% -0.91% $0
TARS 0.22% 0.89% -0.67% $8M
CYTK 0.99% 1.61% -0.62% $36M
ITGR 1.48% 2.07% -0.59% $53M
GILD 0.00% 0.59% -0.59% $0
0LOV.L 0.00% 0.46% -0.46% $0
AMGN 0.00% 0.37% -0.37% $0
VERA 0.00% 0.31% -0.31% $0
NPCE 0.81% 1.11% -0.30% $29M

Sector Allocation Over Time

Market Cap Concentration

TierHoldingsValueWeight
Mega Cap 2 $368M 10.3%
Large Cap 20 $1.5B 41.0%
Mid Cap 26 $898M 25.0%
Small Cap 36 $720M 20.1%
Micro Cap 19 $130M 3.6%

Portfolio Analytics

Avg Market Cap
$28.5B
Median Market Cap
$1.7B
Avg P/E
37.1
Median P/E
29.4
Avg Dividend Yield
0.00%
Avg Beta
0.83
# Stocks
103
# ETFs / Funds
0

Top Holdings (103 total)

# Symbol % Port Shares Value Avg Price Q/Q Value Chg Share Chg Chg % Status
1 BSX 8.42% 2,813,200 $302M $107.41 $18M
2 LLY 7.33% 337,600 $263M $779.53 -$16M
3 EWTX 5.67% 15,518,492 $203M $13.11 -$127M +496,771 +3.3%
4 ELVN 4.45% 7,959,538 $160M $20.06 $3M
5 ISRG 4.41% 291,000 $158M $543.41 $14M
6 SPRY 4.03% 8,288,510 $145M $17.45 $40M
7 SYK 3.96% 359,200 $142M $395.63 $8M
8 EW 3.72% 1,708,000 $134M $78.21 $23M +176,000 +11.5%
9 ARGX 3.19% 208,000 $115M $551.22 -$8M +1,300 +0.6%
10 ALNY 3.11% 341,900 $111M $326.09 $18M -4,200 -1.2%
11 UNH 2.92% 336,300 $105M $311.97 -$463K +135,100 +67.2%
12 NTRA 2.79% 593,434 $100M $168.94 $23M +46,434 +8.5%
13 VRTX 2.61% 210,287 $94M $445.20 $16M +50,387 +31.5%
14 THC 2.28% 465,000 $82M $176.00 $19M
15 CAI 2.26% 3,034,858 $81M $26.72 +3,034,858 NEW
16 IRON 2.09% 1,415,020 $75M $52.96 $5M
17 AVBP 1.84% 3,027,328 $66M $21.77 $10M
18 SION 1.79% 3,704,959 $64M $17.35 $26M
19 UPB 1.74% 5,693,589 $63M $10.98 $28M
20 NBIX 1.54% 438,540 $55M $125.69 -$48M -496,100 -53.1%
21 ITGR 1.48% 433,400 $53M $122.97 -$25M -229,100 -34.6%
22 RNAM 1.43% 1,812,886 $51M $28.40 -$2M
23 CGON 1.36% 1,877,850 $49M $26.00 -$12M -594,144 -24.0%
24 SIBN 1.35% 2,578,979 $49M $18.82 $233K -863,874 -25.1%
25 MBX 1.27% 4,002,887 $46M $11.41 $16M
26 AXSM 1.24% 427,900 $45M $104.39 -$432K +41,200 +10.7%
27 CMPX 1.10% 15,219,994 $40M $2.60 -$3M -7,142,856 -31.9%
28 CYTK 0.99% 1,077,000 $36M $33.04 -$25M -432,205 -28.6%
29 CRNX 0.92% 1,149,000 $33M $28.76 -$461K +150,000 +15.0%
30 EXAS 0.90% 607,316 $32M $53.14 $3M -72,500 -10.7%
31 THRD 0.87% 5,779,071 $31M $5.43 $11M
32 ROIV 0.87% 2,779,427 $31M $11.27 +2,779,427 NEW
33 XENE 0.83% 947,877 $30M $31.30 -$2M
34 NPCE 0.81% 2,614,184 $29M $11.14 -$13M -792,151 -23.3%
35 CRVS 0.80% 7,165,006 $29M $4.00 $7M +221,352 +3.2%
36 TERN 0.79% 7,562,971 $28M $3.73 $7M
37 JANX 0.78% 1,210,300 $28M $23.10 $7M +451,734 +59.5%
38 APLS 0.71% 1,482,300 $26M $17.31 -$6M +50,000 +3.5%
39 GPCR 0.69% 1,199,300 $25M $20.74 $14M +547,272 +83.9%
40 SCPH 0.64% 6,059,528 $23M $3.81 $7M
41 CTMX 0.54% 8,461,500 $19M $2.27 +8,461,500 NEW
42 TMO 0.53% 46,500 $19M $405.46 -$45M -82,500 -64.0%
43 AGIO 0.52% 557,900 $19M $33.26 $9M +232,400 +71.4%
44 TRVI 0.50% 3,308,400 $18M $5.47 $11M +2,188,400 +195.4%
45 ADCT 0.44% 5,907,351 $16M $2.68 $7M -61,100 -1.0%
46 RYTM 0.44% 248,512 $16M $63.19 -$4M -131,488 -34.6%
47 CGEM 0.40% 1,923,855 $14M $7.53 -$77K
48 KROS 0.38% 1,018,734 $14M $13.35 $3M
49 RAPT 0.37% 1,641,906 $13M $8.00 +1,641,906 NEW
50 FOLD 0.36% 2,285,400 $13M $5.73 -$6M
51 VIR 0.33% 2,380,715 $12M $5.04 -$3M +132,466 +5.9%
52 ABCL 0.32% 3,344,568 $11M $3.43 $2M -836,200 -20.0%
53 AKRO 0.31% 211,300 $11M $53.36 $4M +31,400 +17.4%
54 MLYS 0.29% 760,351 $10M $13.53 +760,351 NEW
55 DYN 0.27% 1,031,400 $10M $9.52 -$794K +16,789 +1.6%
56 CCCC 0.27% 6,830,300 $10M $1.43 -$1M
57 ORIC 0.25% 899,281 $9M $10.15 $5M +199,281 +28.5%
58 CPRX 0.25% 416,900 $9M $21.70 +416,900 NEW
59 PRLD 0.25% 10,909,256 $9M $0.81 $452K
60 0SZI.L 0.23% 1,172,287 $8M $6.90 $2M
61 ZLAB 0.23% 231,000 $8M $34.97 +231,000 NEW
62 TARS 0.22% 197,900 $8M $40.51 -$26M -455,843 -69.7%
63 WHWK 0.22% 4,166,000 $8M $1.87 $375K
64 TYRA 0.21% 804,603 $8M $9.57 -$9M -948,228 -54.1%
65 ACET 0.19% 11,447,140 $7M $0.61 -$2M
66 ITOS 0.19% 700,000 $7M $9.97 +700,000 NEW
67 PMVP 0.19% 6,475,291 $7M $1.06 -$194K
68 URGN 0.18% 478,400 $7M $13.70 +478,400 NEW
69 ALMS 0.16% 1,926,423 $6M $3.00 +1,926,423 NEW
70 JBIO 0.15% 531,163 $5M $9.99 +531,163 NEW
71 IKNA 0.13% 3,539,358 $5M $1.34 $212K
72 RPTX 0.13% 3,322,488 $5M $1.39 $1M
73 IMTX 0.11% 719,901 $4M $5.38 -$10M -2,367,561 -76.7%
74 BIOA 0.11% 921,959 $4M $4.13 $341K
75 QTTB 0.09% 2,252,987 $3M $1.49 -$360K
76 AMLX 0.06% 313,200 $2M $6.41 $776K -34,800 -10.0%
77 INSM 0.04% 13,459 $1M $100.64 -$832K -15,200 -53.0%
78 KRYS 0.04% 9,200 $1M $137.46 -$3M -14,300 -60.9%
79 TSBX 0.03% 3,099,265 $1M $0.36 -$158K
80 TRAW 0.02% 605,531 $896K $1.48 -$497K
81 ANRO 0.02% 250,000 $550K $2.20 $10K
82 LYEL 0.01% 51,727 $457K $8.84 +51,727 NEW
83 KRRO 0.01% 32,400 $405K $12.49 -$159K
84 XERS 0.01% 80,420 $376K $4.67 -$66K
85 LSBCF —% 54,799 $56K $1.02 -$288K -85,629 -61.0%
86 KMTS —% -$6M -250,000 -100.0% SOLD
87 SRRK —% -$5M -151,800 -100.0% SOLD
88 IONS —% -$77M -2,540,136 -100.0% SOLD
89 ADGI —% -$565K -933,500 -100.0% SOLD
90 BCAX —% -$4M -298,301 -100.0% SOLD
91 NKTX —% -$2M -821,400 -100.0% SOLD
92 CRDF —% -$2M -573,884 -100.0% SOLD
93 SLRN —% -$10M -4,001,711 -100.0% SOLD
94 TNGX —% -$754K -550,000 -100.0% SOLD
95 XTNT —% -$34M -73,114,592 -100.0% SOLD
96 AMGN —% -$14M -44,200 -100.0% SOLD
97 VERA —% -$12M -481,065 -100.0% SOLD
98 0LOV.L —% -$17M -2,862,448 -100.0% SOLD
99 GILD —% -$22M -197,500 -100.0% SOLD
100 FATE —% -$1M -1,680,580 -100.0% SOLD

Options Breakdown

7 Calls $20M Call Value 1 Puts $116K Put Value 0.01 P/C Ratio

Top Calls

SymbolSharesValueStatus
UNH 50,000 $16M NEW
CGON 150,000 $4M NEW
APLS 50,000 $866K NEW
SWTX $0 SOLD
PFE $0 SOLD
GPCR $0 SOLD
XBI $0 SOLD

Top Puts

SymbolSharesValueStatus
INMB 50,000 $116K NEW

New Positions

SymbolValue% Port
CAI $81M 2.26%
ROIV $31M 0.87%
CTMX $19M 0.54%
RAPT $13M 0.37%
MLYS $10M 0.29%
CPRX $9M 0.25%
ZLAB $8M 0.23%
ITOS $7M 0.19%
URGN $7M 0.18%
ALMS $6M 0.16%
JBIO $5M 0.15%
LYEL $457K 0.01%

Sold Out Positions

SymbolValue% Port
PFE —%
CBLL —%
BCAX —%
FATE —%
GILD —%
CRDF —%
IONS —%
KMTS —%
AMGN —%
XTNT —%
VERA —%
NKTX —%
SRRK —%
TNGX —%
0LOV.L —%
View SEC EDGAR Filings for ORBIMED ADVISORS LLC →

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For informational purposes only. Not investment advice. Data sourced from SEC filings. Privacy Terms